Immunodeficiencies and Histiocytosis Program Services
The Immunodeficiencies and Histiocytosis Program at Cincinnati Children's Hospital Medical Center offers a full spectrum of laboratory and clinical services ranging from diagnosis to treatment. It interfaces with the Blood and Marrow Transplantation Program to offer state-of-the-art treatment for children with immunodeficiency disorders.
Primary immunodeficiency disorders treated at Cincinnati Children's include over 80 genetically defined diagnoses. Many of these diseases are rare, and Cincinnati Children's offers specialists with extensive experience in their diagnosis and management. Our close collaboration with the Molecular Genetics Laboratory, part of the Division of Human Genetics, is reflected in the establishment of a joint Diagnostic Center for Heritable Immunodeficiencies.
Immunodeficiencies Treated (selected)
- X-linked Agammaglobulinemia (XLA)
- Severe Combined Immunodeficiencies (SCIDs)
- Wiskott Aldrich syndrome (WAS)
- Common Variable Immunodeficieny (CVID)
- X-linked CD40 Ligand Deficiency (X-linked-hyper IgM syndrome, HIM)
- Autosomal recessive hyper IgM syndrome (HIGM2-HIGM4)
- X-linked Lymphoproliferative syndrome (XLP)
- Immune dysregulation, Polyendocrinopathy, Enteritis, X-linked (IPEX)
- Autoimmune Lymphoproliferative syndrome (ALPS)
- Hypogammaglobuliunemia
- X-linked NFkB Essential Modifier Deficiency (NEMO)
- Chronic Granulomatous disease (CGD)
Clinical Services Offered
- Initial diagnostic evaluations and ongoing management of immunodeficiency disorders
- Second opinions for diagnoses of (suspected) immunodeficiency disorders
- Immunologic Testing
- Genetic diagnosis of many immunodeficiency disorders, in collaboration with the Diagnostic Center for Heritable Immunodeficiencies
- Home-based therapies
- Treatment and participation in national trials (e.g. using IVIG)
- Hematopoietic Stem Cell Transplantation using related and unrelated donors (marrow, cord blood, peripheral stem cells)
- Comprehensive evaluation of chronic/recurrent immune cytopenias, in collaboration with the Blood Disease Center
Histiocytosis Program
The Comprehensive Histiocytosis Program at Cincinnati Children's Hospital Medical Center specializes in the diagnosis and treatment of Langerhans Cell Histiocytosis (LCH) and Hemophagocytic Lymphohistiocytosis (HLH).
Program Highlights
- World-renowned program for the treatment of children with Hemophagocytic Lymphohistiocytosis (HLH) using blood and marrow transplantation. This program is led by Dr. Alexandra Filipovich, who serves on the boards of the Histiocyte Society and Histiocytosis Association of America.
- National Reference Laboratory for immunologic testing of HLH, including testing of natural killer cell function, perforin expression and genetic testing. Dr. Filipovich and colleagues have developed a rapid screening assay for HLH and have made it available through referral to pediatricians across the nation and the world.
- Comprehensive LCH Clinic: provides patients with Langerhans Cell Histiocytosis (LCH) comprehensive multidisciplinary management, follow up for late effects and second opinions.
- Cincinnati Children's participates in national and international protocols for treatment of histiocytic disorders.
