Allergy and Immunology

J. Pablo Abonia, MD

Title

Assistant Professor

Email

pablo.abonia@cchmc.org

Phone

513-636-9463

Fax

513-636-3310

Bio

J. Pablo Abonia, MD, provides the bulk of the clinical allergy care for patients with eosinophilic disease. He is currently involved in a multicenter clinical research trial of anti-IL5 (reslizumab) for patients with eosinophilic esophagitis. His research focuses on mining the research databanks (patient characteristics, tissue samples, RNA, and DNA) to elucidate the mechanisms, diagnosis and treatment of eosinophilic esophagitis. He is particularly interested in the role of mast cells in eosinophilic esophagitis.

Credentials

MD: University of Buffalo, Buffalo, NY, 1997.

Residency: Pediatrics, Children's Hospital of Buffalo, Buffalo, NY, 2000.

Certification: American Board of Pediatrics, 2001; American Board of Allergy and Immunology, 2003.

Research

Mast cell progenitor homing / recruitment and its involvement in allergic disorders

Research Grants and Contracts

Principal Investigator, NIAID/NIH, Recruitment of Murine Mast Cell
Progenitors, 2004.

Co-Investigator, NIH, Pediatric Center for Gene Expression and Development, 2002

Aventis / AAAAI President's Grant-in-Aid Award in Allergy, 2001.

Sepracor Rapid Program Grant, 2001.

Publications, Most Recent

Abonia, J.P., Abel, K.J., Eddy, R.L., Elliot, R.W., Chapman, V.M., Shows, T.B. and Gross, K.W.: Linkage of Agt and Actsk-1 to distal mouse Chromosome 8 loci: a new conserved linkage.Mammalian Genome 4: 25-32, 1993.

Abonia, J.P., Howles, P.N., and Gross, K.W.: Evaluating the importance of NRE-1 in tissue specific expression of the murine renin genes.Fourteenth Annual Student Research Forum − School of Medicine and Biomedical Sciences, SUNY at Buffalo: 17, 1994.

Petrovic, N., Black , T.A., Fabian, J.R., Kane, C., Jones, C.A., Loudon, J.A., Abonia, J.P., Sigmund, C.D. and Gross, K.W.: Role of proximal promoter elements in regulation of renin gene transcription. Journal of Biological Chemistry 271: 22499-22505, 1996.

Abonia, J.P., Howles, P.N., Abel, K.J., Black, T.A., Jones, C.A., and Gross, K.W.: Evaluating a model of a NRE mediated tissue-specific expression of the murine renin genes. Hypertension 37: 105-109, 2001.

Gurish, M.F., Tao, H., Abonia, J.P., Arya, A., Friend, D.S., Parker, C.M., and Austen. K.F.: Intestinal mast cell progenitors require CD49dβ7 (α4β7 integrin) for tissue specific homing.Journal of Experimental Medicine 194: 1243-1252, 2001.

Abonia, J.P. and Castells, M.C.: Common Variable Immunodeficiency.Allergy and Asthma Proceedings 23: 53-57, 2002.

Abonia, J.P., Gurish, M.F., Austen, K.F., Friend, D.S., and Boyce, J.A.: CXCR2 is a required Chemokine Receptor for Mast Cell Progenitor Homing to the Murine Intestine (Abstract) Journal of Allergy and Clinical Immunology 111: s186, 2003.

Abonia, J.P., Gurish, M.F., Friend, D.S., Austen, K.F and Boyce, J.A.: α4β7 integrin is required for the inflammatory recruitment of mast cell progenitors to the lung (Abstract) Journal of Allergy and Clinical Immunology 113:  s86, 2004.

Abonia, J.P., Austen, K.F., Rollins, B.J., Joshi, S.K, Flavell, R.A., Kuziel, W.A., Koni, P.A., and Gurish, M.F.: Constitutive homing of mast cell progenitors to the intestine depends on autologous expression of the chemokine receptor CXCR2. Blood 105: 4308-4313, 2005.

Abonia, J.P., Friend, D.S., Austen, Jr., W.G., Moore, Jr., F.D., Carroll, M.C., Chan, R., Humbles, A., Gerard, C., Knight, P., Kanaoka, Y., Yasuda, S., Austen, K.F., Stevens, R.L., and Gurish, M.F.: Mast cell protease 5 mediates post-ischemic reperfusion injury to mouse skeletal muscle. Journal of Immunology 174: 7285-7291, 2005.

Blanchard, C., Wang, N., Stringer, K. S., Mishra, A., Fulkerson, P. C., Abonia, J.  P., Jameson, S. C., Kirby, C., Konikoff, M., Collins, M. H., Cohen, M. B., Akers, R., Hogan, S. P., Assa'ad, A. H., Putnam, P. E., Aronow, B. J., and Rothenberg, M. E.: Eotaxin-3/CCL26 and a uniquely conserved gene-expression profile in eosinophilic esophagitis. Journal of Clinical Investigation 116: 536-547, 2006

Abonia, J.P., Hallgren, J., Jones, T., Shi, T., Xu, Y., Koni, P., Flavell, R.A., Boyce, J.A., Austen, K.F., and Gurish. M.F.: α4 integrins and VCAM-1, but not MAdCAM-1, are essential for recruitment of mast cell progenitors to the inflamed lung.Blood 108: 1588-1594, 2006.

Hallgren, J., Jones, T. G., Abonia, J. P., Xing, W., Humbles, A., Austen, K. F. and Gurish, M. F.: Pulmonary CXCR2 regulates VCAM-1 and antigen-induced recruitment of mast cell progenitors. Proc.Natl.Acad.Sci.U.S.A 104:20478-20483, 2007.

Mishra, A., Wang, M., Pemmaraju, V. R., Collins, M.H., Fulkerson, P.C., Abonia, J.P., Blanchard, C.  Putnam, P. E., and Rothenberg, M. E.: Esophageal remodeling develops as a consequence of tissue specific IL-5-induced eosinophilia. Gastroenterology 134:204-214, 2008.

Collins,M.H., Blanchard, C., Abonia, J.P., Kirby, C., Akers, R., Wang, N., Putnam, P.E., Jameson, S.C., Assa'ad, A.H., Konikoff, M.R., Stringer, K.F. and Rothenberg M.E.: Clinical, Pathologic, and Molecular Characterization of Familial Eosinophilic Esophagitis Compared With Sporadic Cases. Clin.Gastroenterol.Hepatol., 2008.