Radiology and Medical Imaging

Kim M. Cecil, PhD

Title

Spectroscopist

Appointment

Professor of Radiology, Pediatrics and Neuroscience, University of Cincinnati College of Medicine

Email

kim.cecil@cchmc.org

Phone

513-636-8559

Fax

513-636-3754

Bio

Kim M. Cecil, PhD, received her undergraduate and postgraduate training in chemistry. After a post-doctoral fellowship in magnetic resonance spectroscopy and imaging at the Hospital of the University of Pennsylvania, Dr. Cecil joined the Radiology Department and the Imaging Research Center at Cincinnati Children’s Hospital Medical Center in 1998. She serves as an imaging research scientist and clinical MR spectroscopist.

In 2000, Kim M. Cecil, PhD, Antonius deGrauw, MD, PhD and Gajja Salomons, PhD, discovered creatine transporter deficiency syndrome, a genetic disorder caused by mutations in the creatine transporter gene (SLC6A8). Male patients demonstrate a significant reduction or absence of creatine in the brain, as indicated by MR spectroscopy. This is an X-linked mental retardation disorder thought to be second only to fragile X in prevalence.

Credentials

BS: Chemistry & Mathematics (Magna Cum Laude), Kentucky Wesleyan College, 1988
MS: Chemistry, Vanderbilt University, 1991
PhD: Chemistry, Vanderbilt University, 1993
Fellowship: Hospital of the University of Pennsylvania, Philadelphia, PA

Awards and Honors

Derek Harwood Nash Award for Research in Pediatric Neuroradiology from the American Society of Neuroradiology, 2000
Point of Care Award from the American Association for Clinical Chemistry, 2003
Caffey Award for the Best Clinical Science or Education Paper from the Society for Pediatric Radiology, 2008
General Neuroradiology Outstanding Presentation Award from the American Society of Neuroradiology, 2008

Research

Dr. Cecil’s research efforts focus on the application of MR spectroscopy and imaging in several populations by characterizing the features of inborn errors in metabolism and evaluating the effects of environmental neurotoxicants and radiation, respectively, on brain anatomy and function.

Research Grants and Contracts

R01 ES015559, Early Lead Exposure, ADHD and Persistent Criminality, 2007-2012, Co-Principal Investigator

R01 CA112182, Neurobehavioral Late-Effects in Pediatric Brain Tumors, 2005-2011, Co-Investigator

R01 ES015689, Effects of Lead, Manganese and Stress During Development, 2006-2011, Co-Investigator

P50 MH077138, Bipolar Disorder Imaging & Treatment Research Center, 2007-2012, Co-Investigator

R01 MH07043, Neurofunctional and Neurochemical Markers of Treatment Response in Early Onset Bipolar Mania, 2007-2012, Co-Investigator

Publications, Most Recent

Cecil KM: MR spectroscopy of metabolic disorders.Neuroimaging Clinics of North America, 2006; 16:87-116.

DelBello MP, Cecil KM, Adler CM, Strakowski SM: Neurochemical effects of olanzapine in first-hospitalization manic adolescents: a proton magnetic resonance spectroscopy study. Neuropsychopharmacology, 2006; 31:1264-1273.

Yuan W, Holland SK, Cecil KM, Dietrich KN, Wessel SD, Altaye M, Hornung RW, Ris MD, Egelhoff JC, Lanphear BP: The Impact of Early Childhood Lead Exposure on Brain Organization. An fMRI Study of Language Function.Pediatrics, 2006; 118: 971-977.

Patel NC, DelBello MP, Cecil KM, Adler CM, Bryan HS, Stanford KE, Strakowski SM: Lithium treatment effects on myo-inositol in adolescents with bipolar depression. Biological Psychiatry, 2006; 60:998-1004.

Cecil KM, Kos RS: MRS and metabolic imaging in white matter diseases and pediatric disorders. Top Magnetic Resonance Imaging, 2006; 17:275-293.

Yuan W, Holland SK, Schmithorst VJ, Walz NC, Cecil KM, Jones BV, Karunanayaka P, Michaud L and Wade SL: Diffusion Tensor MRI Reveals Persistent White Matter Alteration after Traumatic Brain Injury Experienced During Early Childhood.American Journal of Neuroradiology, 2007; 28:1919-1925.

Walz NC, Cecil KM, Michaud LJ and Wade SL: Late Proton Magnetic Resonance Spectroscopy following Traumatic Brain Injury during Early Childhood: Relationship with Neurobehavioral Outcomes. Journal of Neurotrauma, 2008; 25:94-103.

Patel NC, DelBello MP, Cecil KM, Adler CM, Stanford KE and Strakowski SM: Temporal Change in N-Acetyl-Aspartate Concentrations in Adolescents with Bipolar Depression Treated with Lithium.Journal of Child& Adolescent Psychopharmacology. 2008; 18:132-139.

Cecil KM, Brubaker CJ, Adler CM, Dietrich KN, Altaye M, Egelhoff JC, Wessel S, Elangovan I, Jarvis K and Lanphear BP: Decreased Brain Volume in Adults with Childhood Lead Exposure. PLoS Medicine 5:e112, 2008, doi:10.1371/journal.pmed.0050112.

Miles L, DeGrauw TJ, Dinopoulos A, Cecil KM, van der Knaap MS and Bove KE: Megalencephalic Leukoencephalopathy with Subcortical Cysts (MLC): a third confirmed case with literature review.Pediatric and Developmental Pathology, 2008 Sep 26:1 epub.

Patel NC, Cecil KM, Strakowski SM, Adler CM, and DelBello MP: Neurochemical Alterations in Adolescent Bipolar Depression: A Proton Magnetic Resonance Spectroscopy Pilot Study of the Prefrontal Cortex. Journal of Child Adolescent Psychopharmacology, 2008; 18: 623-627.

Presentations, Most Recent

Cecil, K.M, DelBello, M.P., Patel, N.C., Adler, C.M., and Strakowski, S.M.: The Effects of Lithium on Myo-Inositol in Adolescents with Bipolar Depression: An MR Spectroscopy Study. Presented at the 44th Annual Meeting of the American Society of Neuroradiology, San Diego, CA, May 1, 2006.

Cecil, K.M., Adler, C.M., Jarvis, K., Egelhoff, J.C., Dietrich, K.N., Elangovan, I. and Lanphear, B.P.: Evidence of Volume Loss in an Adult Population with Childhood Lead Exposure: Voxel-Based Morphometric Analyses of MR Imaging. Presented at the 44th Annual Meeting of the American Society of Neuroradiology, San Diego, CA, May 1, 2006, 13.

Cecil, K.M., Yuan, W., Holland, S.K., Dietrich, K.N., Lanphear, B.P., and Altaye, M.: Early Childhood Lead Exposure Alters Language Organization in Adulthood: A Functional MRI Study. Presented at the 44th Annual Meeting of the American Society of Neuroradiology, San Diego, CA, May 2, 2006, 187.

Cecil, K.M, DelBello, M.P., Adler, C.M., Daniels, J. and Strakowski, S.M: Olanzapine Treatment Effects in Adolescents with Bipolar Mania: A Proton Magnetic Resonance Specctroscopy Study. Presented at the 44th Annual Meeting of the American Society of Neuroradiology, San Diego, CA, May 1, 2006, 197.

Cecil, K.M., Brubaker, C.J., Adler, C.M., Jarvis, K., Egelhoff, J.C., Dietrich, K.N., Elangovan, I. and Lanphear, B.P.: Environmental Lead Exposure Alters Brain Volume: Results of a VBM Analysis. Presented at the International Society for Magnetic Resonance in Medicine, 14th Scientific Meeting and Exhibition, Seattle, WA, May 8, 2006. 3126..

Cecil, K.M, DelBello, M.P., Adler, C.M., Daniels, J. and Strakowski, S.M: Treatment of Adolescent Bipolar Depression with Lithium: Effects on Brain Myo-Inositol Levels Measured by Proton MR Spectroscopy. Presented at the International Society for Magnetic Resonance in Medicine, 14th Scientific Meeting and Exhibition, Seattle, WA, May 10, 2006. 2075.

Miles, L., van der Knaap, M. Cecil, K.M., deGrauw, T. and Bove, K.: Brain Histopathology in Leukoencephalopathy Due to MLC1 Gene Mutation. Presented at the 10th International Child Neurology Congress, Montreal, Quebec, Canada, June 11-16, 2006.

Brubaker, C.J., Elangovan, I., Lanphear, B.P., Adler, C.M., Dietrich, K.N., and Cecil, K.M.: Childhood Lead Exposure Decreases Adult Gray Matter Volume. Presented at the Neuroscience 2006, 36th Annual Meeting of the Society for Neuroscience, Atlanta, GA, October 15, 2006, 159.

Ajam, A.A., Glasier, C.M., and Cecil, K.M.: MR Spectroscopy Findings in Patients with Zellweger Syndrome. Presented at the 45th Annual Meeting of the American Society of Neuroradiology, Chicago, IL, June 2007, 162.

Yuan, W., Holland, S.K., Walz, N.C., Cecil, K.M., Jones, B.V., Karunanayaka, P., Michaud, L., and Wade, S. L.: Assessing White Matter Diffusion Abnormality with DTI in Young Children with Traumatic Brain Injury. Presented at the 13th Annual Meeting of the Organization for Human Brain Mapping, Chicago IL, June 13, 2007, 291.

Brubaker, C.J., Elangovan, I., Lanphear, B.P., Adler, C.M., Dietrich, K.N., and Cecil, K.M.: Childhood Lead Exposure Decreases Adult Gray Matter Volume. Presented at the Neurobehavioral Teratology Society Annual Meeting, Pittsburgh, PA, June 25, 2007.

Brubaker, C.J., Schmithorst, V.J., Haynes, E.N., Dietrich, K.N. and Cecil, K.M.: A Diffusion Tensor Study of the Effects of Childhood Lead Exposure. Presented at Neuroscience 2007, 37th Annual Meeting of the Society for Neuroscience, San Diego, CA, November 3, 2007, 535..

Hornung, R., Dietrich, K.N., Brubaker, C.J., Cecil, K.M. and Lanphear, B.P.: Determining the Age of Greatest Vulnerability to Lead Exposure Related to Cognitive Ability and Deficits in Prefrontal Cortex Gray Matter. Presented at the 2008 Pediatric Academic Societies’ Annual Meeting, Honolulu, HI, May 4, 2008, 4035.1.

Rao, H., Wang, S., Giannetta, J. Cecil, K.M., VanMeter, J., Zeffiro, T., Hurt, H., Detre, J.A. and Wang, J.J.: Perfusion Imaging of Normal Brain Development from Childhood to Young Adulthood. Presented at the International Society for Magnetic Resonance in Medicine, 16th Scientific Meeting and Exhibition, Toronto, Ontario, CA, May 6, 2008, accepted as a traditional poster, 2054.

Wu, W.-C., Rao, H., Pawlak, M., Cecil, K.M., VanMeter, J., Zeffiro, T., Hurt, H. Detre, J.A., Melhem, E. and Wang, J.J.: Venous Outflow of Label in ASL Perfusion MRI of Healthy Children and Children with Sickle Cell Disease. Presented at the International Society for Magnetic Resonance in Medicine, 16th Scientific Meeting and Exhibition, Toronto, Ontario, CA, May 6, 2008, 1987.

Cecil, K.M., Dietrich, K.N., Altaye, M., Egelhoff, J.C., Wessel, S.D., and Lanphear, B.P.: Adults with Significant Childhood Lead Exposure Evaluated with Proton MR Spectroscopy. Presented at the International Society for Magnetic Resonance in Medicine, 16th Scientific Meeting and Exhibition, Toronto, Ontario, CA, 2008, 3455.

Cecil, K.M., Dietrich, K.N., Altaye, M., Egelhoff, J.C., Brubaker, C.J., Schmithorst, V.J., Haynes, E.N., Wessel, S.D., and Lanphear, B.P.: Evaluating the Effects of Childhood Lead Exposure with Proton MR Spectroscopy & Diffusion Tensor Imaging. Presented at the Society for Pediatric Radiology, 51st Annual Meeting, Scottsdale, AZ, May 10, 2008, PA80. Caffey Award Winner for Best Clinical Science Paper

Cecil, K.M., Dietrich, K.N., Adler, C. M., Brubaker, C.J., Wessel, S.D., and Lanphear, B.P.: Voxel-Based Morphometric Analysis Demonstrates Evidence of Volume Loss in an Adult Population with Childhood Lead Exposure. Presented at the Society for Pediatric Radiology, 51st Annual Meeting, Scottsdale, AZ, May 10, 2008, PA81.

Cecil, K.M, Patel, N.C., DelBello, M.P., Stanford, K.E., Adler, C.M., and Strakowski, S.M.: Adolescent Bipolar Depression: Effects of Lithium Therapy on Brain NAA Concentrations. Presented at the Society for Pediatric Radiology, 51st Annual Meeting, Scottsdale, AZ, May 10, 2008, PA85

Cecil, K.M., Dietrich, K.N., Altaye, M., Egelhoff, J.C., Wessel, S.D., and Lanphear, B.P.: Lead Exposure During Childhood Disrupts Adult Brain Metabolism. Presented at the 46th Annual Meeting of the American Society of Neuroradiology, New Orleans, LA, June 2, 2008, 35. Outstanding Presentation Award Winner in General Neuroradiology.

Cecil, K.M, Patel, N.C., DelBello, M.P., Stanford, K.E., Adler, C.M., and Strakowski, S.M.: Effects of Lithium Therapy on Brain NAA Concentrations in Adolescent Bipolar Depression. Presented at the 46th Annual Meeting of the American Society of Neuroradiology, New Orleans, LA, June 3, 2008, 192.

Cecil, K.M., Brubaker, C.J., Schmithorst, V.J., Haynes, E.N., Dietrich, K.N.: Diffusion Tensor Analysis of Adults with Significant Childhood Lead Exposure. Presented at the 46th Annual Meeting of the American Society of Neuroradiology, New Orleans, LA, June 2, 2008, 36.

Invited Speaker

44th Annual Meeting of the American Society of Neuroradiology, “Advanced Imaging Seminar- Spectroscopy: Clinical State of the Art,” May 4, 2006, San Diego, CA.

14th Scientific Meeting of the International Society for Magnetic Resonance in Medicine, “MRS in Congenital Metabolic Disorders,” May 6, 2006, Seattle, WA.

The International Pediatric Radiology 5th Conjoint Meeting, “MR Spectroscopy of the Body,” May 19, 2006, Montreal, Quebec, Canada.

15th Scientific Meeting of the International Society for Magnetic Resonance in Medicine, “MR Spectroscopy of Perinatal Asphyxia,” May 19, 2007, Berlin, Germany.

2nd Annual Meeting of the American Society of Functional Neuroradiology, “MRS for Cerebral Metabolic Disease and Lesion Characterization”, February 29, 2008, Orlando, FL.

National Institute of Neurological Disorders and Stroke Workshop, “Mitochondrial Encephalopathies: Potential Relationships to Autism?” June 29, 2008, Indianapolis, IN.