Repository of Tissue Samples and Data from Patients with Fanconi Anemia
Date Last Modified: 2003-03-25
Date First Published: 2002-03-14
Basic Study Information
| Type of Trial | Status of Trial | Age Range (yrs.) | Sponsor of Trial | Protocol IDs |
|---|
| Research | Active | | CCHMC | |
Objectives
- To collect bone marrow, peripheral blood, and skin tissue samples from patients with Fanconi anemia (FA).
- To collect tumor samples from Fanconi anemia patients diagnosed with a malignancy.
- To provide a facility for long-term storage of cells and tissues collected from bone marrow, tumors, peripheral blood and skin tissue samples of patients with Fanconi anemia. These samples may be used in future research studies by investigators with IRB approved protocols.
- To generate fibroblast cultures from patients with Fanconi anemia for storage in the tissue repository.
- To generate immortalized B-cell lines from patients with Fanconi anemia for storage in the tissue repository.
- To collect demographic information, past medical history, family history, and clinical test results to create a longitudinal research database of patients with Fanconi anemia.
Entry Criteria
Disease Characteristics:
- Patients must have Fanconi anemia.
Prior/Concurrent Therapy:
Biologic therapy:
Chemotherapy:
Endocrine therapy:
Radiotherapy:
Surgery:
Other:
Patient Characteristics:
Age:
Performance status:
Life expectancy:
Hematopoietic:
Hepatic:
Renal:
Cardiovascular:
Pulmonary:
Neurologic:
Other:
- Signed informed consent or ability to undergo informed consent process by the patient or legally authorized representative.
Projected Accrual
A total of 30-40 patients will be accrued for this study.
Outline
This research proposal will provide a tissue repository and longitudinal database that will aid in the development of new diagnostic tools and treatment strategies for patients with Fanconi anemia. This proposal will also provide a basis for the collection and storage of cells derived from bone marrow, peripheral blood, skin tissue and tumor samples from patients with Fanconi anemia. Investigators will have access to samples for research in the future. Samples will be released only after verification of local IRB approval of submitted research protocols.
