Thrombotic Microangiopathy (aHUS and TTP)

  • Meet the Team

    The thrombotic microangiopathy (TMA) team at Cincinnati Children’s is comprised of specialists in human and molecular genetics, hematology and nephrology.

  • Show All

    Doctors and Researchers

    A photo of Bradley P. Dixon.

    Bradley P. Dixon, MD
    Pediatric Nephrologist

    513-636-4531

    bradley.dixon@cchmc.org

    Bradley P. Dixon, MD

    Pediatric Nephrologist

    Assistant Professor, UC Department of Pediatrics

    Phone: 513-636-4531

    Fax: 513-636-7407

    Email: bradley.dixon@cchmc.org

    Show All

    Specialties

    DNA damage response; DNA repair; hyperosmolal microenvironments; atypical hemolytic uremic syndrome; thrombotic microangiopathies; complement-mediated renal diseases.

    Visit the Dixon Lab.

    Biography

    Bradley Dixon, MD, joined the faculty in the Division of Nephrology and Hypertension at Cincinnati Children's in 2006. He has received support for his research from a William Cooper Procter Pediatric Research Award in 2006, a Child Health Research Career Development Award (K12) in 2009, and is currently funded by a K08 through the National Institute of Diabetes, Digestive and Kidney Diseases. Dr. Dixon’s research interests focus on the effects of hyperosmolal microenvironments such as the renal medulla and urinary bladder upon vital cellular processes such as the DNA damage response pathway and activation of cell cycle checkpoints and apoptosis. This research focus attempts to understand the susceptibility of the gastrointestinal tissues used in bladder reconstructions to carcinogenesis.

    In addition to his basic science research interests, Dr. Dixon has a clinical research interest in thrombotic microangiopathies such as atypical hemolytic uremic syndrome (aHUS) and thrombotic thrombocytopenic purpura (TTP), and is an investigator in a number of clinical trials and registries for these diseases. Dr. Dixon is also involved in clinical research studying cystic kidney diseases such as autosomal dominant polycystic kidney disease (ADPKD).

    Education and Training

    BA: College of Wooster, Wooster, OH, 1995.

    MD: University of Tennessee, Memphis, 1999.

    Residency: Cincinnati Children's Hospital Medical Center, 1999-2002.

    Chief Residency: Cincinnati Childrens Hospital, 2002-2003.

    Fellowship: Cincinnati Childrens Hospital, 2003-2006.

    Publications

    View PubMed Publications

    Grants

    DNA Damage and Response in the Bladder Microenvironment. Principal Investigator. National Institutes of Health. Jul 2011 - Apr 2015. #K08 DK081737.
    A photo of Ralph A. Gruppo.

    Ralph A. Gruppo, MD
    Director, Comprehensive Hemophilia and Thrombosis Center

    513-636-4269

    ralph.gruppo@cchmc.org

    Ralph A. Gruppo, MD

    Director, Comprehensive Hemophilia and Thrombosis Center

    Director, Research Coagulation Laboratory

    Director, Special Hemostasis & Thrombosis Laboratory

    Professor, UC Department of Pediatrics

    Phone: 513-636-4269

    Fax: 513-636-5845

    Email: ralph.gruppo@cchmc.org

    Show All

    Specialties

    Coagulation; hemophilia; thrombosis

    Education and Training

    MD: Johns Hopkins Medical School, Baltimore, MD, 1967.

    Residency: Children's Hospital Medical Center, Cincinnati, Ohio; Johns Hopkins School of Medicine, Baltimore, MD, 1970.

    Fellowship: Children's Hospital Medical Center, Cincinnati, OH, 1974.

    Certification: Pediatrics, 1975; Pediatric Hematology/Oncology, 1976.

    Publications

    View PubMed Publications

    Sonata Jodele, MD

    Associate Professor, UC Department of Pediatrics

    Phone: 513-636-1565

    Fax: 513-636-3549

    Email: sonata.jodele@cchmc.org

    Show All

    Specialties

    Bone marrow transplantation

    Education and Training

    MD: Vilnius University School of Medicine, 1988-1994.

    Residency: Pediatrics, Downstate HSC at Brooklyn, Brooklyn, NY, 1998-2001.

    Fellowship: Pediatric Hematology Oncology, Children's Hospital Los Angeles and Saban Research Institute, Keck School of Medicine University of Southern California, Los Angeles, CA, 2001-2004.

    Certifications: Pediatrics, 2001; Pediatric Hematology / Oncology, 2004.

    Licenses: California, 2001-present; Ohio, 2004-present.

    Publications

    View PubMed Publications