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The Ventricular Assist Device (VAD) Program at Cincinnati Children's is home to specialists with a wide variety of backgrounds and areas of focus. As a team, this diversity makes us better prepared to care for your child’s unique needs.
For immediate assistance please contact:
Lauren BurkhartAdministrative Coordinator513-803-4580Lauren.Burkhart@cchmc.org
Angela Lorts, MD Director, Ventricular Assist Device Program 513-803-4580 firstname.lastname@example.org
Director, Ventricular Assist Device Program
Associate Professor, UC Department of Pediatrics
Advanced heart failure; cardiopulmonary bypass mediated myocardial dysfunction; novel uses of pediatric VADs; cardiomyopathy; mechanical circulatory support and transplant
MD: Creighton University Medical School, Omaha, NE, 1998.
Residency: The Children’s Hospital, Denver, CO, 2001.
Fellowship: Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, 2004; University of Michigan Medical Center, Ann Arbor, MI, 2006.
Certifications: American Board of Pediatrics, 2001; American Board of Pediatrics, Sub-Board of Pediatric Cardiology, 2004; American Board of Pediatrics, Sub-Board of Pediatric Critical Care, 2006.
Towbin JA, Lorts A, Jefferies JL. Left ventricular non-compaction cardiomyopathy. Lancet. 2015 Apr 9.
Benoit S, Antommaria AH, Weidner N, Lorts A. Difficult decision: what should we do when a VAD-supported child experiences a severe stroke? Pediatr Transplant. 2015 Mar;19(2):139-43.
Zafar F, Castleberry C, Khan MS, Mehta V, Bryant R 3rd, Lorts A, Wilmot I, Jefferies JL, Chin C, Morales DL. Pediatric heart transplant waiting list mortality in the era of ventricular assist devices. J Heart Lung Transplant. 2015 Jan;34(1):82-8.
Thomas TO, Chandrakasan S, O'Brien M, Jefferies JL, Ryan TD, Wilmot I, Baker ML, Madueme PC, Morales D, Lorts A. The use of a Berlin Heart EXCOR LVAD in a child receiving chemotherapy for Castleman's disease. Pediatr Transplant. 2015 Feb;19(1):E15-8.
Thomas TO, Jefferies JL, Lorts A, Anderson JB, Gao Z, Benson DW, Hor KN, Cripe LH, Urbina EM. Autonomic dysfunction: a driving force for myocardial fibrosis in young Duchenne muscular dystrophy patients? Pediatr Cardiol. 2015 Mar;36(3):561-8.
Friess MR, Marino BS, Cassedy A, Wilmot I, Jefferies JL, Lorts A. Health-related quality of life assessment in children followed in a cardiomyopathy clinic. Pediatr Cardiol. 2015 Mar;36(3):516-23.
Ryan TD, Jefferies JL, Zafar F, Lorts A, Morales DL. The evolving role of the total artificial heart in the management of end-stage congenital heart disease and adolescents. ASAIO J. 2015 Jan-Feb;61(1):8-14.
Moore RA, Madueme PC, Lorts A, Morales DL, Taylor MD. Virtual implantation evaluation of the total artificial heart and compatibility: Beyond standard fit criteria. J Heart Lung Transplant. 2014 Nov;33(11):1180-3.
Lorts A, Zafar F, Adachi I, Morales DL. Mechanical assist devices in neonates and infants. Semin Thorac Cardiovasc Surg Pediatr Card Surg Annu. 2014;17(1):91-5.
Ryan TD, Jefferies JL, Sawnani H, Wong BL, Gardner A, Del Corral M, Lorts A, Morales DL. Implantation of the HeartMate II and HeartWare left ventricular assist devices in patients with duchenne muscular dystrophy: lessons learned from the first applications. ASAIO J. 2014 Mar-Apr;60(2):246-8.
David L. S. Morales, MD Chief of Cardiovascular Surgery, Heart Institute, Cardiothoracic Surgery 513-803-9150 email@example.com
Chief of Cardiovascular Surgery, Heart Institute, Cardiothoracic Surgery
Clark-Helmsworth Chair of Cardiovascular Surgery
Professor, UC Department of Pediatrics
UC Division of Surgery
Congenital heart surgery; heterotaxy syndrome; pediatric heart and lung transplantation; mechanical circulatory support
MD: Yale University School of Medicine, New Haven, CT.
Residency: General and cardiothoracic surgery, New York-Presbyterian Medical Center, Columbia University, New York, NY.
Fellowships: Congenital heart surgery, Texas Children’s Hospital, Baylor University, Waco, TX.
Board certifications: Surgery, thoracic surgery, congenital heart surgery.
Clifford Chin, MD Co-Director, Advanced Heart Failure and Cardiomyopathy 513-803-3151 firstname.lastname@example.org
Co-Director, Advanced Heart Failure and Cardiomyopathy
Pediatric cardiology; cardiomyopathy and transplantation
MD: SUNY Downstate Medical Center, Brooklyn, NY, 1989.
Residency: Pediatrics, University of California Davis Medical Center, Sacramento, CA, 1989.
Fellowship: Stanford University, Stanford, CA, 1992.
Castleberry C, Ryan T, Chin C. Transplantation in the Highly Sensitized Pediatric Patient. Circulation. 2014;129:2313-2319.
Chin C. Pediatric Antibody Mediated Rejection. Pediatric Transplantation. 2012;16:404-4012.
Pietra B, Kantor P, Bartlett H, Chin C, Canter C, Larsen R, Edens E, Colan C, Towbin T, Lipshultz S, Kirklin J, Naftel D, Sleeper L, Hsu D. Early Predictors of Survival to and After Clinical Heart Transplantation in Children’ with Dilated Cardiomyopathy. Circulation. 2012;126:1079-86.
Chin C, Chen G, Sequeria F, Berry G, Siehr S, Bernstein D, Rosenthal D, Reinhartz O, Tyan D. Clinical usefulness of a novel C1q assay to detect immunoglobulin G antibodies capable of fixing complement in sensitized pediatric heart transplant patients. J Heart Lung Transplant. 2011 Feb;30(2):158-63.
Chin C, Lukito SS, Shek J, Bernstein D, Perry SB. Prevention of pediatric graft coronary artery disease: atorvastatin. Pediatr Transplant. 2008 Jun;12(4):442-6.
Potena L, Fearon WF, Sydow K, Holweg C, Luikart H, Chin C, Weisshaar D, Mocarski ES, Lewis DB, Valantine HA, Cooke JP. Asymmetric dimethylarginine and cardiac allograft vasculopathy progression: modulation by sirolimus. Transplantation. 2008 Mar 27;85(6):827-33.
Tu W, Potena L, Stepick-Biek P, Liu L, Dionis KY, Luikart H, Fearon WF, Holmes TH, Chin C, Cooke JP, Valantine HA, Mocarski ES, Lewis DB. T-cell immunity to subclinical cytomegalovirus infection reduces cardiac allograft disease. Circulation. 2006 Oct 10;114(15):1608-15.
Potena L, Holweg CT, Chin C, Luikart H, Weisshaar D, Narasimhan B, Fearon WF, Lewis DB, Cooke JP, Mocarski ES, Valantine HA. Acute rejection and cardiac allograft vascular disease is reduced by suppression of subclinical cytomegalovirus infection. Transplantation. 2006 Aug 15;82(3):398-405.
Chin C, Naftel D, Pahl E, Shankel T, Clark ML, Gamberg P, Kirklin J, Webber S; Pediatric Heart Transplant Study. Cardiac re-transplantation in pediatrics: a multi-institutional study. J Heart Lung Transplant. 2006 Dec;25(12):1420-4.
Chin C, Naftel DC, Singh TP, Blume ED, Luikart H, Bernstein D, Gamberg
P, Kirklin JK, Morrow WR, Pediatric Heart Transplant Study Group. Risk
factors for recurrent rejection in pediatric heart transplantation: a
multicenter experience. J Heart Lung Transplant. 2004 Feb;23(2):178-85.
John Lynn Jefferies, MD, MPH, FAAP, FACC Co-Director, Advanced Heart Failure and Cardiomyopathy 513-803-1675 email@example.com
Advanced heart failure; cardiomyopathy; mechanical circulatory support and transplant
Dr. Jefferies, an associate professor of pediatric cardiology and adult cardiovascular diseases within the University of Cincinnati College of Medicine, is the director of Advanced Heart Failure / Cardiomyopathy in the Heart Institute at Cincinnati Children's Hospital Medical Center.
He completed his combined pediatric and adult cardiology training at the Baylor College of Medicine in Houston, Texas at the Texas Children's Hospital and the Texas Heart Institute. He has authored or co-authored over 120 peer-reviewed manuscripts and book chapters on cardiomyopathy, cardiovascular genetics, and adults with congenital heart disease.
His current research interests include heritable causes of cardiovascular disease, novel drug therapies for advanced heart failure, novel gene discovery in cardiomyopathy, characterization and management of left ventricular noncompaction (LVNC), and early diagnosis and management of chemotherapy induced cardiotoxicity.
He is on the editorial board of the Texas Heart Institute Journal and is an active member of numerous professional organizations, including the Heart Failure Society of America, the American College of Cardiology and the American Heart Association. He is the lead editor for two textbooks that focus on the management of heart disease in children and young adults entitled “Heart Failure in the Child and Young Adult: From Bench to Bedside” and “Cardioskeletal Myopathies in Children and Young Adults.”
BS: University of Tennessee, Knoxville, TN, 1992.
MD: University of Tennessee, Knoxville, TN, 1996.
Residency: University of Kentucky, Lexington, KY, 2000.
MPH: University of Kentucky, Lexington, KY, 2001.
Fellowship: Baylor College of Medicine, Houston, TX, 2006.
Certification: Pediatrics, Internal Medicine, Cardiology, Advanced Heart Failure, Cardiac Transplant.
Towbin JA, Lorts A, Jefferies JL. Left ventricular noncompaction cardiomyopathy. Lancet. 2015;Apr 9. Epub ahead of print.
McCullough PA, Jefferies JL. Novel Markers And Therapies For Patients With Acute Heart Failure And Renal Dysfunction. Am J Med. 2015 Mar;128(3):312.e1-22.
Villa CR, Ryan TD, Collins JJ, Taylor MD, Lucky AW, Jefferies JL. Left ventricular non-compaction cardiomyopathy associated with epidermolysis bullosa simplex with muscular dystrophy and PLEC1 mutation. Neuromuscul Disord. 2015 Feb;25(2):165-8.
Raman SV, Hor KN, Halnon NJ, Kissel JT, He X, Tran T, Smart S, McCarthy B, Taylor MD, Jefferies JL, Rafael-Fortney JA, Lowe J, Roble SL, Cripe LH. Eplerenone for early cardiomyopathy in Duchenne muscular dystrophy: a randomised, double-blind, placebo-controlled trial. Lancet Neurol. 2015 Feb;14(2):153-61.
Jefferies JL. Barth syndrome. Am J Med Genet C Semin Med Genet. 2013 Aug;163C(3):198-205.
Breinholt JP, Moulik M, Dreyer WJ, Denfield SW, Kim JJ, Jefferies JL, Rossano JW, Gates CM, Clunie SK, Bowles KR, Kearney DL, Bowles NE, Towbin JA. Viral epidemiologic shift in inflammatory heart disease: the increasing involvement of parvovirus B19 in the myocardium of pediatric cardiac transplant patients. J Heart Lung Transplant. 2010 Jul;29(7):739-46.
Carlson P, Jefferies JL, Kearney D, Russell H. Refractory dilated cardiomyopathy associated with metastatic neuroblastoma. Pediatr Blood Cancer. 2010 Jun 29.
Shah AM, Jefferies JL, Rossano JW, Decker JA, Cannon BC, Kim JJ. Electrocardiographic abnormalities and arrhythmias are strongly associated with the development of cardiomyopathy in muscular dystrophy. Heart Rhythm. 2010 Jun 18.
Rossano JW, Morales DL, Zafar F, Denfield SW, Kim JJ, Jefferies JL, Dreyer WJ. Impact of antibodies against human leukocyte antigens on long-term outcome in pediatric heart transplant patients: An analysis of the United Network for Organ Sharing database. J Thorac Cardiovasc Surg. 2010 May 26.
Thomas D. Ryan, MD, PhD Heart Failure, Transplant, VAD Physician 513-803-2913 firstname.lastname@example.org
Heart Failure, Transplant, VAD Physician
Assistant Professor, UC Department of Pediatrics
Cardiomyopathy; advanced heart failure; heart transplantation; mechanical circulatory support and transplant
Thomas D Ryan, MD, PhD, was born and raised in Wichita, KS and graduated magna cum laude from Wichita State University in 1996 with a BS in biological sciences.
In 1997 he began training in the MD/PhD program at the University of Alabama at Birmingham, and studied the molecular, cellular, and whole organ aspects of cardiac remodeling in a rat model of volume overload. His general pediatrics residency training took place at Cincinnati Children’s Hospital Medical Center from 2006-2009, as did his pediatric cardiology fellowship training from 2009-2012 and advanced fellowship in Pediatric Heart Failure/Transplant from 2012-2013. His clinical and research interests focus on heart failure, cardiomyopathy, cardiac transplantation, and mechanical circulatory support.
BS: Wichita State University, Wichita, KS, 1996.
PhD: University of Alabama at Birmingham, Birmingham, AL, 2004.
MD: University of Alabama at Birmingham, Birmingham, AL, 2005.
Residency: Pediatrics, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, 2006-2009.
Fellowship: Pediatric Cardiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 2009-2012.
Advanced Fellowship: Pediatric Heart Failure/Transplant, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 2012-2013.
Certification: American Board of Pediatrics, 2010; American Board of Pediatrics, Sub-board of Pediatric Cardiology, 2012.
Ryan TD, Jefferies JL, Chin C, Sticka JJ, Taylor MD, Harris R, Moore J, Goodridge E, Mount L, Bolyard AA, Otto B, Jones A, Shimamura A, Davies S, Myers K. Abnormal circumferential strain measured by echocardiography is present in patients with shwachman-diamond syndrome despite normal shortening fraction. Pediatr Blood Cancer. 2015 Mar 2.
Ryan TD, Jefferies JL, Wilmot I. Managing heart failure in adults with congenital heart disease. Curr Treat Options Cardiovasc Med. 2015 Feb;17(2):376.
Dandoy CE, Davies SM, Hirsch R, Chima RS, Paff Z, Cash M, Ryan TD, Lane A, El-Bietar J, Myers KC, Jodele S. Abnormal echocardiography seven days after stem cell transplant may be an early indicator of thrombotic microangiopathy. Biol Blood Marrow Transplant. 2015 Jan;21(1):113-8.
Ryan TD, Jefferies JL, Zafar F, Lorts A, Morales DLSM. The evolving role of the total artificial heart in the management of end-stage congenital heart disease and adolescents. ASAIO Journal. 2015 Jan-Feb;61(1):8-14.
Chin C, Ryan TD, Castleberry CD. Transplantation in the highly sensitized pediatric patient. Circulation. 2014 Jun 3;129:2313-19.
Ryan TD, Jefferies JL, Sawnani H, Wong BL, Gardner A, Del Corral M, Lorts A, Morales DLS. Implantation of the HeartMate II and HeartWare left ventricular assist devices in patients with Duchenne muscular dystrophy: lessons learned from the first applications. ASAIO Journal. 2014 Mar-Apr;60(2):246-8.
Ryan TD, Taylor MD, Wojciech M, Cripe LH, Pratt J, King EC, Lao K, Grenier MA, Jefferies JL, Benson DW, Hor KH. Abnormal circumferential strain is present in young Duchenne muscular dystrophy patients. Pediatric Cardiol. 2013 Jun;34(5):1159-65.
Ryan TD, Ware SM, Lucky AW, Towbin JA, Jefferies JL, Hinton RB. Left ventricular noncompaction cardiomyopathy and aortopathy in a patient with recessive dystrophic epidermolysis bullosa. Circ Heart Fail. 2012 Sep 1;5(5):e81-2.
Ryan TD, Rothstein EC, Aban I, Tallaj JA, Husain A, Lucchesi PA, Dell'Italia LJ. Left ventricular eccentric remodeling and matrix loss are mediated by bradykinin and precede cardiomyocyte elongation in rats with volume overload. J Am Coll Cardiol. 2007 Feb 20;49(7):811-21.
Chet R. Villa, MD Attending Physician, Heart Institute 513-636-8481 email@example.com
Attending Physician, Heart Institute
Advanced heart failure; heart transplantation; cardiomyopathy; mechanical circulatory support and transplant
MD: University of Cincinnati College of Medicine, Cincinnati, OH, 2007.
Residency: Pediatrics, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH.
Certification: American Board of Pediatrics, 2010.
Ivan Wilmot, MD Heart Failure, Transplant, Ventricular Assist Device Physician 513-803-2913 firstname.lastname@example.org
Heart Failure, Transplant, Ventricular Assist Device Physician
Advanced heart failure; transplantation; mechanical circulatory support and transplant; cardiomyopathy
Ivan Wilmot, MD, graduated summa cum laude from Louisiana State University with a Bachelor of Science in zoology.
In 1998 he began medical school at Emory University. His general pediatrics residency training took place at the Emory Affiliated Hospitals from 2002 to 2006. He completed his pediatric cardiology fellowship training from 2006 to 2009, and advanced fellowship in heart failure and transplant from 2009 to 2010.
His clinical and research interests focus on heart failure, cardiac transplantation and mechanical circulatory support (MCS).
BS: Louisiana State University, Baton Rouge, LA, 1998.
MD: Emory University School of Medicine, Atlanta, GA, 2002.
Residency: Emory Affiliated Hospitals, Atlanta, GA, 2005; Chief Resident: Emory Affiliated Hospitals, Atlanta, GA, 2006.
Fellowship: Baylor College of Medicine, Texas Children’s Hospital, Houston, TX, 2009.
Advanced Fellowship: Heart Failure and Transplant, Baylor College of Medicine, Texas Children’s Hospital, Houston, TX, 2010.
Certification: American Board of Pediatrics; American Board of Pediatrics Sub-board of Pediatric Cardiology.
Ryan T, Jefferies J, Wilmot I. Managing Heart Failure in Adults with Congenital Heart Disease. 2014. Curr Treat Options Cardiovasc Med. 2015 Feb;17(2):376.
Czosek R, Wilmot I, Jefferies J, Spar D, Anderson J, Khoury P, Knilans T. Outcomes, Arrhythmic Burden and Ambulatory Monitoring of Pediatric Patients with Left Ventricular Non-Compaction and Preserved Left Ventricular Function. AJC. 2015 April;115(7);962-6.
Fries M, Marino B, Cassedy A, Wilmot I, Jefferies J, Lorts A. Health-Related Quality of Life Assessment in Children Followed in a Cardiomyopathy Clinic. Pediatric Cardiol. 2014 Oct 7.
Stapleton GE, Wilmot I, Suh EJ. Cardiac catheterisation of patients with common arterial trunk and transposition of the great arteries. Cardiol Young. 2012 Dec:22(6), 687–690.
Dadlani GH, Braley K, Perez-Colon E, Stapleton G, Crawford M, Turpin D, Wilmot I, Freire G, Decker J, Martinez R. Long-term management of patients with hypoplastic left heart syndrome: the diagnostic approach at All Children's Hospital. Cardiol Young. 2011 Dec:21 Suppl 2, 80–87.
Asante-Korang A, Jacobs JP, Ringewald J, Carapellucci J, Rosenberg K, McKenna D, McCormack J, Wilmot I, Gjeldum A, Lopez-Cepero M, Sleasman J. Management of children undergoing cardiac transplantation with high Panel Reactive Antibodies. Cardiol Young. 2011 Dec:21 Suppl 2, 124–132.
Wilmot I, Morales DL, Price JF, Rossano JW, Kim JJ, Decker JA, McGarry MC, Denfield SW, Dreyer, WJ, Towbin JA, Jeffries JL. Effectiveness of mechanical circulatory support in children with acute fulminant and persistent myocarditis. J Card Fail. 2011 June:17(6), 487–494.
Perez-Colon E, Dadlani GH, Wilmot I, Miller M. Mesalamine-induced myocarditis and coronary vasculitis in a pediatric ulcerative colitis patient: a case report. Case Rep Peditr. 2011; 524364.
Amanda Schubert, BSN, RN
Coordinator, VAD Program 513-803-8691 email@example.com
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