Daniel R. Prows, PhD
Title
Research Assistant Professor
Appointment
Primary appointment - Pediatrics<br>Secondary appointment - Environmental Health
Email
daniel.prows@cchmc.org; daniel.prows@uc.edu
Phone
513-636-5440
Fax
513-636-3486
Office Location
TCHRF 1464
Credentials
BS: Biology, University of Cincinnati, Cincinnati, Ohio, 1983.
BS: Pharmacy, University of Cincinnati, Cincinnati, Ohio, 1988.
PhD: Pharmaceutical Sciences, University of Cincinnati, Cincinnati, Ohio, 1995.
Publications, Most Recent
Peer-Reviewed Journal Articles:
McDowell SA, Mallakin A, Bachurski CJ, Toney-Earley K, Prows DR, Bruno T, Kaestner KH, Witte DP, Melin-Aldana H, Degen SJ, Leikauf GD, Waltz SE: Accelerated acute lung injury in mice deficient in the cytoplasmic domain of Ron.Am J Respir Cell Mol Biol 2002, 26:99-104.
Leikauf GD, McDowell SA, Wesselkamper SC, Hardie WD, Leikauf JE, Korfhagen TR, Prows DR: Acute lung injury: functional genomics and genetic susceptibility.Chest 2002, 121:70S-75S.
Prows DR, Horner ML: Parental genetic contributions in the AXB and BXA recombinant inbred mouse strains.Mamm Genome 2002, 13:127-133.
Stark JM, McDowell SA, Koenigsknecht V, Prows DR, Leikauf JE, Le Vine AM, Leikauf GD: Genetic susceptibility to respiratory syncytial virus infection in inbred mice.J Med Virol 2002, 67:92-100.
Hardie WD, Prows DR, Piljan-Gentle A, Dunlavy MR, Wesselkamper SC, Leikauf GD, Korfhagen TR: Dose-related protection from nickel-induced lung injury in transgenic mice expressing human transforming growth factor-alpha.Am J Respir Cell Mol Biol 2002, 26:430-437.
Leikauf GD, Borchers MT, Prows DR, Simpson LG: Mucin apoprotein expression in COPD.Chest 2002, 121:166S-182S.
McDowell SA, Gammon K, Zingarelli B, Bachurski CJ, Aronow BJ, Prows DR, Leikauf GD: Inhibition of nitric oxide restores surfactant gene expression following nickel-induced acute lung injury.Am J Respir Cell Mol Biol 2003, 28:188-198.
Prows DR, McDowell SA, Aronow BJ, Leikauf GD: Genetic susceptibility to nickel-induced acute lung injury.Chemosphere 2003, 51:1139-1148.
Prows CA, Prows DR: Medication selection by genotype: How genetics is changing drug prescribing and efficacy.Am J Nurs 2004, 104:60-70; quiz 71.
Leikauf GD, Hardie WD, Wesselkamper SC, Bachurski CJ, Medvedovic M, Sartor MA, Tomlinson CR, McDowell SA, Henning LN, Case LM, Tichelaar JW, Prows DR, Korfhagen TR: Resolving gene-environmetn interactions in complex traits: acute lung injury.Am J Respir Cell Mol Biol 2004, 31:S23-S34.
Professional Organization Memberships
- American Thoracic Society, ATS
- International Mammalian Genome Society, IMGS
Special Interests
Genetic (QTL, quantitative trait locus) analysis of complex traits using mouse models of human disease; current research projects involve genetic analysis of pulmonary, cardiovascular, and eye diseases.
A focus on complex traits of the lung, including genes controlling susceptibility or resistance to acute lung injury, respiratory syncytial virus (RSV) infection, and interstitial lung diseases.
Primary focus on mouse models of acute lung injury, especially survival from acute lung injury induced by inhalation of agents (e.g., hyperoxia, ozone, nickel sulfate aerosol).
Use of additional strategies (e.g., microarrays, breeding methods) to identify candidate and positional candidate genes.
Related Areas
This person works in these other areas at Cincinnati Children's Hospital Medical Center:
