Human Genetics

Hong Du, PhD

Title

Associate Professor

Appointment

Associate Professor of Pediatrics, University of Cincinnati College of Medicine

Email

hong.du@cchmc.org

Phone

513-636-7136

Fax

513-636-3486

Credentials

PhD: Biochemistry, City University of New York, NY, 1989.

Postdoctoral Fellow: The Rockefeller University, 1989-1992, the Laboratory of Biochemistry and Molecular Biology.

Awards and Honors

Patent filed in US Patent Office: Gene-based Lipid Hydrolysis Therapy for Atherosclerosis and Related Disease. USPTO#20070264249. Inventor: Gregory A. Grabowski, MD, Co-inventor: Hong Du, Ph.D. 11/05/2007

Research

Molecular pathophysiology of Wolman Disease and cholesteryl ester storage disease: To evaluate the role of lysosomal acid lipase in cholesterol and fat acid metabolism in vivo using gene targeted mouse model; to study the pathogenesis of lysosomal acid lipase deficiency to Wolman disease and cholesteryl ester storage disease; and to test the gene therapy in this animal model.

Research Grants and Contracts

NIH, 1 R01HL087001-01A2 P.I.: Du, H., Scored 121--1.3%, 6.0-month Pathophysiology of PPARy in the lung

Publications, Most Recent

Du, H., Cameron, T.C., Garger, S.J., Pogue, G.P., Hamm, L.A., White, E., Hanley, K.M., Grabowski, G.A. (2008) Wolman disease/cholesteryl ester storage disease: efficacy of plant-produced human lysosomal acid lipase in mice. J. Lipid Res.49:1646-1657.

Qu, P., Roberts, J., Li, Y., Albrecht, M., Cummings, O.W., Eble, J.N., Du, H., and Yan, C., Stat3 downstream genes serve as biomarkers in human lung carcinomas and chronic pulmonary disease. Lung Cancer (2008), doi:10.1016/j.lungcan.2008.05.025

Li, Y., Qin, Y., Li, H., Wu, R.L., Yan, C., and Du, H. (2007) Lysosomal acid lipase overexpression disrupts lamellar body genesis and alveolar structure in the lung. International J. Experimental Pathology. On-line published July 1, 2007.

Yan, C., Lian, X., Dai, Y., Qin, Y., White, A., Akinbi, H., Wang, X., and Du, H. (2007) Gene delivery by hSP-B promoter in lung alveolar type II epithelial cells in LAL knock out mice through bone marrow mesenchymal stem cells. Gene Therapy. 14:1461-1470.

Li, Y., Du, H., Qin, Y.L., Roberts, J., Cummings, O.W., and Yan, C. (2007) Activation of the signal transducers and activators of transcription 3 pathway in alveolar epithelial cells induces inflammation and adenocarcinomas in mouse lung. Cancer Research. 67:8494-8503.

Wu, D.F., Sharan, C., Yang, H., Goodwin, S.J., Zhou, L., Grabowski, G.A., Du, H., Guo, Z.M. (2007) Apolipoprotein E-deficient lipoproteins induce foam cell formation by down regulation of lysosomal hydrolases in macrophages. J. Lipid Res. 48:2571-2578.

Nohturfft, A., Castoreno, A.B., Wang, Y., Bojkovic, J., Stockinger, W., Jarzylo, L.A., Du, H., Shieh, E.C., and Pagnon, J.C. (2006) Coordination of lipid synthesis during membrane biogenesis. FASEB J. 20:A520-A521.

Yan, C., Lian, X., Li, Y., Dai, Y., White, A., Qin, Y., Li, H., Hume, D.A., and Du, H. (2006) Macrophage-specific expression of human lysosomal acid lipase corrects inflammation and pathogenic phenotypes in lal-/- mice. Am. J. Pathol. 169:916-926.

Presentations, Most Recent

Du, H.: Lysosomal acid lipase deficiency causes pulmonary inflammation and remodeling Invited Seminar at University of Pennsylvania Medical Center, Institute for Environmental Medicine, A Center for Lung Biology and Baromedicine, Philadelphia, PA, December 14, 2007.

Du, H.: Lysosomal acid lipase deficiency causes pulmonary inflammation and remodeling Invited in Grant Round Seminar. Division of Pulmonary, Critical Care and Sleep medicine, University of Cincinnati, College of Medicine, Cincinnati, OH. June 4, 2007.

Du, H.: Overexpression of Dominant Negative Peroxisome Proliferator-Activated Receptor-gamma in Respiratory Epithelia Cells Caused Pulmonary Emphysema and Aberrant Gene Expression American Thoracic Society International Conference, San Diego, LA. May 23, 2006.

Professional Organization Memberships

Abstracts

Du, H., Qu, P., Li, Y., Wilkes, D.S., and Yan, C. (2008) Immune dysfunction in lysosomal acid lipase deficiency mice. American Thoracic Society 104th International Conference. May 16-21, 2008. Toronto, Ontario, Canada.

Yan, C., Qu, P., and Du, H. (2008) Api6 Over-expression in myeloid lineage cell lines induces bone marrow mesenchymal stem cell conversion into alveolar type II epithelial cells. American Thoracic Society 104th International Conference. May 16-21, 2008. Toronto, Ontario, Canada.

Yan, C., Li, Y., Qin, Y.L., and Du, H. (2007) Overexpression of Stat3C in lung epithelial cells causes lung inflammation and tumorigenesis. Submitted to Keystone Symposia of “Jaks, Stats and Immunity” January 5-10, 2007, Steamboat Springs, Colorado, USA.

Du, H., Li, Y., Qin, Y.L., Li, H.M., and Yan, C. (2007) Lysosomal acid lipase over-expression disrupts lamellar body biogenesis and alveolar structure in the lung. American Thoracic Society 103rd International Conference. May 18-23, 2007. San Francisco, CA, USA.

Li, Y., Yan, C., and Du, H. (2007) Regulation of the apoptosis inhibitor 6 gene expression by MafB and TTF-1 in respiratory epithelial cells. American Thoracic Society 103rd International Conference. May 18-23, 2007. San Francisco, CA, USA.

Yan, C., Li, Y., Qin, Y.L., and Du, H. (2007) Overexpression of Stat3C promotes epithelial proliferation and retards alveolarization during lung development American Thoracic Society 103rd International Conference. May 18-23, 2007. San Francisco, CA, USA.

Du, H., Dai, Y., Lian, X. M., White, A., Qin, Y. L., Li, H.M., Hume, D.A., and Yan, C. (2006) Macrophage-specific over-expression of human lysosomal acid lipase corrects inflammation and pathogenic phenotypes in lal-/- mice. American Thoracic Society 102nd International Conference. May 19-24, 2006. San Diego, CA, USA.

Yan, C., Lian, X.M., Dai, Y., White, A., Qin, Y. L., Wang, X., and Du, H. (2006) Gene delivery by the human surfactant protein B promoter into lung alveolar type II epithelial cells during pulmonary inflammation in lysosomal acid lipase knock-out mice through bone marrow mesenchymal stem cells. American Thoracic Society 102nd International Conference. May 19-24, 2006. San Diego, CA, USA.

Li, Y., Qin, Y., Du, H., and Yan, C. (2006) Up-regulation of the apoptosis inhibitor 6 promoter by MafB and TTF-1 in lung epithelial cells. American Thoracic Society 102nd International Conference. May 19-24, 2006. San Diego, CA, USA.

Li, Y., Qin, Y., Du, H., and Yan, C. (2006) Overexpression of Stat3C in lung epithelial cells causes lung bronchoalveolar carcinoma. American Thoracic Society 102nd International Conference. May 19-24, 2006. San Diego, CA, USA.

Dai, D., Du, H., Qin, Y., White, A., Li, T., and Yan, C. (2006) *Overexpression of Dominant Negative Peroxisome Proliferator-activated Receptor-gamma in Respiratory Epithelial Cells Caused Pulmonary Emphysema and Aberrant Gene Expression. American Thoracic Society 102nd International Conference. May 19-24, 2006. San Diego, CA, USA *The abstract was selected (one of 24 out of 5000 abstracts) as best representing the focus and quality of the research presented at the conference.

Du, H., Heubi, J., Tso, P., Rider, T., and Jandacek, R. (2006) Dietary fat absorption with sucrose polybehenate marker in lysosomal acid lipase null mice. Submitted to FASEB Conference on Molecular Biology of Lipid Transport and Metabolism. July, 2006. Tucson, AZ, USA.