Cincinnati Center for Eosinophilic Disorders

Anil Mishra, PhD

Appointment

Assistant Professor

Email

anil.mishra@cchmc.org

Phone

513-636-3347

Fax

513-636-3310

Bio

Anil Mishra, PhD, scientific objective includes elucidating the mechanism for the recruitment of inflammatory cells into the mucosal allergic tissue. Dr. Mishra is actively involved in managing a research program focused on understanding the molecular mechanisms of eosinophilic esophageal and lower gastrointestinal tract inflammation.

Dr. Mishra's important contribution was to establish that eosinophils are the resident cell that home prenatally in the gastrointestinal tract and the gastrointestinal tract (esophagus to colon) constitutively expresses eotaxin (an eosinophil selective chemoattractant). These finding indicated that the esophagus is devoid of resident eosinophils at baseline and eotaxin is not sufficient for eosinophil trafficking and homing into the tissues. In an effort to further understand the mechanisms and significance of eosinophil accumulation in the lung and esophagus at disease states, Dr. Mishra prioritized his research to focus on lung inflammation associated eosinophilic esophagitis, aiming to gain insight into this poorly understood disease. He developed a murine model of asthma associated eosinophilic esophagitis. These findings implicated aeroallergens in the etiology of EE and suggested that esophageal eosinophilic inflammation is mechanistically associated with pulmonary inflammation.

Recently, he showed that CD4 T cells dependency is less important in the esophageal eosinophilic inflammation compared to the lung. Dr. Mishra's is an elected fellow of the American Academy of Allergy, Asthma and Immunology. He has over a 50 articles on molecular mechanisms of the pulmonary toxicity and allergic responses. His research has been supported by the National Institutes of Health to understand the mechanism that induce eosinophilic esophagitis.

Credentials

PhD: Kanpur University, Kanpur, India

Awards and Honors

1987: Student Award for attending research workshop at Duke University Medical
Center, Durham, NC.
1988: Visiting Scientist Award, GSF, Munchen, Germany.
1993: Research Fellowship Award from National Research Council, Washington, DC, on the grant of Ozone effect on the lungs of rodents.
1996: Best Research Work Presentation Award, Tulane University, New Orleans, LA. p53 role in the development of lung fibrosis.
1997: Young Investigator Award from Central Society of Clinical Research,
Washington, DC, on KGF regulates surfactant proteins.
1999: Travel grant from American Academy of Allergy and Asthma
to present eosinophils homing into GI tract.
2000: Travel grant from American Academy of Allergy and Asthma. To present eosinophils traffickingto the esophagus.

Presentations

A. Mishra, S.P. Hogan, F. El-Awar, M.E Rothenberg. Regulation of gastrointestinal eosinophils. Presented at AAAAI annual meeting 1999 at Orlando, Florida.

A. Mishra , Hogan SP, Brandt EB, Rothenberg ME. Esophageal eosinophils are regulated by allergen challenge, IL-5 and eotaxin. Presented at AAAAI, 2000 annual meeting at Sandiago, California.

Hogan SP, Brandt E, Mishra A, Foster PS, Rothenberg ME. The chemokine eotaxin is a central mediator of experimental eosinophilic gastrointestinal allergy. Presented at AAAAI annual meeting 2000 at Sandiago, Califirnia.

Brandt, EB, Hogan SP, Mishra A, Rothenberg ME. A novel murine model of gastrointestinal allergy demonstrates the occurrence of early and late phase allergic reactions. Presented at AAAAI, annual meeting 2000 at Sandiago, California.

Bodette, Zimmermann, Mishra A, Rothenberg ME. Murine eotaxin-2: a constitutive chemokine induced by allergen challenge and IL-4. Presented at AAAAI annual meeting 2000 at Sandiago, California.

A. Mishra , Weaver TE, Bachurski CJ, Rothenberg ME. Allergic airway inflammation inhibits the expression of human surfactant protein c promoter in transgenic mice. Presented at ATS annual meeting 2000 at Toronto, Canada.

Publications, Most Recent

Mishra A, Hogan SP, Brandt E, and Rothenberg ME (2001). An etiological role foraeroallergens and eosinophils in experimental esophagitis.J. Clin. Invest. 107 (1)83-90.

Mishra A, Weaver T, Beck DC and Rothenberg ME (2001). IL-5 mediated allergic inflammation inhibits the human surfactant protein C promoter in transgenic mice.J.Biol. Chem. (Published online 11, December 2000).

Mishra A, Hogan,SP, Brandt,E and Rothenberg ME (2000). Regulation of eosinophils trafficking to Peyer's patches by mucosal allergen exposure, interleukin-5, and eotaxin.Blood. 96 (4), 1538-44.

Mishra A, Doyel N, Martin WJ II. (2000) Bleomycin –mediated pulmonary toxicity: evidence for a p53-mediated response.Am J. Respir Cell Mol Biol. 22 (5) 543-549 (See Commentary by Prof. J.A.D.Cooper,Jr., University of Alabama, Birmingham, Alabama, USA in Am.J.Respir.Cell Mol Biol .22 (5), 520-23).

Zimmerman N, Hogan SP, Mishra A, Brandt, E and Rothenberg ME (2000). Murine eotaxin-2: a constitutive eosinophil chemokine induced by allergen challenge and IL4 over-expression.J. Immunology. 165: 5839-5846.

Hogan SP , Mishra A, Brandt E, Michael JG, Foster PS and Rothenberg ME (2000). The chemokine eotaxin is a center mediator of gastrointestinal allergy.Proc. Natl. Acd. Sci., USA. 97 (12), 6681-6686.(See commentary by Paul M. Rowe in Lancet, vol. 355:9220 June 10, 2000).

Mishra A, Simon Hogan, James J. Lee, Paul Foster and Marc E. Rothenberg (1999). Fundamental signals regulating eosinophil homing into the gastrointestinal tract.J. Clin. Invest. 103 (12), 1719-1727 (See Commentary by Prof. Furuta, GT and Sherman, P of Harvard University, Boston, USA and University of Toronto, Toronto Canda in J. Peditric. Gastro. Neutrition. Vol. 30, 229 March 2000 in the section of News and Views).

Rothenberg ME, Zimmermann N, Mishra A, Brandt E, Birkenberger LA, Hogan,SP and Foster PS (1999). Chemokines and chemokine receptors: Their role in allergic airway disease.J. Allergy & Clinical. Immunology. 19 (5), 250-265.