Donald L. Gilbert, MD, MS
Title
Director, Movement Disorder Clinic and Tourette's Syndrome Clinic
Appointment
Associate Professor of Pediatric Neurology
Email
donald.gilbert@cchmc.org
Phone
513-636-4222
Fax
513-636-3980
Bio
Donald Gilbert, MD, earned his Bachelor of Arts at Princeton University, where he majored in philosophy. He subsequently earned his MD at the University of Michigan and spent a year at the National Institutes of Health as a Howard Hughes Medical Institute Research Scholar. Dr. Gilbert did his pediatrics and neurology training at Johns Hopkins in Baltimore and is board certified in neurology with special competence in child neurology. Dr. Gilbert has an MS in Clinical Research Design and Statistical Analysis from the University of Michigan.
At Cincinnati Children's, Dr. Gilbert directs the Movement Disorders and Tourette's Syndrome Clinics, which specialize in evaluation and pharmacologic treatment of tics, chorea, tremor, dystonia, stereotypies, ataxia, and other movement disorders. Dr. Gilbert directs or participates in a number of single and multi-center studies into causes and treatments of Tourette's Syndrome. Dr. Gilbert directs the Transcranial Magnetic Stimulation Laboratory at CCHMC.
Credentials
BA: Philosophy, Princeton University, Princeton, NJ, 1987
MD: Medicine, University of Michigan School of Medicine, Ann Arbor, MI, 1993
MS: Clinical Research Design and Statistical Analysis, University of Michigan, Ann Arbor, MI, 2003
Residency: Pediatrics, Johns Hopkins School of Medicine, Baltimore, MD, 1995
Fellowship: Pediatric Neurology, Johns Hopkins School of Medicine, Baltimore, MD, 1995
Certification: Board Certified in Neurology with Special Competence in Child Neurology, 2000. Board eligible in Pediatrics.
Appointment: Associate Professor of Pediatric Neurology
Awards and Honors
- 1982 American Field Service Scholarship, to France
- 1983 Presidential Scholar
- 1983 High School Valedictorian
- 1987 Graduated Cum Laude, Princeton University
- 1998 Thomas Preziosi Award for Excellence in Clinical Care, Johns Hopkins
- 1999 Commencement Address, A.E. Stevenson High School
- 2000 Mead Johnson Excellence in Teaching Award
- 2000 NIDA/NIMH Junior Investigator Travel Award
- 2001 Mead Johnson Excellence in Teaching Award
- 2003 Mead Johnson Excellence in Teaching Award
- 2004 Tourette Syndrome Association Promising Young Investigator Travel Award
- 2006 M. Harold Fogelson MD Pediatric Neurology Teaching Award
Research
Visit Dr. Gilbert's Lab Site.
Clinical trials in Tourette's Syndrome and Associated ADHD.
Epidemiology of Tourette's Syndrome and PANDAS.
Clinical effectiveness of multi-drug treatments in Tourette's Syndrome.
Transcranial Magnetic Stimulation in Tourette's Syndrome and pediatric movement disorders.
Functional Neurosurgery for Pediatric Dystonia.
Research Grants and Contracts
Anomalous Motor Physiology in ADHD. R01 MH078160 (NIMH) 9/1/2006 – 6/30/2011. Investigator.
The Role of SLITRK 1 in Tourette and Related Disorders R01 NS056276-01 NINDS. 9/1/2006 – 6/30/2011 Investigator.
Neuroplasticity and learning in Neurofibromatosis Translational Research Initiative, Cincinnati Children’s Hospital Medical Center. 4/1/2009-3/30/2010 Principal Investigator.
Additional Pilot Research in Progress: Characterization of Novel Dystonia/Spastic Paraplegia Syndrome; Psychiatric Outcomes of Sydenham's Chorea; Neuroplasticity in Tourette Syndome, Transcranial Magnetic Stimulation Induced Motor Evoked Potentials in Pediatric Movement Disorders; Neuroplasticity in Neonatal Brachial Plexus Injuries.
Publications, Most Recent
Gilbert DL, Leslie EJ, Keddache M, Leslie ND. A novel Hereditary Spastic Paraplegia with Dystonia linked to chromosome 2q24-2q31.Movement Disorders 2009. In Press.
DeRoos ST; Chillag K; Keeler M; Gilbert DL. The Effects of Sleep Deprivation on the Pediatric Electroencephalogram.Pediatrics 2009. 123:703-708.
Lit L, Enstrom A, Sharp FS, Gilbert DL. Age-related gene expression in Tourette syndromeJournal of Psychiatric Research. 2009. 43:319-330.
Gilbert DL, "Paroxysmal Movement Disorders." In Current Management in Child Neurology, 4th edition. Ed. Maria B. BC Decker, Inc. People’s Medical Publishing House, Shelton, CT 2009.
Wong LJ, Naviaux RK, Brunetti-Pierri N, Zhang Q, Schmitt ES, Truong C, et al. Molecular and clinical genetics of mitochondrial diseases due to POLG mutations.Hum Mutat 2008. 29:E150-E172.
Kurlan R, Johnson D, Kaplan EL, and the Tourette Syndrome Study Group. Streptococcal Infection and Exacerbations of Childhood Tics and Obsessive-Compulsive Symptoms.Pediatrics 2008. 121:1188-1197
Singer HS, Gause C, Morris C, and the Tourette Syndrome Study Group. Serial Immune Markers Do Not Correlate with Clinical Exacerbations in PANDAS.Pediatrics 2008. 121:1198-1205.
Spencer TJ, Sallee FR, Gilbert DL, et al. Atomoxetine Treatment of ADHD in Children With Comorbid Tourette Syndrome.J Atten Disord 2008;11:470-481.
Hershey AD, Burdine D, Liu C, Nick TG, Gilbert DL, Glauser TA. Assessing Quality and Normalization of Microarrays.Acta Neurologica Scandinavica 2008. DOI: 10.1111 ÿ j.1600-0404.2007.00979.x.
Giles LL, Delbello MP, Gilbert DL, Stanford KE, Shear PK, Strakowski SM. Cerebellar ataxia in youth at risk for Bipolar Disorder.Bipolar Disorders 2008; 10:733-737.
Gilbert DL. Drug Induced Movement Disorders in Children.Annals of the New York Academy of Sciences 2008; 1472: 72-84.
Gilbert DL. Commentary/Focus on Subspecialties: Strep may be one of many triggers for tic, OCD exacerbations.American Academy of Pediatrics News Vol. 29 No. 8 August 2008, p. 16.
Gilbert DL, "Design and analysis of motor-evoked potential data in pediatric neurobehavioral disorder investigations." In The Oxford Handbook of Transcranial Stimulation. Ed. Wassermann EM, Epstein CM, Ziemann U, Walsh V, Paus T, Lisanby SH. Oxford University Press, Oxford UK 2008.
Gilbert DL. Zhang J. Lipps TD. Natarajan N. Brandyberry J. Wang Z. Sallee FR. Wassermann EM. Atomoxetine treatment of ADHD in Tourette syndrome: reduction in motor cortex inhibition correlates with clinical improvement.Clinical Neurophysiology 2007; 118:1835-41.
Litt L, Gilbert DL, Walker W, Sharp F. Tourette Syndrome subgroups identified using blood gene expression profiling and principal components analysis.Am J Med Genetics, Part B: Neuropsychiatric Genetics. 2007; 144B:958-963.
Wu S, Graham B, Gelfand MJ, Gruppe RE, Dinopolous A, Gilbert DL. Clinical and positron emission tomography findings of chorea associated with primary antiphospholipid antibody syndrome.Movement Disorders 2007; 22:1813-1815.
Gilbert DL. Low and high-frequency repetitive transcranial magnetic stimulation for the treatment of spasticityDevelopmental Medicine & Child Neurology 2007;49:486.
Gilbert DL. Highlight and Commentary: Deep brain stimulation for a teen with tics?Neurology 2007;68:85.
Gilbert DL, Christian BT, Gelfand MJ, Shi B, Mantil J, Sallee FR. Altered Mesolimbocortical and Thalamic Dopamine in Tourette Syndrome.Neurology 2006; 67:1695-1697.
Gilbert DL, Wang Z, Sallee FR, et al. Dopamine transporter genotype influences the physiological response to medication in ADHD.Brain 2006. 129:2038-2046. doi:10.1093/brain/awl147.
Gilbert DL, Ridel KR, Sallee FR, Zhang J, Lipps T, Wassermann EM. Comparison of the inhibitory and excitatory effects of ADHD medications on motor cortex.Neuropsychopharmacology 2006; 31:442-449.
Gilbert DL. Treatment of Children and Adolescents with Tics and Tourette Syndrome.The Journal of Child Neurology 2006:21: 690-700.
Gilbert DL. Motor Cortex Inhibitory function in Tourette Syndrome, Attention Deficit Hyperactivity Disorder, and Obsessive Compulsive Disorder: Studies Using Transcranial Magnetic Stimulation.Advances In Neurology 2006; 99:107-114.
Sharp FR, Xu H, Lit L, Walker W, Apperson M, Gilbert DL, Glauser TA, Wong B, Hershey A, Liu D-Z, Pinter J, Zhan X, Liu X and Ran R. The Future of Genomic Profiling of Neurological Diseases Using Blood.Arch Neurol 2006; 63: 1529-1536.
Sharp FR, Lit L, Xu H, Apperson M, Walker W, Wong B, Gilbert DL, Hershey A and Glauser TA. Genomics of brain and blood: progress and pitfalls.Epilepsia 2006; 47: 1603-7.
Tang Y, Gilbert DL, Glauser TA, Hershey AD, Lu A, Ran R, Xu H, Sharp FR. "Blood Genomic Fingerprints of Brain Diseases." In Surrogate Tissue Analysis: Genomic, Proteomic, and Metabolomic Approaches. Eds. Burczynski ME, Rockett JC. Taylor & Francis, Boca Raton, FL. 2006.
Gilbert DL. "Treatment of Tourette Syndrome." In Current Therapy in Neurologic Disease 7th edition. Eds. Johnson, Griffin, McArthur. 2006.
Presentations, Most Recent
"Distinguishing Normal and Abnormal Movements in Children." 13th International Congress of Parkinson’s Disease and Movement Disorders, Paris, France, June 9, 2009.
"Pediatric Tremor." American Academy of Neurology Meeting, Seattle, WA, April 26, 2009.
"Pediatric Movement Disorders – Ataxias; Drug Induced Movement Disorders; Transcranial Magnetic Stimulation Research" – Visiting Professor; Pediatric Neurology Symposium, University of Alberta, Canada. January 15-16, 2009.
"Common Office Movements: Tics, Chorea, PANDAS: What should I do?" American Academy of Pediatrics 2008 National Conference and Exhibition, Boston, MA, October 11, 2008.
"Pediatric Ataxia" in Course "Diagnosis and Management of Movement Disorders in Children" at American Academy of Neurology Meeting, Chicago, IL, April 19, 2008.
"Iatrogenic Movement Disorders" in Course "Diagnosis and Management of Movement Disorders in Children" at American Academy of Neurology Meeting, Boston, MA May 4, 2007.
"Tics: Is this Tourette’s and What Does That Mean" American Academy of Pediatrics 2007 National Conference and Exhibition, San Francisco, CA, October 29, 2007.
"PANDAS: Real or Imagined" American Academy of Pediatrics 2007 National Conference and Exhibition, San Francisco, CA, October 29, 2007.
"Diagnosis and Treatment of Tourette Syndrome" Grand Rounds, Duke University, April 24, 2007.
"Tics: When is it Tourette’s and What Do I Do?" American Academy of Pediatrics 2006 National Conference and Exhibition, Atlanta, GA, October 9, 2006.
"Clinical Research in Neurology"American Neurological Association Resident Career Day, Invited Speaker at ANA meeting, Chicago, IL, October 7, 2006.
"Compounds targeting monoaminergic systems (DA, 5-HT, NE) in the treatment of TS" NINDS/NIMH Tourette Syndrome Workshop, Washington DC, September 12, 2006.
"Pediatric Neurology" American Academy of Pediatrics PREP Course, Denver, Colorado, June 24-26, 2006.
"Tic Disorders and Associated Symptoms" in Course "Diagnosis and Management of Movement Disorders in Children" at American Academy of Neurology Meeting, San Diego, CA, April 5, 2006.
"Neurologic Disorders" at the 31st Annual Review Course of the American Academy of Child and Adolescent Psychiatry, Cincinnati, OH, March 2, 2006.
Professional Organization Memberships
- Member, American Academy of Pediatrics
- Member, American Academy of Neurology
- Member, American Neurological Association
- Member, Movement Disorder Society
- Medical Advisory Board Member, Tourette Syndrome Association, 1999-present
- Member, Child Neurology Society, 2000-present
Special Interests
Movement disorders; Tourette's Syndrome; Sydenham's Chorea; Kernicterus; Dystonia; Ataxia; clinical research; transcranial magnetic stimulation
Editing
Editorial Board, American Academy of Pediatrics PREP" Self-Assessment
National Medical Advisory Board, Tourette Syndrome Association
Related Areas
This person works in these other areas at Cincinnati Children's Hospital Medical
Center:
