Gamble Program for Clinical Studies

Monica Malone McNeal, MS

Title

Associate Director of the Laboratory of Specialized Clinical Studies, Division of Infectious Diseases

Appointment

Field Service Instructor, University of Cincinnati College of Medicine

Email

monica.mcneal@cchmc.org

Phone

513-636-7648

Fax

513-636-0950

Bio

Monica Malone McNeal, MS, is a virologist in the Division of Infectious Diseases at Cincinnati Children’s Hospital Medical Center. She has more than 23 years of experience in rotavirus research. She has established an adult mouse model that has been used extensively in this facility and labs around the world. Her major expertise is in immunology and vaccine development. Currently she is the Associate Director of the Laboratory for Specialized Clinical Studies. This lab provides support for clinical studies involved in vaccine development. They perform work for several major pharmaceutical companies in addition to supporting other clinical researchers at Cincinnati Children’s.

Credentials

MS: University of Cincinnati, Cincinnati, OH, 1981

Research

Immunology of rotavirus infection

Publications, Most Recent

McNeal, M. M., S. C. Stone, M. Basu, J. A. Bean, J. D. Clements, B. A. Hendrickson, A. H. Choi, and R. L. Ward. Protection against rotavirus shedding after intranasal immunization of mice with a chimeric VP6 protein does not require intestinal IgA. Virology 346:338-47, 2006.

VanCott, J. L., A. E. Prada, M. M. McNeal, S. C. Stone, M. Basu, B. Huffer, Jr., K. L. Smiley, M. Shao, J. A. Bean, J. D. Clements, A. H. Choi, and R. L. Ward. Mice develop effective but delayed protective immune responses when immunized as neonates either intranasally with nonliving VP6/LT(R192G) or orally with live rhesus rotavirus vaccine candidates. J Virol 80:4949-61, 2006.

Allen, S. R., M. Jafri, B. Donnelly, M. McNeal, D. Witte, J. Bezerra, R. Ward, and G. M. Tiao. The effect of rotavirus strain on the murine model of biliary atresia. J Virol, 81(4), 167-9, 2007.

Choi, A. H., K. Smiley, M. Basu, M. M. McNeal, M. Shao, J. A. Bean, J. D. Clements, R. R. Stout and R. L. Ward. Protection of mice against rotavirus challenge following intradermal DNA immunization by Biojector needle-free injection. Vaccine 25(16) 3215-8, 2007.

Smiley, K. L., McNeal, M. M., Basu, M., Choi, A. H., Clements, J. D., and Ward, R. L. Association of gamma interferon and interleukin-17 production in intestinal CD4+ T cells with protection against rotavirus shedding in mice intranasally immunized with VP6 and the adjuvant LT(R192G). J Virol 81(8), 3740-8, 2007.

McNeal, M. M., Basu, M., Bean, J. A., Clements, J. D., Choi, A. H., and Ward, R. L.. Identification of an immunodominant CD4(+) T cell epitope in the VP6 protein of rotavirus following intranasal immunization of BALB/c mice. Virology 363(2), 410-8, 2007.

McNeal, M. M., Basu, M., Bean, J. A., Clements, J. D., Lycke, N. Y., Ramne, A., Lowenadler, B., Choi, A. H., and Ward, R. L. Intrarectal immunization of mice with VP6 and either LT(R192G) or CTA1-DD as adjuvant protects against fecal rotavirus shedding after EDIM challenge. Vaccine 25(33), 6224-31, 2007.

Shivakumar, P., Sabla, G., Mohanty, S., McNeal, M., Ward, R., Stringer, K., Caldwell, C., Chougnet, C., and Bezerra, J. A.. Effector role of neonatal hepatic CD8+ lymphocytes in epithelial injury and autoimmunity in experimental biliary atresia. Gastroenterology 133(1), 268-77, 2007.

McNeal, M. M., Stone, S. C., Basu, M., Clements, J. D., Choi, A. H., and Ward, R. L. IFN-gamma is the only anti-rotavirus cytokine found after in vitro stimulation of memory CD4+ T cells from mice immunized with a chimeric VP6 protein. Viral Immunol 20(4), 571-84, 2007

Jafri, M., Donnelly, B., McNeal, M., Ward, R., and Tiao, G. MAPK signaling contributes to rotaviral-induced cholangiocyte injury and viral replication. Surgery 142(2), 192-201, 2007

Ward, R.L., McNeal, M.M., Farone, M.B., and Farone, A.L.: Reoviridae. In: Smith A. L., Fox, J.G. (eds.), The Mouse in Biomedical Research, Second edition, Elsevier/Academic Press, Chapter 9, 2007.

McNeal, M. M. and Bernstein, D. Rotavirus Vaccines. In: Barrett, A. and Stanberry, L (eds.), Vaccines for Biodefense and Emerging and Neglected Diseases, Elsevier/ Academic Press, (submitted ) 2007.

Jafri, M., Donnelly, B., Allen, S., Bondoc, A., McNeal, M., Rennert, P. D., Weinreb, P. H., Ward, R., and Tiao, G. Cholangiocyte expression of alpha2beta1-integrin confers susceptibility to rotavirus-induced experimental biliary atresia. Am J Physiol Gastrointest Liver Physiol 295(1), G16-G26, 2008

Ward, R.L., M.M. McNeal, and A.D. Steele, Why does the world need another rotavirus vaccine?Ther Clin Risk Manag, 4(1): p. 49-63, 2008

Presentations, Most Recent

Smiley, K., McNeal, M., Basu, M., Choi, A.,and Ward, R. Protection of nice after intranasal VP6 immunization is associated with upregulation of intestinal CD4 T cell IFNγ and IL-17 genes. Keystone Meeting, Steamboat Springs, CO, March 2006.

McNeal, M. M., Kristi Smiley, Mitali Basu, Anthony H.-C. Choi, Richard L. Ward. Identification of the immunodominant CD4 T cell epitope within VP6 responsible for protection against rotavirus challenge after intranasal immulnization of mice. 25th Annual Meeting of the American Society for Virology, University of Wisconsin, Madison, WI, June, 2006.

Choi, Anthony H.-C, Kristi Smiley, Mitali Basu, Monica M. McNeal, Richard L. Ward. Administration of plasmids encoding rotavirus VP6 protein and LT(R192G) adjuvant to the skin of mice induced protection against an oral rotavirus challenge. 25th Annual Meeting of the American Society for Virology, University of Wisconsin, Madison, WI, June, 2006.

McNeal, M. M., Bert Huffer, Barbara Hendrickson, Richard Ward. Protection against fecal rotavirus shedding after oral immunization of mice with a live heterotypic rotavirus was dependent on non-neutralizing intestinal rotavirus IgA. 26th Annual Meeting of the American Society for Virology, Oregon State University, Corvallis, OR, July, 2007.