Theodosia A. Kalfa, MD, PhD
Title
Sickle Cell Scholar
Appointment
Research Assistant Professor of Pediatrics
Email
theodosia.kalfa@cchmc.org
Phone
513-636-0989
Fax
513-636-3549
Credentials
MD: Aristotle University Medical School, Thessaloniki, Greece, 1990.
PhD: Aristotle University Medical School, Thessaloniki, Greece, 1997.
Residency: Pediatrics, University Of North Carolina, Chapel Hill, NC.
Fellowship: Pediatric Hematology / Oncology, Duke University Medical Center, Durham, NC.
Certification:
Board Certified in Pediatric Hematology-Oncology (American Board of Pediatrics), 2004
Board Certified in Pediatrics (American Board of Pediatrics), 2000
ECFMG Certification, 1995
Licenses:
Full and Unrestricted Medical License (OH Medical Board), 2003-present
Full and Unrestricted Medical License (NC Medical Board), 2000-present
Full and Unrestricted license of Medical Practice in Greece, 1990-present
Awards and Honors
- ASPHO Young Investigator Award, 2006
- Fellow of The American Academy of Pediatrics (F.A.A.P.), 2005
- Research Scholar, Cincinnati Comprehensive Sickle Cell Center, 2003-2008
- Research Scholar, Pediatric Center for Gene Expression and Development, 2004-2006
- Fellowship for AACR workshop on Molecular Biology in Clinical Oncology, 2003
- Medical Diploma awarded with honors, (Summa Cum Laude).
- Scholarship for academic excellence, awarded by the National Honor Foundation (IKY), Greece, every year while in Medical School.
Research
Connect to Theodosia Kalfa's laboratory website
- Signaling in erythrocytes
- Erythropoiesis
- Sickle Cell disease
- Endothelial cell biology
Research Grants and Contracts
U54 HL70871 (Joiner) 07/11/03 – 03/31/08 NIH/NHLBI
Cincinnati Comprehensive Sickle Cell Center: Project 8 Sickle Cell Scholars Program
K12 HD28827 (Boat) 05/01/04-04/30/06 NIH/NICHD
Pediatric Center for Gene Expression and Development
Publications, Most Recent
Connect to Theodosia Kalfa's publications on PubMed
D. Daria, M.D. Filippi, E.S. Knudsen, R. Faccio, Z. Li, T. Kalfa, H. Geiger (2007): The retinoblastoma tumor suppressor is a critical intrinsic regulator for hematopoietic stem and progenitor cells under stress.Blood. 2007 Nov 29 [Epub ahead of print]
L. Yang, L. Wang, T.A. Kalfa, J.A. Cancelas, X. Shang, S. Pushkaran, J. Mo, D.A. Williams, Y. Zheng (2007): Cdc42 critically regulates the balance between myelopoiesis and erythropoiesis.Blood. 2007 Dec 1;110(12):3853-61.
Diwan, A.G. Koesters, A.M. Odley, S. Pushkaran, C.P. Baines, B.T. Spike, D. Daria, A.G. Jegga, H. Geiger, B.J. Aronow, J.D. Molkentin, K.F. Macleod, T.A. Kalfa, and G.W. Dorn, 11 (2007): Unrestrained erythroblast development in Nix mice reveals a mechanism for apoptotic modulation of erythropoiesis.Proc Natl Acad Sci USA. 2007 Apr 17; 104(16):6794-9.
T.A. Kalfa, Pushkaran S, Mohandas N, Hartwig JH, Fowler VM, Johnson JF, Joiner CH, Williams DA, Zheng Y. Rac GTPases regulate the morphology and deformability of the erythrocyte cytoskeleton. Blood. 2006 Dec 1;108(12):3637-45.
Kalfa TA, Zimmerman SA, Goodman BK, McDonald MT, Ware RE. Pelger-Huet anomaly in a child with 1q42.3-44 deletion.Pediatr Blood Cancer. 2005 Jul 8.
Gonzalez-Gronow M, Kalfa T, Johnson CE, Gawdi G, Pizzo SV. The voltage-dependent anion chennel (VDAC) is a receptor for plasminogen kringle 5 on human endothelial cells.J Biol Chem. 2003 Jul 18;278(29): 27312-8.
Abstracts
T.A. Kalfa, S. Pushkaran, J.A. Cancelas, J.F. Johnson, D. Daria, H. Geiger, D.A. Williams, Y. Zheng (2007). Rac GTPases Regulate Erythropoiesis Both in the Early Steps of Differentiation and in Enucleation.Blood, 110 (1 I), p5 10a.
A. Diwan, A.G. Koesters, A.M. Odley, T.A. Kalfa, G.W. Dom (2007). Enhanced Erythroblast Mobilization in Nix-Deficient Mice Confers Resistance to Phenylhydrazine-Induced Anemia Despite Accelerated Erythrocyte Turnover.Blood, 110 (ll),p1068a.
D. Pan, T.A. Kalfa, D. Wang, M. Risinger, S. Crahle, P. Ciraolo, R.S. Franco, C.H. Joiner (2007). Change in Expressional Profile of KC1 Cotransporter Genes during Human Erythroid Differentiation.Blood, 110 (1 I), p509a.
T.A. Kalfa, S. Pushkaran, J.A. Cancelas, M. Jansen, J.F. Johnson, K. Hebel, D.A. Williams, Y. Zheng (2006). Deficiency of Rac1 and Rac2 GTPases Perturbs Erythroid Proliferation and Differentiation but Not Enucleation.Blood, 108 (11), p142a.
H. Geiger, M-D. Filippi, T.A. Kalfa, D. Daria (2006). A Critical Role for the Retinoblastoma Tumor Suppressor Gene in Hematopoietic Stem Cells. Blood, 108 (11), p720a.
Presentations, Most Recent
T.A. Kalfa, S. Pushkaran, J.A. Cancelas, M. Jansen, J.F. Johnson, K. Hebel, D.A. Williams, Y. Zheng (2006). Deficiency of Rac1 and Rac2 GTPases Perturbs Erythroid Proliferation and Differentiation but Not Enucleation. Podium presentation in the ASH meeting, December 8-13, 2006, Orlando, Florida.
T.A. Kalfa, S. Pushkaran, N. Mohandas, J.H. Hartwig, V.M. Fowler., J.F. Johnson, C.H. Joiner, D.A. Williams, Y. Zheng (2006): Rac GTPases in Erythroid Function and Differentiation. Podium presentation in the Red Cell Conference, November 3-4, 2006, New Haven, Connecticut.
T.A. Kalfa, S. Pushkaran, N. Mohandas, J.H. Hartwig, J.F. Johnson, C.H. Joiner, D.A. Williams, Y. Zheng. Rac GTPases Regulate the Morphology and Deformability of the Erythrocyte Cytoskeleton. Young Investigator Award presentation in the Presidential Symposium, ASPHO, 2006, San Francisco, California.
T.A. Kalfa, S. Pushkaran, N. Mohandas, J.H. Hartwig, J.F. Johnson, C.H. Joiner, D.A. Williams, Y. Zheng. Rac GTPases Regulate the Morphology and Deformability of the Erythrocyte Cytoskeleton. Podium presentation in the National Sickle Cell meeting, April 8-12, 2006, Memphis, Tennessee.
Kalfa TA, Pushkaran S, Mohandas N, Hartwig JH, Johnson JF, Joiner CH, Williams DA, Zheng Y. Erythrocyte Cytoskeletal Defects Induced in Mice by Deletion of Rac GTPases. Podium presentation in the National Sickle Cell meeting, April 10-13, 2005, Cincinnati, Ohio.
Kalfa TA, Wahl ML, Pizzo SV. Angiostatin and Kringle 5 Interact with Adhesion Complexes of the Human Microvascular Endothelial Cells and Induce Tyrosine Phosphorylation of Focal Adhesion Kinase. Poster presentation in the AACR New Directions in Angiogenesis Research Conference, Chicago, Illinois.
Kalfa TA, Pizzo SV. Angiostatin and kringle 5 interact with adhesion complexes of the human microvascular endothelial cells. Podium presentation in the Duke Pediatric Fellow Research Symposium, Durham, North Carolina.
Invited Lectures
Respiratory therapy seminar. Cincinnati Children's Hospital Medical Center. Acute Chest Syndrome in children with Sickle Cell Disease. (October 16, 2006).
Hoxworith Blood Center (SRAG Seminar). Erythrocyte Cytoskeletal Defects Induced in Mice by Deletion of Rac GTpases. (June 24, 2005).
Professional Organization Memberships
- American Society of Pediatric Hematology-Oncology
- American Society of Hematology
- American Academy of Pediatrics
- American Association for Cancer Research
- Medical Association of Thessaloniki and Panhellenic Medical Association, Greece
Service
Sickle Cell Scholar, Comprehensive Sickle Cell Center
Hematologist, Cincinnati Children's Hospital Medical Center
Related Areas
This person works in these other areas at Cincinnati Children's Hospital Medical Center:
