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Jeffery Towbin Lo

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Jeffrey A. Towbin, MD, FAAP, FACC, FAHA

Title

Executive Co-Director, The Heart Institute

Chief, Pediatric Cardiology

Email

jeffrey.towbin@cchmc.org

Credentials

Pediatric Cardiology Fellowship: Baylor College of Medicine, Texas Children's Hospital, 1989
Pediatric Residency: Cincinnati Children's Hospital Medical Center, 1985
MD: University of Cincinnati, 1982
MS: Cell Biology, University of Cincinnati, 1977
BS: Biology, University of Cincinnati, 1974

Position History

  • 2009-present Executive Co-Director, The Heart Institute Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio
  • 2009-present Chief, Pediatric Cardiology Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio
  • 2009-present Professor (Tenured), Departments of Pediatrics, Human Genetics and Cardiovascular Sciences, University of Cincinnati College of Medicine, Cincinnati, Ohio
  • 2003-2009 Chief, Pediatric Cardiology Texas Heart Institute, Houston, Texas
  • 2003-2009 Chief, Pediatric Cardiology, Texas Children’s Hospital, Houston, Texas
  • 2003-2009 Chief, Pediatric Cardiology, Baylor College of Medicine, Houston, Texas
  • 1998-2009 Professor (Tenured), Departments of Pediatrics, Molecular and Human Genetics and Internal Medicine-Cardiovascular Sciences, Baylor College of Medicine, Houston, Texas
  • 1997-2009 Texas Children’s Hospital Foundation Chair in Pediatric Cardiac Research, Texas Children’s Hospital, Houston, Texas
  • 1997-2003 Associate Chief Pediatric Cardiology, Baylor College of Medicine, Texas Children’s Hospital, Houston, Texas
  • 1996-1998 Associate Professor of Cardiovascular Sciences, Baylor College of Medicine, Houston, Texas
  • 1995-2009 Visiting Member Graduate Faculty, Texas A & M University, College Station, Texas
  • 1994-2009 Adjunct Associate Professor, College of Veterinary Medicine Department of Small Animal Medicine and Surgery, Texas A & M University, College Station, Texas
  • 1993-1998 Associate Professor (Tenured) of Pediatrics and Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas
  • 1989-1993 Assistant Professor Department of Pediatrics and Institute for Molecular Genetics, Baylor College of Medicine, Houston, Texas

Awards and Honors

 

(Most Recent)

 

  • Alexander Iams Lectureship, University of Wisconsin, Madison, Wisconsin, May, 2008
  • 2008  17th Annual Texas Children’s International Recognition Award, Texas Children’s Hospital, April, 2008
  • Distinguished/Elite Reviewer, Journal of the American College of Cardiology (JACC), 2007, 2008
  • T. Duckett Jones Lectureship 2007, American Heart Association Scientific Sessions, San Francisco, California, 2007
  • Robert Freedom Lecture, Hospital for Sick Children Symposium in Heart Disease in Children, , Toronto, Canada, June, 2007
  • 2007 American College of Cardiology (ACC) Distinguished Scientist (Basic Science) Award, New Orleans, Louisiana,  March, 2007

Research Grants and Contracts

NIH – NHLBI – RO1 Pediatric Cardiac Specimen Repository

Overall Principal Investigator, Jeffrey A. Towbin, M.D.
$2,217,054 (Total)
August 1, 2007 – April 30, 2011

"Heart Failure Fellowship Training in Pediatrics"

Scios, Inc/ Johnson & Johnson
Principal Investigator: Jeffrey A. Towbin, M.D.
$69,500
July 1, 2007-June 30, 2008

"Genetics of Dilated Cardiomyopathy"

Vivian L. Smith Foundation
Principal Investigator: Jeffrey A. Towbin, M.D.
$200,000
December 1, 2006-November 30, 2008


"Long QT Syndrome: Translational Aspects"

Children’s Memorial Hospital-Scholl’s Foundation
Principal Investigator: Jeffrey A. Towbin, M.D.
$150,000
December 1, 2006-November 30, 2008


JLH Transplant Fund for Children

Principal Investigator: Jeffrey A. Towbin, M.D.
$200,000
July 1, 2006- June 30 2008

"Pediatric Cardiomyopathy Genetics"

Chidren’s Cardiomyopathy Foundation
Principal Investigator: Jeffrey A. Towbin, M.D.
$125,000
July 1, 2006-June 30, 2008


"Pediatric Cardiomyopathy Repository"

Children’s Cardiomyopathy Foundation
Principal Investigator: Jeffrey A. Towbin, M.D.
$85,000
July 1, 2006-June 30, 2008

NIH Long QT Syndrome: Genetic Studies

Primary Institution:  University of Rochester
Principal Investigator:  Arthur Moss, M.D.
Subcontract Principal Investigator:  Jeffrey Towbin, M.D.
$902,554 Direct/$1,347,513 Total 5 yr
July 1, 2005-June 30, 2010

NIH – NHLBI- U01 HL65652-01 Cluster Grant, "Genetics of Arhythmogenic Right Ventricular Dysplasia"

Overall Principal Investigator, Frank Marcus, M.D.
R01 Principal Investigator, Jeffrey A. Towbin, M.D.
$1,966,647 (Total)
July 1, 2001 – June 30, 2008

NIH – NHLBI  2 RO1 HL53392-06A1, "Pediatric Cardiomyopathy Registry"

Principal Investigator, Steven Lipshultz, M.D.
Sub-Contract Principal Investigator, Jeffrey A. Towbin, M.D.
$3,155,917 (Total)
$409,617 (Subcontract)
September 28, 2006-August 31, 2011 

"Identification  and Novel Therapies of Disease-Causing Genes in Dilated Cardiomyopathy"

The John Patrick Albright Foundation
Principal Investigator, Jeffrey A. Towbin, M.D.
$25,000 (Total)December 31, 2006-December 30, 2007

 

Publications, Most Recent

  • Arimura T, Inagaki N, Hayashi T, Shichi D, Sato A, Hinohara K, Vatta M, Towbin JA, Chikamori T, Yamashina A, Kimura A. Impaired Binding of ZASP/Cypher with Phosphoglucomutase 1 is Associated With Dilated Cardiomyopathy.Cardiovasc Res [Epub. ahead of print, April 17, 2009], 2009.
  • Singh HR, Yang Z, Siddiqui S, Peña LS, Westerfield BH, Fan Y, Towbin JA, Vatta M. A Novel Alu-Mediated Xq28 Microdeletion Ablates TAZ and Partilly Deles DNL1L in a Patient With Barth Syndrome. Am J Med Genet 149A:1082-1085, 2009.
  • Harmon WG, Sleeper LA, Cuniberti l, Messere J, Coan SD, Orav EJ, Towbin JA, Wilkinson JD, Lipshultz SE. Treating Children with Idiopathic Dilated Cardiomyopathy (from the Pediatric Cardiomyopathy Registry).Am Heart J, in press 2009.
  • McBride KL, Zender GA, Fitzgerald-Butt SM, Koehler D, Menesses-Diaz A, Fernbach S, Lee K, Towbin JA, Leal S, Belmont JW. Linkage Analysis of Left Ventricular Outflow Tract Malformations (Aortic Valve Stenosis, Coarctation of the Aorta, Hypoplastic Left Heart Syndrome).Eur J Hum Genet  [Epub. ahead of print, January 14, 2009], 2009.
  • Wu G, Ai T, Kim JJ, Mohapatra B, Xi Y, Lu Z, Abbasi S, Purevjav E, Samani K, Ackerman MJ, Moss AJ, Towbin JA, Cheng J, Vatta M.  A Novel Alpha-1-Syntrophin Mutation May Cause Long QT Syndrome.  Circulation: Arrhythmias and Electrophysiology.  [Epub. ahead of print, August, 2008], 2009.
  • Hershberger RE, Lindenfeld J, Mestroni L, Seidman CE, Taylor MR, Towbin JA. Genetic Evaluation of Cardiomyopathy- A Heart Failure Society of America Guideline.J Card Fail 15:83-97, 2009.
  • Mohapatra B, Casey B, Li H, Ho-Dawson T, Smith L, Fernbach SD, Molinari L, Niesh SR, Jefferies JL, Craigen WJ, Towbin JA, Belmont JW, Ware SM. Identification and functional characterization of NODAL rare variants in heterotaxy and isolated cardiovascular malformations.Hum Mol Genet 18:861-71, 2009.
  • Rossano J, Denfield SW, Kim JJ, Price JF, Jefferies JL, Decker J,  Smith EO, Clunie SK, Towbin JA, Dreyer WJ. Assessment of the Cylex® ImmuKnowT Cell Function Assay in Pediatric Heart Transplant Patients Journal of Heart and Lung Transplantation.J Heart Lung Transplant 28:26-31, 2009.
  • Lalani SR, Thakuria JV, Cox GF, Wang X, Bi W, Bray MS, Shaw C, Cheung SW, Chinault AC, Boggs BA, Ou Z, Brundage EK, Lupski JR, Gentile J, Waisbren S, Pursley A, Ma L, Khajavi M, Zapata G, Friedman R, Kim JJ, Towbin JA, Stankiewicz P, Schnittger S, Hansmann I, Ai T, Sood S, Wehrens XH, Martin JF, Belmont JW, Potocki L. 20p12.3 Microdeletion Predisposes to Wolff-Parkinson-White Syndrome with Variable Neurocognitive Defecits.J. Med Genet  46:168-175, 2009.
  • Lipshultz SE, Colan SD, Towbin JA, Wilkinson JD. Idiopathic and Primary Cardiomyopathies in Children.Prog Pediatr Cardiol 25:1, 2008.
  • Kaufman BD, Shaddy RE, Shirali GS, Tanel R, Towbin JA. Assessment and Management of the Failing Heart in Children.Cardiol Young Suppl 3:63-71, 2008.
  • Towbin JA. Arrhythmogenic Right Ventricular Cardiomyopathy: A Paradigm of Overlapping Disorders.Ann Noninvasive Electrocardiol 13:327-331, 2008.
  • Thottahil P, Acharya J, Moss AJ, Jons C, McNitt S, Goldenberg I, Zareba W, Kaufman E, Qi M, Robinson JL, Ackerman MJ, Benhorin J, Kaufman E, Locati E, Napolitano C, Priori S, Schwartz PJ, Spazzolini C, Towbin JA, Vincent GM,. Zhang L. Risk of Cardiac Events in Patients with Asthma and Long-QT Syndrome Treated with Beta(2) Agonists. Am J Cardiol 102:871-874, 2008.
  • Sze E, Moss AJ, Goldenberg I, McNitt S, Jons C, Zareba W, Ackerman MJ, Benhorin J, Kaufman E, Locati E, Napolitano C, Priori S, Schwartz PJ, Spazzolini C, Towbin JA, Vincent GM,. Zhang L. Long QT Syndrome in Patients Over 40 Years of Age: Increased Risk for LQTS-Related Cardiac Events in Patients with Coronary Disease.Ann Noninvasive Electrocardiol 13:327-331, 2008.
  • Qian L, Mohapatra B, Akasaka T, Liu J, Occor K, Towbin JA, Bodmer R. Transcription factor neuromancer/TBX20 is required for cardiac function in Drosophila with implications for human heart disease.  Proc Natl Acad Sci, USA (PNAS) 105:19833-19838, 2008.
  • McBride KL, Riley MF, Zender GA, Fitzgerald-Butt SM, Towbin JA, Belmont JW, Cole SE. NOTCH1 Mutations in Individuals with Left Ventricular Outflow Tract Malformations Reduce Ligand-Indiuced Signaling.Hum Mol Genet 17:2886-1893, 2008.
  • Ly S, Butman SL, Xu T, Marcus FI, Towbin JA. Ventricular Aneurysms and a Desmosomal Cardiomyopathy: Plakoglobin-Related Cardiomyopathy.Heart Rhythm 5:1455-1457, 2008.
  • Wu G, Ai T, Kim JJ, Mohapatra B, Xi Y, Li Z, Abbasi S, Purevjav E, Samani K, Ackerman MJ, Qi M, Mpss AJ, Towbin JA, Cheng J, Vatta M. Alpha-1 Syntrophin Mutation and the Long-QT Syndrome: A Disease of Sodium Channel Disruption. Circulation Electrophysiol Arrhythmias, in press, 2008.
  • Roessler E, Ouspenskaia MV, Pei W, Karkera JD, Mohapatra B, Banerjee-Basu S, Gibney G, Kantipong A, Goldmuntz E, Bowers P, Schier AF, Baxevanis AD, Towbin JA, Belmont JW, Feldman B, Muenke M. Reduced Nodal Signaling Strength Via Mutation of Several Pathway Members Including FOXH1 is Linked to Human Heart Defect and Holoprosencephaly.Am J Hum Genet 83:18-29, 2008.
  • Price JF, Mott AR, Dickerson HA, Jefferies JL, Nelson DP, Chang AC, Smoth EO, Towbin JA, Dreyer WJ, Denfield SW, Goldstein SL. Worsening Renal Function in Children Hospitalized with Decompensated Heart Failure: Evidence for Cardiorenal Syndrome?Pediatr Crit Care Med 9:279-284, 2008.
  • Lu X, Xie M, Tomberlin D, Klas B, Nodvoretskiy V, Ayres N, Towbin JA. How Accurately, Reproducibly, and Efficietly Can We Measure Left Ventricular Indices Using M-Mode, 2-Dimensional, and 3-Dimensional Echocardiography in Children? Am Heart J 155:946-953, 2008.
  • Rossano JW, Denfield SW, Kim JJ, Price JF, Jefferies JL, Decker JA, Smith EO, Clunie SK, Towbin JA, Dreyer WJ. B-Type Natriuretic Peptide is a Sensitive Screening Test for Acute Rejection in Pediatric Heart Transplant Patients.J Heart Lung Transplant, 27:649-654, 2008.
  • Goldenberg I, Moss AJ, Bradley J, Polonnsky S, Peterson DR, McNitt S, Zareba W, Andrews ML, Robinson JL, Ackerman MJ, Benhorin J, Kaufman ES, Locati EH, Napolitano C, Priori SG, Qi M, Schwartz PJ, Towbin JA, Vincent GM, Zhang L.  Long-QT Syndrome After Age 40.Circulation 117:2192-2201, 2008.
  • Goldenberg I, Moss AJ, Peterson DR, McNitt S, Zareba W, Benhorin J, Kaufman ES, Napolitano C, Priori SG, Qi M, Andrews ML, Robinson JL, Locati EH, Ackerman MJ, Schwartz PJ, Towbin JA, Vincent GM, Zhang L. Risk Factors for Aborted Sudden Cardiac Death in Children with Congenutal Long-QT Syndrome.Circulation 117:2184-2191, 2008.
  • Morita H, Rehm HL, Menesses A, McDonough B, Roberts AE, Kucherlapati R, Towbin JA, Seidman JG, Seidman CE. Shared Genetic Causes of Cardiac Hypertrophy in Children and Adults.N Engl J Med 358: 1899-1908 [Epub Ahead of Print, April 10, 2008], 2008.
  • Connuck DM, Sleeper LA, Colan SD, Cox GF, Towbin JA, Lowe AM, Wilkinson JD, Orav EJ, Cuniberti L, Salbert BA, Lipshultz SE. Characteristics and Outcomes of Cardiomyopathy in Children with Duchenne or Becker Muscular Dystrophy: A Comparitive Study From the Pediatric Cardiomyopathy Registry.Am Heart J, 155:998-1005, 2008.
  • Towbin JA. Molecular Mechanisms of Pediatric Cardiomyopathies and New Targeted Therapies.Progr Pediatr Cardiol 25:3-21, 2008.
  • Breinholt JP, Vallejo JP, Gates CM, Clunie SK, Kearney DL, Dreyer WJ, Towbin JA, Bowles NE. Myocardial Pro-Inflammatory Cytokine Expression and Cellular Rejection in Pediatric Heart Transplant Recipients.J Heart Lung Transplant 27:317-324, 2008.
  • Shan L, Makita N, Xing Y, Watanabe S, Futatani T, Ye F, Saito K, Ibuki K, Watanabe K, Hirono K, Uese K, Ichida F, Miyawaki T, Origasa H, Bowles NE, Towbin JA. SCN5A variants in Japanese patients with left ventricular noncompaction and arrhythmia.Mol Genet Metab 93:468-74, 2008.
  • Breinholt JP, Fraser CD, Dreyer WJ, Chang AC, Smith EO, Heinle JS, McKenzie ED, Clunie SK, Towbin JA, Denfield SW. The Efficacy of Mitral Valve Surgery in Children With Dilated Cardiomyopathy and Severe Mitral Regurgitation.Pediatr Cardiol, 29:13-18, 2007.
  • Taylor M, Ku L, Slavov D, Cavanaugh J, Boucek M, Zhu X, Graw S, Carniel E, Barnes C, Quan D, Prall R, Lovell M, Mierau G, Ruegg P, McNair WP, Mandava N, Bristow MR, Towbin JA, Mestroni L. Danon Disease Presenting with Dilated Cardiomyopathy and a Complex Phenotype.J Hum Genet 52:830-835, 2007.
  • Towbin JA, Vatta M. Myocardial Infarction, Viral Infection, and the Cytoskeleton: Final Common Pathways of a Common Disease?J. Am Coll. Cardiol, 50:2215-2217, 2007.
  • Cooper LT, Baughman K, Feldman AM, Frustaci A, Jessup M, Kuhl U, Levine GN, Narula J, Starling RC, Towbin JA, Virmani R. The Role of Endomayocardial Biopsy in the Management of Cardiovascular Disease. A Scientific Statement from the American Heart Association, American College of Cardiology, and European Society of Cardiology, Endorsed by the Japanese Circulation Society and the Heart Failure Society of America.Eur Heart J 28:3076-3093, 2007.
  • Gamane J, Mertens L, Eidem BW, Claus P, D’hooge J, Haverman LM, McMahon CJ, Elayda MA, Vaughn WK, Towbin JA, Ayres NA, Pignatelli RH. Regional Myocardial Deformation in Children with Hypertrophic Cardiomyopathy: Morphological and Clinical Correlations.Eur Heart J 28:2886-2894, 2007.
  • Cooper LT, Baughman K, Feldman AM, Frustaci A, Jessup M, Kuhl U, Levine GN, Narula J, Starling RC, Towbin JA, Virmani R. The Role of Endomayocardial Biopsy in the Management of Cardiovascular Disease. A Scientific Statement from the American Heart Association, American College of Cardiology, and European Society of Cardiology, Endorsed by the Japanese Circulation Society and the Heart Failure Society of America.Circulation 116:2216-2233, 2007.
  • Purevjav E, Nelson DP, Varela JJ, Jimenez S, Kearney DL, Sanchez XV, Defreitas G, Carabello B, Taylor MD, Vatta M, Shearer WT, Towbin JA, Bowles NE. Myocardial Fas Ligand Expression Increases Susceptibility to AZT-Induced Cardiomyopathy.Cardiovasc Toxicol, 7:255-263 [Epub ahead of print, October 2007], 2007.
  • Lehnart S, Ackerman MJ, Brugada R, Benson DW, Clancy CE, Donahue JK, George AL Jr, Grant AO, Groft SC, January CT, Lathrop DA, Lederer WJ, Makielski JC, Mohler PJ, Moss AJ, Nerbonne JM, Olson TM, Przywara DA, Towbin JA, Wang L-H, Marks AR.: Inherited Arrhythmias – A NHLBI-ORD Workshop Consensus Report About the Diagnosis, Phenotyping, Molecular Mechanisms, and Therapeutic Approaches for Primary Cardiomyopathies of Gene Mutations Affecting Ion Transport Function.Circulation, 116:2325-2345, 2007.
  • Cooper LT, Baughman K, Feldman AM, Frustaci A, Jessup M, Kuhl U, Levine GN, Narula J, Starling RC, Towbin JA, Virmani R. The Role of Endomayocardial Biopsy in the Management of Cardiovascular Disease. A Scientific Statement from the American Heart Association, American College of Cardiology, and European Society of Cardiology, Endorsed by the Japanese Circulation Society and the Heart Failure Society of America.J Am Coll Cardiol, 50:1914-1931, 2007.
  • Karkera JD, Lee JS, Roessler E, Banerjee-Basu S, Ouspenskaia V, Mez J, Goldmuntz E, Bowers P, Towbin JA, Belmont JW, Baxevanis AD, Schier AF, Muenke M. Loss-of-Function Mutations in Growth Differentiation Factor-1 (GDF1) are Associated With Congenital Heart Disease in Humans.Am J Hum Genet,81:987-994, 2007.
  • Towbin JA. Scarring in the Heart: A Reversible Phenomenon?N. Engl J. Med, 351:1767-1768, 2007.
  • Beffagna G, De Bortoli M, Nava A, Salamon M, Lorenzon A, Zaccolo M, Mancuso L, Sigalotti L, Bauce B, Occhi G, Basso C, Lanfranchi G, Towbin JA, Thiene G, Danieli GA, Rampazzo A. Missense Mutations in Desmocollin-2 N-Terminus, Associated With Right Ventricular Cardiomyopathy, Affect Intracellular Localization of Desmocollin-2 in vitro.BMC Medical Genetics 8:65-73, 2007.
  • Jefferies JL, Price JF, Denfield SW, Chang AC, Dreyer WJ, McMahon CJ, Grenier MA, Clunie SK, Thomas A, Moffett BS, Wann RS, Smith EO, Towbin JA. Safety and efficacy of Nesiritide in Pediatric Heart Failure. J Card Fail 13:541-548, 2007.
  • Moss AJ, Shimizu W, Wilde AA, Towbin JA, Zareba W, Robinson JL, Qi M, Vincent GM, Ackerman MJ, Kaufman ES, Hofman N, Seth R, Kamakura S, Miyamoto Y, Goldenberg I, Andrews ML, McNitt S. Clinical Aspects of Type-1 Long-QT Syndrome by Location, Coding Type, and Biophysical Function of Mutations Involving the KCNQ1 Gene.Circulation 115:2481-2489, 2007.
  • Tan LH, Jefferies JL, Liang JF, Denfield SW, Dreyer WJ, Mott AR, Grenier MA, Dickerson HA, Price JF, Towbin JA, Ou CN, Chang AC. Concentrations of Brain Natriuretic Peptide in the Plasma Predict Outcomes of Treatment of Children with Decompensated Heart Failure Admitted to the Intensive Care Unit.Cardiol Young 18: 1-10, 2007.
  • Rossano JW, Grenier MA, Dreyer WJ, Kim JJ, Price JF, Jefferies JL, Smith EO, Clunie SK, Moulik M, Decker JA, Breinholt JP, Morales DL, McKenzie ED, Towbin JA, Denfield SW. Effect of Body Mass Index on Outcome in Pediatric Heart Transplant Patients.J Heart Lung Transplant 26: 718-723, 2007.
  • Sauer AJ, Moss AJ, McNitt S, Peterson DR, Zareba W, Robinson JL, Qi M, Goldenberg I, Hobbs JB, Ackerman MJ, Benhorin J, Hall WJ, Kaufman ES, Locati EH, Napolitano C, Priori SG, Schwartz PJ, Towbin JA, Vincent  GM, Zhang L. Long QT Syndrome in Adults.J Am Coll Cardiol 49: 329-337, 2007.
  • Morales DL Dreyer WJ, Denfield SW, Heinle JS, McKenzie ED, Graves DE, Price JF, Towbin JA, Frazier OH, Cooley DA,  Fraser CD, Jr. Over Two Decades of Pediatric Heart Transplantation: How Has Survival Changed?J Thorac Cardiovasc Surg 133:632-639, 2007.
  • Arola AM, Sanchez X, Murphy RT, Hasle E, Li H, Elliott PM, McKenna WJ, Towbin JA, Bowles NE. Mutations in PDLIM3 and MYOZ1 Encoding Myocyte Z Line Proteins Are Infrequently Found in Dilated Cardiomyopathy.Mol Genet Metab 90:435-440, 2007.
  • Vatta M, Marcus FI, Towbin JA. Arryhthmogenic Right Ventricular Cardiomyopathy: A “Final Common Pathway” That Defines Clinical Phenotype.Eur Heart J 28: 529-530, 2007.
  • Seth R, Moss AJ, McNitt S, Zareba W, Andrews ML, Qi M, Robinson JL, Goldenberg I, Ackerman MJ, Benhorin J, Kaufman ES, Locati EH, Napolitano C, Priori SG, Schwartz PJ, Towbin JA, Vincent GM, Zhang L.  Long QT Syndrome and Pregnancy.  J. Am Coll Cardiol 49:1092-1098, 2007.
  • Shuraih M, Ai T, Vatta M, Sohma Y, Merkle EM, Taylor E, Li Z, Razavi M, Towbin JA, Cheng J.  A Common SCN5A Variant Alters the Responsiveness of Human Sodium Channels to Class I Antiarrhythmic Agents.J.Cardiovasc Electrophysiol, 18:434-440, 2007.
  • Colan SD, Lipshultz SE, Lowe AM, Sleeper LA, Messere J, Cox GF, Lurie PR, Orav EJ, Towbin JA.  Epidemiology and Cause-Specific Outcome of Hypertrophic Cardiomyopathy in Children: Findings froe the Pediatric Cardiomyopathy Registry.  Circulation 115:773-781, 2007.

Presentations, Most Recent

  • Webber S, Lipshultz SE, Sleeper LA, Wilkinson JD, Addonizzio LJ, Canter CE, Everett MD, Kantor P, Lamour JM, Lu M, Margossian R, Pahl E, Rusconi P, Colan SD, Towbin JA. Presented at: American Heart Association Scientific Sessions 2008, New Orleans, LA, November, 2008.
  • Lipshultz SE, Orav EJ, Wilkinson JD, Towbin JA, Messerte J, Lowe AM, Sleeper LA, Clunie SK, Cox GF, Lurie PR, Hsu DT, Canter CE, Colan SD. A Risk Stratification Analysis of Predictors of Death or Transp[lant in Children with Hypertrophic Cardiomyopathy. Presented at: American Heart Association Scientific Sessions 2008, New Orleans, LA, November, 2008.
  • Larsen R, Naftel DC, Rosenthal DN, Blume ED, Mahle WT, Yung D, Morrow WR, Orav EJ, Wilkinson J, Towbin JA, Lipshultz SE, Canter CE. The Impact of Heart Failure Severity at Time of Listing for Cardiac Transplantation on Short and Long Term Stability with Pediatric Cardiomyopathy. Presented at: American Heart Association Scientific Sessions 2008, New Orleans, LA, November, 2008.
  • Brescia S, Towbin J, Jefferies JL, Rossano J, Denfield S, Price J, Dreyer WJ,  Kim, JJ. Fatal Arrhythmias in Pediatric Left Ventricular Noncompaction. Presented at: American Heart Association Scientific Sessions 2008, New Orleans, LA, November, 2008.
  • Wu J, Xie M, Zheng M, Ge X, Kendall K, Jefferies JL, Towbin JA, Pignatelli R, Ayres NA, Ge S. Alterations in Biomechyanical Properties of Ascending Aorta in Marfan Syndrome by Real-Time 2-D Ultrasound Speckle Track Imaging. Presented at: American Heart Association Scientific Sessions 2008, New Orleans, LA, November, 2008.
  • Stewart GC, Lipes MA, Anello MS, Pratibhu PP, Gottumukkala R, Winters GL, Towbin JA, Baughman KL. Parvovirus B19 and Cardiomyopathy- The New Coxsackie. Presented at: American Heart Association Scientific Sessions 2008, New Orleans, LA, November, 2008.
  • Kim JJ, Vatta M, Towbin JA. Alpha-1 Syntrophin Mutation and the Long-QT Syndrome: A Disease of Sodium Channel Disruption. SADS Young Investigator Award. Heart Rhythm 2008, 29TH Annual Scientific Sessions, San Francisco, CA, May, 2008.
  • Junttila J, Lizotte E, Dube MP, Hong K, Benito B, DeZutter M, Sarkozy A, Huikori H, Vatta M, Towbin JA, Brugada P, Brugada J, Brugada R. H558R is a Genetic Modifier in Brugada Syndrome. Heart Rhythm 2008, 29TH Annual Scientific Sessions, San Francisco, CA, May, 2008.
  • Rossano JW, Denfield SW, Smith EO, Kim JJ,  Price JF,  Jefferies JL, Decker JA,  Clunie SK, Towbin JA, Dreyer WJ. Assessment of the Cylex ImmuKnow Cell Function Assay in Pediatric Heart Transplant Patients. International Society for Heart and Lung Transplant 28th Annual Meeting and Scientific Sessions, Boston, MA, April, 2008.
  • Pietra B, Kantor P, Bartlett H, Chin C, Canter C, Larsen R, Edens RE, Colan S, Towbin J, Lipshultz S, Kirklin J, Naftel D, Hsu D. Clinical Factors Associated with UNOS Status and Outcome After Listing for Heart Transplantation in Children with Dilated Cardiomyopathy. American Heart Association Scientific Sessions, Orlando, FL, November, 2007.
  • Foerster S, Canter C, Carey A, Sleeper LA, Jefferies JL, Kantor P, Lamour J, Margossian R, Jane Messere J, Elfriede Pahl E, Paolo Rusconi P, Shaddy R, Webber S, Towbin J, Lipshultz L. A Comparative Analysis of Outcomes for Pediatric Patients with Biopsy-Proven Myocarditis, Clinically-Diagnosed Myocarditis and Idiopathic Dilated Cardiomyopathy. Presented at: American Heart Association Scientific Sessions, Orlando, FL, November, 2007.
  • Wilkinson J, Lowe A, Salbert B, Sleeper L, Towbin J, Colan S, Cox G, Connuck D, Cadregari E, Clunie S, Lipshultz S. Outcomes in Children with Noonan Syndrome and Cardiomyopathy. Presented at: American Heart Association Scientific Sessions, Orlando, FL, November, 2007.
  • Decker JA, Rossano JW, Smith EO, Cannon BC, Clunie SK, Jefferies JL, Kim JJ, Price JF, Dreyer WJ, Towbin JA, Denfield SW. Hypertrophic Cardiomyopathy in Children: Do Adult Risk Factors for Cardiac Death Apply? Presented at: American Heart Association Scientific Sessions, Orlando, FL, November, 2007.
  • Rossano JW, Denfield SW, Smith EO, Kim JJ, Price JF, Jefferies JL, Heinle JS, Morales DL, Clunie SK, Decker JA, Towbin JA, Dreyer WJ. B-Type Natriuretic Peptide Levels at Greater Than One Year Post-Transplant Predict Graft Survival in Pediatric Heart Transplant Patients. Presented at: American Heart Association Scientific Sessions, Orlando, FL, November, 2007.
  • Vatta M, Ai T, Wu G, Kim JJ, Mohapatra B, Xi Y, PhD2, Ackerman MJ, Abbasi S, Li Z, Cheng J, Towbin JA. A Novel Variant of Alpha-1-Syntrophin May Cause Long-QT Syndrome. Presented at: American Heart Association Scientific Sessions, Orlando, FL, November, 2007.
  • Marcus FI, Calkins H, Zareba W, Gear K, Towbin JA for the North American ARVD Registry Investigators. Late Breaking Clinical Trials: Multidisciplinary Study of ARVD. Presented at: Heart Rhythm 2007, Denver, CO, May, 2007.
  • Zhang L, Fontaine GH, Zareba W, Martini B, Long M, Stephan C, Pu J, Hu D, Liu W, Towbin JA, Compton SJ, Anderson JL, Vincent GM. A Spectrum of ECG Abnormalities in Patients with Arrhythmogenic Right Ventricular Dysplasia: Can ECG Predict the Disease? Presented at: Heart Rhythm 2007, Denver, CO, May, 2007.
  • Purevjav E, Varela J, Kearney DL, Labeit S, Moncman CL, Bowles NE, Towbin JA. Role of Myopalladin-CARP Interactions in Myocyte Differentiation and Proliferation. Presented at: Pediatric Academic Societies’ 2007, Toronto, Canada, May, 2007.
  • Xu T, Yang Z, Marcus F, Calkins H, Judge D, Vatta M, Towbin JA. Mutations in Desmosomal Cadherins Cause Arrhythmogenic Right Ventricular Dysplasia/Cardiomyopathy. Presented at: Pediatric Academic Societies’ 2007, Toronto, Canada, May, 2007.

Abstracts

(Most Recent) 

 

  • Zheng M, Xie M, Qu J, Yang Z, Fan Y, Vatta M, Towbin JA, Geng Y-J, Ge S. Quantitatative Assessment of Regional Myocardial Function By Ultrasound Biomicroscopy Based Tissue Doppler Imaging in a mdx Transgenic Mouse Modsl of Cardiomyopathy.J Am Coll Cardiol, Supplement A; 53: A242, 2009.
  • Webber S, Lipshultz SE, Sleeper LA, Wilkinson JD, Addonizio LJ, Canter CE, Everitt MD, Kantor P, Lamour JM, Lu M, Margossian R, Pahl E, Rusconi P, Colan SD, Towbin JA. Phenotypic Heterogeneity and Outcomes of Restrictive Cardiomyopathy in Childhood-A Report from the NHLBI Pediatric Cardiomyopathy Registry.Circulation 118, Suuplement 2; S1055:6071, 2008.
  • Lipshultz SE, Orav EJ, Wilkinson JD, Towbin JA, Messere J, Lowe AM, Sleeper LA, Clunie SK, Cox GF, Lurie PR, Hsu DT, Canter CE, Colan SD. A Risk Stratification Analysis of Predictors of Death or Transplant in Children with Hypertrophic Cardiomyopathy.Circulation 118, Suuplement 2; S964:4956, 2008.
  • Larsen R, Naftel DC, Rosenthal DN, Blume ED, Mahle WT, Yung D, Morrow WR, Orav EJ, Wilkinson J, Towbin JA, Lipshultz SE, Canter CE. The Impact of Heart Failure Severity at Time of Listing for Cardiac Transplantation on Short and Long Term Stability with Pediatric Cardiomyopathy.Circulation 118, Suuplement 2; S963:4953, 2008.
  • Brescia S, Towbin JA, Jefferies JL, Rossano J, Denfield SW, Price J, Dreyer WJ, Kim JJ. Fatal Arrhythmias in Pediatric Left Ventricular Non-Compaction.Circulation 118, Suuplement 2; S813:3093, 2008.
  • Wu J, Xie M, Zheng M, Ge X, Kendall K, Jefferies JL, Towbin JA, Pignatelli R, Ayres NA, Ge S. Alterations in Biomechanical Properties of Ascending Aorta in Marfan Syndrome by Real-Time 2-D Ultasound Speckle Tracking Imaging.Circulation 118, Suuplement 2; S752:2608, 2008.
  • Stewart GC, Lipes MA, Anello MS, Pratibhu PP, Gottumukkala R, Winters GL, Towbin JA, Baughman KL. Parvovirus B19 and Cardiomyopathy-The New Coxsackievirus.Circulation 118, Suuplement 2; S720:2409, 2008.
  • Junttila J, Lizotte E, Dube MP, Hong K, Benito B, DeZutter M, Sarkozy A, Huikori H, Vatta M, Towbin JA, Brugada P, Brugada J, Brugada R. H558R is a Genetic Modifier in Brugada Syndrome. Heart Rhythm 5(5S):S130;PO1-81, 2008.
  • Rossano JW, Denfield SW, Smith EO, Kim JJ,  Price JF,  Jefferies JL, Decker JA,  Clunie SK, Towbin JA, Dreyer WJ. Assessment of the Cylex ImmuKnow Cell Function Assay in Pediatric Heart Transplant Patients.J Heart Lung Transplant, 2008.
  • Pietra B, Kantor P, Bartlett H, Chin C, Canter C, Larsen R, Edens RE, Colan S, Towbin J, Lipshultz S, Kirklin J, Naftel D, Hsu D. Clinical Factors Associated with UNOS Status and Outcome After Listing for Heart Transplantation in Children with Dilated Cardiomyopathy.Circulation, 2007.
  • Foerster S, Canter C, Carey A, Sleeper LA, Jefferies JL, Kantor P, Lamour J, Margossian R, Jane Messere J, Elfriede Pahl E, Paolo Rusconi P, Shaddy R, Webber S, Towbin J, Lipshultz L. A Comparative Analysis of Outcomes for Pediatric Patients with Biopsy-Proven Myocarditis, Clinically-Diagnosed Myocarditis and Idiopathic Dilated Cardiomyopathy.Circulation, 2007.
  • Wilkinson J, Lowe A, Salbert B, Sleeper L, Towbin J, Colan S, Cox G, Connuck D, Cadregari E, Clunie S, Lipshultz S. Outcomes in Children with Noonan Syndrome and Cardiomyopathy.Circulation, 2007.
  • Decker JA, Rossano JW, Smith EO, Cannon BC, Clunie SK, Jefferies JL, Kim JJ, Price JF, Dreyer WJ, Towbin JA, Denfield SW. Hypertrophic Cardiomyopathy in Children: Do Adult Risk Factors for Cardiac Death Apply?Circulation, 2007.
  • Rossano JW, Denfield SW, Smith EO, Kim JJ, Price JF, Jefferies JL, Heinle JS, Morales DL, Clunie SK, Decker JA, Towbin JA, Dreyer WJ. B-Type Natriuretic Peptide Levels at Greater Than One Year Post-Transplant Predict Graft Survival in Pediatric Heart Transplant Patients. Circulation, 2007.
  • Vatta M, Ai T, Wu G, Kim JJ, Mohapatra B, Xi Y, PhD2, Ackerman MJ, Abbasi S, Li Z, Cheng J, Towbin JA. A Novel Variant of Alpha-1-Syntrophin May Cause Long-QT Syndrome.Circulation, 2007.
  • Marcus FI, Calkins H, Zareba W, Gear K, Towbin JA for the North American ARVD Registry Investigators. Late Breaking Clinical Trials: Multidisciplinary Study of ARVD.Heart Rhythm 4:, 2007.
  • Zhang L,Fontaine GH, Zareba W, Martini B, Long M, Stephan C, Pu J, Hu D, Liu W, Towbin JA, Compton SJ, Anderson JL, Vincent GM. A Spectrum of ECG Abnormalities in Patients with Arrhythmogenic Right Ventricular Dysplasia: Can ECG Predict the Disease? Heart Rhythm 4:S243, 2007.
  • Purevjav E, Varela J, Kearney DL, Labeit S, Moncman CL, Bowles NE, Towbin JA. Role of Myopalladin-CARP Interactions in Myocyte Differentiation and Proliferation. Pediatr Res, 2007.
  • Xu T, Yang Z, Marcus F, Calkins H, Judge D, Vatta M, Towbin JA. Mutations in Desmosomal Cadherins Cause Arrhythmogenic Right Ventricular Dysplasia/Cardiomyopathy.Pediatr Res, 2007.
  • Marcus FI, Calkins H, Zareba W, Gear K, Towbin JA for the North American ARVD Registry Investigators. Multidisciplinary Study of ARVD.Heart Rhythm 4:S-Late Breaking, 2007.
  • Zhang L, Fontaine GH, Zareba W, Martini B, Long M, Stephan C, Pu J, Hu D, Liu W, Towbin JA, Compton SJ, Anderson JL, Vincent GM. A Spectrum of ECG Abnormalities in Patients with Arrhythmogenic Right Ventricular Dysplasia: Can ECG Predict the Disease? Heart Rhythm 4:S243, 2007.

Books

  • The Science and Practice of Pediatric Cardiology, 3rd Edition. Bricker JT, Neish SR, Geva T, Friedman RA, Towbin JA, Editors.
  • Heart Failure in Children and Young Adults.  From Molecular Mechanisms to Medical and Surgical Strategies.  Chang AC, Towbin JA, Eds.  Saunders Elsevier, Inc., Philadelphia, PA, 2006.
  • The Molecular and Clinical Genetics of Cardiac Electrophysiological Disease.  Berul CI, Towbin JA, Eds.  Kluwer Academic Publishers, 2000.
  • The Brugada Syndrome. Clinical Approaches to Tachyarrhythmias.  Antzelevitch C, Brugada P, Brugada J, Brugada R, Nadenamee K, Towbin J, Camm AJ, Eds. Futura Publishing Co., Inc., NY, 1999.

Related Areas

This person works in these other areas at Cincinnati Children's Hospital Medical Center: