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Critical Care

Basilia Zingarelli, MD, PhD

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Basilia Zingarelli, MD, PhD

Title

Research Associate Professor

Appointment

Research Associate Professor -AFF, Department of Pediatrics

Email

basilia.zingarelli@cchmc.org

Phone

513-636-8704

Fax

513-636-4892

Bio

Basilia Zingarelli, MD, PhD, received her MD degree in 1990 and her PhD degree in Experimental Medicine in 1997 from the University of Messina, Italy.

Following a two-year research fellowship at the Medical University of South Carolina, Charleston, Dr. Zingarelli was recruited as research fellow at Cincinnati Children's Hospital Medical Center in 1995. She is presently a faculty member of the School of Medicine at the University of Cincinnati.

Dr. Zingarelli's research focuses on the mechanisms of cardiovascular dysfunction during sepsis, hemorrhagic shock, and ischemia and reperfusion injury, and the alteration of the microcirculation and tissue structure and function during inflammatory bowel diseases.

Specifically, her research efforts concentrate on studying the regulation of infiltration of inflammatory cells and the release of inflammatory mediators in the site of injury, and on the investigation of novel therapeutic approaches.

Credentials

MD: School of Medicine, University of Messina, Italy, 1990.

PhD: Experimental Medicine, School of Medicine, University of Messina, Italy, 1997.

Residency: Medical Toxicology, School of Medicine, University of Messina, Italy, 1990-1992.

Fellowship: Research Fellow, Division of Critical Care Medicine, Children's Hospital Medical Center, Cincinnati, Ohio, 1995-1997.

Certification: General Medicine (Italian), 1990.

Research

Cardiovascular shock, myocardial infarction, ischemia and reperfusion injury, inflammatory bowel diseases; specifically the pathological properties of nitric oxide, peroxynitrite, free radicals and inflammatory cytokines and the regulation of infiltration of inflammatory cells.

Special Interests:

Myocardial infarction, ischemia-reperfusion injury, mechanisms of inflammatory cells in the site of injury.

Honors:

  • "Fondazione Bonino-Pulejo" Award, Messina-Italy, 1991.
  • "Centro Nazionale delle Ricerche" Award, Rome-Italy, 1993.
  • Travel Grant Award, Seventeenth Annual Conference on Shock, Big Sky, MT, 1994.
  • Young Investigator Award, Seventeenth Annual Conference on Shock, Big Sky, MT, 1994.
  • "Società Italiana di Farmacologia" Award, Rome-Italy, 1995.
  • "Centro Nazionale delle Ricerche" Award, Rome-Italy, 1995.
  • Travel Grant Award, Eighteenth Annual Conference on Shock, Asheville, NC, 1995.

Grants:

  • Crohn's & Colitis Foundation of America, 2000-2003. Role of Poly (ADP-Ribose) Synthetase in the Regulation of Nuclear Transcription and Inflammatory Response in Inflammatory Bowel Disease.
  • National Institutes of Health, 2000-2004. Role of Poly (ADP-Ribose) Synthetase and Expression of Adhesion Molecules.
  • National Institutes of Health, 2003-2007. The role of PPARy and PPARy agonists in septic shock.
  • Co-investigator, 2003-2008. National Institues of Health. The heat shock response and cytoprotection.

Presentations:

  • Zingarelli B. Peroxynitrite as an inducer of divergent necrotic and apoptotic events encountered in shock and sepsis. The Twenty Fourth Annual Conference on Shock, June 2001, Marco Island, Florida, USA.
  • Zingarelli B. The NF-kB and AP-1 pathways in endotoxic shock and ischemia and reperfusion injury. Medical University of South Carolina, March 2000, Charleston, South Carolina, USA.
  • Zingarelli B. Nuclear control of inflammation: a role of poly (ADP-ribosyl)ation. Cellular and Molecular Pathology. Medical University of South Carolina, Graduate Program in Molecular and Cellular Pathology, March 2002, Charleston, South Carolina, USA.

Memberships and professional services:

  • Italian Society of Pharmacology, 1992 to present.
  • Shock Society, 1993 to present.
  • Women Faculty Association, 1998 to present.
  • American Gastroenterology Society, 1999 to present.
  • Editorial Board of SHOCK, official journal of the Shock Society, 2002 to present.
  • Society for Pediatric Research, 2002 to present.

Publications, Most Recent

Andreone TL, Denenberg A, O'Connor M, Hake PW, Zingarelli B. Poly (ADP-ribose) polymerase-1 regulates activation of activator protein-1 in murine fibroblasts.J Immunol, 2003;170:2113-2120.

McDowell SA, Gammon K, Zingarelli B, Bachurski CJ, Aronow BJ, Prows DR, Leikauf GD. Inhibition of NO restores surfactant gene expression following nichel-induced acute lung injury.Am J Resp Cell Biol, 2003;28:188-9.

Irazuzta J, Pretzlaff RK, Zingarelli B, Xue V, Zemlan F. Modulation of NF-kB activation and decreased markers of neurological injury associated with hypothermic therapy in experimental bacterial meningitis.Crit Care Med, 2002;30:2553-2559.

Sheehan M, Wong HR, Hake PW, Zingarelli B. Protective effects of isohelenin, an inhibitor of nuclear factor-kB, in endotoxic shock in rats. J Endotoxin Res, 2002;8:99-107.

Sheehan M, Wong HR, Hake PW, Zingarelli B. Parthenolide, an inhibitor of the nuclear factor-kB pathway, ameliorates cardiovascular derangement and outcome in endotoxic shock in rodents.Mol Pharmacol, 2002;61:953-963.

Zingarelli B, Hake PW, Cook JA. Inducible nitric oxide synthase is not required in the development of endotoxin tolerance in mice.Shock, 2002;17:478-484.

Zingarelli B, O'Connor M, Hake PW, Denenberg A, Wong HR. Absence of inducible nitric oxide synthase modulates early reperfusion-induced NF-kB and AP-1 activation and enhances myocardial damage.FASEB J, 2002;16:327-342.

Zingarelli B, Hake PW, Denenberg A, Wong HR. Sesquiterpene lactone parthenolide, an inhibitor of IkB kinase complex and nuclear factor-kB, exerts beneficial effects in myocardial reperfusion injury.Shock, 2002;17:127-134.

Zingarelli B, Yang Z, Hake PW, Denenberg A, Wong HR. Absence of endogenous interleukin-10 enhances early stress response during postischemic injury in mice intestine.Gut, 2001;5:610-622.

Yang Z, Zingarelli B, Szabó C. Crucial role of endogenous interleukin-10 production in myocardial ischemia / reperfusion injury.Circulation, 2000;101:1019-1026.

Irazuzta J, Pretzlaff R, Rowin M, Milam K, Zeemlan FP, Zingarelli B. Hypothermia as an adjunctive treatment for bacterial meningitis in rabbits.Brain Research, 2000;881:88-97.

Zingarelli B, Scott GS, Hake P, Salzman AL, Szabó C. Effects of nicaveran and peroxynitrite related pathways in vitro and in various models of shock and inflammation in vivo.Shock, 2000;13:126-134.

Zingarelli B, Szabó C, Salzman AL. Blockade of poly (ADP-ribose) synthetase inhibits neutrophil recruitment, oxidant generation, and mucosal injury in murine colitis.Gastroenterology, 1999;116:335-345.

Zingarelli B, Szabó C, Salzman AL. Reduced oxidative and nitrosative damage in murine experimental colitis in the absence of inducible nitric oxide synthase.Gut, 1999;45:199-209.

Zingarelli B, Haskó G, Salzman AL, Szabó C. Effects of a novel guanylyl cyclase inhibitor on vascular actions of nitric oxide and peroxynitrite in immunostimulated smooth muscle cells and in endotoxic shock.Critical Care Medicine, 1999;27:1701-1707.

Stern Y, Salzman AL, Cotton RT, Zingarelli B. Protective effect of 3-Aminobenzamide, an inhibitor of poly (ADP-ribose) synthetase, against laryngeal injury in rats.American Journal of Respiratory and Critical Care Medicine, 1999;160:1743-1749.

Zingarelli B, Cuzzocrea S, Zsengeller Z, Salzman AL, Szabó C. Protection against myocardial ischemia and reperfusion injury by 3-aminobenzamide, an inhibitor of poly (ADP ribose) synthetase.Cardiovascular Research, 1997;36:205-215.

Zingarelli B, Salzman AL, Szabó C. Genetic disruption of poly (ADP-rbose) synthetase inhibits the expression of P-selectin and intercellular adhesion molecule-1 in myocardial ischemia-reperfusion injury.Circulation Research, 1998;83:85-94.

Zingarelli B, Szabó C, Salzman AL. Mercaptoethylguanidine, a combined inhibitor of nitric oxide synthase and peroxynitrite scavenger, reduces trinitrobenzene sulfonic acid-induced colonic damage in rats. Journal of Pharmacology and Experimental Therapeutics, 1998;287:1048-1055.

Zingarelli B, Day BJ, Crapo JD, Salzman AL, Szabó C. The potential role of peroxynitrite in the vascular contractile and cellular energetic failure in endotoxic shock.British Journal of Pharmacology, 1997;120:259-267.

Zingarelli B, Southan GJ, Gilad E, Salzman AL, Szabó C. The inhibitory effects of mercaptoalkyguanidines on cyclo-oxygenase activity. British Journal of Pharmacology, 1997;120:357-366.

Zingarelli B, O'Connor M, Wong H, Salzman AL, Szabó C. Peroxinitrite -mediated DNA strand breakage activates poly-ADP ribosyl synthetase and causes cellular energy depletion in macrophages stimulated with bacterial lipopolysaccharide. Journal of Immunology, 1996;156:350-358.

Szabó C, Zingarelli B, O'Connor M, Salzman AL. DNA strand breakage, activation of poly-ADP ribosyl synthetase, and cellular energy depletion are involved in the cytotoxicity in macrophages and smooth muscle cells exposed to peroxynitrite.Proceedings of the National Academy of Science USA, 1996;93:1753-1758.

Zingarelli B, Salzman AL, Szabó C. Protective effects of nicotinamide against nitric oxide-mediated delayed vascular failure in endotoxin shock: potential involvement of poly-ADP ribosyl synthase. Shock, 1996;5:258-264.

Related Areas

This person works in these other areas at Cincinnati Children's Hospital Medical Center: