Patient Vignette - Part 1
A Season of Spring in the DIL
Spring is the season of change; a fresh start; a transition from old into new. The patient vignette in this issue is dedicated to the concept of a fresh start, as experienced at Cincinnati Children's Hospital Medical Center.
A major emphasis of the DIL is on performing and developing screening assays for primary immunodeficiency disorders. The central theme is that these immunodeficiencies can be — and in many cases should be — corrected by hematopoietic stem cell transplantation (HSCT).
Examples include CD127 / CD132, Foxp3, CD40L, WASP, oxidative burst, SAP and perforin / granzyme B.
The figures on this page (and continued on Patient Vignette - part 2) show several examples. Instead of the usual comparison between patients and healthy control subjects, this time the comparison is between before SCT (old) and after SCT (new). For consistency, all figures are shown as single-parameter histograms, with green lines representing either baseline or control antibody staining.
