Ramu A. Subbramanian, PhD
Title
Assistant Professor
Appointment
Assistant Professor, Pediatrics
Email
ramu.subbramanian@cchmc.org
Phone
513-636-8041
Fax
513-636-7655
Credentials
PhD: University of Montreal, Faculty of Medicine, 1998.
Fellowship: Research Fellow in Medicine, Harvard Medical School.
Research
Dr. Subbramanian's lab focuses on immunological mechanisms underlying the generation of optimal host responses against the mutable RNA viruses, influenza and HIV. Current paradigms of immune protection against mutable viral pathogens in general suggests that long-lived immune responses that are of broadest diversity and highest magnitude are likely to result in the optimal protection of the host.
This lab utilizes influenza and human immunodeficiency viruses (HIV) to assess the quality and quantity of antigen specific immune responses generated during infection and vaccination, emphasizing generation of memory pools and development of cross protection. A spectrum of current and emerging immunological technologies including neutralization assays, polychromatic flowcytometry and ELISPOT are used in the lab to assess immunogenicity of viral antigens.
Research projects include:
- Novel influenza vaccination approaches geared toward generating optimal cross protection and long-lived memory pools
- Characterization of candidate avian influenza vaccine immunogenicity in humans
- Novel vaccine vector design and delivery modalities for the mutable Influenza and HIV viral models
Publications, Most Recent
Subbramanian, R.A.; Charini, W.A.; Kuroda, M.J.; Seman, M.: Expansion following epitope peptide exposure in vitro predicts CTL epitope dominance hierarchy in lymphocytes of vaccinated Mamu-A*01+ rhesus monkeys. AIDS Res Hum Retroviruses, 2006; 22(5):445-52.
Sun, Y.; Schmitz, J.E.; Acierno, P.M.; Santra, S.; Subbramanian, R.A.: Dysfunction of simian immunodeficiency virus / simian human immunodeficiency virus-induced IL-2 expression by central memory CD4+ T lymphocytes. J Immunol, 2005; 174(8):4753-60.
Subbramanian, R.A.; Chikaya, M.; Martin, K.L.; Peyerl, F.W.: Engineered T-cell receptor tetramers bind MHC-peptide complexes with high affinity. Nature Biotechnol. 2004; 22:1429-34.
Subbramanian, R.A.; Kuroda, M.J.; Charini, W.A.; Barouch, D.H.; Costantino, C.: Magnitude and diversity of cytotoxic T-Lymphocyte responses elicited by multiepitope DNA vaccination in rhesus monkeys. J Virol, 2003; 77:10113-10118.
Professional Organization Memberships
Infectious Diseases Society of America
American Association of Immunologists
International AIDS Society
Canadian Society for Immunology
Federation of American Societies for Experimental Biology
Special Interests
- Mechanisms of CTL diversity generation
- Vaccine immunology
Presentations, Most Recent
Subbramanian, R.A.: HIV Vaccines, Original Antigenic Sin and Prime Boost Vaccine Regimens. Presented at the Keystone Symposia; 2006.
Subbramanian, R.A.: Expansion Following Epitope Peptide Exposure in Vitro Predicts CTL Epitope Dominance Hierarchy in Lymphocytes of Vaccinated Mamu-A*01+ Rhesus Monkeys. Presented for the American Association of Immunologists; 2006; Boston, MA.
Professional Affiliation
Immunobiology Graduate Training Program
Related Areas
This person works in these other areas at Cincinnati Children's Hospital Medical Center:
