Enkhsaikhan Purevjav, MD, PhD
Title
Assistant Professor
Appointment
Assistant Professor, University of Cincinnati College of Medicine
Email
enkhsaikhan.purevjav@cchmc.org
Phone
513-803-2576
Fax
513-636-5958
Bio
Enkhsaikhan Purejav's, MD, PhD research will be focused on screening the potential genes responsible for inherited and acquired cardiac diseases and performing functional studies of mutations in these genes by creating in vitro and in vivo models. In addition, he will investigate the effects of factors such as viral infections, drugs including ACE inhibitors and beta-blockers, and mechanical stress (cyclic mechanical stretch, acute and chronic exercise) on cardiac function in these models.
Credentials
MD: Leningrad Pediatric Medical Institute, Russia, 1989
Residency: Saint’s Petersburg Pediatric Medical Academy, Russia
Certification: Pediatric Cardiology, 1994
PhD: Shimane Medical University, Japan, 2003
Position History
1989-1997-Lecturer, National Medical University of Mongolia
2003-2007-Research Associate, Baylor College of Medicine, Houston, Texas
2007-2009-Instructor, Baylor College of Medicine, Houston, Texas
2007-present-Assistant Professor, Cincinnati Children’s Hospital, Cincinnati, Ohio
Awards and Honors
- 1982-1989 Award for excellence from Ministry of Education of Mongolia (Undergraduate and Medical education)
- 1997- 2003 Award from Ministry of Health, Education, Sport and Welfare of Japan
- 2006 Fellow’s Basic Research Award, Society of Pediatric Research
- 2007 Fellow’s Basic Research Award, Japan Pediatric Society
Research
Enkhsaikhan Purejav's, MD, PhD research interest is focused in studying how genetic abnormalities contribute to the cardiac disease in humans and understanding of the mechanisms of these diseases. Specifically, he will focus on studying roles of mutations in structural proteins that make up the heart in cardiac mechanosensing and remodeling and their roles in the development of cardiac diseases including cardiomyopathies.
Research Grants and Contracts
2005-2007 Postdoctoral Fellowship, AHA
2007-2009 Beginning-Grant-In-Aid, AHA, PI
2008-2009 Research Grant, Children’s Cardiomyopathy Foundation, PI
2008-2009 Science Education Leadership Fellows (SELF), Howard Hughes Medical Institute and Baylor College of Medicine, Scientist
2008-2009 T32 grant, NIH, Fellow
Publications, Most Recent
Wu G, Ai T, Kim JJ, Mohapatra B, Xi Y, Li Z, Abbasi S, Purevjav E, Samani K, Ackerman MJ, Qi M, Moss AJ, Towbin JA, Cheng J, and Vatta M. Alpha-1-Syntrophin Mutation and the Long QT Syndrome: a disease of sodium channel disruption. Circulation: Arrhythmia and Electrophysiology. 2008;1:193-201.
Purevjav E, Nelson DP, Varela JJ, Jimenez S, Kearney DL, Sanche XV, DeFreitas G, Carabello B, Taylor MD, Vatta M, Shearer WT, Towbin JA, Bowles NE. Myocardial Fas Ligand Expression increases Susceptibility to AZT-Induced Cardiomyopathy. Cardiovasc Toxicol. 2007 Oct 18; 2007;7(4):255-63
Hardarson HS, Baker JS, Yang Z, Purevjav E, Huang CH, Alexopoulou L, Li N, Flavell R, Bowles NE, Vallejo JG. Toll-like receptors 3 is an Essential Component of the Innate Stress Response in Virus-Induced Cardiac Injury. Am J Physiol Heart Circ Physiol. 2007 Jan;292(1):H251-8.
Presentations, Most Recent
Purevjav, E.; Morgado, M.; Effects of ACE Inhibitors and Beta-Blockers on Cardiac Function in Murine Models of Inherited Dilated Cardiomyopathy Due to Mutations in the Nebulette Gene. Presented at the Pediatric Academic Society, May 2-5, 2009
Purevjav, E.; Varela, J.; Nebulette Functions as a Mechano-Sensor in the Differentiating Muscle Cells. Presented at the Pediatric Academic Society, May 2-5, 2008
Buyan-Ochir, O.; Kuroe, K.;Heart Saving Project: Catheter Intervention and Screening of Heart Diseases in Mongolian Children. Presented at the Pediatric Academic Society, May 2-5, 2008
Purevjav, E.; Varela, J.; Role of Myopalladin-CARP Interactions in Myocyte Differentiation and Proliferation. Presented at the Pediatric Academic Society, May 2-5, 2007
Professional Organization Memberships
