Heart Center

William L. Border, MBChB

Appointment

Assistant Professor

Email

william.border@cchmc.org

Phone

513-636-3291

Fax

513-636-9667

Credentials

MBChB: University of Cape Town, Cape Town, South Africa, 1993
Clinical Intern in Medicine: Pediatrics and Surgery, Cape Provincial Department of Health, Victoria Hospital, Cape Town, South Africa, 1994
House Officer in Medicine: Department of Cardiology,Charing Cross Hospital, London, UK. Supervisor, 1995
Residency: Pediatric Resident, Department of Pediatrics, Baystate Medical Center, Springfield, Massachusetts, 1998
Residency: Chief Resident, Department of Pediatrics, Baystate Medical Center, Springfield, Massachusetts, 1999
Fellowship: Clinical Cardiology Fellow, Department of Pediatric Cardiology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, 2002
MPH: Masters in Public Health (Epidemiology), Department of Public Health, University of Cape Town, South Africa, 2004
Honorary Lecturer: Pediatric Cardiology, Department of Pediatrics, Red Cross War Memorial Children's Hospital, Cape Town, South Africa, 2004
Research Fellow: Cardiology Research Fellow, Department of Pediatric Cardiology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, 2004

Awards and Honors

Arthur Bostock Merit Scholarship, academic award
Yvonne Parfitt Scholarship, academic merit
Mauerberger Foundation Scholarship, academic merit
David Waddel Scholarship, academic award
Outstanding Resident Teacher Award, Baystate Medical Center
Nominated for Young Investigator Competition (AAP Section on Cardiology, San Francisco, October)
Short presentation award (shared), South African Heart Congress, November, Cape Town, South Africa

Research

Cardiac systolic and diastolic function in children; myocardial function during exercise; outcomes in single ventricle patients; fetal twin-twin transfusion syndrome

Research Grants and Contracts

Early ventricular filling in Fontan patients during exercise: the role of intraventricular pressure gradients, 07/01/05 – , PI.

Preoperative therapy for prevention of postoperative low cardiac output syndrome. Resulted in inclusion as a center within the Pediatric Heart Network, NIH/NHLBI Pediatric Heart Network, IH/UO1-HL085057, 09/01/06 – 08/31/11, co-investigator.

The impact of a cardiac exercise rehabilitation program on exercise tolerance, cardiac function and quality of life in children with complex congenital heart disease, 09/01/06 – 09/01/07, Co-PI.

Publications, Most Recent

Mitsnefes MM, Kimball TR, Border WL, Witt SA, Glascock BJ, Khoury PR, Daniels SR. Impaired left ventricular diastolic function in children with chronic renal failure. Kidney Int. 2004 Apr; 65(4):721-6.

Mitsnefes MM, Kimball TR, Border WL, Witt SA, Glascock BJ, Khoury PR, Daniels SR. Abnormal cardiac function in children after renal transplantation.Am J Kidney Dis. 2004 Apr;43(4):721-6.

Michelfelder EC, Gomez C, Border WL, Gottliebson W, Franklin C. Predictive value of fetal pulmonary venous flow patterns in identifying the need for atrial septoplasty in the newborn with hypoplastic left ventricle.Circulation 2005;112:2974-2979.

Gottliebson WM, Border WL, Franklin CM, Meyer RA, Michelfelder EC. Accuracy of fetal echocardiography: a cardiac segment-specific analysis.Ultrasound in Obstetrics and Gynecology. 2006 Jul;28(1):15-21

8. Markham LW, Michelfelder EC, Border WL, Khoury PR, Spicer RL, Wong BL, Benson DW. Abnormalities of diastolic function precede dilated cardiomyopathy associated with Duchenne muscular dystrophy.J Am Soc Echocardiogr. 2006 Jul;(7):865-71

Carlo WF, Kimball TR, Michelfelder EC, Border WL. Persistent diastolic flow reversal in abdominal aortic Doppler flow profiles predicts increased risk of necrotizing enterocolitis in term infants with congenital heart disease.Pediatrics 2007;119;330-335.

Border WL, Benson DW. Sudden infant death syndrome and long QT syndrome: The zealots versus the naysayers. Heart Rhythm 2007;4(2):167-169.

Border WL, Kimball TR, Witt SA, Glascock BJ, Khoury P, Daniels SR. Diastolic
filling abnormalities in children with essential hypertension.Journal of Pediatrics, in press.

Presentations, Most Recent:

Border WL, Swingler GH, Kimball TR. The Diagnostic Accuracy of Transthoracic Echocardiography in Pediatric Heart Disease: a Systematic Appraisal by Anatomic Region. Presented at the Scientific Sessions of the American College of Cardiology, New Orleans, March, 2004.

Border WL, Swingler GH, Kimball TR. Why is Echo Sometimes Inaccurate When Assessing Pediatric Heart Disease? Presented at the Scientific Sessions of the American College of Cardiology, New Orleans, March, 2004.

Michelfelder EC, Gomez C, Border WL, Franklin C. Predictive Value of Fetal Pulmonary Flow Patterns in Identifying the Need for Urgent Atrial Septostomy in the Newborn with Hypoplastic Left Heart Syndrome. Presented at American Heart Association, New Orleans, November 2004.

Border WL, Swingler GH, Kimball TR. The Discriminatory Ability of Doppler
Echocardiography to Assess Clinically Significant Heart Disease in Children. Presented at the American Society of Echocardiography, Boston, June 2005.

Itikala P, Border WL, Michelfelder EC, Gottliebson WM, Cripe L, Witt S, Uzark KC, Spicer R, Kimball TR. Impact of Intravenous Transpulmonary Contrast on the Diagnostic Accuracy of Dobutamine Stress Echocardiography in Pediatric Heart Transplant Recipients. Presented at the American Heart Association meeting, November 2005.

Kinsel ML, Border WL, Michelfelder EC. Myocardial performance index in the fetus: an assessment of diagnostic feasibility and reproducibility of both pulsed-wave and Doppler tissue imaging methods. Presented at the American Society of Echocardiography meeting, Baltimore, June 2006.

Ashcroft T, Jones K, Border WL, Khoury P, Pearl J, Eghtesady P, Manning P. Factors affecting long term risk of aortic arch re-coarctation following the Norwood operation. Presented at STSA meeting, November 2006.

Manning PB, Rutter MJ, Border WL. Slide tracheoplasty in infants and children: risk factors for prolonged postoperative ventilatory support. Presented at STSA meeting, November 2006.

Shah A, Border WL, Crombleholme T, Michelfelder EC. The relationship between cardiovascular status and recipient twin outcomes in twin-twin transfusion syndrome: assessment by fetal cardiovascular profile score. Abstract presented at the AHA, Chicago 2006.

Professional Organization Memberships

American Academy of Pediatrics, Fellow
American College of Cardiology, Member
American Society of Echocardiography, Member
American Heart Association, Council on Cardiovascular Disease in the Young, Member