Simon Patrick Hogan, PhD
Appointment
Assistant Professor of Pediatrics
Email
simon.hogan@cchmc.org
Phone
513-636-6620
Fax
513-636-3310
Credentials
BS Microbiology, Biochemistry and Molecular Biology. Australian National University 1991.
PhD Medical Sciences, Department of Biochemistry and Molecular Biology, John Curtin School of Medical Research, Australian National University. 1997.
Position History
1997. Postdoctoral Fellow, Cellular Signal Transduction Laboratory, Division of Biochemistry and Molecular Biology, John Curtin School of Medical Research, Australian National University.
1998-2000. NHMRC CJ Martin Postdoctoral Fellow, Department of Allergy, Immunology and Pulmonary Medicine, Childrens Hospital Medical Center, Cincinnati, OH, USA.
2000. NHMRC CJ Martin Postdoctoral Fellow Allergy and Inflammation Research Group, Division of Biochemistry and Molecular Biology, John Curtin School of Medical Research, Australian National University.
2001. Promoted to Research Fellow level B, Allergy and Inflammation Research Group, Division of Molecular Bioscience, John Curtin School of Medical Research, Australian National University.
2003-2004. Promoted to Research Fellow level C, Allergy and Inflammation Research Group, Division of Molecular Bioscience, John Curtin School of Medical Research, Australian National University.
2004. Head, Gastrointestinal Research Laboratory, Allergy and Inflammation Research Group, Division of Molecular Bioscience, John Curtin School of Medical Research, Australian National University.
2004. Assistant Professor of Pediatrics, Division of Allergy & Immunology, Cincinnati Children's Hospital Medical Center
Awards and Honors
1993-1995. John Curtin School of Medical Postgraduate Research Scholarship.
1995-1997. Australian National University Postgraduate Research Scholarship.
1998. Frank Fenner Medal for the Most outstanding PhD thesis at the John Curtin School of Medical Research, Canberra, Australia
1998. NHMRC CJ Martin Post-doctoral Fellowship Award
1998-2000. Jaffe Family Foundation Food Allergy Research Award, American Academy of Allergy, Asthma and Immunology
2000. Travel Grant Award, American Academy of Allergy, Asthma and Immunology, Annual Meeting, San Diego, California.
2001. AMRAD Post-Doctoral Fellowship Award.
2002. ACT Tall Poppy Award
2003. NSW Biofirst Award
Publications, Most Recent
Mishra, A, Hogan, SP, Rothenberg, ME (2002) Interleukin-5 promotes eosinophil trafficking to the esophagus.J. Immunol. 168: p. 162-7.
Mattes, J, Yang, M, Mahalingam, S, Kuehr, J, Webb, DC, Simson, L, Hogan, SP, Koskinen, A, Dent, L, Rothenberg, ME, Matthaei, KI, Young, IG, and Foster, PS. (2002) Intrinsic defect in T cell production of Interleukin-(IL)-13 in the absence of both IL-5 and eotaxin precludes the development of airways hyperreactivity in experimental asthma.J. Exp. Med. 195: p. 1433-44
Mattes, J, Hulett, M, Xie, W, Hogan, SP, Rothenberg, ME, Foster, PS, Parish, C. (2003) Th2 cell induced tumour regression.J. Exp. Med. 197: p. 387-393
Yang, M, Hogan, SP, Mahalingam, S, Matthaei, KI, Pope, MM, Zimmermann, N, Dent, L, McKenzie, ANJ, Young, IG, Rothenberg, ME, Foster, PS (2003) Eotaxin-2 induces IL-5 dependent pulmonary eosinophilia and IL-13 dependent AHR.J. Allergy Clin. Immunol. 112: p. 935-43.
Smart, V, Foster, PS, Rothenberg, ME, Higgins, TJV, Hogan SP. (2003). A plant-based vaccine suppresses experimental allergy.J. Immunol. 171: p. 2116-36.
Forbes, E, Smart, S, D'Aprile, A, Henry, P, Yang, M, Matthaei, K, Rothenberg, ME, Foster, PS and Hogan SP. (2004). T helper-2 Immunity regulates bronchial hyperresponsiveness in eosinophil-associated gastrointestinal disease in mice.Gastroenterology, 127: p. 105-18.
Forbes, E, Murase, T, Yang, M, Matthaei, KI, Lee, JJ, Lee, NA, Foster, PS and Hogan, SP (2004). Immunopathogenesis of experimental ulcerative colitis is mediated by eosinophil peroxidase.J. Immunology, 172: p5664-5675 .
Special Interests
During my PhD studies and also post-doctoral studies I have focused on defining the key cellular and molecular processes that regulate eosinophilic inflammation and Th2 cell mediated immune responses. These inflammatory processes underlie the pathogenesis of asthma, rhinitis, allergic disorders of the skin and gastrointestinal tract, and host defence against parasitic infection. Research is being conducted with a view to identify the underlying immunopathological mechanisms involved in allergic diseases including allergic airways disease, allergic skin diseases and gastrointestinal allergy.
Communications to Learned Societies
Hogan SP, Smart, V, Forbes, E, Rothenberg ME, Foster PS. Eosinophils and Allergic Diseases.Proceedings of the Canberra Region 9th Annual Scientific Meeting, Bench to Bedside & Beyond. Canberra, Australia, 21st - 22nd November , 2002.
Smart, V, Foster, PS, Mattes, J, Rothenberg, ME, Higgins, TJV, Hogan SP. (2001). A genetically modified plant expressing a gene for a potential allergen can suppress experimental allergy.Proceedings of the Canberra Region 9th Annual Scientific Meeting, Bench to Bedside & Beyond. S1 Canberra, Australia, 21st - 22nd November , 2002.
Smart, V, Foster, PS, Mattes, J, Rothenberg, ME, Higgins, TJV, Hogan SP. (2003). A genetically modified plant expressing a gene for a potential allergen can suppress experimental allergy.J. Allergy Clin. Immunol. 2003; 111:S342.
Smart, V, Foster, PS, Rothenberg, ME, Higgins, TJV, Hogan SP. (2004). A genetically modified plant expressing a gene for a potential allergen can suppress experimental allergy.J. Allergy Clin. Immunol. 2003; 111:S342
Smart, VS, Campbell, PM, Mattes, J, Rothenberg, ME, Foster, PS, Higgins, TVJ and Hogan, SP (2004). Expression of a foreign gene in a plant can alter protein structure and immunogenicity.Late Breaking Abstract Proceedings of the AAAI Meeting, San Francisco, CA. 3rd-8th March 2004.
