Cincinnati Children's Hospital Medical Center Logo

Immunodeficiencies and Histiocytosis Program

<Click for High-Res Image>

Alexandra H. Filipovich, MD

Title

Ralph J. Stolle Chair in Clinical Immunology; Director, Immunodeficiency and Histiocytosis Program; Medical Director, Hematology/Oncology Diagnostic Laboratory

Appointment

Professor of Pediatrics

Email

lisa.filipovich@cchmc.org

Phone

513-636-7206

Credentials

MD: University of Minnesota, Minneapolis, MN, 1974.

Residency: Pediatrics, University of Minnesota Hospitals, Minneapolis, MN 1975-1978.

Fellowship: Immunopathology, Departments of Pediatrics, Laboratory Medicine and Pathology, University of Minnesota 1978-1979.

Fellowship: Pediatric Immunology, Department of Pediatrics, University of Minnesota 1979-1980.

Certification: Pediatrics, 1980.

Position History

1980-1981: Instructor, Department of Pediatrics, University of Minnesota Medical School, Minneapolis MN.

1981-1985: Assistant Professor, Department of Pediatrics, University of Minnesota Medical School.

1985-1992: Associate Professor, Department of Pediatrics, University of Minnesota Medical School.

1986-1996: Head, Division of Immunology, Department of Pediatrics, University of Minnesota Medical School.

1992-1996: Professor, Department of Pediatrics, University of Minnesota.

1996-Present: Professor, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Ralph J. Stolle Chair in Clinical Immunology, Division of Hematology/Oncology, Cincinnati Children's Hospital Medical Center, Director, Immunodeficiency and Histiocytosis Program, Division of Hematology/Oncology, Cincinnati Children's Hospital Medical Center.

2000-2001: Associate Director and Acting Interim Director, Division of Hematology/Oncology, Cincinnati Children's Hospital Medical Center.

2001-Present: Medical Director, Hematology/Oncology Diagnostic Laboratory, Division of Hematology/ Oncology, Cincinnati Children's Hospital Medical Center.

Awards and Honors

  • Best Doctors in America, 2008
  • Awarded "2005 Best Doctors"
  • 2004-Present: Director, Federation of Clinical Immunology Societies (FOCIS) Center of Excellence.
  • Awarded "2004 Best Doctors"
  • 2001-2004: Chair, The International Bone Marrow Transplant Registry
  • 1998-Present: Member, Board of Trustees, Histiocytosis Association of America
  • 1999-Present: Secretary, Board of Directors, Histiocyte Society
  • 1995-Present: Chair, Working Committee for Metabolic Disorders and Immune Deficiencies, Bone Marrow Transplant Registry

Research

  • Immunoreconstitution Following Pediatric Stem Cell Transplantation
  • Clinical Investigation of Hematopoietic Stem Cell Transplantation for Genetic Immunodeficiencies
  • Biology and Genetics of Hemophagocytic Lymphohistiocytosis

Publications, Most Recent

Connect to Lisa Filipovich's publications on PubMed

Bhatla D, Davies SM, Shenor S, Harris RE, Smolarek T, Blessing J, Hansen M, Jodele S, Jordan M, Filipovich AH, Mehta PA. Reduced Intensity Conditioning is Safe and Effective for Transportation of Patients with Shwachman Diamond Syndrome. Bone Marrow Transplantation. Submitted, 2007

Mischler M, Flemming G, Shanley TP, Castle V, Filipovich AH, Cornell TT. Epstein Barr virus induced hemophagocytic lymphohistiocytosis and XLP: a mimicker of sepsis and multiple organ dysfunction syndrome in the pediatric ICU. Pediatrics 119 (5): 1212-1218, 2006.

Gross TG, Loechelt BL, Boyer MW, Harris RE, Witte DP, Filipovich AH. GM-CSF as pre-emptive therapy for Epstein-Barr virus associated post-transplant lymphoproliferative disease following blood and marrow transplantation. In press

Trizzino A, zur Stadt U, Ueda I, Risma K, Janka G, Ishi E, Beutel K, Sumegi J, Cannella S, Pende D, Mian A, Henter J-I, Santoro A, Filipovich A, Aricò M for the Histiocyte Society HLH Study Group. Genotype-phenotype study of familial hemophagocytic lymphohistiocytosis is due to perforin mutations. Submitted, 2007, In press 2007.

Friedlander SL, Dooms KT, Voss CY, Agger WA, Zhang K, Bleesing J, Filipovich AH, Seroogy CM. Adolescent presentation of X-linked lymphoproliferative disease: case report and review of the literature. Submitted, 2007.

Dewey RA, Avedillo Diez I, Ballmaier M, Filipovich AH, Greil J, Gungor T, Happel C, Maschan, A, Noyan F, Panicake U, Schwarz K, Snapper S, Welte K, Klein C. Retroviral WASP gene transfer into human hematopoietic stem cells reconstitutes the actin cytoskeleton in myeloid progeny cells differentiated in vitro. Experimental Hem. 34 (9): 390-395, 2006.

Zhang K, Johnson JA, Biroschak J, Villanueva J, Lee SM, Bleesing JJ, Wenstrup RJ, Filipovich AH. The A91V substitution in the Perforin 1 (PRF1) gene is found in patients with Familial Hemophagocytic Lymphohistiocytosis (FHL) in combination with other PRF1 or Munc13-4 mutations. International Journal of Immunogenetics. International Journal of Immunogenetics 34 (4): 231-233, 2007.

Nicolaou S, Szigligeti P, Neumeier L, Molleran Lee S, Duncan HJ, Kant SK, Mongey AB, Filipovich AH, Conforti L. Altered dynamics of Kv1.3 channel compartmentalization in the immunological synapse in systemic lupus erythematosus. Journal of Immunology 179 (1): 346-356, 2007.

Bullock JZ, Villanueva JM, Blanchard C, Filipovich AH, Putnam PE, Collins MH, Risma KA, Akers RM, Kirby CL, Buckmeier BK, Assa'ad AH, Hogan SP, Rothenberg ME. Elevated levels of esophageal eotaxin-3, eisonophil C-C chemokine receotor 3 expression, and T cell-derived interleukin 5 in pediatric eosinophilic esophagitis. Journal of Pediatric Gastrointerol Nutr 45 (1): 22-31, 2007.

Eapen M, DeLaat C, Baker S, Cairo M, Cowan M, Kurtzberg J, Steward C, Veys P, Filipovich A. Hematopoietic cell transplantation for Chediak-Higashi syndrome. Bone Marrow Transplantation 39:411-415, 2007.

Farzin A, Davies SM, Smith FO, Filipovich A, Hansen M, Auerbach A, Harris RE. Matched sibling donor hematopoietic stem cell transplantation in Fanconi anemia: an update of the Cincinnati Children's experience. Br. J. Haematol. 136:633-640, 2007.

Filipovich AH, Bleesing J, Goldman F. Emerging targets for hematopoietic cell transplantation (HCT): genetic disorders of hematopoiesis and immunity. Biol. Blood Marrow Transplant. 13S1:58-63, 2007.

Henter J-I, Horne AC, Arico M, Egeler RM, Filipovich AH, Imashuku S, Ladisch S, McClain K, Webb D, Winiarski J, Janka G, for the Histiocyte Society. HLH-2004: diagnostic and therapeutic guidelines for hemophagocytic lymphohistiocytosis. Pediatr. Blood Cancer 48(2):124-131, 2007.

Rao A, Kamani N, Filipovich A, Lee SM, Davies S, Dalal J, Shenoy S. Successful bone marrow transplantation for IPEX syndrome following reduced-intensity conditioning. Blood 109(1):383-385, 2007.

Filipovich AH, Conley ME, Nichols KE, Sullivan KE. X-linked lymphoproliferative syndrom: an X-cellent question. Clin. Immunol. 119(3):241-244, 2006.

Villanueva J, Pullen J, Zewge Y, Filipovich A. Perforin polymorphism A91V and susceptibility to B-precursor childhood acute lymphoblastic leukemia: a report from the Children's Oncology Group. Leukemia 29(9):1539-1541, 2006.

Stein ML, Collins MH, Villanueva JM, Kushner JP, Putnam PE, Buckmeier BK, Assa'ad AH, Filipovich AH, Rothenberg ME. Anti-Interleukin-5 (mepolizumab) therapy for eosinophilic esophagitis. J. Allergy Clin. Immunol. 118(6):1312-1319, 2006.

Mehta PA, Davies SM, Kumar A, Devidas M, Lee S, Zamzow T, Elliott J, Villanueva J, Pullen J, Zewge Y, Filipovich A. Perforin polymorphism A91V and susceptibility to B-precursor childhood acute lymphoblastic leukemia: a report from the Children's Oncology Group. Leukemia 20(9):1539-1541, 2006.

Dewey RA, Avedillo Diez I, Ballmaier M, Filipovich A, Greil J, Gungor T, Happel C, Maschan A, Noyan F, Pannicke U, Schwarz K, Snapper S, Welte K, Klein C. Retroviral WASP gene transfer into human hematopoietic stem cells reconstitutes the actin cytoskeleton in myeloid progeny cells differentiated in vitro. Exp. Hematol. 34(9):1161-1169, 2006.

Filipovich AH. Hemophagocytic lymphohistiocytosis (HLH) and related disorders. Curr. Opin. in Allergy and Clin. Immunol. 6(6):410-415, 2006.

Filipovich A, Conley ME, Nichols KE, Sullivan KE. X-linked lymphoproliferative syndrome: an X-cellent question. Clin. Immunol. 119(3):241-244, 2006.

Szigligeti P, Neumeier L, Duke E, Chougnet C, Takimoto K, Molleran Lee S, Filipovich AH, Conforti L. Signaling during hypoxia in human T lymphocytes—critical role of the src protein tyrosine kinase p56Lck in the O2 sensitivity of Kv1.3 channels. J. Physiol. 573(2):357-370, 2006.

Martin PJ, Weisdorf D, Przepiorka D, Hirschfeld S, Farrell A, Rizzo JD, Foley R, Socie G, Carter S, Couriel D, Schultz KR, Flowers ME, Filipovich AH, Saliba R, Vogelsang GB, Pavletic SZ, Lee SJ; design of Clinical Trials Working Group. National Institutes of Health Consensus Development Project on Criteria for Clinical Trials in Chronic Graft-versus-Host Disease: VI. Design of Clinical Trials Working Group report. Biol. Blood Marrow Transplant. 12(5):491-505, 2006.

Couriel D, Carpenter PA, Cutler C, Bolanos-Meade J, Treister NS, Gea-Banacloche J, Shaughnessy P, Hymes S, Kim S, Wayne AS, Chien JW, Neumann J, Mitchell S, Syrjala K, Moravec CK, Abramovitz L, Liebermann J, Berger A, Gerber L, Schubert M, Filipovich AH, Weisdorf D, Schubert MM, Shulman H, Schultz K, Mittelman B, Pavletic S, Vogelsang GB, Martin PJ, Lee SJ, Flowers ME. Ancillary therapy and supportive care of chronic graft-versus-host disease: National Institutes of Health Consensus Development Project on Criteria for Clinical Trials in Chronic Graft-versus-Host Disease: V. Ancillary Therapy and Supportive Care Working Group Report. Biol. Blood Marrow Transplant. 12(4):375-396, 2006.

Lee S, Sumegi J, Villanueva J, Tabata Y, Zhang K, Chakraporty R, Sheng X, Clementi R, de Saint Basile G, Filipovich AH. Patients of African ancestry with hemophagocytic lymphohistiocytosis share a common haplotype of PRF1 with a 50delT mutation. J. Pediatr. 149(1):134-137, 2006.

Schultz KR, Miklos DB, Fowler D, Cooke K, Shizuru J, Zorn E, Holler E, Ferrara J, Shulman H, Lee SJ, Martin P, Filipovich AH, Flowers ME, Weisdorf D, Couriel D, Lachenbruch PA, Mittleman B, Vogelsang GB, Pavletic SZ. Toward Biomarkers for chronic graft-versus-host disease: National Institutes of Health Consensus Development Project on Criteria for Clinical Trials in Chronic Graft-versus-Host Disease: III. Biomarker Working Group Report. Biol. Blood Marrow Transplant. 12(2):126-137, 2006.

Mehta P, Vinks A, Filipovich A, Vaughn G, Fearing D, Sper C, Davies S. High-dose weekly AmBisome anti-fungal prophylaxis in pediatric patients undergoing hematopoietic stem cell transplantation: a pharmacokinetic study. Biol. Blood Marrow Transplant. 12(2):235-240, 2006.

Risma KA, Frayer RW, Filipovich AH, Sumegi J. Aberrant maturation of mutant perforin underlies the clinical diversity of hemophagocytic lymphohistiocytosis. J. Clin. Invest. 116(1):182-192, 2006.

Filipovich AH, Weisdorf D, Pavletic S, Socie G, Wingard JR, Lee SJ, Martin P, Chien J, Przepiorka D, Couriel D, Cowen EW, Dinndorf P, Farrell A, Hartzman R, Henslee-Downey J, Jacobsohn D, McDonald G, Mittleman B, Rizzo JD, Robinson M, Schubert M, Schultz K, Shulman H, Turner M, Vogelsang G, Flowers ME. National Institutes of Health Consensus Development Project on Criteria for Clinical Trials in Chronic Graft-Versus-Host Disease: I. Diagnosis and Staging Working Group Report. Biol. Blood Marrow Transplant. 11(12):945-956, 2005.

Filipovich AH. Life-threatening hemophagocytic syndromes: current outcomes with hematopoietic stem cell transplantation. Ped. Transplantation 9(7):87-91, 2005.

Filipovich AH, Imashuku S, Henter J-I, Sullivan KE. Healing hemophagocytosis. Clin. Immunol. 117:121-124, 2005.

Guthery SL, Heubi JE, Filipovich AH. Enteral metronidazole for the prevention of graft versus host disease in pediatric marrow transplant recipients: results of a pilot study. Bone Marrow Transplant. 36(4):371, 2005.

Zarzour W, Kleta R, Frangoul H, Suwannarat P, Jeong A, Kim SY, Wayne AS, Gunay-Aygun M, White J, Filipovich AH, Gahl WA. Two novel CHSI (LYST) mutations: clinical correlations in an infant with Chediak-Higashi syndrome. Molec. Genet. and Metab. 85:125-132, 2005.

Robbins JR, Molleran Lee S, Filipovich AH, Szigligeti P, Neumeier L, Petrovic M, Conforti L. Hypoxia modulates early events in T cell receptor-mediated activation in human T lymphocytes via Kv1.3 channels. J. Physiol. 564(1):131-143, 2005.

Tabata Y, Villanueva J, Molleran Lee S, Zhang K, Kanegane H, Miyawaki T, Sumegi J, Filipovich AH. Rapid detection of intracellular SH2D1A protein in tytotoxic lymphocytes from patients with X-linked lymphoproliferative disease and their family members.Blood. Apr 15;105(8):3066-71.

Villanueva J, Lee S, Giannini EH, Graham TB, Passo MH, Filipovich AH, Grom AA. Natural killer cell dysfunction is a distinguishing feature of systemic onset juvenile rheumatoid arthritis and macrophage activation syndrome.Arthritis Res. Therapy 7(1):R 30-37, 2005.

Guthery SL, Heubi JE, Filipovich AH. Enteral metronidazole for the prevention of graft versus host disease in pediatric marrow transplant recipients: results of a pilot study. Bone Marrow Transplantation. 2004 Jun;33(12):1235-9.

Horne AC, Janka G, Egeler RM, Gadner H, Imashuku S, Ladisch S, Locatelli F, Montgomery SM, Webb D, Winiarski J, Filipovich AH, Henter JI; for the Histiocyte Society. Hematopoietic stem cell transplantation in hemophagocytic lymphohistiocytosis: results of the HLH-94 study. Br. J. Haematol. 129:622-630, 2005.

Flomenberg N, Baxter-Lowe LA, Confer D, Fernandez-Vina M, Filipovich AH, Horowitz M, Hurley CK, Kollman C, Anasetti C, Noreen H, Begovich A, Hildebrand W, Petersdorf E, Schmeckpeper B, Setterholm M, Trachtenberg E, Williams T, Yunis E, and Wiesdorf D. Impact of HLA Class I and Class II high-resolution matching on outcomes of unrelated donor bone marrow transplantation: HLA-C mismatching is associated with a strong adverse effect on transplant outcome. Blood 104(7):1923-1930, 2004.

Blackman SC, Lurain NS, Witte DP, Filipovich AH, Groen P, Schleiss MR. Emergence and compartmentalization of multi-drug resistant cytomegalovirus infection in a patient with autosomal-recessive severe combined immune deficiency.J. Ped Hematol and Oncol. 26(9): 601-605, 2004.

Gluckman E, Rocha V, Chevret S, Michel G, Sanz G, Chan KW, Takahashi T, Ortega J, Filipovich AH, Locatelli F, Asano S, Fagioli F, Vowels M, Gratecos N, Laporte JP, Tiedemann K, Amadori S, Abecassis M, Bordigoni P, Diez B, Shaw P, Vora A, Caniglia M, Garnier F, Ionescu I and Arcese W. On behalf of Eurocord Group. Factors associated with outcome of unrelated cord blood transplant: Guidelines for donor choice. Exp. Hematol. 32: 397-407, 2004.

Molleran Lee S, Villanueva J, Sumegi J, Zhang K, Kogawa K, Davis J, Filipovich AH. Characterization of diverse PRF1 mutations leading to decreased natural killer cell activity in North American families with hemophagocytic lymphohistiocytosis. J Med Genet. 41(2):137-144, 2004.

Garrett JK, Jameson SC, Thompson B, Collins MH, Wagoner LE, Freese DK, Beck LA, Boyce JA, Filipovich AH, Villanueva JM, Assa'ad AH, Rothenberg ME. Anti-interleukin-5 (mepolizumab) therapy for hypereosinophilic syndromes. J. Allergy Clin. Immunol. 113:115-119, 2004.

Book Chapters, Most Recent

Filipovich AH, Gross TG. Immunodeficiency and Cancer, Clinical Oncology, 3rd Edition, WB Saunders Company, Philadelphia, PA., 2003.

Abstracts, Most Recent

Filipovich AH. Interim report of outcomes of recent hematopoietic stem cell transplantation for severe combined immunodeficiencies and Wiskott Aldrich syndrome: review of data from the IBMTR and North American studies. To be presented at Fifth Meeting of EBMT Working Party of Pediatric Diseases, June 2005.

Mehta P, Vinks A, Filipovich AH, Vaughn G, Fearing D, Sper C, Davies S. Pharmacokinetics of high-dose weekly ambisome (liposomal amphotericin B) anti-fungal prophylaxis in pediatric bone marrow transplant (BMT) patients. American Society for Blood and Marrow Transplantation, February 10-14, 2005, Keystone CO.

Tabata Y, Villanueva J, Lee SM, Zhang K, Kanegane H, Miyawaki T, Sumegi J, Filipovich AH. Rapid detection of SAP deficiency in cytotoxic lymphocytes from patients with X-linked lymphoproliferative disease and their family members. Presented at 46th annual meeting of American Society of Hematology, December 4-7, 2004, San Diego CA.

Tabata Y, Villanueva J, Lee S, Zhang K, Kanegane H, Miyawaki T, Sumegi J, Filipovich AH. Rapid detection of X-linked lymphoproliferative disease by flow cytometry: an aid to differential diagnosis of EBV-associated hemophagocytosis. Histiocyte Society, Submitted 2004.

Tabata Y, Risma K, Villanueva J, Lee S, Zhang K, Sumegi J, Filipovich AH. Characterization of Herpesvirus saimiri-transformed cytotoxic T lymphocytes from patients with mutations in perforin or SAP/SH2D1A. Histiocyte Society, Submitted 2004.

Risma K, Frayer R, Lee S, Villanueva J, Sumegi J, Filipovich AH. Perforin (PRF1) mutations in hemophagocytic lymphohistiocytosis (HLH): what about A91V? Histiocyte Society, Submitted 2004.

Risma K, Frayer R, Filipovich AH, Sumegi J. So many mutants—so little information: an in vitro model to study perforin (PRF1) missense mutations. Histiocyte Society, Submitted 2004.

Grom AA, Filipovich AH. Natural killer cell dysfunction is a distinguishing feature of systemic onset juvenile rheumatoid arthritis and macrophage activation syndrome. The Lancet, 2004.

Robbins JR, Lee S, Filipovich AH, Conforti L. Hypoxia modulates T-cell receptor-mediated activation in a subset of human T lymphocytes via Kv1.3 channels. Keystone Symposium, Submitted 2004.

Conforti L, Robbins JR, Lee SN, Filipovich AH. Hypoxia modulates membrane potential and Ca2+ homeostasis in human T cells. FASER, Submitted 2004.

Presentations, Most Recent

Filipovich AH Haemopagocytic Lymphohistiocytosis (HLH) and Related Disorders of Immune Regulation. ESPHI Biannual Meeting, Athens, Greece, September 2007.

Horne AC, Trottestam H, Aricò M, Egeler M, Filipovich A, Gadner H, Imashuku S, Ladisch S, Webb D, Janka G, Henter J-I. Frequency and spectrum of CNS involvement in 193 children with hemophagocytic lymphohistiocytosis.

Risma KA, Frayer RW, Filipovich AH, Sumegi J. Aberrant maturation of human perforin: analysis of naturally occurring mutations reveals the functional capacity of mature versus precursor protein. FOCIS annual meeting, San Francisco CA, June 2006.

Stein ML, Villanueva JM, Filipovich AH, Collins MH, Buckmeier B, Assa'ad A, Rothenberg ME. Anti-IL-5 therapy (Mepolizumab) for eosinophilic esophagitis: cytokine secretion and decreased peripheral blood and esophageal eosinophilia. FOCIS annual meeting, San Francisco CA, June 2006.

Filipovich AH. Successes and challenges of hematopoietic stem cell transplantation for heritable immunodeficiencies. University of Texas M. D. Anderson Cancer Center, Pediatric Grand Rounds, Houston TX, March 2005.

Filipovich AH. Genetic disorders of inflammation: lessons learned from hemophagocytic lymphohistiocytosis. Stanford University, Pediatric Grand Rounds, Palo Alto CA, March 2005.

Filipovich AH. Genetic disorders of inflammation: lessons learned from hemophagocytic lymphohistiocytosis. New York University, Pediatric Grand Rounds, New York NY, February 2005.

Filipovich AH. Hemophagocytosis lymphohistiocytosis. Stem Cell Transplantation in Children, eighth meeting, Scottsdale AZ, January 2005.

Flesch L, Filipovich AH. Update on nursing management and clinical recognition of hemophagocytic lymphohistiocytosis. European Society for Immunodeficiencies, bi-annual meeting, Paris, France, October 2004.

Johnson JA, Filipovich AH, Zhang K, Loechelt BJ. Recent advances in the molecular diagnoses of inherited immunodeficiencies: implications for genetic counselors. National Society of Genetics Counselors, annual education conference, Washington D.C., October 2004.

Filipovich AH. Immunology and immunodeficiency for the hematologist-oncologist. ASPH/O review course, Chicago IL, October 2004.

Risma K, Frayer R, Filipovich AH, Sumegi J. So many mutants…so little information: an in vitro model to study perforin missense mutations. Histiocyte Society annual meeting, Stockholm, Sweden, September 2004.

Tabata Y, Risma K, Villanueva J, Lee S, Zhang K, Sumegi J, Filipovich AH. Characterization of Herpes virus Saimiri-transformed cytotoxic T lymphocytes from patients with mutations in perforin or SAP/SH2D1A. Histiocyte Society annual meeting, Stockholm, Sweden, September 2004.

Tabata Y, Villanueva J, Lee S, Zhang K, Kanegane H, Miyawaki T, Sumegi J, Filipovich AH. Rapid detection of X-linked lymphoproliferative disease by flow cytometry: an aid to differential diagnosis of EBV-associated hemophagocytosis. Histiocyte Society annual meeting, Stockholm, Sweden, September 2004.

Risma K, Frayer R, Lee S, Villanueva J, Sumegi J, Filipovich AH. Perforin mutations in hemophagocytic lymphohistiocytosis: what about A91V? Histiocyte Society annual meeting, Stockholm, Sweden, September 2004.

Filipovich AH. HSCT for WAS: interim analysis of CIBMTR studies. NIH First International Workshop on WAS, Bethesda MD, September 2004.

Filipovich AH. Hematopoietic stem cell Tx for heritable immunodeficiencies. European BMT Working Party – Paediatric Diseases, bi-annual meeting, The Netherlands, June 2004.

Filipovich AH. Hematopoietic stem cell transplant for primary immunodeficiency disorders: Update of outcomes unrelated cord blood. ASPH/O & PAS Annual Meeting, May, 2004.

Filipovich AH, Risma K, Lee S, Villanueva J, Tabata Y, Zhang K, Frayer R, Sumegi J. Heterozygous inheritance of the A91V genetic variant of PRF1: Is it related to disease susceptibility? 8th Annual Mtg. of the Society for Natural Immunity and 20th International Natural Killer Workshop. (#C018) April, 2004.

Villanueva J, Filipovich AH, Lee S, Passo M, Grom A. (#C066) Natural killer cell dysfunction in patients with systemic juvenile rheumatoid arthritis and macrophage activation syndrome. 8th Annual Mtg. of the Society for Natural Immunity and 20th International Natural Killer Workshop. (#C066) April, 2004.

Filipovich AH. BMT for genetic immune/inflammatory disorders of childhood. Histiocytosis Symposium and Board Meeting, Buenos Aires, Argentina, March, 2004.

Filipovich AH. Hemophagocytic Lymphohistiocytosis: From bedside to bench. Histiocytosis Symposium and Board Meeting, Buenos Aires, Argentina, March, 2004.

Filipovich AH. Late Effects, Quality of Life, Pediatric Disorders, Supportive Care, 2004 TANDEM BMT Meetings. Coronado Springs, FL., February 2004.

Filipovich AH. Allogeneic, 2004 TANDEM BMT Meetings. Coronado Springs, FL, February 2004.

Filipovich AH. BMT for genetic immune/inflammatory disorders of childhood. Fujisawa Health Care Meeting, Anti-Infectives Visiting Faculty Program, Columbus, OH., January 2004.

Professional Organization Memberships

  • American Association of Immunologists
  • Society for Pediatric Research
  • International Society of Experimental Hematology
  • American Society of Hematology
  • Clinical Immunology Society
  • American Society for Blood and Marrow Transplantation
  • European Society for Immunodeficiency

Special Interests

  • Primary immunodeficiencies
  • BMT for primary immunodeficiencies
  • Hemophagocytic lymphocytosis
  • Post-BMT immune reconstruction

Related Areas

This person works in these other areas at Cincinnati Children's Hospital Medical Center: