Ongoing Liver Studies and Trials
At Cincinnati Children's Hospital Medical Center, there are numerous ongoing studies and trials related to the liver.
Research Funded by the National Institutes of Health
- A multi-center therapy trial for acute liver failure
This project is funded by the National Institutes of Health with The Acute Liver Failure Study Groups. It consists of 25 adult centers and 23 pediatric centers with headquarters at the University of Texas Southwestern Medical Center at Dallas.
The study group is gathering demographic, clinical and outcome data on patients who present to these medical centers with acute liver failure.
The goal of the study group is to improve our understanding of the causes and course of acute liver failure, which will provide direction in development of new therapies for this rare and serious condition. Co-investigators: John Bucuvalas, MD and Nada Yazigi, MD
- Immunologic dysfunction in biliary atresia
This NIH-funded project, led by Jorge Bezerra, MD, is trying to show that biliary atresia results from an immune-mediated destruction of the biliary cells.
- Cytokine regulation of liver growth hormone signaling
This project, funded by NIH / NIDDK, with Ted Denson, MD, as principal investigator, is looking at characterization of cytokine regulation of liver Ghr and Socs-3 gene expression.
The findings will have implications for therapeutic strategies to ameliorate acquired GH resistance diseases complication by liver inflammation, including chronic cholestatic liver diseases.
- Regulation of the hepatic negative acute phase response
The major goals of this NIH-funded project with Ted Denson, MD, as principal investigator, are to examine regulation of growth hormone receptor gene expression in models of acute liver inflammation.
- Quality of life in children after liver transplantation
This grant is funded by the Agency for Health Care Research and Quality / AHRQ, a branch of the National Institutes of Health / NIH. The long-term goal of this project is to improve outcomes, quality of care and promote cost-savings for pediatric liver transplant recipients.
The primary objectives of the proposed study are to describe the health-related quality of life of children who survive liver transplantation and to examine the impact of disease severity at transplant and the type of graft received (living-donor or cadaveric) on long-term health-related quality of life. Co-investigator: John Bucuvalas, MD.
2004 Funded Clinical and Industry Trials
- Functional health status of children with chronic illness
The purpose of this study is to determine, from the patient and family perspective, the functional health status (including physical, emotional and social health) of children with chronic illness and to compare the results of the functional health measure with more traditional physiological and clinical measurements. Primary investigator: John Bucuvalas, MD.
- Safety and pharmacokinetics of intravenous ganciclovir and oral valganciclovir syrup formulation in pediatric liver transplant recipients receiving treatment with IV ganciclovir for prevention of cytomegalovirus and Epstein-Barr virus
Hoffman-LaRoche, Inc. funds this project. Primary investigator: John Bucuvalas, MD.
- Liver based biological systems for studies of metabolism
This project is funded by Procter and Gamble, Inc. The long-term objectives of this project are to establish a line of human hepatocytes which contain phenotypic features of normal cells and to humanize murine livers using experimental conditions for selected clones. Primary investigator: Jorge Bezerra, MD.
Last updated: May 25, 2005
