General and Community Pediatrics

Karen S. Wosje, PhD

Appointment

Research Assistant Professor

Email

karen.wosje@cchmc.org

Phone

513-636-2412

Fax

513-636-4402

Bio

Karen S. Wosje, PhD, has an overall research objective to make meaningful contributions to the understanding and prevention of obesity and poor bone health throughout the lifespan. Improving child health by reducing adiposity and optimizing bone strength is imperative because obesity and osteoporosis are likely to originate in childhood. It makes sense to study adiposity and bone health together because obesity and osteoporosis have common antecedents, and both diseases are related to significant morbidity in adulthood. Furthermore, obesity is a known risk factor for many diseases. Using an approach that focuses on modifiable environmental, lifestyle, and behavioral factors, Dr. Wosje's long term goals are to conduct research that will be used to set evidence-based recommendations for:

Reducing obesity and optimizing bone health (mass and strength) in young children
Reducing the public health burden of obesity and osteoporosis in adults

Credentials

Postdoctoral Research Fellow: Cincinnati Children's Hospital Medical Center, Division of General and Community Pediatrics, Cincinnati, OH, 2003-2006

PhD: Biological Sciences (Human Nutrition and Food Science), South Dakota State University, Brookings, SD, 2003.

MS: Family and Consumer Science (Human Nutrition and Food Science), South Dakota State University, Brookings, SD, 2000.

BS: Business Administration, Aquinas College, Grand Rapids, MI, 1991.

Research

Pediatric bone health and obesity

Research Grants and Contracts

Principal Investigator, "Dietary patterns in relation to adiposity and bone mass in young children," NIH, July 1, 2007 – June 30 2009.

Principal Investigator, "Least Significant Changes in Fat and Lean Mass by Dual Energy X-ray Absorptiometry in Obese Children and Adolescents," Children's Hospital Medical Center, Division of General and Community Pediatrics and General Clinical Research Center, 2004.

Publications, Most Recent

Wosje, K.S.; Kalkwarf, H.J.. Bone density in relation to alcohol intake among men and women in the United States.Osteoporos Int, 2007; 18:391-400.

Wosje, K.S.; Knipstein, B.L.; Kalkwarf, H.J.. Measurement error of DXA: interpretation of fat and lean mass changes in obese and non-obese children.J Clin Densitom, 2006; 9:335-340.

Saelens, B.E.; Couch, S.C.; Wosje, K.S.; Stark, L.J.; Daniels, S.R.: Relations among milk and non-milk beverage consumption, calcium, and relative weight in high weight status children.J Clin Psychol in Med Settings, 2006; 13:121-129.

Wosje, K.S.; Kalkwarf, H.J.: Lactation, weaning and calcium supplementation – effects on body composition in postpartum women.Am J Clin Nutr, 2004; 80:429-429.

Wosje, K.S.; Binkley, T.L.; Kalkwarf, H.J.; Specker, B.L.: Relationships between bone mass and circulating leptin concentrations in Hutterites.Bone, 2004; 34:1017-1022.

Presentations, Most Recent

Wosje, K.S.; Khoury, P.R.; Daniels, S.R. Fat mass is inversely related to subsequent change in bone size and mass in young prepubertal children. To be presented at the American Society for Bone and Mineral Research Annual Meeting; 2007; Honolulu, HI.

Buckley, D.; Dosani, R.; Uetrecht, G.; Wosje, K.; Kalkwarf, H.: What do forearm ultrasound and DXA measure in children? Interpretation relative to peripheral QCT (pQCT). Oral presentation at the American Society for Bone and Mineral Research Annual Meeting; 2006; Philadelphia, PA..

Wosje, K.S.; Knipstein, B.; Kalkwarf, H.J.: Imprecision of whole body DXA measurements: implications for interpretation of within person changes in fat, lean and bone mass in obese and non-obese children. Presentation at the American Society for Bone and Mineral Research Annual Meeting; 2005; Nashville, TN.

Wosje, K.S.; Kalkwarf, H.J.: Higher bone density among males and postmenopausal females who consume alcohol compared with those who abstain. Oral presentation at the Experimental Biology Annual Meeting; 2005; San Diego, CA.