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The Tuberous Sclerosis Clinic at Cincinnati Children's is home to specialists with a variety of backgrounds and areas of focus. As a team, this diversity makes us better prepared to care for your child's unique needs.
David Neal Franz, MD Director, Tuberous Sclerosis Clinic
Director, Tuberous Sclerosis Clinic
Associate Director of Clinical Affairs, Division of Neurology
Professor, UC Department of Pediatrics
Tuberous sclerosis (adults and children); neuropharmacology; neurocutaneous disorders; general pediatric neurology
David Neal Franz, MD, was born and raised in Dayton, Ohio. He received his undergraduate degree in history and literature from Earlham College in Richmond, Indiana.
After completing his training, he served as assistant professor of neurology and pediatrics at Wright State University before returning to Cincinnati Children's Hospital Medical Center.
He established the Cincinnati Tuberous Sclerosis Clinic in 1993, to assist in the medical care of patients who have or are suspected of having tuberous sclerosis. The purpose of the clinic is not to replace care from the child's pediatrician or family physician, but to assist the primary care physician in dealing with those aspects unique to tuberous sclerosis that affect the child's health or development. The basis of the clinic is the realization that people with tuberous sclerosis are different from other individuals who have epilepsy, learning disabilities, behavior problems, etc.
For too long, the unique problems found in this disease have been lumped together with similar disorders, despite the fact that research has shown that disorders of the brain, heart, kidney, and other organs in tuberous sclerosis are quite different.
Franz DN, Bissler JJ, McCormack FX. Tuberous sclerosis complex: neurological, renal and pulmonary manifestations. Neuropediatrics. 2010 Oct;41(5):199-208.
Krueger DA, Care MM, Holland K, Agricola K, Tudor C, Mangeshkar P, Wilson KA, Byars A, Sahmoud T, Franz DN. Everolimus for subependymal giant-cell astrocytomas in tuberous sclerosis. N Engl J Med. 2010 Nov 4;363(19):1801-11.
Young LR, Vandyke R, Gulleman PM, Inoue Y, Brown KK, Schmidt LS, Linehan WM, Hajjar F, Kinder BW, Trapnell BC, Bissler JJ, Franz DN, McCormack FX. Serum vascular endothelial growth factor-D prospectively distinguishes lymphangioleiomyomatosis from other diseases. Chest. 2010 Sep;138(3):674-81.
Young LR, Franz DN, Nagarkatte P, Fletcher CD, Wikenheiser-Brokamp KA, Galsky MD, Corbridge TC, Lam AP, Gelfand MJ, McCormack FX. Utility of [18F]2-fluoro-2-deoxyglucose-PET in sporadic and tuberous sclerosis-associated lymphangioleiomyomatosis. Chest. 2009 Sep;136(3):926-33.
Schmithorst VJ, Altes TA, Young LR, Franz DN, Bissler JJ, McCormack FX, Dardzinski BJ, Brody AS. Automated algorithm for quantifying the extent of cystic change on volumetric chest CT: initial results in Lymphangioleiomyomatosis. AJR Am J Roentgenol. 2009 Apr;192(4):1037-44.
Krueger DA, Franz DN. Current management of tuberous sclerosis complex. Paediatr Drugs. 2008;10(5):299-313. Review.
Bissler JJ, McCormack FX, Young LR, Elwing JM, Chuck G, Leonard JM, Schmithorst VJ, Laor T, Brody AS, Bean J, Salisbury S, Franz DN. Sirolimus for angiomyolipoma in tuberous sclerosis complex or lymphangioleiomyomatosis. N Engl J Med. 2008 Jan 10;358(2):140-51.
Levine NB, Collins J, Franz DN, Crone KR. Gradual formation of an operative corridor by balloon dilation for resection of subependymal giant cell astrocytomas in children with tuberous sclerosis: specialized minimal access technique of balloon dilation. Minim Invasive Neurosurg. 2006 Oct;49(5):317-20.
Collins JJ, Tudor C, Leonard JM, Chuck G, Franz DN. Levetiracetam as adjunctive antiepileptic therapy for patients with tuberous sclerosis complex: a retrospective open-label trial. J Child Neurol. 2006 Jan;21(1):53-7.
Franz DN, Leonard J, Tudor C, Chuck G, Care M, Sethuraman G, Dinopoulos A, Thomas G, Crone KR. Rapamycin causes regression of astrocytomas in tuberous sclerosis complex. Ann Neurol. 2006 Mar;59(3):490-8.
Jamie K. Capal, MD Pediatric Neurologist, Division of Neurology
Pediatric Neurologist, Division of Neurology
Assistant Professor, UC Department of Pediatrics
Child neurology; developmental pediatrics; autism; tuberous sclerosis
Autism spectrum disorders; tuberous sclerosis
Dr. Capal’s clinical and research interests focus on children with autism spectrum disorders and related neurodevelopmental conditions. Current research projects include understanding the cognitive, behavioral, and language aspects of children with autism spectrum disorders and abnormal EEG but not always with concurrent clinical seizures. A natural extension of my research has led to interest in tuberous sclerosis complex (TSC), where autism, abnormal EEG, and seizures are frequent and interdependent. The genetic and molecular basis of TSC is well established, which provides an ideal platform for further investigation into the underlying mechanisms responsible and, in turn, discover new molecular-based targeted therapies. The TSC Clinic at Cincinnati Children’s Hospital Medical Center is the largest of its kind in the world, providing comprehensive, multidisciplinary clinical care to TSC patients of any age. This work led efforts that resulted in the first ever FDA-approved medical therapy for TSC in 2010 using the mTOR inhibitor everolimus. Our long-term goal is to refine and apply these and next-generation therapies for patients with TSC.
BA: Biology with Honors, Ithaca College, Ithaca, NY, 2002.
MD: Albany Medical College, Albany, NY, 2002.
Internship: Pediatrics, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, 2006-2007.
Residency: Pediatrics, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, 2007-2008.
Resident/Fellow: Pediatric Neurodevelopmental Disabilities, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, 2008-1012.
Kerry R. Crone, MD
Professor, UC Department of Surgery
Minimal access surgery; including endoscopic surgery; chiari malformations; brain tumors; design and implementation of patient safety initiatives and clinical outcomes studies
Chiari malformations; brain tumors; telemedicine
MD: University of Cincinnati, Cincinnati, OH, 1978.
Residency: Neurosurgery, Bowman-Gray School of Medicine, Winston-Salem, NC.
Fellowship: Pediatric Neurosurgery, The Hospital for Sick Children, Toronto, Ontario, Canada, 1986.
Phillips CL, Miles L, Jones BV, Sutton M, Crone K, Fouladi M. Medulloblastoma with melanotic differentiation: case report and review of the literature. J Neurooncol. 2010 Oct 16. Stevenson CB, Leach JL, Gupta A, Crone KR. Cystic degeneration of the cerebellar tonsils in pediatric patients with Chiari Type I malformation. J Neurosurg Pediatr. 2009 Dec;4(6):557-63. Air E, Ghomri YM, Tyagi R, Grande AW, Crone K, and Mangano FT. Management of Vagal Nerve Stimulator Infections. Do they need to be removed? J Neurosurg Pediatr. 2009; 3(1): 73-78.Yuan W, Holland S, Jones BV, Crone K, and Mangano FT. Characterization of Abnormal Diffusion Properties of Supratentorial Brain Tumors: A Preliminary DTI Study. J Neurosurg Pediatr. 2009; 1(4): 263-269.Agabegi SS, Antekeier DP, Crawford AH, Crone KR. Postlaminectomy kyphosis in an achondroplastic adolescent treated for spinal stenosis. Orthopedics. 2008 Feb;31(2):168. Neely JC 2nd, Jones BV, Crone KR. Spontaneous extracranial decompression of epidural hematoma. Pediatr Radiol. 2008; 38(3):316-8.
Levine NB, Miller MN, Crone KR. Endoscopic resection of colloid cysts: Indications, technique, and results during a 13-year period. Minim Invas Neurosurg. 2007; 50:313-317.
Murray Dock, DDS, MSD Director, Residency Program
Director, Residency Program
Associate Professor, UC Department of Pediatrics
Primary care; cleft palate; sedation; dental pharmacology, dental treatment resident education
Enamel pitting and oral fibromas in tuberous sclerosis patients; familial vs. sporadic disease; comparison of PACU recovery in children undergoing dental rehabilitation; effectiveness of periodic reminder cards as a means to improve plaque index scores; dental health of patients following sialodochoplasty
DDS: Indiana University School of Dentistry, Indianapolis, IN, 1983.MSD: Indiana University School of Dentistry, Indianapolis, IN, 2000.BSPharm: Butler University College of Pharmacy, Indianapolis, IN, 1979.
Residency: Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 1987.Fellowship: Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 1988.Certification: American Board of Pediatric Dentistry, 1994.
Visscher MO, Sullivan D, Sullivan S, Barford B, Dock M, Sommers MS. Quantitation of epidermal and mucosal tissue injury using contrast agents and imaging techniques. Skin Res Technol. 2009 May;15(2):180-6.Park S, Dock M. Xeroderma pigmentosum: a case report. Pediatr Dent. 2003 Jul-Aug;25(4):397-400.
Dock, M. Pharmacologic Management of Patient Behavior. In McDonald and Avery’s (eds.) Dentistry for the Child and Adolescent. Mosby Elsevier, 2011.|Dock M, Greenhill W. Topics in Dentistry. In Shweder R (ed.) The Child – An Encyclopedic Companion. The University of Chicago Press: Chicago and London, 2009.Campbell R, Dock M. Dental Anomalies Associated with Cleft Palate. In Cleft Palate and Craniofacial Anomalies. 2nd ed. Clifton Park, NY: Thomson Delmar Learning, 2008. Greenhill W, Dock M. Dental Trauma in Pediatric Critical Care Medicine. In Pediatric Critical Care Medicine: Basic Science and Clinical Evidence. Springer Publication, 2007.
Dock M, Creedon RL. The Teeth and Oral Cavity. In Rudolph's Pediatrics. 21st ed. Appleton and Lange, March 2002.Dock M. Wet-Fingered Dentistry: Practical Advice from Experienced Dentists. Kenny and Casas (eds).Quintessence Publishing Company, 2002.
Timothy K. Knilans, MD Director, Clinical Cardiac Electrophysiology and Pacing
Director, Clinical Cardiac Electrophysiology and Pacing
Cardiac electrophysiology and pacing; radio frequency ablation; tilt table testing
Cardiac arrest; sudden cardiac death
Czosek RJ, Anderson JB, Marino BS, Mellion K, Knilans TK. Noninvasive risk stratification techniques in pediatric patients with ventricular preexcitation. Pacing Clin Electrophysiol. 2011 May;34(5):555-62.
Eghtesady P, Michelfelder EC, Knilans TK, Witte DP, Manning PB, Crombleholme TM. Fetal surgical management of congenital heart block in a hydropic fetus: Lessons learned from a clinical experience. J Thorac Cardiovasc Surg. 2011 Mar;141(3):835-7.
Czosek RJ, Anderson J, Marino BS, Connor C, Knilans TK. Linear lesion cryoablation for the treatment of atrioventricular nodal re-entry tachycardia in pediatrics and young adults. Pacing Clin Electrophysiol. 2010 Nov;33(11):1304-11.
Czosek RJ, Anderson JB, Cao J, Knilans TK. Assessment of T-wave oversensing in an infant with an implanted defibrillator. Heart Rhythm. 2010 Oct;7(10):1516-7.
Mays WA, Border WL, Knecht SK, Gerdes YM, Pfriem H, Claytor RP, Knilans TK, Hirsch R, Mone SM, Beekman RH 3rd. Exercise capacity improves after transcatheter closure of the Fontan fenestration in children. Congenit Heart Dis. 2008 Jul;3(4):254-61.
Knecht SK, Mays WA, Gerdes YM, Claytor RP, Knilans TK. Exercise evaluation of upper- versus lower-extremity blood pressure gradients in pediatric and young-adult participants. Pediatr Exerc Sci. 2007 Aug;19(3):344-8.
Wright KN, Knilans TK, Irvin HM. When, why, and how to perform cardiac radiofrequency catheter ablation. J Vet Cardiol. 2006 Nov;8(2):95-107.
Knilans TK. Multielectrode coronary artery catheterization: still an effective tool in ablation of right free-wall accessory pathways. J Cardiovasc Electrophysiol. 2004 Nov;15(11):1244-5.
Markham LW, Knecht SK, Daniels SR, Mays WA, Khoury PR, Knilans TK. Development of exercise-induced arm-leg blood pressure gradient and abnormal arterial compliance in patients with repaired coarctation of the aorta. Am J Cardiol. 2004 Nov 1;94(9):1200-2.
Beery TA, Dyment M, Shooner K, Knilans TK, Benson DW. A candidate locus approach identifies a long QT syndrome gene mutation. Biol Res Nurs. 2003 Oct;5(2):97-104.
Darcy A. Krueger, MD, PhD Associate Director of Research, Division of Neurology
Associate Director of Research, Division of Neurology
Tuberous sclerosis; general neurology
Tuberous sclerosis; clinical use of mTOR inhibitors; role of mTOR pathway in neurological disease
Greiner H, Leach JL, Lee KH, Krueger DA. Anti-NMDA receptor encephalitis presenting with imaging findings and clinical features mimicking Rasmussen syndrome. Seizure. 2011 Apr;20(3):266-70. Krueger DA, Care MM, Holland K, Agricola K, Tudor C, Mangeshkar P, Wilson KA, Byars A, Sahmoud T, Franz DN. Everolimus for subependymal giant-cell astrocytomas in tuberous sclerosis. N Engl J Med. 2010 Nov 4;363(19):1801-11.
Krueger DA, Franz DN. Current management of tuberous sclerosis complex. Paediatr Drugs. 2008;10(5):299-313.
Daniel A. Nelson, MD Medical Director, Child Psychiatry Unit
Medical Director, Child Psychiatry Unit
Associate Professor, Division of Pediatric Psychiatry
Inpatient and outpatient child psychiatry diagnosis, treatment and research; bipolar and mood disorders; attention deficit hyperactivity disorder; childhood trauma; behavioral disorders
Dr. Nelson is a recognized authority in counseling children and families who have experienced trauma -- from natural and man-made disasters to abuse. After the September 11th attacks in New York City, Nelson, along with other psychiatrists and psychologists, provided assistance to many victims' families.
In addition, Dr. Nelson supervised the Family Notification Center after the Oklahoma City bombing, which he designed to provide comprehensive psychological support to minimize the effects of trauma in that city. Nelson, who directs the inpatient child psychiatric unit at Cincinnati Children's Hospital Medical Center, also provides training and education in response to trauma. In 1999, he worked with teachers and counselors following a tornado that killed four people in the Cincinnati area and destroyed dozens of homes.
Dr. Nelson is on the advisory board for the National Center for School Crisis and Bereavement.
Elizabeth K. Schorry, MD Director, Neurofibromatosis Clinic
Director, Neurofibromatosis Clinic
Director, Adult Neurofibromatosis Clinic
Elizabeth Schorry, MD, received her undergraduate degree at the University of Cincinnati and her MD at the University of Michigan in Ann Arbor, Michigan.
Dr. Schorry completed a residency in pediatrics and a fellowship in medical genetics at Cincinnati Children's Hospital Medical Center. She has been a faculty member in the Division of Human Genetics at Cincinnati Children's since 1988.
Dr. Schorry provides medical management, genetic assessment and genetic counseling for children with a wide range of genetic disorders and congenital anomalies. She has a special interest in neurofibromatosis and tuberous sclerosis.
BS: Biology, University of Cincinnati, Cincinnati, OH, 1977.
MD: University of Michigan, Ann Arbor, MI, 1982.
Residency: Pediatrics, Children's Hospital Medical Center, Cincinnati, OH, 1982-1985.
Fellowship: Genetics, Children's Hospital Medical Center, Cincinnati, OH, 1985-1988.
Certification: American Board of Pediatrics, 1987; Clinical Genetics, American Board of Medical Genetics, 1987.
Prada CE, Zarate YA, Hagenbuch S, Lovell A, Schorry EK, Hopkin RJ. Lethal presentation of neurofibromatosis and Noonan syndrome. Am J Med Genet A. 2011 Jun;155A(6):1360-6.
Rieley MB, Stevenson DA, Viskochil DH, Tinkle BT, Martin LJ, Schorry EK. Variable expression of neurofibromatosis 1 in monozygotic twins. Am J Med Genet A. 2011 Mar;155A(3):478-85.
Huson SM, Acosta MT, Belzberg AJ, Bernards A, Chernoff J, Cichowski K, Gareth Evans D, Ferner RE, Giovannini M, Korf BR, Listernick R, North KN, Packer RJ, Parada LF, Peltonen J, Ramesh V, Reilly KM, Risner JW, Schorry EK, Upadhyaya M, Viskochil DH, Zhu Y, Hunter-Schaedle K, Giancotti FG. Back to the future: proceedings from the 2010 NF Conference. Am J Med Genet A. 2011 Feb;155(2):307-21.
Hummel TR, Jessen WJ, Miller SJ, Kluwe L, Mautner VF, Wallace MR, Lázaro C, Page GP, Worley PF, Aronow BJ, Schorry EK, Ratner N. Gene expression analysis identifies potential biomarkers of neurofibromatosis type 1 including adrenomedullin. Clin Cancer Res. 2010 Oct 15;16(20):5048-57.
Stevenson DA, Viskochil DH, Carey JC, Slater H, Murray M, Sheng X, D'Astous J, Hanson H, Schorry E, Moyer-Mileur LJ. Tibial geometry in individuals with neurofibromatosis type 1 without anterolateral bowing of the lower leg using peripheral quantitative computed tomography. Bone. 2009 Apr;44(4):585-9.
Elefteriou F, Kolanczyk M, Schindeler A, Viskochil DH, Hock JM, Schorry EK, Crawford AH, Friedman JM, Little D, Peltonen J, Carey JC, Feldman D, Yu X, Armstrong L, Birch P, Kendler DL, Mundlos S, Yang FC, Agiostratidou G, Hunter-Schaedle K, Stevenson DA. Skeletal abnormalities in neurofibromatosis type 1: approaches to therapeutic options. Am J Med Genet A. 2009 Oct;149A(10):2327-38.
Schorry EK, Keddache M, Lanphear N, Rubinstein JH, Srodulski S, Fletcher D, Blough-Pfau RI, Grabowski GA. Genotype-phenotype correlations in Rubinstein-Taybi syndrome. Am J Med Genet A. 2008 Oct 1;146A(19):2512-9. Crawford AH, Parikh S, Schorry EK, Von Stein D. The immature spine in type-1 neurofibromatosis. J Bone Joint Surg Am. 2007 Feb;89 Suppl 1:123-42. Zarate YA, Kogan JM, Schorry EK, Smolarek TA, Hopkin RJ. A new case of de novo 11q duplication in a patient with normal development and intelligence and review of the literature. Am J Med Genet A. 2007 Feb 1;143(3):265-70.
Tinkle BT, Miller E, Schorry EK. Gene symbol: COL1A2. Disease: osteogenesis imperfecta type II. Hum Genet. 2006 Jul;119(6):677.
Constance E. West, MD Pediatric Ophthalmologist
Associate Professor, UC Department of Ophthalmology
BS: Massachusetts Institute of Technology, Cambridge, MA, 1980.
MD: University of Massachusetts Medical School, North Worcester, MA, 1986.
Internship: St. John's Mercy Medical Center, St. Louis, MO, 1986-1987.
Residency: Ophthalmology,Barnes Hospital, Washington University Medical Center, St. Louis, MO, 1987-1990.
Fellowship: Pediatric Ophthalmology and Strabismus,Wilmer Ophthalmological Institute, Johns Hopkins University School of Medicine, Baltimore, MD 1990-1991.
Qu J, Wang Y, Tong Y, Zhou X, Zhao F, Yang L, Zhang S, Zhang J, West CE, Guan MX. Leber’s hereditary optic neuropathy affects only female matrilineal relatives in two Chinese Families. Invest Ophthalmol Vis Sci 2010; 51: 4906-12.
Motley WW 3rd, Vanderveen DK, West CE. Surgical management of infantile cataracts in dystrophic epidermolysis bullosa. J AAPOS. 2010 Jun;14(3):283-4.
Qu J, Zhou X, Zhang J, Zhao F, Sun YH, Tong Y, Wei QP, Cai W, Yang L, West CE. Extremely low penetrance of Leber's hereditary optic neuropathy in 8 Han Chinese families carrying the ND4 G11778A mutation. Ophthalmology. 2009;116:558-564 e3.
Bollinger KE, Kattouf V, Arthur B, Weiss AH, Kivlin J, Kerr N, West CE, Kipp M, Traboulsi EI. Hypermetropia and esotropia in myotonic dystrophy. J AAPOS. 2008; 12:69-71.
Li R, Qu J, Zhou X, Tong Y, Hu Y, Qian Y, Lu F, Mo JQ, West CE, Guan MX. The mitochondrial tRNA(Thr) A15951G mutation may influence the phenotypic expression of the LHON-associated ND4 G11778A mutation in a Chinese family. Gene. 2006 Jul 5;376(1):79-86.
Qu J, Li R, Zhou X, Tong Y, Lu F, Qian Y, Hu Y, Mo JQ, West CE, Guan M-X. The Novel A4435G Mutation in the Mitochondrial tRNAMet May Modulate the Phenotypic Expression of the LHON-Associated ND4 G11778A Mutation. Invest Ophthalmol Vis Sci. 2006; 47: 475-483.
Karen D. Agricola, MSN, APRN, FNP-BC Advanced Practice Registered Nurse, Tuberous Sclerosis
Advanced Practice Registered Nurse, Tuberous Sclerosis
MSN-FNP: University of Kentucky, Kentucky, 1990.Internship: Family Practice, Portland Family Health Center, Louisville, Ky 1990.
Certification: Family Nurse Practitioner since 1990.
Jennifer E. Glass, LGC Genetic Counselor II, Division of Human Genetics
Cindy Tudor, RN, APRN, CNP Nurse Practitioner, Division of Neurology
Nurse Practitioner, Division of Neurology
Linda L. Wallace, LISW Social Worker, Division of Social Services
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