Lupus Center

Hermine I. Brunner, MD, MSc

Appointment

Associate Professor of Pediatric Rheumatology

Email

hermine.brunner@cchmc.org

Phone

513-636-4676

Fax

513-636-4116

Bio

Dr. Brunner is a pediatric rheumatologist with a special clinical and research interest in pediatric lupus. Her research is focused on biomarker discovery and the testing of new medications for lupus. She is also involved in trial design and provides statistical support at CCHMC. As head of the Lupus Center, she is involved in the conduction of the Lupus Clinic and the organization of Lupus Support Groups. She also pioneers the development of outcome measures and improving the quality of clinical of children with lupus and other rheumatic diseases.

Credentials

MD: Ludwig Maximilan University, Munich, Germany, 1991

Residency: University of Chicago, 1997

Fellowship: University of Toronto & Cincinnati, 1999

MSc: Clinical Epidemiology: University of Toronto, 1999

Certification: Pediatrics 1997; Rheumatology 2002

Position History

Pediatric residency, Dr. von Haunersches Kinderspital, Munich, Germany, 1992-1993

Emergency Medical Care, Province Cunene, Angola, 1993-1994

Pediatric residency, Wyler Children's Hospital, Chicago, USA, 1994-1997

Pediatric rheumatology fellowship, Hospital for Sick Children, Toronto, Canada, 1997-1999

Pediatric rheumatology fellowship, Cincinnati Children's Hospital Medical Center, USA, 1999-2000

Research Associate, Cincinnati Children's Hospital Medical Center, USA, 2000-2001

Instructor of Pediatrics, Cincinnati Children's Hospital Medical Center, USA, 2001-2003

Assistant Professor of Pediatrics, Cincinnati Children's Hospital Medical Center, USA, 2003-2007

Associate Professor of Pediatrics, Cincinnati Children's Hospital Medical Center, USA, 2003-2007

Awards and Honors

National student representative of Friedrich Ebert Foundation
Student representative of Council of Medicine, Ludwig Maximillians University, Munich
Magna cum laude. Dissertation at Faculty of Medicine, Ludwig Maximillians University, Munich
Society of Clinical Decision Making member
Arthritis Foundation, member, presentations, volunteer
International Society of Pharmacoeconomics; member
NIH/NIAMS Study Section
Assistant director MCRC Methodology Core
Scientific Director Pediatric Rheumatology Collaborative Study Group

Research

Economic analyes
HRQOL
Measurement development
Outcome research
Lupus

Research Grants and Contracts

"Meaningful Outcomes of Pediatric Lupus Clinical Trials" U01-AR51868, September 30, 2004 - September 29, 2008, Prinicpal Investigator. The major goal of the project is to develop surrogate markers for pediatric SLE clinical trials in collaboration various pediatric rheumatology research groups.

"Towards Biomarkers for Lupus Renal Disease", Alliance for Lupus Research, January 1, 2006 - March 30, 2008, Principal Investigator. The major goal of the project is to identify and validate biomarkers for SLE using proteomics and to establish the predictive properties of neutrophil gelatinase associated lipocalin (NGAL) to serve as renal biomarker of SLE.

"Biomarkers for Patient-tailored Therapies in Pediatric Lupus Nephritis using Mycophenolic Acid" CCHMC Translational Research Initiative, July 1, 2007 - June 30, 2008, Principal Investigator. The major goal of the project is to pharmacokinetic, pharmacodynamic and pharmacogenetic markers of MMF response in SLE.

"Clinical Trials Outcomes for Pediatric Lupus Trials" U01 AR06-006, October 1, 2007 - September 30, 2010, Principal Investigator. The major goal of this project is develop criteria of remission and flare as well as a National CARRA Lupus Registry.

"Early Biomarkers for Lupus Nephritis" P035278 Department of Defense, July 1, 2007 - June 30, 2010. The major goal of the project is to identify and validate biomarkers for SLE using proteomics

"Improving Adherence To Medical Interventions In Childhood-Onset Lupus." CCHMC Health-Services Matrix, January 1, 2008 - December 30, 2010, Principal Investigator. The major goal of the project is to use interventions at the level of the health delivery system for improving visit and medication adherence in children, adolescent and young adults with SLE.

Publications, Most Recent

H.I. Brunner, T.M. Sherrard, M. Klein-Gitelman. Cost of care of children with systemic lupus Erythematosus. Arthritis & Rheum, No. 55, pp. 184-188, 2006.

H.I. Brunner, A. Bishnoi, A. C. Barron, L. J. Houk, A. Ware, Y. Farhey, A. B. Mongey, C. F. Strife, T. B. Graham, M. H. Passo. Long-term outcomes and ovarian function in childhood-onset Systemic lupus erythematosus (cSLE). Lupus, No. 15, pp. 198-206, 2006.

H. I. Brunner, J. Taylor, M. T. Britto, M. S. Corcoran, S. L. Kramer et al. Differences in disease outcomes between Medicaid and privately insured children: possible health disparities in juvenile rheumatoid arthritis (JRA). Arthritis Rheum, No. 55, pp. 378-384, 2006.

H. I. Brunner, M Mueller, C Rutherford, M H Passo, A A Grom, J Mishra, P Devarajan. Urinary Neutrophil Gelatinase Associated Lipocalin (NGAL) as a Biomarker of Nephritis in Childhood-onset Systemic Lupus Erythematosus. Arthritis Rheum, Vol# 54, No. 8, pp. 2577-2584, 2006.

M Chaudari, M Moroldo, S. K. Thompson, P. Hillard, B Huang, H.I. Brunner, D.N. Glass: Decreased reproductive fitness in childhood autoimmune arthropathy families. Rheumatology, No. 45, pp.1282-1287, 2006.

E. Sommers, H.I. Brunner. L. Nabors. Pain, Fatigue, Family Functioning, and Attitude Toward Illness in Children with Juvenile Rheumatic Diseases. J Dev Phys Disabil, No. 18, pp. 11-23, 2007.

L Nabors, E Jobst, J Wesiman, B. Precht, P Chiu, H.I. Brunner. School support and Functioning for Children with Juvenile Rheumatic Diseases. J. Dev Phys Disabil, DOI 10, p. 1007.

Bleesing J, Prada E, Siegel DM, Villanueva J, Olson J, Ilowite N, Brunner HI, Griffin T, Graham TB, Sherry DD, Passo MH, Filipovich A, and Grom AA. The Diagnostic Significance of soluble CD163 and soluble IL2Ra chains in Macrophage Activation Syndrome and Untreated New Onset Systemic Juvenile Idiopathic Arthritis. Arthritis Rheum, pp. 965 -971, 2007.

S. Koneru, M. Shishov, A. Ware, Y. Farhey, A. B. Mongey, J. L. Houk, and H.I. Brunner. Effectively Measuring Adherence to Medications For Systemic Lupus Erythematosus In A Clinical Setting. Arthritis Rheum, No. 57, pp. 1000-1006, 2007.

Mikdashi (Co-Chair), JM Esdaile (Co-Chair), GS Alarcón (Co-Chair), L Crofford, BJ Fessler, L Schanberg, H Brunner, V Gall, JR Kalden, MD Lockshin, MH Liang, N Roberts Jr and M Schneider. for the Ad Hoc Committee on Lupus Response Criteria: Cognition Sub-committee: Proposed response criteria for neurocognitive impairment in systemic lupus erythematosus clinical trials. Lupus, No. 16, pp. 418–425, 2007.

H. I. Brunner, N. M. Ruth, A. German, S. Nelson, M.H. Passo, T. Roebuck-Spencer, J. Ying, D. Ris. Initial validation of the pediatric automated neuropsychological assessment metrics for childhood-onset systemic lupus erythematosus. Arthritis Rheum, No. 57, pp. 1174-1182, 2007.

M. Suzuki, K.Wiers, S Nelson, C Rutherford, P Devarjan, H I Brunner. Identification of urinary proteomic signature for nephritis in children. Pediatr Nephrol, Vol# 22, No. 12, pp. 2047-2057, Dec 2007.

M. DiFrancesco, S. Holland, D. Ris C. Adler, M. DeBello, M. Altaye, H.I. Brunner. Functional magnetic resonance imaging of cognitive function in childhood-onset systemic lupus erythematosus: a pilot study. Arthritis Rheum, Vol# 56, No. 12, pp. 51-63, 2007.

M. Suzuki, K. M. Wiers, M. Klein-Gitelman, K. A. Haines, J. Olson, K.B. Onel, K. O’Neil, M.H. Passo, N.G. Singer, L. Tucker, J. Ying, P. Devarajan, H.I. Brunner. Neutrophil Gelatinase Associated Lipocalin as a Biomarker of Disease Activity In Pediatric Lupus Nephritis.Pediatr Nephrol,Vol# 23, No. 3, pp. 403-12, Mar 2008.

H.I. Brunner, D. D. Gladman, D. Ibañez, M. D. Urowitz, E. D. Silverman. Difference in disease features between childhood-onset and adult systemic lupus erythematosus (SLE). Arthritis Rheum, Vol# 58, No. 2, pp. 556–562, 2008.

S. Koneru, L Kochrala, G. C. Higgins, A. Ware, M. H. Passo, Y. D. Farhey, A-B Mongey, T.B. Graham, J.L. Houk, and H. I. Brunner. Adherence to medications in systemic lupus erythematosus. Journal of Clinical Rheumatology; Vol# 14, No. 4, pp. 195-20, 2008.

M. Suzuki, K. Wiers, E.B. Brooks, K.D. Greis, K. Haines, M.S. Klein-Gitelman, J. Olson, K. Onel, K.M. O'Neil, E.D. Silverman, L. Tucker, J. Ying, P. Devarajan, H. I. Brunner. Initial validation of a novel protein biomarker panel for active pediatric lupus nephritis. Ped Research, No. 64, Doi: 10.1203/PDR.0b013e31819e4305, 2009.

H.I. Brunner, M.S. Klein-Gitelman, J.Ying,L.B. Tucker, E. D. Silverman. Corticosteroid use in childhood-onset systemic lupus erythematosus – practice patterns at four pediatric rheumatology centers.Clin Exp Rheumatol, No. 27, pp. 155-162, 2009.

S Collins, DP Schauer, A Gupta, H Brunner, AB Storrow, MH Eckman. Cost-Effectiveness Analysis of Emergency Department Decision Making in Non-High Risk Heart Failure Patients. American Journal of Emergency Medicine, No. 27, pp. 293-302, 2009.

L. E. Schanberg, C. Sandborg, H.X. Barnhart, S. P. Ardoin, … H.I. Brunner, L. Jung, J. B. Soep, A. Reed. Understanding Premature Atherosclerosis in Pediatric SLE: Risk Factors of Increased Carotid Intima Medial Thickness (CIMT) in the Atherosclerosis Prevention in Pediatric Lupus Erythematosus (APPLE) Cohort. Arthritis Rheum, No. 60, pp. 1496-1507, 2009.

H. I. Brunner, G. C. Higgins, K. Wiers, S.K. Lapidus, J.C. Olson, K. Onel, M. Punaro, J. Ying, M. S. Klein-Gitelman, M. Seid. Health-related Quality of Life (HRQoL) and its Relationship to Patient Disease Course in Childhood-onset Systemic Lupus Erythematosus (cSLE). J Rheumatology, No. 36, pp.1536-45, 2009.

C. H. Hinze, M. Suzuki, M. Klein-Gitelman, M. H. Passo, J. Olson, N. G. Singer, K. A. Haines, K. Onel, K. O’Neil, E. D. Silverman, L. Tucker, J. Ying, P. Devarajan, H. I. Brunner. Neutrophil Gelatinase-associated Lipocalin (NGAL) Predicts the Course of Global and Renal Childhood-Onset Systemic Lupus Erythematosus (SLE) Disease Activity. Arthritis Rheum, Vol# 60, No.9, pp. 2772-278, 2009.

L Kocharla, J Taylor, T Weiler, T. V. Ting, M Luggen, H. I. Brunner. Monitoring of methotrexate toxicity in juvenile idiopathic arthritis. J Rheumatology, 2009 (in press).

H.I. Brunner, G.C. Higgins, K. Wiers, S.K. Lapidus, J.C. Olson, K. Onel, M. Punaro, J. Ying, M.S. Klein-Gitelman, E.H. Giannini. Validation of the Provisional Criteria for the Evaluation of Response to Therapy in Childhood-onset Systemic Lupus Erythematosus (cSLE). Arthritis Rheum, (in press).

H.I. Brunner, G.C. Higgins, K. Wiers, S.K. Lapidus, J.C. Olson, K. Onel, M. Punaro, J. Ying, M.S. Klein-Gitelman, E.H. Giannini. Minimal clinically important difference in disease activity measures for childhodd-onset systemic lupus erythematosus. Arthritis Rheum, accepted with revision.

H.I. Brunner, M.S. Klein-Gitelman, G.C. Higgins, S.K. Lapidus, D.,Levy, A. Eberhard, N. Singer, J.C. Olson, K. Onel, M. Punaro, L. Schanberg, E. Van Scheven, J. Ying, E.H. Giannini. Towards the Development of Criteria for Global Flares in Juvenile Systemic Lupus Erythematosus. Arthritis Rheum, accepted with revision.