Mass Spectrometry Laboratory
The Clinical Mass Spectrometry Laboratory at Cincinnati Children's Hospital Medical Center provides an analytical resource focusing on the application of mass spectrometry and allied chromatographies to the analysis of small molecules, generally of less than 1000 daltons molecular weight, in complex clinical and biological samples. The goals of the program are to better understand the biochemical basis of disease, to improve diagnostic approaches to detection of early-stage disease and to explore mechanisms that lead to improved treatments or prevention.
Meeting Client Needs
The Cincinnati Center for Clinical Research Mass Spectrometry Laboratory recognizes your requirements for timelines, accuracy of data, and accessibility to data in order to make critical decisions affecting your compounds progress toward marketability. Our leadership in innovative compound development is demonstrated by:
- Service
- Scientific Excellence
- Regulatory Compliance and Guidance
- Investment
- Capacity
- GLP Capabilities
Our scientists develop and validate many methods using a variety of instrumental techniques. We develop both proprietary and non-proprietary methods according to our clients' needs. We offer flexibility to make adjustments to the protocol and report format according to your requirements. From late discovery pharmacokinetic studies through phase III trials, we have the scientific and operational excellence to deliver on-time accurate data.
Instrumentation
We are equipped with a high-resolution VG Autospec Q " GC-MS-MS instrument, a Micromass LC Quattro Electrospray Triple" quadrupole instrument and two Waters Micro" LC-MS instruments. These instruments are complemented with four capillary column gas chromatography instruments and four high-pressure liquid chromatography (HPLC) systems having ultraviolet, fluorescence and electrochemical detectors that are available for method development and analytical support.
Current Testing
- Sirolimus
- Tacrolimus
- Fast atom bombardment ionization mass spectrometry (FAB-MS) of urinary bile acids for detection of inborn errors in bile acid synthesis
- Plasma Topiramate (Topamax)
- Acylcarnitine
- Serum bile acids by GC-MS
- Risperidone
- Organic Acids
- Assay development
For more information about the Cincinnati Center for Clinical Research Central Laboratory services at Cincinnati Children's, please contact Cheri Scott (cheri.scott@cchmc.org), 513-803-2730.
