Cincinnati Center for Eosinophilic Disorders

Suggested Literature

Diagnostic Criteria and Recommendations for EE Now Published

Long-awaited summary recommendation concerning the diagnosis and treatment of eosinophilic esophagitis have now been published. The recommendations were derived from the First International Gastrointestinal Eosinophil Research Symposium (FIGERS) composed of several members of the CCED faculty. Read abstract.

Connections Between Reflux, EE and Allergies

Download a .pdfIn an article titled "Researchers See Novel Connections Between Reflux and Allergies," author Sharon L. Cross, PhD, discusses the link between reflux, eosinophilic esophagitis and allergies. Read full article.

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Doctors who study eosinophils at Cincinnati Children's Hospital Medical Center recommend the following journal articles for more information about research about eosinophilic disorders.

  1. Marc E. Rothenberg, MD, PhD, Amy D. Klion, MD, Florence E. Roufosse, MD, PhD, Jean Emmanuel Kahn, MD, Peter F. Weller, MD, Hans-Uwe Simon, MD, PhD, Lawrence B. Schwartz, MD, PhD, Lanny J. Rosenwasser, MD, Johannes Ring, MD, PhD, Elaine F. Griffin, D.Phil., Ann E. Haig, B.S.N., Paul I.H. Frewer, M.Sc., Jacqueline M. Parkin, M.B., B.S., PhD, Gerald J. Gleich, MD, for the Mepolizumab HES Study Group, Treatment of Patients with the Hypereosinophilic Syndrome with Mepolizumab. The New England Journal of Medicine. March 16. 2008.
  2. Gastrointestinal Endoscopy Clinics: Eosinophilic Esophagitis. Edited by G.T. Furuta. Volume 18, Issue 1, Pages 1-224 (January 2008).
  3. Furuta GT, Liacouras CA, Collins MH, Gupta SK, Justinich C, Putnam PE, Bonis P, Hassall E, Straumann A, Rothenberg ME, Members of the First International Gastrointestinal Eosinophil Research Symposium (FIGERS) Subcommittees. Eosinophilic Esophagitis in Children and Adults: A Systematic Review and Consensus Recommendations for Diagnosis and Treatment. Gastroenterology. 2007 Oct;133(4):1342-63. [abstract]
  4. Zuo L, Rothenberg ME. Gastrointestinal eosinophilia. Immunol Allergy Clin North Am. 2007 Aug;27(3):443-55. [abstract]
  5. Liacouras CA, Bonis P, Putnam PE, Straumann A, Ruchelli E, Gupta SK, Lee JJ, Hogan SP, Wershil BK, Rothenberg ME, Ackerman SJ, Gomes I, Murch S, Mishra A, Furuta GT. Summary of the first international gastrointestinal eosinophil research symposium. J Pediatr Gastroenterol Nutr. 2007 Sep;45(3):370-91. [abstract]
  6. Foroughi S, Foster B, Kim N, Bernardino LB, Scott LM, Hamilton RG, Metcalfe DD, Mannon PJ, Prussin C. Anti-IgE treatment of eosinophil-associated gastrointestinal disorders. J Allergy Clin Immunol. 2007 Sep;120(3):594-601. [abstract]
  7. Vanderheyden AD, Petras RE, DeYoung BR, Mitros, FA. Emerging Eosinophilic (Allergic) Esophagitis: Increased Incidence or Increased Recognition? Arch Pathol Lab Med. 2007 May;131(5):777-9. [abstract]
  8. Lucendo AJ, Castillo P, Martín-Chávarri S, Carrión G, Pajares R, Pascual JM, Manceñido N, Erdozain JC. Manometric findings in adult eosinophilic oesophagitis: a study of 12 cases. Eur J Gastroenterol Hepatol. 2007 May;19(5):417-24. [abstract] 
  9. Balatsinou C, Milano A, Caldarella MP, Laterza F, Pierdomenico SD, Cuccurullo F, Neri M: Eosinophilic esophagitis is a component of the anticonvulsant hypersensitivity syndrome: Description of two cases. Digestive and Liver Disease 2007 Mar 27. [abstract]
  10. Lucendo A, Navarro M, Comas C, Pascual J, Burgos E, Santamarı´a L, Larrauri J: Immunophenotypic Characterization and Quantification of the Epithelial Inflammatory Infiltrate in Eosinophilic Esophagitis Through Stereology: An Analysis of the Cellular Mechanisms of the Disease and the Immunologic Capacity of the Esophagus. Am J Surg Pathol. 2007 Apr;31(4):598-606. [abstract]
  11. Aceves S, Newbury R, Dohil R, Bastian J, Broide D: Esophageal remodeling in pediatric eosinophilic esophagitis. J Allergy Clin Immunol, 2007 Jan;119(1):206-12. [abstract]
  12. Kirsch R, Bokhary R, Marcon M, Cutz E: Activated Mucosal Mast Cells Differentiate Eosinophilic (Allergic) Esophagitis From Gastroesophageal Reflux Disease. J Pediatr Gastroenterol Nutr, Vol. 44, No. 1, January 2007. [abstract]
  13. Rothenberg M: Fluticasone propionate effective against eosinophilic esophagitis. Gastroenterology Nov 21 2006;131:1381-1391,1629-1631.
  14. Boyer D, Vargas SO, Slattery D, Rivera-Sanchez YM, Colin AA: Churg-Strauss syndrome in children: a clinical and pathologic review. Pediatrics 2006 Sep;118(3):e914-20. [abstract]
  15. Fulkerson PC, Fischetti CA, Hassman LM, Nikolaidis NM, Rothenberg ME. Persistent Effects Induced by IL-13 in the Lung. Am J Respir Cell Mol Biol. 2006 Sep;35(3):337-46. Epub 2006 Apr 27. [abstract]
  16. Forbes E, Hulett M, Ahrens R, Wagner N, Smart V, Matthaei KI, Brandt EB, Dent LA, Rothenberg ME, Tang M, Foster PS, Hogan SP. ICAM-1-dependent pathways regulate colonic eosinophilic inflammation. J Leukoc Biol. 2006 Aug;80(2):330-41. Epub 2006 May 26. [abstract]
  17. Hogan SP, Seidu L, Blanchard C, Groschwitz K, Mishra A, Karow ML, Ahrens R, Artis D, Murphy AJ, Valenzuela DM, Yancopoulos GD, Rothenberg ME. Resistin-like molecule beta regulates innate colonic function: barrier integrity and inflammation susceptibility. J Allergy Clin Immunol. 2006 Jul;118(1):257-68. [abstract]
  18. Munitz A, Bachelet I, Eliashar R, Khodoun M, Finkelman FD, Rothenberg ME, Levi-Schaffer F. CD48 is an allergen and IL-3-induced activation molecule on eosinophils. J Immunol. 2006 Jul 1;177(1):77-83. [abstract]
  19. Brandt EB, Zimmermann N, Muntel EE, Yamada Y, Pope SM, Mishra A, Hogan SP, Rothenberg ME. The alpha4bbeta7-integrin is dynamically expressed on murine eosinophils and involved in eosinophil trafficking to the intestine. Clin Exp Allergy. 2006 Apr;36(4):543-53. [abstract]
  20. Hogan SP, Rothenberg ME. Eosinophil Function in Eosinophil-Associated Gastrointestinal Disorders. Curr Allergy Asthma Rep. 2006 Feb;6(1):65-71. [abstract]
  21. Yamada Y, Rothenberg ME, Lee AW, Akei HS, Brandt EB, Williams DA, Cancelas JA. The FIP1L1-PDGFRA fusion gene cooperates with IL-5 to induce murine hypereosinophilic syndrome (HES) / chronic eosinophilic leukemia (CEL)-like disease. Blood. 2006 May 15;107(10):4071-9. Epub 2006 Jan 17. [abstract]
  22. Katzka, David A. Eosinophilic esophagitis. Current Opinion in Gastroenterology 2006, 22:429 - 432. [abstract]
  23. Klion A, Bochner B, Gleich G, Nutman T, Rothenberg M, Simon H-U, Wechsler M, Weller P, the Hypereosinophilic Syndromes Working Group: Approaches to the treatment of hypereosinophilic syndromes: A workshop summary report. [abstract] Journal of Clinical Investigation.
  24. Blanchard C, Wang N, Stringer KF, Mishra A, Fulkerson PC, Abonia JP, Jameson SC, Kirby C, Konikoff MR, Collins MH, Cohen MB, Akers R, Hogan SP, Assa'ad AH, Putnam PE, Aronow BJ, Rothenberg ME: Eotaxin-3 and a uniquely conserved gene-expression profile in eosinophilic esophagitis. J. Clin. Invest. 116:536-547 (2006). [abstract]
  25. Noel RJ, Rothenberg ME. Eosinophilic esophagitis. Curr Opin Pediatr. 2005 Dec;17(6):690-4. [abstract]
  26. Rothenberg ME, Hogan SP: The Eosinophil. The Annual Review of Immunology, November 2005; 5.1-5.28. [abstract]
  27. Ngo P, Furuta GT: Treatment of Eosinophilic Esophagitis in Children. Curr Treat Options Gastroenterol. 2005 Oct;8(5):397-403. [abstract]
  28. Akei HS, Mishra A, Blanchard C, Rothenberg ME: Epicutaneous antigen exposure primes for experimental eosinophilic esophagitis in mice. Gastroenterology, 2005 Sep;129(3):985-94. [abstract]
  29. De Angelis P, Markowitz JE, Torroni F, Caldaro T, Pane A, Morino G, Sforza Wietrzykowska R, Federici di Abriola G, Ponticelli A, Dall'oglio L: Paediatric eosinophilic oesophagitis: Towards early diagnosis and best treatment. Dig Liver Dis. 2005 Sep 28; Epub ahead of print. [abstract]
  30. Aceves SS, Dohil R, Newbury RO, Bastian JF: Topical viscous budesonide suspension for treatment of eosinophilic esophagitis. J Allergy Clin Immunol. 2005 Sep;116(3):705-6. No abstract available.
  31. Blanchard C, Mishra A, Saito-Akei H, Monk P, Anderson I, Rothenberg ME: Inhibition of human interleukin-13-induced respiratory and oesophageal inflammation by anti-human-interleukin-13 antibody (CAT-354). Clin Exp Allergy. 2005 Aug;35(8):1096-103. [abstract]
  32. Zimmerman SL, Levine MS, Rubesin SE, Mitre MC, Furth EE, Laufer I, Katzka DA: Idiopathic eosinophilic esophagitis in adults: the ringed esophagus. Radiology. 2005 Jul;236(1):159-65. Epub 2005 Jun 27. [abstract]
  33. Meyer GW: Eosinophilic esophagitis in a father and a daughter. Gastrointest Endosc. 2005 Jun;61(7):932. No abstract available.
  34. Desai TK, Stecevic V, Chang CH, Goldstein NS, Badizadegan K, Furuta GT: Association of eosinophilic inflammation with esophageal food impaction in adults. Gastrointest Endosc. 2005 Jun;61(7):795-801. [abstract]
  35. Spergel J, Rothenberg ME, Fogg M: Eliminating eosinophilic esophagitis. Clin Immunol. 2005 May;115(2):131-2. No abstract available.
  36. Simon D, Marti H, Heer P, Simon HU, Braathen LR, Straumann A: Eosinophilic esophagitis is frequently associated with IgE-mediated allergic airway diseases. J Allergy Clin Immunol. 2005 May;115(5):1090-2. No abstract available.
  37. Lucendo Villarin AJ, Carrion Alonso G, Navarro Sanchez M, Martin Chavarri S, Gomez Senent S, Castillo Grau P, Pascual Turrion JM, Gonzalez Sanz-Agero P: Eosinophilic esophagitis in adults, an emerging cause of dysphagia. Description of 9 cases. Rev Esp Enferm Dig. 2005 Apr;97(4):229-39. English, Spanish. [abstract]
  38. Cantu P, Velio P, Prada A, Penagini R: Ringed oesophagus and idiopathic eosinophilic oesophagitis in adults: an association in two cases. Dig Liver Dis. 2005 Feb;37(2):129-34. [abstract]
  39. Straumann A, Simon HU: Eosinophilic esophagitis: escalating epidemiology? J Allergy Clin Immunol. 2005 Feb;115(2):418-9. No abstract available.
  40. Nostrant TT: Esophageal Dilation / Dilators. Curr Treat Options Gastroenterol. 2005 Feb;8(1):85-95. [abstract]
  41. Patel SM, Falchuk KR: Three brothers with dysphagia caused by eosinophilic esophagitis. Gastrointest Endosc. 2005 Jan;61(1):165-7. No abstract available.
  42. Spergel JM, Brown-Whitehorn T: The use of patch testing in the diagnosis of food allergy. Curr Allergy Asthma Rep. 2005 Jan;5(1):86-90. Review. [abstract]
  43. Mann NS, Leung JW: Pathogenesis of esophageal rings in eosinophilic esophagitis. Med Hypotheses. 2005;64(3):520-3. [abstract]
  44. Kukuruzovic RH, Elliott EE, O'Loughlin EV, Markowitz JE: Non-surgical interventions for eosinophilic oesophagitis. Cochrane Database Syst Rev. 2004;(3):CD004065. Review. [abstract]
  45. Kim YJ, Prussin C, Martin B, Law MA, Haverty TP, Nutman TB, Klion AD. Rebound eosinophilia after treatment of hypereosinophilic syndrome and eosinophilic gastroenteritis with monoclonal anti-IL-5 antibody SCH55700. J Allergy Clin Immunol. 2004 Dec;114(6):1449-55. [abstract]
  46. Hogan SP, Rothenberg ME: Review article: The eosinophil as a therapeutic target in gastrointestinal disease. Aliment Pharmacol Ther. 2004 Dec;20(11-12):1231-40. Review. [abstract
  47. Higashi N, Mita H, Taniguchi M, Turikisawa N, Higashi A, Ozawa Y, Tohma S, Arimura K, Akiyama K. Urinary eicosanoid and tyrosine derivative concentrations in patients with vasculitides. J Allergy Clin Immunol. 2004 Dec;114(6):1353-8. [abstract]
  48. Lucendo AJ, Carrion G, Navarro M, Pascual JM, Gonzalez P, Castillo P, Erdozain JC: Eosinophilic esophagitis in adults: an emerging disease. Dig Dis Sci. 2004 Nov-Dec;49(11-12):1884-8. No abstract available.
  49. Karthik SV, Casson DH: Bilateral atopic cataracts in a child with eosinophilic esophagitis: an association to look out for. J Pediatr Gastroenterol Nutr. 2004 Nov;39(5):557-9. No abstract available.
  50. Wei L, MacDonald TM, Walker BR. Summaries for patients. Glucocorticoid medications and the risk for cardiovascular disease. Ann Intern Med. 2004 Nov 16;141(10):I58. [abstract] [free full-text summary for patients]
  51. Sant'Anna AM, Rolland S, Fournet JC, Yazbeck S, Drouin E: Eosinophilic Esophagitis in Children: Symptoms, Histology and pH Probe Results. J Pediatr Gastroenterol Nutr. 2004 Oct;39(4):373-377. [abstract]
  52. Liacouras CA, Ruchelli E: Eosinophilic esophagitis.
    Curr Opin Pediatr. 2004 Oct;16(5):560-6. Review. [abstract]
  53. Straumann A, Spichtin HP, Bucher KA, Heer P, Simon HU: Eosinophilic esophagitis: red on microscopy, white on endoscopy. Digestion. 2004;70(2):109-16. Epub 2004 Sep 20. [abstract]
  54. Garrett JK, Jameson SC, Thomson B, Collins MH, Wagoner LE, Freese DE, Boyce JA, Beck LA, Filipovich A, Villanueva JM, Sutton SA, Assa'ad AH, Rothenberg ME. Anti-interleukin-5 (mepolizumab) therapy for hypereosinophilic syndromes. J Allergy Clin Immunol, 2004; 113: 115-9. [abstract]
  55. Noel RJ, Putnam PE, Rothenberg ME. Eosinophilic Esophagitis, N Engl J Med, 2004; 351(9):940-1. [abstract]
  56. Noel RJ, Putnam PE, Collins MH, Assa'ad AH, Guajardo JR, Jameson SC, Rothenberg ME. Heterogeneous clinical and immunopathological responses to swallowed fluticasone propionate for eosinophilic esophagitis, Clin Gastroenterol Hepatol, 2004; 2:568-75. [abstract]
  57. Dahms BB: Reflux esophagitis: sequelae and differential diagnosis in infants and children including eosinophilic esophagitis. Pediatr Dev Pathol. 2004 Jan-Feb;7(1):5-16. Review. [abstract]
  58. Rothenberg ME. Eosinophilic gastrointestinal disorders (EGID). J Allergy Clin Immunol. 2004 Jan;113(1):11-28 [abstract]
  59. Lack G, Fox D, Northstone K, Golding J.  Factors associated with the development of peanut allergy in childhood.  N Engl J Med. 2003 Mar 13;348(11):977-85 [abstract] [comment]
  60. Leung DY, Sampson HA, Yunginger JW, Burks AW Jr, Schneider LC, Wortel CH, Davis FM, Hyun JD, Shanahan WR Jr. Effect of anti-IgE therapy in patients with peanut allergy.  N Engl J Med. 2003 Mar 13;348(11):986-93 [abstract] [comment]
  61. Furuta, GT Eosinophilic esophagits: an emerging clinicopathologic entity. Curr Allergy Asthma Rep 2002. Jan; 2(1):67-72 Review [abstract]
  62. Fox VL, Kurko S, Furuta GT. Eosinophilic esophagitis: it's not just kid's stuff. Gastrointest Endosc. 2002 August;56(2):260-70. Abstract not available.
  63. Teitelbaum JE, Fox VL, Twarog FJ, Nurko S, Antonioli D, Gleich G, Badizadegan K, Furuta GT. Eosinophilic esophagitis in children: immunopathological analysis and response to fluticasone propionate. Gastroenterology. 2002 May; 122(5):1216-25 [abstract]
  64. Guajardo JR, Plotnick LM, Fende JM, Collins MH, Putnam PE, Rothenberg ME. Eosinophil-associated gastrointestinal disorders: A world-wide-web based registry. J Pediatr. 2002 Oct;141(4):576-81.  [abstract]
  65. Kokkonen J, Ruuska T, Karttunen TJ, Niinimaki A. Mucosal pathology of the foregut associated with food allergy and recurrent abdominal pains in children. Acta Paediatr 2001 Jan;90(1):16-21 [abstract]
  66. Mishra A, Hogan SP, Brandt EB, Rothenberg ME.An etiological role for aeroallergens and eosinophils in experimental esophagitis. J Clin Invest 2001 Jan;107(1):83-90 [abstract]
  67. Orenstein SR, Shalaby TM, Di Lorenzo C, Putnam PE, Sigurdsson L, Kocoshis SA. The spectrum of pediatric eosinophilic esophagitis beyond infancy: a clinical series of 30 children. Am J Gastroenterol 2000 Jun;95(6):1422-30 [abstract]
  68. Ahmad M, Soetikno RM, Ahmed A.The differential diagnosis of eosinophilic esophagitis. J Clin Gastroenterol 2000 Apr;30(3):242-4 [abstract]
  69. Liacouras CA, Markowitz JE.Eosinophilic esophagitis: A subset of eosinophilic gastroenteritis. Curr Gastroenterol Rep 1999 Jun;1(3):253-8 [abstract]
  70. Ruchelli E, Wenner W, Voytek T, Brown K, Liacouras C.Severity of esophageal eosinophilia predicts response to conventional gastroesophageal reflux therapy. Pediatr Dev Pathol 1999 Jan-Feb;2(1):15-8 [abstract]
  71. Rothenberg ME. Eosinophilia. N Engl J Med, 1998; 338:1592-1600. [abstract]
  72. Liacouras CA, Wenner WJ, Brown K, Ruchelli E.Primary eosinophilic esophagitis in children: successful treatment with oral corticosteroids. J Pediatr Gastroenterol Nutr 1998 Apr;26(4):380-5 [abstract]
  73. Liacouras CA. Failed Nissen fundoplication in two patients who had persistent vomiting and eosinophilic esophagitis. J Pediatr Surg 1997 Oct;32(10):1504-6 [abstract]
  74. Kelly KJ, Lazenby AJ, Rowe PC, Yardley JH, Perman JA, Sampson HA.Eosinophilic esophagitis attributed to gastroesophageal reflux: improvement with an amino acid-based formula. Gastroenterology 1995 Nov;109(5):1503-12 [abstract]
  75. Vitellas KM, Bennett WF, Bova JG, Johnson JC, Greenson JK, Caldwell JH Radiographic manifestations of eosinophilic gastroenteritis. Abdom Imaging 1995 Sep-Oct;20(5):406-13 [abstract]