Jens W. Goebel, MD
Title
Associate Professor of Pediatrics; Medical Director of Kidney Transplantation
Appointment
Associate Professor of Pediatrics
Email
jens.goebel@cchmc.org
Phone
513-636-4531
Fax
513-636-7407
Bio
Dr. Goebel was recruited by Cincinnati Children's Hospital Medical Center in 2002 from the University of Kentucky to enhance the institution's kidney transplant program. His efforts along these lines focus both on further improving the clinical care of pediatric kidney transplant recipients and their families, as well as advancing basic and translational investigations into immunological aspects especially relevant to the field of transplantation.
Credentials
MD: University of Heidelberg (Germany), 1991.
Residency and Chief Residency: Deptartment of Pediatrics, University of South Alabama, Mobile, AL, 1991 to 1995.
Fellowship: Section of Pediatric Nephrology, Tulane University Medical Center, New Orleans, LA, 1995 to 1998.
Certifications: General Pediatrics, 1994, 2002; Pediatric Nephrology, 1999.
Awards and Honors
- 1987/8 Fulbright Travel Scholar
- 1988/9 Scholar of the German Academic Exchange Service
- 1993 Robert O. Harris III Award for outstanding performance as a resident, Department of Pediatrics, University of South Alabama
- 1995 NIH Young Investigator Travel Fellowship
- 1996 Oustanding House Officer Teaching Award (Fellow), Department of Pediatrics, Tulane University Medical Center
- 1997 Clinical Young Investigator Award, Southern Society for Pediatric Research
- 1998 Basic Science Young Investigator Award, Southern Society for Pediatric Research
- 1998/9 Young Investigator Awards, American Societies of Transplant Physicians and Transplantation as well as Transplantation Society
- 1999, 2002 Chairman's Research Award, Department of Pediatrics, University of Kentucky
- 2000-2 Director, Pediatric Hypertension Program, University of Kentucky
- 2003-8 Best Doctors in America
Research
Immunology
Research Grants and Contracts
OngoingNIH RO1 CD40 Ligand Dyregulation and HIV Pathogenesis
(PI: Claire Chougnet, PhD, Division of Molecular Immunology, Cincinnati Children's Hospital)
NIH UO1 Noninvasive Monitoring to Predict Outcome in de novo Kidney Transplant Recipients (CTOT-01, Protocol Chair: Peter Heeger, MD, Mt. Sinai School of Medicine.
Roche Pharmaceuticals: Development of Population Pharmacokinetic models of Mycophenolic Acid for use in Bayesian Dose Individualization in Pediatric Kidney Transplant Patients
(PI: Sander Vinks, PhD; Pharm D, Pediatric Pharmacology Research Unit, Cincinnati Children's Hospital)
Cincinnati Children's Hospital Medical Center Translational Research Initiative:
Statin Therapy for Pediatric Kidney Transplant Recipients — Molecular Basis of Cardiovascular and Immunological Effects
Completed
NIH KO8 The Cytoskeleton, Rafts and the Interleukin-2 Receptor
Roche Pharmaceuticals: Molecular Mechanisms of Immunomodulation Affected by Daclizumab in Kidney Transplant Recipients
National Kidney Foundation Young Investigator: Characterization of the Enrichment of the Interleukin-2 Receptor ß-Chain in Membrane Rafts of Human T-Cells
Publications, Most Recent
Forrest K, Logan B, Strange J, Roszman TL, Goebel J (2005) Daclizumab Therapy in Kidney Transplantation - Different Mechanisms of Action in- versus ex-vivo?Transplant Immunology 14 (1):43-7
Goebel J, Forrest K, Jackson EC (2005) Anti-CD25 Antibody Therapy in Kidney Transplantation - Different Mechanisms of Action In- Versus Ex-Vivo?Transplant Immunol 14:43-7
Mitsnefes MM, Subat-Dezulovic M, Khoury PR, Goebel J, Strife CF (2005) Increasing Incidence of Post Transplant Anemia in Children: Does It Affect Graft Survival?Am J Transplant 5:1713-8
Goebel J, Logan B, Forrest K, Mieczkowski A, Roszman TL, Wills-Karp M (2005) Atorvastatin Attenuates Interleukin-2 (IL-2) Signaling by Altering the Lipid Raft Enrichment of the IL-2 Receptor β-Chain.J Invest Med 53:322-8
Goebel J, Forrest K, Wills-Karp M, Roszman TL (2006) Tubulin Polymerization Modulates Interleukin-2 Receptor Signaling In T Cells.Journal of Receptors and Signal Transduction 26:87-106
VanDeVoorde R, Witte D, Kogan J, Goebel J (2006) Pierson Syndrome - A Novel Cause of Congenital Nephrotic Syndrome.Pediatrics 118:e501-5
Flynn JT, Nahata MC, Mahan Jr JD, Portman RJ, PATH-2 Investigators (2006) Population Pharmacokinetics of Amlodipine in Hypertensive Children and Adolescents.J Clin Pharmacol 46:905-16 (listed as local center PI in appendix)
Professional Organization Memberships
- American Academy of Pediatrics
- American Society of Nephrology
- American Society of Pediatric Nephrology
- American Society of Transplantation
- International Pediatric Transplant Association
- Society for Pediatric Research
Books
Dharamsi N, Sheldon C, Goebel J (2006) Kidney Transplantation. Chapter 25 in: The Kelalis-King-Belman Textbook of Clinical Pediatric Urology (Docimo SG, Canning DA, Khoury AE, editors), 5th edition, Taylor & Francis, London/NewYour/Philadelphia, pp. 367-85
Sheldon C, DeFoor W, Goebel J (submitted for the 2nd edition of Pediatric Urology, eds: Gearhart J, Rink R, Mouriquand P) Medical and Surgical Aspects of Kidney Transplantation.
Goebel J (in preparation for Pediatric Nephrology in the ICU, eds: Kiessling S, Goebel J, Somers M) PICU Management of Kidney Transplant Recipients.
Special Interests
Pediatric kidney transplantation
Editorial Positions:
American editorial board, Clinical Nephrology
Kiessling S, Goebel J, Somers M (eds.): Pediatric Nephrology in the ICU, Springer Verlag (Heidelberg, Germany) - in preparation.
Presentations, Most Recent:
Chair of and presenter at the American Federation for Medical Research Translational Symposium "Lipid Rafts - Floating from Bench to Bedside" at the Experimental Biology/IUPS meeting, San Diego, 04/03/05
"Transplantation Immunology/Tolerance" lecturer, CCHMC immunobiology Graduate Program (2005)
Kathy Newman Lecturer with Pediatric Grand Round presentation ("Pediatric Kidney Transplantation - Come a Long Way or a Long Way To Go?") and case discussion at pediatric residents' lunch conference, Departments of Pediatrics, Tulane University and Ochsner Medical Center, New Orleans, LA, 02/28/07 - 03/01/07.
Co-organizer and chair of the symposium "Genetic Renal Disease 2: Lipid Rafts -- Floating from Bench to Bedside. Structure and function of the slit diaphragm. Mutational analysis" at the upcoming 2007 meeting of IPNA.
Co-organizer and chair of the ASPN-sponsored symposium "Pediatric Nephrology in Non-Kidney Organ Transplantation" at the upcoming 2007 ASPN Annual Meeting in conjunction with the Pediatric Academic Societies' Annual Meeting.
Related Areas
This person works in these other areas at Cincinnati Children's Hospital Medical Center:
