Margaret H. Collins, MD
Appointment
Professor of Pathology
Email
margaret.collins@cchmc.org
Phone
513-636-4261
Fax
513-636-3924
Credentials
BS: Fordham University, N.Y., 1972.
MD: Georgetown University, Washington, D.C., 1977.
Residency: Pathology, New York Hospital, N.Y., 1977-80; Pathology, Columbia-Presbyterian Medical Center, N.Y., 1980-83.
Fellowship: Research, New York Lung Association, Columbia-Presbyterian Medical Center, N.Y., 1983-85; Research, American Lung Association, Columbia-Presbyterian Medical Center, N.Y., 1985-87.
Certification: Pathology, 1981; Pediatric Pathology, 1991.
Research Grants and Contracts
Co-Investigator RO1 AI061097 "The Hypereosinophilic Syndromes and Mepolizumab" PI: Gerald J. Gleich, M.D., University of Utah; Project Period: 15 June 2004-30 May 2007; 5% effort
Associate Investigator NIH "Bench to Bedside" Award, Childhood Cancer and Plexiform Neurofibroma Tissue Microarray for Molecular Target Screening and Clinical Drug Development", PI: Elizabeth Fox, M.D.
GSK subcontract, "Use of Mepolizumab for Hypereosinophilic Syndrome", MHE100185, 2005-2007, Review Pathologist
GSK subcontract, "A Randomized, Double-Blind, Parallel Group Clinical Trial to Assess Safety, Tolerability, Pharmcokinetics, and Pharmacodynamics of Intravenous Mepolizumab (SB240563) (0.55 mg/kg, 2.5 mg/kg, or 10 mg/kg) in Pediatric Subjects with Eosinophilic Esophagitis, Aged 2 to 17 Years", 2006-2008, Review Pathologist
Ception Therapeutics subcontract, "An Efficacy and Safety Study of Reslizumab in the Treatment of Eosinophilic Esophagitis", 2007-2009, Review Pathologist
Publications, Most Recent
Collins MH: Histopathologic Features of Eosinophilic Esophagitis. Gastrointestinal Endoscopy Clinics of North America 18(1):59-71, 2008.
McKenney JK, Collins MH, Carretero A, Boyd TK, Redman JF, Parham DM: Penile Myotintimoma in Children and Adolescents: A Clinicopathologic Study of Five Cases Supporting a Distinct Entity. Am J Surg Pathol 31:1622-6, 2007
Lentsch AB, Pathrose P, Kader S, Kuboki S, Collins MH, Waltz SE. The Ron Receptor Tyrosine Kinase Regulates Acute Lung Injury and Suppresses Nuclear Factor kB Activation. Shock 27(3):274-280,2007
Bullock JZ, Villanueva JM, Blanchard C, Filipovich AH, Putnam PE, Collins MH, Risma KA, Akers RM, Kirby CL, Buckmeier BK, Assa'ad AH, Hogan SP, Rothenberg ME: Interplay of Adaptive Th2 Immunity with Eotaxin-3/C-C Chemokine Receptor 3 in Eosinophilic Esophagitis. J Pediatr Gastroenterol Nutr 45:22-31, 2007
Wang L, Bhargava R, Zheng T, Wexler L, Collins MH, Roulston D, Ladanyi M: Undifferentiated Small Round Cell Sarcomas with Rare EWS Gene Fusions. Identification of a Novel EWS-SP3 Fusion and of Additional Cases with the EWS-ETV1 and EWS-FEV Fusions.J Molecular Diagn 2007;9(4):498-509.
Furuta GT, Liacouras CA, Collins MH, Gupta SK, Justinich C, Putnam PE, Bonis P, Hassall E, Straumann A, Rothenberg ME: Eosinophilic Esophagitis in Children and Adults: A Systematic Review and Consensus Recommendations for Diagnosis and Treatment. Sponsored by the American Gastroenterological Association (AGA) Institute and North American Society of Pediatric Gastroenterology, Hepatology, and Nutrition. Gastroenterology 133(4):1342-63, 2007.
Chan EL, Peace BE, Toney K, Kader SA, Pathrose P, Collins MH, Waltz SE: Homozygous K5Cre Transgenic Mice have Wavy Hair and Accelerated Malignant Progression in a Murine Model of Skin Carcinogenesis.Mol Carcinogen 46(1):49-59, 2007
Chan EL, Harris RE, Emery KH, Gelfand MJ, Collins MH, Gruppo RA: Favorable Histology, myc-N Amplified 4S Neonatal Neuroblastoma.Pediatr Blood Cancer 48(4):479-482, 2007
Mahller YY, Vaikunth SS, Currier MA, Miller SJ, Ripberger MC, Hsu Y-H, Mehrian-Shai R, Collins MH, Crombleholme TM, Ratner N, Cripe TP: Oncolytic HSV and Erlotinib Inhibit Tumor Growth and Angiogenesis in a Novel Malignant Peripheral Nerve Sheath Tumor Xenograft Model.Molecular Therapy 15(2):279-286, 2007
Zinser GM, Leonis MA, Toney K, Pathrose P, Thobe M, Kader SA, Peace BE, Beauman SR, Collins MH, Waltz SE: Mammary-specific Ron receptor overexpression induces highly metastatic mammary tumors associated with beta-catenin activationCancer Research 66(24):11967-74, 2007.
Assa'ad AH, Putnam PE, Collins MH, Akers RM, Jameson SC, Kirby CL, Buckmeier BK, Bullock JZ, Collier AR, Konikoff MR, Noel RJ, Guajardo JR, Rothenberg ME: Pediatric Patients with Eosinophilic Esophagitis: An Eight-Year Follow-up.J Allergy Clin Immunol 119(3):731-738, 2007
Martin DT, Gendron RL, Jarzembowski JA, Perry A, Collins M, Pushpanathan C, Miskiewicz E, Castle V, Paradis H: Tubedown Expression Correlates with the Differentiation Status and Aggressiveness of Neuroblastic Tumors.Clin Cancer Res 13(5):1480-1487, 2007
Wagner LM, Garret JK, Ballard ET, Hill DA, Perry A, Biegel JA, Collins MH: Malignant Rhabdoid Tumor Mimicking Hepatoblastoma: A Case Report and Literature Review.Pediatr Develop Pathol 10(5):409-15, 2007
Debrosse C, Case J, Collins MH, Putnam PE, Rothenberg ME: Quantity and Distribution of Eosinophils in the Gastrointestinal Tract of Children. Pediatr Develop Pathol 9:210-219, 2006
Shinde A, Mehlman CT, Collins MH: Aneurysmal Bone Cysts Express Vascular Markers.Pediatr Develop Pathol 9:38-43, 2006
Blanchard C, Wang N, Stringer KF, Mishra A, Fulkerson PC, Abonia JP, Jameson SC, Kirby C, Konikoff MR, Collins MH, Cohen MB, Akers R, Hogan SP, Assa'ad AH, Putnam PE, Aronow BJ, Rothenberg ME. Eotaxin-3 and a Uniquely Conserved Gene-expression Profile in Eosinophilic Esophagitis. J Clin Invest 116:536-47, 2006
DeBurger B.A., Collins M, Mortensen JE: Case Thirteen: Difficult Breathing.Journal of Continuing Education Topics and Issues 8:68-69, 76-80, 2006
Stein M, Collins MH, Villaneuva JM, Kushner JP, Putnam PE, Buckmeier BK, Assa'ad AH, Filipovich AH, Rothenberg ME: Anti-Interleukin-5 (Mepolizumab) Therapy for Eosinophilic Esophagitis. J Allergy Clin Immunol 118:1312-9, 2006
Konikoff MR, Noel RJ, Blanchard C, Kirby C, Jameson SC, Buckmeier B, Akers R, Cohen MB, Collins MH, Assa'ad AH, Aceves SS, Putnam PE, Rothenberg ME: A Randomized Double-Blind Placebo-Controlled Trial of Fluticasone Propionate for Pediatric Eosinophilic Esophagitis. Gastroenterol 131:1381-1391, 2006
Rutter MJ Vijayasekaran S Salamone FN Cohen AP Manning P Collins MH Mortelliti A: Deficient Tracheal RingssInt J Pediatr Otorhinolaryngol 70(11):1981-4, 2006
Chan E, Peace M, Collins MH, Toney-Earley K, Waltz S: Ron tyrosine kinase receptor regulates papilloma growth and malignant conversion in a murine model of skin carcinogenesis. Oncogene 24:479-488, 2005.
Parikh NS, Currier MA, Mahller YY, Adams LC, Di Pasquale B, Collins MH, Cripe TP: Oncolytic Herpes Simplex Virus Mutants are more Efficacious than Wild-Type Adenovirus Type 5 for the Treatment of High-Risk Neuroblastomas in Preclinical Models. Pediatr Blood Cancer 44:469-478, 2005.
Argani P, Lae M, Hutchinson B, Reuter VE, Collins MH, Perentesis J, Tomaszewski JE, Brooks JSJ, Acs G, Bridge JA, Vargas SO, Davis IJ, Fisher DE, Ladanyi M: Renal Carcinomas With the t(6;11)(p21;q12). Clinicopathologic Features and Demonstration of the Specific Alpha-TFEB Gene Fusion by Immunohistochemistry RT-PCR and DNA PCR.Am J Surg Pathol 29:230-240, 2005.
Applebaum H, Kieran MW, Cripe TP, Coffin CM, Collins MH, Shamberger RC: The Rationale for Non-Steroidal Anti-inflammatory Drug Therapy of Inflammatory Myofibrobastic Tumors: A Children's Oncology Group Study.J Pediatr Surg 40:999-1003, 2005.
Presentations, Most Recent
Workshop-Panel 4808 Consensus Report on Eosinophilic Esophagitis "Pathology" American Academy of Allergy Asthma and Immunology Annual Meeting, San Diego. February 26, 2007.
"Literature Update of Pathology of Eosinophilic Esophagitis", Pre-First International Gastrointestinal Research Symposium, pre-Digestive Disease Weekly Meeting, Los Angeles. May 21, 2006.
"Literature Summary of Pathology of Eosinophilic Esophagitis", First International Gastrointestinal Research Symposium, Orlando. October 16, 2006.
Collins MH, Kirby C, Akers R, Jameson S, Blanchard C, Wang N, Rothenberg ME. Familial Eosinophilic Esophagitis. DDRDC Retreat, CCHMC, January 22, 2005.
Collins MH, Kirby C, Akers R, Jameson S, Blanchard C, Wang N, Rothenberg ME. Familial Eosinophilic Esophagitis. International Eosinophil Society Biannual Meeting, Bern, Switzerland, June, 2005.
Collins MH, Kocoshis S, Nikiforova M, Mortensen J, Witte DP. Viral Surveillance of small bowel allografts in children. IXth International Small Bowel Transplantation Symposium, Brussels, Belgium, July 1, 2005.
Collins MH, Kocoshis S, Nikiforova M, Mortensen J, Witte DP. Viral Surveillance of pediatric small bowel transplants. Semiannual meeting/Joint meeting of the Society for Pediatric Pathology and the European Pediatric Pathology Society, Tours, France, Sept 1, 2005.
"Pathology of Eosinophilic GI Diseases", APFED Patient Education Conference, Cincinnati, OH July 16, 2005.
Professional Organization Memberships
- Society for Pediatric Pathology
- US Canadian Academy of Pathology
- American Society for Clinical Pathology
Special Interests
Pediatric tumors; GI pathology
Related Areas
This person works in these other areas at Cincinnati Children's Hospital Medical
Center:
