Kamyar A. Zahedi, PhD
Appointment
Research Assistant Professor
Email
kamyar.zahedi@cchmc.org
Phone
513-636-4531
Fax
513-636-7407
Credentials
BS: Utah State University, Logan, Utah, 1981.
MS: Utah State University, Logan, Utah, 1984.
PhD: Ohio State University, Columbus, Ohio, 1987.
Post-Doctoral:
Children's Hospital, Harvard Medical School, Boston, Mass.
Children's Hospital Research Foundation, Children's Hospital Medical Center, Cincinnati, Ohio.
Awards and Honors
Research Grants and Contracts
NIH Subcontract (HD33727-06A1) from Center for Blood Research August, 2000 to July, 2005.
Transcriptional regulation of C Inhibitor
NIH-HD 33727-06A1Subcontract from Center for Blood Research 08/01/00 to 07/31/05
Transcriptional Regulation of C1 Inhibitor.
Publications, Most Recent
- Zahedi K, Bissler JJ, Wang Z, Josyula A, Lu L, Diegelman P, Kisiel N, Porter CW, Soleimani M. (2006) Spermidine/Spermine N1-Acetyltransferase Over-Expression in Kidney Epithelial Cells Disrupts the Polyamine Homeostasis, Leads to DNA Damage and Causes G2 Arrest.Am J Physiol Cell Physiol.
- Zahedi K, Revelo MP, Barone S, Wang Z, Tehrani K, Citron DP, Bissler JJ, Rabb H, Soleimani M. (2006) Stathmin-deficient mice develop fibrosis and show delayed recovery from ischemic-reperfusion injury.Am J Physiol Renal Physiol 290:F1559-67.
- Tarabishi R, Zahedi K, Mishra J, Ma Q, Kelly C, Tehrani K, Devarajan P. (2005) Induction of Zf9 in the kidney following early ischemia/reperfusion.Kidney Int 68:1511-9.
- Barone S, Okaya T, Rudich S, Petrovic S, Tenrani K, Wang Z, Zahedi K, Casero RA, Lentsch AB, Soleimani M. (2005) Distinct and sequential upregulation of genes regulating cell growth and cell cycle progression during hepatic ischemia-reperfusion injury.Am J Physiol Cell Physiol 289:C826-35.
- Thakar CV, Zahedi K, Revelo MP, Wang Z, Burnham CE, Barone S, Bevans S, Lentsch AB, Rabb H, Soleimani M. (2005) Identification of thrombospondin 1 (TSP-1) as a novel mediator of cell injury in kidney ischemia.J Clin Invest 115:3451-9.
- Mishra J, Dent C, Tarabishi R, Mitsnefes MM, Ma Q, Kelly C, Ruff SM, Zahedi K, Shao M, Bean J, Mori K, Barasch J, Devarajan P. (2005) Neutrophil gelatinase-associated lipocalin (NGAL) as a biomarker for acute renal injury after cardiac surgery.Lancet 365:1231-8.
- Zahedi K, Wang Z, Barone S, Tehrani K, Yokota N, Petrovic S, Rabb H, Soleimani M. (2004) Identification of stathmin as a novel marker of cell proliferation in the recovery phase of acute ischemic renal failure.Am J Physiol Cell Physiol 286:C1203-11.
- Braun MC, Kelly CN, Prada AE, Mishra J, Chand D, Devarajan P, Zahedi K. (2004) Human PRMT5 expression is enhanced during in vitro tubule formation and after in vivo ischemic injury in renal epithelial cells.Am J Nephrol 24:250-7.
- Wang Z, Zahedi K, Barone S, Tehrani K, Rabb H, Matlin K, Casero RA, Soleimani M. (2004) Overexpression of SSAT in kidney cells recapitulates various phenotypic aspects of kidney ischemia-reperfusion injury.J Am Soc Nephrol 15:1844-52.
- Mishra J, Ma Q, Prada A, Mitsnefes M, Zahedi K, Yang J, Barasch J, Devarajan P. (2003) Identification of neutrophil gelatinase-associated lipocalin as a novel early urinary biomarker for ischemic renal injury.J Am Soc Nephrol 14:2534-43.
- Zahedi K, Wang Z, Barone S, Prada AE, Kelly CN, Casero RA, Yokota N, Porter CW, Rabb H, Soleimani M. (2003) Expression of SSAT, a novel biomarker of tubular cell damage, increases in kidney ischemia-reperfusion injury.Am J Physiol Renal Physiol 284:F1046-55.
- Liu D, Scafidi J, Prada AE, Zahedi K, Davis AE, 3rd. (2002) Nuclear phosphatases and the proteasome in suppression of STAT1 activity in hepatocytes.Biochem Biophys Res Commun 299:574-80.
- Zahedi K, Prada AE, Mulligan A, Prada JA, Davis AE, 3rd. (2002) Normal transcription of the C1 inhibitor gene is dependent upon a polypurine-polypyrimidine region within the promoter.Inflammation 26:183-91.
Special Interests
Acute renal failure and polyamine metabolism.
Gene regulation and cellular differentiation.
Related Areas
This person works in these other areas at Cincinnati Children's Hospital Medical Center:
