Cincinnati Children's Hospital Medical Center Logo

Clinical Laboratories

<Click for High-Res Image>

Peter H. Tang, PhD

Title

Clinical Chemist

Appointment

Assistant Professor

Email

peter.tang@cchmc.org

Phone

513-636-3357

Fax

513-636-8850

Credentials

PhD: Analytical Chemistry, University of Cincinnati, Cincinnati, OH, 1990.

MS: Biochemistry, Northeast Louisiana University, Monroe, LA, 1985.

BS: Pharmacy, Taipei Medical College, Taipei, Taiwan, 1978.

Awards and Honors

  • Heineman, W.R. Halsall, H.B.; Pesce, A.J.; Tang, P.H. Analysis of whole blood. U.S. Patent 5,240,571, 1994.
  • Tang, P.H.; Miles, M.V.; DeGraw, T. Analysis of coenzyme Q10 by HPLC with coulometric detection.U.S. Patent (6984308) 2006.

Research

Peter H. Tang has research interests in mitochondrial dysfunction, metabolic disorder, neurodegenerative disease, neuromuscular disease, cardiomyopathy, vascular disease, cardiac risk factors, oxidative stress, free radicals, antioxidants, biological markers, and therapeutic drug monitoring.

Research Grants and Contracts

  • Clinical Sub-Investigator. "Pediatric pharmacology research unit program." Principle Investigator: Floyd R. Sallee, M.D., Ph.D. NIH Grant. 1999-present.
  • Clinical Sub-Investigator. "Lamotrigine pharmacokinetics in infants." Principle Investigator: Michael V. Miles, Pharm.D. Glaxo Wellcome, Inc. 2000.
  • Clinical Sub Investigator. "Bioavailability of three coenzyme Q10 formulations." Principle Investigator: Michael V. Miles. Pharm.D. Tischon, Inc. 2000.
  • Clinical Sub-Investigator. "Carbamazepine kinetics and metabolism during pregnancy." Principle Investigator: Bill Cahill, M.D. MFMU Network/NIH-NICHD Grant, 2001-2003.

Publications, Most Recent

Grim SA, Ryan MA, Miles MV, Tang PH, Strawsburg RH, DeGrauw TJ, and Baumann RJ. Correlation of levetiracetam concentrations between serum and saliva.Ther Drug Monit 2003;25:61-66.

Miles MV, Tang PH, Glauser TA, Ryan MA, Grim SA, Strawsburg RH, DeGrauw TJ, and Baumann RJ. Topiramate concentrations in saliva: an alternative to serum monitoring.Pediatric Neurology 2003;29(2):143-147.

Miles MV, Horn PS, Morrison JA, Tang PH, DeGrauw T, and Pesce AJ. Plasma coenzyme Q10 reference intervals, but not redox status, are affected by gender and race in self-reported healthy adults.Clin Chim Acta 2003;332:123-132.

Ryan M, Grim SA, Miles MV, Tang PH, Fakhoury TA, Strawsburg RH, DeGrauw TJ, and Baumann RJ. Correlation of lamotrigine concentrations between serum and saliva.Pharmacotherapy 2003;23:1550-7.

Tang PH, Miles MV, Miles L, Quinlan J, Wong B, Wenisch A, and Bove K. Measurement of reduced and oxidized coenzyme Q9 and coenzyme Q10 levels in mouse tissues by HPLC with coulometric detection.Clin Chim Acta 2004;341:173-184.

Miles MV, Tang PH, Ryan MA, Grim SA, Fakhoury TA, Strawsburg RH, DeGrauw TJ, and Baumann RJ. Feasibility and limitation of oxcarbazepine monitoring using salivary monohydroxycarbamazepine (MHD).Ther Drug Monit 2004;26:300-4.

Miles MV, Morrison JA, Horn PS, Tang PH, and Pesce AJ. Coenzyme Q10 changes are associated with metabolic syndrome.Clin Chim Acta 2004;344:173-179.

Miles MV, Horn PS, Tang PH, Morrison JA, Miles L, DeGrauw T, and Pesce AJ. Age-related changes in plasma coenzyme Q10 concentrations and redox state in apparently healthy children and adults.Clin Chim Acta 2004;347:139-144.

Steele PE, Tang PH, DeGrauw T, and Miles MV. Clinical laboratory monitoring of coenzyme Q10 use in neurologic and muscular diseases.Am J Clin Path 2004;121:S113-120.

Tang PH and DeGrauw T. Redox cycling of coenzyme Q9 as a new measure of plasma reducing power.Clin Chem 2004;50:1930-2.

Miles L, Miles MV, Tang PH, Horn PS, Wong BL, DeGrauw TJ, Morehart PJ, and Bove KE. Ubiquinol: a potential biomarker for tissue energy requirements and oxidative stress.Clin Chim Acta 2005;360:87-96.

Miles L, Miles MV, Tang PH, Horn PS, Wong BL, DeGrauw TJ, Morehart PJ, and Bove KE. Muscle coenzyme Q10: a potential test for mitochondrial activity and redox status.Pediatr Neurol 2005;32:318-324.

Tang PH. Determination of coenzyme Q10 from over-the-counter dietary supplement by high-performance liquid chromatography with coulometric detection.The Journal of AOAC INTERNATIONAL 2006;89(1):35-39.

Presentations, Most Recent

Miles L, Wong B, Tang PH, Bove K, and Miles M. Correlation between muscle coenzyme Q10 and pathologic changes in children. The USCAP 92nd Annual Meeting, Society for Pediatric Pathology, Washington DC, March 22-23, 2003.

Miles L, Mile MV, Tang PH, Horn PS, Wong B, DeGrauw T, Morehart P, and Bove KE. Coenzyme Q: A Potential Marker for Mitochondrial Content and Redox Status in Skeletal Muscle. Fourth Conference of the International Coenzyme Q10 Association, Los Angeles, California, April 14-17, 2005.

Abstracts, Most Recent

Tang PH, Miles MV, and Steele PE. Coenzyme Q10 in healthy volunteers: absorption, determinants, and plasma levels. Cincinnati Translational Neuroscience Symposium, Cincinnati, Ohio, March 15, 2003. [Abst. 33]

Miles L, Wong B, Tang PH, Bove K, and Miles M. Correlation between muscle coenzyme Q10 and pathologic changes in children. The USCAP 92nd Annual Meeting, Society for Pediatric Pathology, Washington DC, March 22-28, 2003. [Modern Pathology 2003;16:5P (Abst. 27)]

Tang PH and DeGrauw TJ. Simultaneous determination of guanidinoacetate, creatine and creatinine in urine by ion-pair high-performance liquid chromatography. The 30th Federation of Analytical Chemistry & Spectroscopy Societies Annual Meeting, Ft. Lauderdale, Florida, October 19-23, 2003. [Book of Abst., No. 284, p 132]

Miles MV, Tang PH, Ryan M, Grim SA, Fakhoury TA, Baumann RJ, Strawsburg RH, and DeGrauw TJ. Oxcarbazepine metabolite (MHD) concentration in saliva offers an alternative to serum for therapeutic monitoring. American Epilepsy Society 56th Annual Meeting, Boston, Massachusetts, December 5-10, 2003. [Epilepsia 2003; 44, Suppl. 9:99 (Abst. 1.276)]

Miles L, Quinlan J, Tang PH, Bove K, Wong B, Wenisch A, and Miles M. Coenzyme Q10 tissue levels and redox state are altered in quadriceps muscle of the mdx mouse. The Society for Pediatric Pathology Annual Meeting, Vancouver, BC, March 6-7, 2004. [Laboratory Investigation 84:272 (Abst. 20), 2004]

Tang PH and DeGrauw TJ. Redox cycling of coenzyme Q9 as a new measure of plasma reducing power. The 36th Annual Oak Ridge Conference, San Jose, California, April 29 & 30, 2004.

Tang PH and DeGrauw TJ. Urinary guanidinoacetate:creatinine and creatine:creatinine are non-invasive indexes for screening of guanidinoacetate methyltransferase and creatine transporter deficiencies. The 56th American Academy of Neurology Annual Meeting, San Francisco, California, April 24-May 1, 2004. [Neurology 2004; 62, Suppl. 5, A68 (Abst. P01.117)]

Miles MV, Morrison JA, Horn PS, Tang PH and Pesce AJ. Coenzyme Q10 associations with metabolic syndrome. The 56th AACC Annual Meeting, Los Angeles, California, July 25-29, 2004. [Clin Chem 2004; 50(6):A60, Suppl. A60 (Abst. B-81)]

Miles MV, Tang PH, DeGrauw T, Schapiro M, Holder D, Wong B, Dinopoulos A, MoreHart P and Miles L. A new liquid formation for high dose coenzyme Q10 treatment of children with mitochondrial diseases. Mitochondrial Medicine 2004-Streams of Energy, Pittsburgh, Pennsylvania, August 4-7, 2004. [Mitochondrion 2004; 4:61 (Abst. 4)]

Miles L, Tang PH, Bove K, Wong B, DeGrauw T, Morehart P and Miles MV. Correlation between muscle coenzyme Q10 and pathologic changes in children. Mitochondrial Medicine 2004-Streams of Energy, Pittsburgh, Pennsylvania, August 4-7, 2004. [Mitochondrion 2004; 4:62-63 (Abst. 7)]

Jones MD, Ryan M, Miles MV, Tang PH, Fakhoury TA, Baumann RJ. Antiepileptic drug saliva concentration stability in the postal system. American College of Clinical Pharmacy 2004 Annual Meeting, Dallas, Texas, October 24-27, 2004. [Abst. 185]

Miles L, Miles MV, Tang PH, Horn PS, Wong BL, DeGrauw TJ, Morehart PJ and Bove KE. Coenzyme Q10 content is associated with mitochondrial activity and redox status in human muscle. Cincinnati Neurofest/Cincinnati Translational Neuroscience Symposium, Cincinnati, Ohio, March 11 & 12, 2005. [Abst. 16]

Miles L, Miles MV, Tang PH, Horn PS, Quinlan JG, Wong BL, Wenisch A and Bove KE. Ubiquinol: a potential biomarker for tissue energy requirements and oxidative stress in the mdx mouse. Cincinnati Neurofest/Cincinnati Translational Neuroscience Symposium, Cincinnati, Ohio, March 11 & 12, 2005. [Abst. 17]

Herring NR, Schaefer TL, Tang PH, Skeleton MR, Able JA, Clark JF, Lucot JP, Vorhees CV and Williams MT. Neurotoxic methamphetamine administration increases plasma corticosterone and brain creatine levels. Cincinnati Neurofest/Cincinnati Translational Neuroscience Symposium, Cincinnati, Ohio, March 11 & 12, 2005. [Abst. 19]

Tang PH and DeGrauw TJ. Urinary clues in inborn errors of creatine metabolism. Cincinnati Neurofest/Cincinnati Translational Neuroscience Symposium, Cincinnati, Ohio, March 11 & 12, 2005. [Abst. 59]

Miles L, Mile MV, Tang PH, Horn PS, Wong B, DeGrauw T, Morehart P, and Bove KE. Coenzyme Q: A potential marker for mitochondrial content and redox status in skeletal muscle. Fourth Conference of the International Coenzyme Q10 Association, Los Angeles, California, April 14-17, 2005. [Abst. p30]

Tang PH and DeGrauw T. HPLC with electrochemical method for measuring coenzyme Q9 and coenzyme Q10 in human plasma. Fourth Conference of the International Coenzyme Q10 Association, Los Angeles, California, April 14-17, 2005. [Abst. p165]

Tang PH and Miles MV. Rapid monitoring of levetiracetam in plasma and saliva by high-performance liquid chromatography. Ninth International Congress of Therapeutic Drug Monitoring and Clinical Toxicology, Louisville, Kentucky, April 23-28, 2005. [Abst. 174] [Ther Drug Monit 2005;27:255-6]

Tang PH. Laboratory assays of carbamazepine in pediatric plasma: Abbott AxSYM" Immunoassay versus high-performance liquid chromatography. Ninth International Congress of Therapeutic Drug Monitoring and Clinical Toxicology, Louisville, Kentucky, April 23-28, 2005. [Abst. 175] [Ther Drug Monit 2005;27:256]

Miles MV, Morrison JA, Horn PS, Ricciard R, Harrison HH, Tang PH, and Pesce AJ. LPL and NQO1 genotypes are associated with decreased coenzyme Q10 redox ratio in adults with metabolic syndrome: an exploratory study. The XIX International Congress of Clinical Chemistry and the 2005 Annual Meeting of AACC, Orlando, Florida, July 24-28, 2005. [Abst. A-37] [Clin Chem 2005;51:A12-13]

Tang PH and DeGrauw T. Coenzyme Q10 and reducing ability of plasma: regeneration of ubiquinol-9 from ubiquinone-9. The XIX International Congress of Clinical Chemistry and the 2005 Annual Meeting of AACC, Orlando, Florida, July 24-28, 2005. [Abst. C-112] [Clin Chem 2005;51:A136]

Herring NR, Schaefer TL, Tang PH, Vorhees CV, and Williams MT. A comparison of the effects of methamphetamine and forced swim on markers of energy metabolism. The Society for Neuroscience Conference, Washington D.C., November 12-16, 2005.

Tang PH. High-performance liquid chromatographic analysis of gabapentin in human serum by automated pre-column derivatization and electrochemical detection. The 2006 Pittsburgh Conference, Orlando, Florida, March 12-17, 2006.

Tang PH and DeGrauw T. Automated pre-column derivatization and LCEC for the determination of -aminobutyric acid in CSF. The 231st ACS National Meeting, Atlanta, Georgia, March 26-30, 2006.

Professional Organization Memberships

Special Interests

Peter H. Tang has special interests in the practice of analytical chemistry in clinical practice, in vitro diagnostics, and disease monitoring procedures.

Related Areas

This person works in these other areas at Cincinnati Children's Hospital Medical Center: