Critical Care

Lesley A. Doughty, MD

Title

Physician

Appointment

Associate Professor

Email

lesley.doughty@cchmc.org

Phone

513-636-4259

Fax

513-636-4267

Credentials

MD: Dartmouth Medical School

Residency: Pediatrics, Tripler Army Medical Center

Fellowship: Critical Care Medicine, Children's Hospital of Pittsburgh

Awards and Honors

New England Pediatric Society Award, Dartmouth Medical School
Educational Scholarship and Pediatric Specialty Awards, Society of Critical Care Medicine
Best Doctors in America, 2008

Research Grants and Contracts

Viral Modulation of the Inflammatory Response, K08, 2004, Principal Investigator

Publications, Most Recent

Thomas NJ, Doughty LA, Heine RP, Mortimer LF, Wisniewski S, Sasser H, Carcillo JA: Circulating Endogenous Antimicrobial Polypeptides: Defensins and Lactoferrin in Children With Severe Sepsis. Ped Inf Dis J. 21:34-38, 2002.

Green J, Doughty L, Kaplan S, Sasser H, Wisniewski S, Carcillo J: The Tissue Factor And Plasminogen Activator Inhibitor Type-1 Response In Pediatric Sepsis And Sepsis-Induced Multiple Organ Failure. Thrombosis and Hemostasis 87:2128-2132, 2002.

Doughty LA, Clark R, Kaplan S, Dickman P, Sasser H, Wisniewski S, Carcillo J: sFas and sFas Ligand in Pediatric Sepsis-Induced Multiple Organ Failure Syndrome. Peds Res. 52: 922-927, 2002.

Han YY, Doughty LA, Kofos D, Sasser H, Carcillo JA: Persistently Increased Procalcitonin Is Associated with Poor Outcome among Children with Bacterial Sepsis. Crit Care Med. 4:21-25, 2003.

Ayala A, Chung CS, Lomas J, Song GY, Doughty LA, Gregory SH, Cioffi WG, LeBlanc BW, Reichner J, Simms HH, Grutkoski P: Shock Induced Neutrophil Mediated Priming for Acute Lung Injury in Mice: Divergent Effects of TLR 4 and TLR 4 / FasL Deficiency. AJP 161:2283-2294, 2003.

Lomas JL, Chung CS, Grutkoski pS, LeBlanc BW, Lavigne L, Reichner J, Gregory SH, Doughty LA, Cioffi WG, Ayala A: Differential Effects of MIP-2 and KC on Hemorrhage Induced Neutrophil Priming for Lung Inflammation: Assessment by Adoptive Cells. Shock 19(4):358-365, 2003.

Carcillo JA, Doughty L, Kofos D, Frye RF, Kaplan SS, Sasser H, Burckart GJ: Cytochrome P450 mediated-drug metabolism is reduced in children with sepsis-induced multiple organ failure. Intensive Care Medicine 29:980-984, 2003.

Durbin J, Doughty L, Nguyen K, Caliguri M, Van Deusen J, Biron C: The role of STAT1 in viral sensitization to LPS. J Endotoxin Res. 9: 313-316, 2003.

Doughty LA: Modulation of the immune response in critical illness / injury. Immunology and Infectious Disease. Eds. Doughty L. and Linden P. Kluwer Academic Publishers, Norwell, MA, 2003.