Steatohepatitis Center

  • Steatohepatitis Services

    Non-Alcoholic Fatty Liver Disease (NAFLD) is a growing epidemic

    With the growing obesity epidemic, NAFLD is now believed to be the most common liver disease worldwide, affecting an estimated 10 percent of children and one-third of adults in the United States alone. The most severe form of NAFLD, nonalcoholic steatohepatitis (NASH) affects 2-3 percent of all adults and children, but is found in approximately 25 percent of children who have fatty liver. Up to one-quarter of patients with NASH may go on to more severe fibrosis, cirrhosis and end-stage liver disease.  Over the last decade, NASH has become the third leading cause of liver transplantation in adults and severe scarring (cirrhosis) can begin to develop in childhood and adolescence.  Therefore, the goal is to identify children and adolescents at risk for NAFLD and NASH, so that progression to cirrhosis and end-stage liver disease can be prevented. The majority of patients with pediatric NAFLD or NASH are overweight or obese, and many have associated health problems, such as insulin resistance, diabetes mellitus, obstructive sleep apnea, hypertension and dyslipidemia (features of metabolic syndrome).  Achieving a healthier weight through better diet and increased activity can be very successful in improving or resolving NALFLD / NASH.  Other treatments are also being evaluated in clinical studies funded by the National Institutes of Health.

    The Steatohepatitis Center can help

    Comprehensive clinical care includes:

    • Standardized care so each patient receives the highest quality and safest care
    • Standard screening for closely related obesity co-morbidities and needed referrals to other subspecialties (endocrinology, pulmonary medicine, cardiology) as needed
    • Comprehensive dietary assessments: a registered dietitian will complete and monitor a dietary assessment for all patients and offer family-based, individualized recommendations
    • Referral of interested patients to the Comprehensive Weight Management Program at Cincinnati Children’s, which includes both non-surgical (HealthWorks!) and surgical (Surgical Weight Loss Program for Teens) weight-management programs

    Cutting-edge research and trials: