Mitchell B. Cohen, MD
Title
Director, Gastroenterology, Hepatology & Nutrition
Appointment
Professor of Pediatrics; Associate Professor of Internal Medicine
Email
mitchell.cohen@cchmc.org
Phone
513-636-3008
Fax
513-636-5581
Bio
Mitchell B. Cohen, MD, completed his pediatric training at Johns Hopkins Hospital and entered the public health service where he served at the Keams Canyon Indian Hospital on the Hopi Reservation in northeast Arizona. Subsequently, he completed a pediatric gastroenterology and nutrition fellowship at Cincinnati Children's Hospital Medical Center.
Dr. Cohen has had a long-standing interest in the pathophysiology of diarrheal diseases and continues to direct basic science and clinical research programs related to intestinal secretion and infection. These programs include studies of the guanylin family of intestinal peptides, epidemiology and pathogenesis of diarrheagenic E. coli and studies of human cholera and typhoid fever vaccines.
Dr. Cohen is the Director of Gastroenterology, Hepatology & Nutrition at Cincinnati Children's. He is also the Director of the NIDDK-funded Silvio O. Conte Digestive Diseases Research Core Centers (DDRCC) entitled Digestive Health Center (DHC): Bench-to-Bedside Research in Pediatric Digestive Disease and the director of the NIH-funded Fellowship Training Program in Pediatric Gastroenterology.
Dr. Cohen is active in the North American Society for Pediatric Gastroenterology, Hepatology and Nutrition (NASPGHAN) where he has served as a councilor, director of the postgraduate course and president. He was chair of the abstract review process for the First World Congress of Pediatric Gastroenterology, Hepatology and Nutrition in 2000. He is also active in the American Gastroenterological Association, where he has served as chair of the section on Growth Development and Nutrition and currently serves on the Executive Steering Committee of the Gastroenterology Research Group (GRG). He is a member of the Clinical Research Committee of the Cystic Fibrosis Foundation (CFFTI), and has served as permanent and ad hoc member on a number of NIH study sections and the National Commission on Digestive Diseases.
Credentials
MD: Mount Sinai School of Medicine, New York, NY, 1977.
Residency: Johns Hopkins Hospital, Baltimore, MD, 1977 to 1980.
Fellowship: Pediatric Gastroenterology and Nutrition, Children's Hospital Medical Center of Cincinnati, 1983 to 1986; Research Scholar, Pediatric Gastroenterology and Nutrition, Children's Hospital Medical Center of Cincinnati, 1986 to 1987.
Certification: Pediatrics, 1981; Pediatric Gastroenterology and Nutrition, 1990, 1997, 2004.
Position History
Public Health Service
- Keams Canyon Indian Hospital, AZ (1980-1982)
- NHSC, New Richmond, OH, (1982-1983)
Cincinnati Children's Hospital Medical Center
- Research Scholar (1986-1987)
- Attending Gastroenterologist (1987-present)
- Director, Fellowship Training Program in Pediatric Gastroenterology (1995-2006)
- Director, Cincinnati Digestive Disease Research Development Center (DDRDC) (2002-2007)
- Director, Cincinnati Digestive Health Center (DDRCC) (2007-present)
- Director, Gastroenterology, Hepatology and Nutrition (2005-present)
- CCHMC Endowed Chair in Pediatric Gastroenterology (2005-present)
University of Cincinnati
- Assistant Professor of Pediatrics (1987-1991)
- Assistant Professor of Medicine (1988-1992)
- Associate Professor of Pediatrics (1991-1998)
- Associate Professor of Medicine (1992- present)
- Professor of Pediatrics (1998-present)
- Faculty, Graduate Program in Cell Biology (1994-present)
- Graduate Program in Molecular and Developmental Biology (1995-present)
- Physician Scientist Training Program (1996-present)
Awards and Honors
- Phi Beta Kappa (1972)
- American Federation for Clinical Research/Central Society for Clinical Research, Midwest Trainee Award (1985)
- Elected, Society for Pediatric Research (1989)
- 1st Hinda Kopelman Memorial Research Award, Canadian Assoc. Gastroenterology (1996)
- Elected, American Pediatric Society (1997)
- Howard Rapaport Lecturer, Mt. Sinai School of Medicine (2003)
- 2nd Silverman Lecturer, U. Colorado HSC and The Children's Hospital (2003)
- Best Doctors in America, 1999 to 2006
- Best Doctors in America, 2008
Research
- Intestinal secretion
- Diarrheal disease
- Developmental biology
Research Grants and Contracts
NIH/NIDDK - R01 DK47318 | 09/30/1995 - 11/30/2009
Role: Principal investigator
Title: Expression and function of the guanylin ligand family.
NIH/NIAID - NIAID-DMID-N01-AI-25459 | 06/01/02-05/31/07
Role: Co-investigator (PI of Part C, Enteric Vaccine Component)
Title: Evaluation of control measures against human infectious diseases other than AIDS.
NIH/NIDDK - T32 DK07727 | 07/01/95 - 06/30/10
Role: Program Director
Title: Training Program in Pediatric Gastroenterology and Nutrition
NIH/NIDDK - P30 DK0789392 | 04/01/07-03/31/12
Role: Principal Investigator
Title: Cincinnati DDRCC: Digestive Health Center: Bench-to-Bedside Research in Pediatric Digestive Disease
NIH/NIDDK - R01 DK58701-04 | 07/01/2001 - 6/30/2006
Role: Principal investigator
Title: Studies on intestine-enriched transcription factor, IKFL
Publications, Most Recent
View Mitchell Cohen's publications at Cincinnati Children's as listed by PubMed.
- Goday PS, Cohen MB (2004). Secretory tumors. Pediatric Gastrointestinal Disease: Pathophysiology, Diagnosis, Management, 4th Edition. WA Walker, O Goulet, RE Kleinmanet al. Hamilton, Ontario, B.C. Decker: 1055-1067.
- Osuntokun B, Falcone R, Alonso M, Cohen MB. (2004) Duodenogastric intussusception: A rare cause of gastric outlet obstruction.J Pediatr Gastroenterol Nutr 39:299-301.
- Elson CO, Ballew M, Barnard J, Berstein SJ, Check IJ, Cohen MB, Fazio S, Johanson JF, Lindor NM, Montgomery E, Richardson LH, Rogers D, Vijan S. (2005) National Institutes of Health Consensus Development Conference Statement on Celiac Disease.Gastroenterology 128:S1-9.
- Crandall WV, Barnard JA, Cohen MB, Colletti RB, Harnsberger JK, Hart MH, Hayes JR, Sherman PM, Smith LJ, Committee NCP. (2005) Pediatric Workforce Survey, 2003-2004: A Report of the North American Society for Pediatric Gastroenterology, Hepatology and Nutrition.J Pediatr Gastroenterol Nutr 397-405.
- Cohen MB. (2005) Presentation of the Julius M. Friedenwald Medal to Ralph A. Giannella, MD.Gastroenterology 2152-2157.
- Zareie M, Riff J, Donato K, McKay DM, Perdue MH, Soderholm JD, Karmali M, Cohen MB, Hawkins J, Sherman PM. (2005) Novel effects of the prototype translocating Escherichia coli, strain C25 on intestinal epithelial structure and barrier function.Cell Microbiol 7:1782-97.
- Cohen MB, Nataro JP, Bernstein DI, Hawkins J, Roberts N, Staat MA. (2005) Prevalence of diarrheagenic Escherichia coli in acute childhood enteritis: a prospective controlled study.J Pediatr 146:54-61.
- Xanthakos SA, Schwimmer JB, Melin-Aldana H, Rothenberg ME, Witte DP, Cohen MB. (2005) Prevalence and outcome of allergic colitis in healthy infants with rectal bleeding: a prospective cohort study.J Pediatr Gastroenterol Nutr 41:16-22.
- Mann EA, Steinbrecher KA, Stroup C, Witte DP, Cohen MB, Giannella RA. (2005) Lack of guanylyl cyclase C, the receptor for Escherichia coli heat-stable enterotoxin, results in reduced polyp formation and increased apoptosis in the multiple intestinal neoplasia (Min) mouse model.Int J Cancer 116:500-5.
- Noel R, Cohen MB (2006). Infectious diarrhea. Philadelphia, WB Saunders.
- Cohen M. (2006) Introduction of WF Balistreri Festschrift.J Pediatr Gastroenterol Nutr 43:S1-S3.
- Blanchard C, Wang N, Stringer KF, Mishra A, Fulkerson PC, Abonia JP, Jameson SC, Kirby C, Konikoff MR, Collins MH, Cohen MB, Akers R, Hogan SP, Assa'ad AH, Putnam PE, Aronow BJ, Rothenberg ME. (2006) Eotaxin-3 and a uniquely conserved gene-expression profile in eosinophilic esophagitis.J Clin Invest 116:536-47.
- Elitsur N, Lorenz JN, Hawkins JA, Rudolph JA, Witte D, Yang LE, McDonough AA, Cohen MB. (2006) The Proximal Convoluted Tubule is a Target for the Uroguanylin-regulated Natriuretic Response.J Pediatr Gastroenterol Nutr 43:S74-S81.
Professional Organization Memberships
North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition (NASPGHAN)
- Assoc. Editor, J. Pediatr. Gastroenterol. Nutr. (1991-1995)
- Councilor 1994-1996, president-elect (2000-2002)
- President (2002-2004)
- Immediate past president (2004-2006)
- Federation of International Societies of Pediatric Gastroenterology, Hepatology and Nutrition (FISPGHAN) Councilor (2002-2006)
- Children's Digestive Health and Nutrition Foundation (CDHNF) Board of Trustees (2002-2006)
American Gastroenterological Association (AGA)
- Vice-Chair (1997-1999)
- Chair (1999-2001) Section on Growth, Development, Nutrition.
- Member, Consensus Development Conference on Escherichia coli O157:H7 Infections: An Emerging National Health Crisis 1994
- Executive Committee, Gastroenterology Research Group, 2004-2006
- Nominating Committee, 2006-2007
Cystic Fibrosis Foundation
- Clinical Research Committee (ad hoc 2001-2002, member 2003-present)
Federal Review Boards (last 5 yrs)
- Temporary Member, NIH: GMA2 Study Section, 2000, 2001, 2002
- Member, (ZAI1) NIAID Panel for "ICIDR", Chair, 2002, Member 2005;
- Member ZDK1 GRB-4, Digestive Disease Core Centers Review Group, 2000, 2001, 2005
- ad hoc reviewer NIH Recombinant DNA Advisory Committee (RAC), 2003
- Member, NIH Review Panel ZAI1 GSM-M S1, Loan Repayment Program, 2003
- Member, ZDK1 GRB-4 02 1, Training Grants in GI and Nutrition, 2003
- Member, NIH Consensus Development Conference on Celiac Disease, 2004
- Temporary Member CIGP, 2004
- Acting Chair, NIDDK, Digestive Diseases Research Core Centers (ZDK1 GRB-8), 2005
- Member, NIH National Commission on Digestive Diseases
- Member, MIDB, NIAID
- Member, CTSA EAB, University of Texas Health Sciences Center, Houston
Teaching
Funded Training Programs
- Training Program in Pediatric Gastroenterology and Nutrition
- Graduate Program in Molecular and Developmental Biology
- Graduate Program in Cell Biology
- Training Program in Biodefense
Special Interests
Related Areas
This person works in these other areas at Cincinnati Children's Hospital Medical Center:
