Allergy and Immunology

Simon P. Hogan, PhD

Title

Assistant Professor of Pediatrics

Email

simon.hogan@cchmc.org

Phone

513-636-6620

Fax

513-636-3310

Credentials

BSC: Australian National University, Canberra, Australia, 1998.

PhD: John Curtin School of Medical Research, Australian National University, Canberra, Australia, 1998.

Awards and Honors

Australian National University Postgraduate Research Scholarship
Frank Fenner Medal for the Most outstanding PhD thesis at the John Curtin School of Medical Research, Canberra, Australia, 1998
NHMRC CJ Martin Post-doctoral Fellowship Award, 1998
Jaffe Family Foundation Food Allergy Research Award, American Academy of Allergy, Asthma and Immunology, 1998-2000
Travel Grant Award, American Academy of Allergy, Asthma and Immunology, Annual Meeting, San Diego, CA, 2000
AMRAD Post-Doctoral Fellowship Award, 2001
ACT Tall Poppy Award, 2002
NSW Biofirst Award, 2003

Publications, Most Recent

Forbes, E., Smart, S., D'Aprile, A., Henry, P., Yang, M., Matthaei, K., Rothenberg, ME., Foster, PS., Hogan, SP., (2004). T helper-2 Immunity regulates bronchial hyperresponsiveness in eosinophil-associated gastrointestinal disease in mice.Gastroenterology. 127:105-18.

Forbes, E., Murase, T., Yang, M., Matthaei, KI., Lee, JJ., Lee, NA., Foster, PS., Hogan, SP., (2004). Immunopathogenesis of experimental ulcerative colitis is mediated by eosinophil peroxidase.J. Immunology. 172(1): 5664-5675.

Smart, V., Foster, PS., Mattes, J., Rothenberg, ME., Higgins, TJV., Hogan, SP., (2005). Oral administration of peas containing bean α-Amylase inhibitor predisposes to allergy in mice.J. Agriculture and Chemistry. 53:9023-9030.

Farzaneh, P., Hassan, ZM., Pourpak, Z., Haseini, AZ., Baghestani, AR., Hogan, SP., (2005). Experimental model of pulmonary allergic inflammation induced by latex in Balb/C.Yakhteh Medical Journal, 7. No 2:92-97.

Blanchard, C., Wang, N., Stringer, KF., Mishra, A., Fulkerson, PC., Jameson, SC., Kirby, C., Konikoff, MR., Collins, MH., Akers, R., Hogan, SP., Assa'ad, AH., Putnam, PE., Aronow, B., Rothenberg, ME., (2006). Eotaxin-3 and a uniquely conserved gene-expression profile in eosinophilic esophagitis.J. Clin. Invest. 116(2):536-47.

Brandt, EB., Zimmermann, N., Muntel, EE., Pope, SM., Yamada, Y., Hogan, SP., Rothenberg, ME., (2006). The α4β7-intergrin is dramatically expressed on murine eosinophils and involved in eosinophil trafficking to the intestine.Clin. Exp. Allergy. 36:543-53.

Forbes, E., Hulett M., Ahrens, R., Tang, M., Brandt, E., Rothenberg, ME., Foster, PS., Hogan, SP., (2006). ICAM-1 dependent pathways regulate colonic eosinophilic inflammation.J. Leuko. Biol. 80:330-341.

Prescott, V., Foster, PS., Matthaei, K., Higgins, TJV., Hogan, SP., (2006). Mechanisms of food antigen-induced subcutaneous hypersensitivity responses and Th2-type pulmonary inflammation.J. Leuko. Biol. 80:258-266.

Farzaneh, P., Hassan, ZM., Pourpak, Z., Haseini, AZ., Baghestani, AR., Hogan, SP., (2006). Experimental model of pulmonary allergic inflammation induced by latex in Balb/C.Basic and Clinical Pharmacology and Toxicity. 99(6):405-11.

Hogan, SP., Seidu, L., Blanchard, C., Groschwitz, K., Mishra, A., Karow, ML., Ahrens, R., Artis, D., Murphy, AJ., Valenzuela, DM., Yancopoulos, GD., Rothenberg, ME., (2006). Resistin-like molecule (RELM)-β regulates innate colonic function: Barrier integrity and inflammation susceptibility.J. Allergy and Clin. Immunol. 118(1):257-68.

Yang, M., Rangasamy, D., Frew, AJ., Mahalingham, S., Webb, DC., Tremethick, DJ., Thompson, PJ., Hogan, SP., Matthaei, KI., Rothenberg, ME., Cowden, WB., Foster, PS., (2006). Inhibition of arginase I activity by RNA interference attenuated interleukin-13 induced airways hyperresponsiveness.J. Immunol. 15:177(8):5595-603.

Sharkhuu, T., Mahalingham, S., Hogan, SP., Rennick, DM., Matthaei, KI., Foster, P., (2006). Mechanism of IL-25 (IL-17E) induced pulmonary inflammation and airways hyperreactivity.Clin. Exp. Allergy. 36(12):1575-83

Fulkerson, PC., Fischetti, CA., Hassman, LM., Pope, SM., Hogan, SP., Rothenberg, ME., (2006). A central regulatory role for eosinophils and the eotaxin/CCR3 axis in chronic experimental asthma.Proc. Natl. Acad. Sci. USA. 103(44):16418-23

Nikolaidis, NM., Wang, TC., Hogan, SP., Rothenberg, ME., (2006). Expression of TFF2 by mucus-producing airway epithelial cells modulates allergen-induced leukocyte recruitment in experimental asthma.Exp. Lung Res. 32(10):483-497.

Bullock, JZ., Villanueva, JM., Blanchard, C., Filipovich, AH., Assa'ad, AH., Putnam, PE., Collins, MH., Hershey, GKK., Risma, KA., Akers, RM., Jameson, SC., Kirby, CL., Buckmeier, BK., Rothenberg, ME., Hogan, SP., (2006). Eotaxin-3, CCR3, and T Cell-derived IL-5 in pediatric eosinophilic esophagitis.J. Ped. Gastro. Nat. Accepted.

Special Interests

Allergies
Food Allergies
Eosinophil biology
Gastrointestinal inflammation

Presentations

SHS North America Pediatric Conference, "Advances in Gastrointestinal Food Allergy," Vancouver, British Columbia, Canada, October 29, 2004.

AAAAI 60th Annual Meeting, Symposium, "Food Allergy: What's new from the bench," San Francisco, CA, March 2004.

AAAAI 60th Annual Meeting, Interactive Workshop, "Molecular pathogenesis of eosinophilic gastroenteritis," San Francisco, CA, March 2004.

AAAI 59th Annual Meeting, Interactive Workshop, "Molecular pathogenesis of eosinophilic gastroenteritis," Denver, CO, March 2003.

AAAAI 59th Annual Meeting, Symposium, "Eosinophilic Gastroenteropathies: The New Epidemic," Denver, CO, March 2003.

The Canberra Region 9th Annual Scientific Meeting, Bench to bedside and Beyond, "Eosinophils and Allergic Diseases", Canberra Australia," November 21-22, 2002.

AAAAI 58th Annual Meeting, Interactive Workshop, "Molecular Pathogenesis of Eosinophilic Gastroenteritis," New York, NY, March 2002.

The 10th Frank and Bobbie Fenner Conference, "Transgenic Plants, Vaccines and Allergens. Vaccines and Vaccinations in the 21st Century..." Canberra, Australia, October 20-22, 2002.

Discipline of Immunology & Microbiology, Faculty of Health, University of Newcastle, "Eosinophil-Associated Gastrointestinal Allergy: Mechanisms and Implications,"
Newcastle, Australia, October 2002.

Plant Biotechnology Center, Kansas State University, "Potential Impact of GM plants on health and disease," KA, July 2002.

Grand Rounds, Mayo Clinic, "Potential Impact of GM plants on health and disease," Scottsdale, AZ, July 2002.