Thomas R. Korfhagen, MD, PhD
Title
Professor of Pediatrics, Neonatology and Pulmonary Biology
Appointment
Professor of Pediatrics, University of Cincinnati College of Medicine
Email
thomas.korfhagen@cchmc.org
Phone
513-636-8920
Fax
513-636-7868
Credentials
BA: Biology, University of Cincinnati, Cincinnati, OH, 1972
PhD: Microbiology, University of Cincinnati, Cincinnati, OH, 1976
MD: University of Cincinnati, Cincinnati, OH, 1981
Residency: In Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 1981-1984
Fellowship: In Medical Genetics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 1984-1987 (Peter Dignan, Director)
Certifications: National Board of Medical Examiners, 7/1982; American Board of Pediatrics, 5/1986; American Board of Medical Genetics, 6/1987
Position History
- 8/1987 - 8/1994 Assistant Professor, Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH
- 9/1994 - 8/2000 Associate Professor with Tenure, Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH
- 9/2000 - present Professor with Tenure, Cincinnati Children's Hospital Medical Center, Cincinnati, OH
Awards and Honors
- BS awarded with Honors, 6/72
- Elected to Alpha Omega Alpha Honor Medical Society, 11/80
- Resident Teaching Award, 12/83
- Abstracts selected for featured presentation, American Thoracic Society 1993, 1994, 1999, 2002
Research
Roles and mechanisms whereby surfactant proteins A, B, D, Relm peptides and EGF-R signaling control lung infections, inflammation and responses to lung injury. Translational studies assessing processes to reduce the extent of lung injury and remodeling in neonates and adults.
Research Grants and Contracts
RO1 (Hardie) 04/01/07-08/30/12 (Co-Investigator)
NIH/NHLBI Epidermal Growth Factor Receptor Activation in Pulmonary Fibrosis.
RO1 (Leikauf) 12/01/05-11/30/09 (Co-Investigator)
NIH/NHLBI Growth Factor Protection in Acute Lung Injury.
U01 (Leikauf) 09/29/06 -05/31/11 (Co-investigator)
NIEHS Growth Factor Protection in Acute Lung Injury.
RO1 (Whitsett) 04/01/09-3/31/13 (Co-Investigator)
Transcriptional Programming of Asthma Related Pathology in Respiratory Epithelial.
RO1 (Glasser) 04/09-03/13 (Co-Investigator)
NIH/NHLBI Role Of Surfactant Protein-C and Innate Lung Defense in Familial Interstitial Lung Disease.
Publications, Most Recent
Glasser, S.W., Witt ,T.L., Senft, A.P., Baatz, J.E., Folger, D., Maxfield, M.D., Akinbi, H.T., Newton, D.A., Prows,D.R.., Korfhagen, T.R. Surfactant Protein C Deficient Mice are Susceptible to Respiratory Syncytial Virus Infection.
Am J Physiol Lung Cell Mol Physiol. 2009
Ikegami, M., Grant, S., Korfhagen, T., Scheule, R.K., Whitsett, J.A. (2009) Surfactant protein-D regulates the postnatal maturation of pulmonary surfactant lipid pool sizes. J Applied Physiology. in press, 2009.
Korfhagen TR, Le Cras TD, Davidson CR, Schmidt SM, Ikegami M, Whitsett JA, Hardie WD. Rapamycin Prevents Transforming Growth Factor-alpha Induced Pulmonary Fibrosis.Am J Respir Cell Mol Biol. in press, 2009.
Kramer EL, Mushaben EM, Pastura PA, Acciani TH, Deutsch GH, Khurana Hershey GK, Korfhagen TR, Hardie WD, Whitsett JA, Le Cras TD. Egr-1 Suppresses EGFR-Mediated Airway Hyperresponsiveness and Lung Remodeling in Mice. Am J Respir Cell Mol Biol. in press, 2009.
Bein K, Wesselkamper SC, Liu X, Dietsch M, Majumder N, Concel VJ, Medvedovic M, Sartor M, Henning LN, Venditto C, Borchers MT, Barchowsky A, Weaver TE, Tichelaar JW, Prows DR, Korfhagen TR, Hardie WD, Bachurski CJ, Leikauf GD.Surfactant Associated Protein B is Critical to Survival in Nickel-induced Injury in Mice. Am J Respir Cell Mol Biol. In press, 2009.
Glasser SW, Senft AP, Whitsett JA, Maxfield MD, Ross GF, Richardson TR, Prows DR, Xu Y, Korfhagen TR. Macrophage dysfunction and susceptibility to pulmonary Pseudomonas aeruginosa infection in surfactant protein C-deficient mice.J Immunol. 181:621-628, 2008.
Deshmukh HS, Shaver C, Case LM, Dietsch M, Wesselkamper SC, Hardie WD, Korfhagen TR, Corradi M, Nadel JA, Borchers MT, Leikauf GD. Acrolein-activated matrix metalloproteinase 9 contributes to persistent mucin production. Am J Respir Cell Mol Biol. 38:446-454, 2008.
Hardie WD, Davidson C, Ikegami M, Leikauf GD, Le Cras TD, Prestridge A, Whitsett JA, Korfhagen TR. EGF receptor tyrosine kinase inhibitors diminish transforming growth factor-alpha-induced pulmonary fibrosis. Am J Physiol Lung Cell Mol Physiol:L1217-L1225, 2008.
Hardie, W.D., Korfhagen, T.R., Sartor, M. A., Prestridge, A., Medvedovic, M., Le Cras, T.D., Ikegami, M., Wesselkamper, S.C., Davidson, C., Dietsch, M., Nichols, W., Whitsett, J.A., Leikauf, G.A. Genomic profile of matrix and vaculature remodeling in TGF-alpha induced pulmonary fibrosis.
Am J Respir Cell Mol Biol 37: 309-321, 2007.
Ikegami, M., Scoville, E.A., Grant S., Korfhagen, T., Brondyk, W., Scheule, R.K., Whitsett, J.A. Surfactant protein-D and surfactant inhibit endotoxin-induced pulmonary inflammation. Chest 132: 1447-1454, 2007.
Kramer, E.L., Deutsch, G.H., Sartor, M.A., Hardie, W.D., Ikegami, M., Korfhagen, T.R., Le Cras, T.D. Perinatal increases in TGF-alpha disrupt the saccular phase of lung morphogenesis and cause remodeling: microarray analysis.Am J Physiol Lung Cell Mol Physiol. 293: L314-L327, 2007.
Park, K.S., Korfhagen, T.R., Bruno, M.D., Kitzmiller, J.A., Wan, H., Wert, S.E., Khuranna Hershey, G.K., Chen, G., Whitsett, J.A. SPDEF regulates goblet cell hyperplasia in the airway epithelium. J. Clin. Invest. 117: 978-988, 2007.
Senft, A.P., Korfhagen, T.R., Whitsett, J.A. LeVine A.M. Surfactant protein D regulates the cell surface expression of alveolar macrophage beta2-integrin. Am J Physiol Lung Cell Mol Physiol. 292:L469-L475, 2007.
Berclaz, P.Y., Carey, B., Fillipi, M.D., Wernke-Dollries, K., Geraci, N., Cush, S., Richardson, T., Kitzmiller, J., O’Connor, M., Hermovian, C., Korfhagen, T., Whitsett, J.A., Trapnell, B. C. GM-CSF regulates a PU.1-dependent transcriptional program determining the pulmonary response to LPS.
Am J Respir Cell Mol Biol 36: 114-121, 2007.
Professional Organization Memberships
Institutional Review Board on Human Investigations and Institutional Biosafety Committees.
Special Interests
Care of High Risk infants; pediatric patients with complex, long term medical problems
Related Areas
This person works in these other areas at Cincinnati Children's Hospital Medical
Center:
