Cancer & Blood Diseases Institute

Punam Malik, MD

Title

Program Leader, Molecular and Gene Therapy Program; Deputy Director, Comprehensive Sickle Cell Program

Appointment

Associate Professor of Pediatrics

Email

punam.malik@cchmc.org

Phone

513-636-1333

Fax

513-636-1330

Credentials

MBBS: University of Delhi, New Delhi, India, 1985

MD: University of Delhi, New Delhi, India, 1989

MS: University of Maryland, Baltimore, MD., 1991

Fellowship: [Hematology-Oncology]: Children's Hospital Los Angeles, University of Sourthern California, 1995

Awards and Honors

National Talent Scholar, National Council for Education, Research and Training, 1978-1987
Proficiency in Medicine Award, 1984
Best III Year Resident Award, 1987
CHLA Research Fellowship Award, 1993
Concern Foundation Fellow, 1993-1996
Scholar, Comprehensive Sickle Cell Center, 1998-2003
Research Career Development Award, CHLA, 2000-2002
Wright Foundation Fellow, 2003-2004
Editorial Board Member, Experimental Hematology, 2003-2005
Editorial Board, Member. Blood, 2005-2007
Outstanding New Investigator Award, 9th Annual Meeting of the American Society of Gene Therapy, 2006
National Sickle Cell Advisory Committee Member, 2006

Research Grants and Contracts

R01 HL70135 (Malik) 04/01/02-03/31/08 NIH-NHLBI Lentiviral vectors for gene therapy for B-thalassemia

P01 HL0731404 (Kohn) 04/01/03-03/31/08 NIH-NHLBI Gene Therapy for Hematopoietic Disorders
Project Leader (Malik) Minimal lentiviral vectors for gene therapy for B-thalassemia

U54 HL070595 (Joiner, C) 04/01/03-03/31/08 NIH-NHLBI
Comprehensive Sickle Cell Center

R01 HL079916 (Malik) 07/01/05-06/31/09 NIH-NHLBI Role of placenta growth factor in sickle acute chest syndrome

Publications, Most Recent

Connect to Punam Malik's publications on PubMed

Moreau-Gaudry F, Xia P, Jiang G, Perelman NP, Bauer G, Ellis J, Surinya KH, Mavilio F, Shen CK, Malik P. High-level erythroid-specific gene expression in primary human and murine hematopoietic cells with self-inactivating lentiviral vectors.Blood. 2001 Nov 1;98(9):2664-2672.

Richard E, Mendez M, Mazurier F, Morel C, Costet P, Xia P, Fontanellas A, Geronimi F, Cario-Andre M, Taine L, Ged C, Malik P, de Verneuil H, Moreau-Gaudry F. Gene therapy of a mouse model of protoporphyria with a self-inactivating erythroid-specific lentiviral vector without preselection.Mol Ther. 2001 Oct;4(4):331-338.

Perelman N, Selvaraj SK, Batra S, Luck LR, Erdreich-Epstein A, Coates TD, Kalra VK, Malik P. Placenta growth factor activates monocytes and correlates with sickle cell disease severity.Blood. 2003 Aug 15;102(4):1506-1514.

Selvaraj SK, Giri RK, Perelman N, Johnson C, Malik P, Kalra VK. Mechanism of monocyte activation and expression of proinflammatory cytochemokines by placenta growth factor.Blood. 2003 Aug 15;102(4):1515-1524.

Batra S, Perelman N, Luck LR, Shimada H, Malik P. Pediatric tumor cells express erythropoietin and a functional erythropoietin receptor that promotes angiogenesis and tumor cell survival.Lab Invest. 2003 Oct;83(10):1477-1487.

Luck L, Zeng L, Hiti AL, Weinberg KI, Malik P. Human CD34(+) and CD34(+)CD38(-) hematopoietic progenitors in sickle cell disease differ phenotypically and functionally from normal and suggest distinct subpopulations that generate F cells.Exp Hematol. 2004 May;32(5):483-493.

Mohamedali A, Moreau-Gaudry F, Richard E, Xia P, Nolta J, Malik P. Self-inactivating lentiviral vectors resist proviral methylation but do not confer position-independent expression in hematopoietic stem cells.Mol Ther. 2004 Aug;10(2):249-259.

Puthenveetil G, Scholes J, Carbonell D, Qureshi N, Xia P, Zeng L, Li S, Yu Y, Hiti AL, Yee JK, Malik P. Successful correction of the human beta-thalassemia major phenotype using a lentiviral vector.Blood. 2004 Dec 1;104(12):3445-3453.

Madigan C, Malik P. Pathophysiology and therapy for haemoglobinopathies; Part I: sickle cell disease.Expert Rev Mol Med. 2006 8(9):1-23.

Urbinati F, Madigan C, Malik P. Pathophysiology and therapy for haemoglobinopathies; Part II: thalassaemias.Expert Rev Mol Med. 2006 8(10):1-26.

Robert-Richard E, Richard E, Malik P, Ged C, de Verneuil H, Moreau-Gaudry F. Murine Retroviral but not Human Cellular Promoters Induce In Vivo Erythroid-specific Deregulation that can be Partially Prevented by Insulators.Mol Ther. 2007 Jan;15(1):173-182.

Cheng JC, Horwitz EM, Karsten SL, Shoemaker L, Kornblum HI, Malik P, Sakamoto KM. Report on the workshop "New Technologies in Stem Cell Research," Society for Pediatric Research, San Francisco, California, April 29, 2006.Stem Cells. 2007 Apr;25(4):1070-1088.