Cincinnati Children's Hospital Medical Center Logo

Radiology and Medical Imaging

Loading...
image

<Click for High-Res Image>

Scott K. Holland, PhD

Title

McLaurin Scholar

Appointment

Professor of Radiology, Pediatrics and Physics, University of Cincinnati College of Medicine

Email

scott.holland@cchmc.org

Phone

513-636-7565

Fax

513-636-0434

Bio

Scott K. Holland, Ph.D. – is the McLaurin Scholar in Pediatric Neurosurgery and Professor of Radiology, Pediatrics, Biomedical Engineering, Neuroscience and Physics at University of Cincinnati, and Director of the Pediatric Brain Imaging Research Center at Children’s Hospital Research Foundation.  A physicist by training, he received his B.S. degree (1980) in Physics from Muhlenberg College, Allentown, PA. and M.S. (1982) and Ph.D. (1985) degrees in Applied Physics from Yale University.

Credentials

PhD: Engineering and Applied Science, Yale University, 1985
MPhil: Engineering & Applied Science, Yale University, 1983
MS: Engineering & Applied Science, Yale University,1982
BS: Physics (Magna Cum Laude), Muhlenberg College, 1980

Position History

2002 - Present:  Professor of Radiology (with joint apt. in Pediatrics, Physics, Bio. Med. Eng. & Neuroscience, University of Cincinnati

2001 - 2002:  Associate Professor of Biomedical Engineering (Secondary) University of Cincinnati 
 
1994 - 2002:  Associate Professor of Radiology, Pediatrics and Physics, University of Cincinnati  

1994 -2002:  Scientific Director, Imaging Research Center, Children's Hospital Medical Center, Cincinnati, Ohio, USA
 
1991 - 1994:  Director, Center for Ultrasonics and Sonics at Yale, Yale University, New Haven, CT
 
1989 - 1994:  Assistant Professor of Mechanical Engineering, Yale University, Joint Appointment with School of Medicine
 
1988 - 1994:  Assistant Professor of Diagnostic Radiology, Yale University School of Medicine (MRI/Ultrasound)
 
1986 - 1988:  Post Doctoral Research Fellow, Dept. of Diagnostic Radiology, Yale University School of Medicine  (NMR Imaging)
 
1985 - 1986:  Research Engineer, Stanford Research Institute, Menlo Park, CA 

Awards and Honors

  • *2008 Hydrocephalus Association Award: Dr. Ellen Air, 3rd year resident in Neurosurgery, “A longitudinal comparison of pre- and postoperative DTI parameters in young hydrocephalic children”. 37th Annual Meeting of the AANS/CNS Section on Pediatric Neurological Surgery at Spokane, Washington. December 2008.  Ellen L. Air, Weihong Yuan, Scott K. Holland, Blaise V. Jones, Karin Bierbrauer and Francesco T. Mangano
  • **2006 “Editor’s Choice” award for Neuroimage: Cognitive Neuroscience section for paper entitled: “Functional MRI evidence for disparate developmental processes underlying intelligence in boys and girls.” Schmithorst, V.J. and Holland, S.K.,. Neuroimage, 31:1366-79, 2006.
  • **2006 Top 5 % of program worthy of mention. “A Longitudinal fMRI Study of Language Development in Children”. 58th Annual Meeting of the American Academy of Neurology, San Diego, CA, April, 2006 J. P. Szaflarski, V. J. Schmithorst, M. Altaye, A. W. Byars, J. Ret, E. Plante and S. K. Holland
  • 2005 The McLaurin “Faculty Development Scholarship In Pediatric Brain Imaging and Functional Neurosurgery” Awarded by Cincinnati Children’s Hospital Medical Center, Division of Surgical Services.  Five year salary support and title.
  • *2005  Medical Student Essay Award, American Academy of Neurology: Jan-Mendelt Tillema, "Functional MRI shows right hemispheric dominance in language processing following perinatal left MCA stroke". AAN Annual Meeting, San Diego, CA, 2005.  Medical Student under mentorship
  • *2002 – Graduate Student Travel Award, Southern Society for Psychology, Nashville, TN, 2002. "fMRI Data from Saccade Sequencing Tasks of Increasing Complexity". Awarded to Anthony Landreth, B.A., Graduate student under mentorship
  • *2001 - Resident Travel Award, Middle Section, Triologial Society  “Functional Magnetic Resonance Imaging of the Pediatric Swallow: Imaging the Cortex and the Brainstem.”  January 21, 2001. Chicago, IL  Awarded to Christopher Hartnick, M.D., Clinical Fellow under mentorship
  • *1999 - John A. Kirkpatrick Young Investigator Award for Paper presentation at the 42nd Annual Meeting of The Society for Pediatric Radiology, May 14-17, 1999, Vancouver, British Columbia, Canada.  Awarded to Raymond Sze, M.D., Clinical Fellow under mentorship
  • 1998 – Derek Harwood-Nash Award for best paper in Pediatric Neuroradiology presented at the 36th annual meeting of the Am. Soc. Neuroradiology, Philadelphia, April 1998
  • 1998 – Session Moderator:  fMRI Pot Pourri,  6th Annual meeting of the International Society of Magnetic Resonance in Medicine, Sydney Australia.
  • 1991 - American Association of Physicists in Medicine/IPSM Medical Physics Travel Award.  Awarded annually to a U.S. Medical Physicist for 3 weeks of travel and lectures in the U.K.
  • 1991 - Moore Fund Award - Yale College Curriculum Development Award For upgrade ME286 - Mechanical Engineering Laboratory Course Curriculum  $4,255 for student stipend, hardware and software development for teaching lab.
  • 1990 - Society of Magnetic Resonance Imaging - Cum Laude Award for Spectroscopy Poster Presentation at 8th Annual Meeting, Washington D.C. 1990 19F NMR of Fluosol for Real-Time, In Vivo Studies of Rat Liver Oxygenation.

 * indicates recipient was a graduate student, post-doc, or clinical fellow under my mentorship

Research

Dr. Holland's research currently focuses on advanced neuroimaging applications of MRI in pediatrics.  His major focus is on functional MRI of language, hearing and neuroplasticity following brain injury.  His research in brain imaging extends to studies in small animals and the use of a 7 Tesla small animal MRI system for micro imaging in mouse and rat models brain development and brain injury. 

Research Grants and Contracts

ACTIVE RESEARCH GRANTS

P.I. Scott K. Holland, Ph.D. "3 Tesla MRI for Studies of Child Development and Disorders" 3/1/08 - 2/28/09  Equip.  NIH  S10-RR-24537 $500,000 TDC


P.I. Scott K. Holland, Ph.D. "fMRI Evidence of Language Reorganization in Children" 8/1/06 - 7/28/11  25%  NIH  2-RO1–HD38578-06  $750,000 TDC


P.I. Scott K. Holland, Ph.D.  12/1/04 - 11/31/09  40% NIH-RO1 – DC007186 $1,951,506 TDC
    
P.I.  Scott K. Holland, Ph.D. (consortium) "fMRI of Language Recovery Following Stroke in Adults"  12/1/08 - 11/31/13 10% Collab. RO1 NS 048281-01 (to Jerzy Szaflarski, MD, Ph.D.) $1,910,000 TDC


P.I. Scott K. Holland, Ph.D. “The McLaurin Faculty Development Scholarship In Pediatric Brain Imaging and Functional Neurosurgery” 7/1/05 - 6/30/10 20%
McLaurin Fund $847,787 TDC


P.I.  Hermine Brunner, M.D. “Improved Diagnostics & Advanced Magnetic Resonance Imaging for Pediatric NPSLE” 4/1/08 - 3/31/13 5%  NIH- P60-AR047784-06/ R01 $4,255,842 /  $854,480

      
P.I. Shari Wade, Ph.D Ohio Department of Public Safety State Board of Emergency Medical Services: 7/1/08 - 6/30/09  5% - 4/31/07 5%  $73,910  TDC   

P.I. Istvan Pirko, M.D. "The role of CD8+ T cells in the formation of T1 black holes in an animal model of MS" 4/1/08 - 3/31/12  Consult.  NIH-R01-NS05698 $700,000 TDC

 

P.I. Shari Wade, Ph.D. Interdisciplinary Faculty Research Grants : “The Neural Substrates of Social, Language, and Executive Function Deficits in Internationally Adopted Children" (CCHMC Rehab) University of Cincinnati 7/1/07 - 6/30/08 Collab.  $25,000 TDC


ACTIVE TRAINING GRANTS


P.I. Thomas Christensen, Ph.D. "Brain Mechanisms Linking Language, Attention and Memory"  4/1/07 - 3/31/12  External-Advisor  NIH- K01-DC008812 $885,500 TDC 


P.I.  Vincent J. Schmithorst, Ph.D. "Cortical Reorganization in Children with Unilateral Sensorineural Hearing Loss" 5/1/05 - 4/30/11  Co-Mentor NIH-K25-DC008110  $ 499,642 TDC


P.I.  Jerzy P. Szaflarski, M.D. Ph.D. “EEG-fMRI in patients with JME”  6/1/06 - 5/31/011  Co-Mentor  NIH-K23 NS052468-01  $434,013 TDC

Publications, Most Recent

Eliassen, J.C., Holland, S.K. and Szaflarski, J.P., "Compensatory brain activation for recognition memory in patients with medication-resistant epilepsy".Epilepsy Behav, 2008.

Szaflarski, J.P., Holland, S.K., Jacola, L.M., Lindsell, C., Privitera, M.D. and Szaflarski, M., "Comprehensive presurgical functional MRI language evaluation in adult patients with epilepsy". Epilepsy Behav, 12:74-83, 2008.

Yuan, W., Holland, S.K., Jones, B.V., Crone, K. and Mangano, F.T., "Characterization of abnormal diffusion properties of supratentorial brain tumors: a preliminary diffusion tensor imaging study". J Neurosurg Pediatrics, 1:263-9, 2008.

Difrancesco, M.W., Holland, S.K. and Szaflarski, J.P., "Simultaneous EEG/Functional Magnetic Resonance Imaging at 4 Tesla: Correlates of Brain Activity to Spontaneous Alpha Rhythm During Relaxation". J Clin Neurophysiol, 2008.

Eaton, K.P., Szaflarski, J.P., Altaye, M., Ball, A.L., Kissela, B.M., Banks, C. and Holland, S.K., "Reliability of fMRI for studies of language in post-stroke aphasia subjects". Neuroimage, 41:311-322, 2008.

Kramer, M.E., Chiu, C.Y., Walz, N.C., Holland, S.K., Yuan, W., Karunanayaka, P. and Wade, S.L., "Long-term neural processing of attention following early childhood traumatic brain injury: fMRI and neurobehavioral outcomes".J Int Neuropsychol Soc, 14:424-35, 2008.

Tillema, J.M., Byars, A.W., Jacola, L.M., Schapiro, M.B., Schmithorst, V.J., Szaflarski, J.P. and Holland, S.K., "Cortical reorganization of language functioning following perinatal left MCA stroke". Brain Lang, 105:99-111, 2008.

Yuan, W., Altaye, M., Ret, J., Schmithorst, V., Byars, A.W., Plante, E. and Holland, S.K., "Quantification of head motion in children during various fMRI language tasks". Hum Brain Mapp, 2008.

Altaye, M., Holland, S.K., Wilke, M. and Gaser, C., "Infant brain probability templates for MRI segmentation and normalization". Neuroimage, 2008.

Pirko, I., Nolan, T.K., Holland, S.K. and Johnson, A.J., "Multiple sclerosis: pathogenesis and MR imaging features of T1 hypointensities in murine model".Radiology, 246:790-5, 2008.

Vannest, J., Szaflarski, J.P., Privitera, M.D., Schefft, B.K. and Holland, S.K., "Medial temporal fMRI activation reflects memory lateralization and memory performance in patients with epilepsy". Epilepsy Behav, 12:410-418, 2008.

Wilke, M. and Holland, S.K., "Structural MR Imaging Studies of the Brain in". Neuroembryology and Aging, 5:6-13, 2008.

Wilke, M., Holland, S.K., Altaye, M. and Gaser, C., "Template-O-Matic: A toolbox for creating customized pediatric templates". Neuroimage, 41:903-913, 2008.

Wilke, M., Krageloh-Mann, I. and Holland, S.K., "Global and local development of gray and white matter volume in normal children and adolescents".Exp Brain Res, 178:296-307, 2007.

Holland, S.K., Vannest, J., Mecoli, M., Jacola, L.M., Tillema, J.M., Karunanayaka, P.R., V.J., S., Yuan, W.H., Plante, E. and Byars, A.W., "Functional MRI of Language Lateralization During Development in Children".International Journal of Audiology., 46:533-551, 2007.

Patel, A., Cahill, L.D., Ret, J.K., Schmithorst, V.J., Choo, D.I. and Holland, S.K., "Functional Magnetic Resonance Imaging of Hearing-Impaired Children Under Sedation Before Cochlear Implantation". Archives of Otolaryngology, Head and Neck Surgery, 133:677-683, 2007.

Karunanayaka, P.R., Holland, S.K., Yuan, W., Altaye, M., Jones, B.V., Michaud, L.J., Walz, N.C. and Wade, S.L., "Neural substrate differences in language networks and associated language-related behavioral impairments in children with TBI: A preliminary fMRI investigation". NeuroRehabilitation, 22:355-69, 2007.

Karunanayaka, P.R., Holland, S.K., Schmithorst, V.J., Solodkin, A., Chen, E.E., Szaflarski, J.P. and Plante, E., "Age-related connectivity changes in fMRI data from children listening to stories". Neuroimage, 34:349-60, 2007.

Difrancesco, M.W., Holland, S.K., Ris, M.D., Adler, C.M., Nelson, S., Delbello, M.P., Altaye, M. and Brunner, H.I., "Functional magnetic resonance imaging assessment of cognitive function in childhood-onset systemic lupus erythematosus: A pilot study". Arthritis Rheum, 56:4151-63, 2007.

Yuan, W., Holland, S.K., Schmithorst, V.J., Walz, N.C., Cecil, K.M., Jones, B.V., Karunanayaka, P., Michaud, L. and Wade, S.L., "Diffusion tensor MR imaging reveals persistent white matter alteration after traumatic brain injury experienced during early childhood". AJNR Am J Neuroradiol, 28:1919-25, 2007.

Schmithorst, V.J., Holland, S.K. and Plante, E., "Object identification and lexical/semantic access in children: A functional magnetic resonance imaging study of word-picture matching". Hum Brain Mapp, 28:1060-74, 2007.

Schmithorst, V.J., Holland, S.K. and Plante, E., "Development of effective connectivity for narrative comprehension in children".NeuroReport, 18:2007.

Schmithorst, V.J., Holland, S.K. and Dardzinski, B.J., "Developmental differences in white matter architecture between boys and girls".Hum Brain Mapp, 2007.

Schmithorst, V.J. and Holland, S.K., "Sex differences in the development of neuroanatomical functional connectivity underlying intelligence found using Bayesian connectivity analysis". Neuroimage, 2007.

Plante, E., Schmithorst, V.J., Holland, S.K. and Byars, A.W., "Sex Differences in the Activation of Language Cortex During Childhood". Neuropsychologia, 44:1210-21, 2006.

Plante, E., Holland, S.K. and Schmithorst, V.J., "Prosodic processing by children: An fMRI study". Brain Lang, 97:332-42, 2006.

Chiu, C.-Y.P., Schmithorst, V.J., Brown, R.D., Holland, S.K. and Dunn, R.S., "Making memories: A cross-sectional investigation of episodic memory encoding in children using fMRI."Developmental Neuropsychology., 29:321–40, 2006.

Adler, C.M., Adams, J., DelBello, M.P., Holland, S.K., V.J., S., Levine, A., Jarvis, K. and Strakowski, S.M., "Evidence of white matter pathology in bipolar disorder adolescents experiencing their first episode of mania: A diffusion tensor imaging study". American Journal of Psychiatry, 163:322-4, 2006.

Yuan, W., Szaflarski, J.P., Schmithorst, V.J., Schapiro, M., Byars, A.W., Strawsburg, R.H. and Holland, S.K., "fMRI shows atypical language lateralization in pediatric epilepsy patients". Epilepsia, 47:593-600, 2006.

Yuan, W., Holland, S.K., Cecil, K.M., Dietrich, K.N., Wessel, S.D., Altaye, M., Hornung, R.W., Ris, M.D., Egelhoff, J.C. and Lanphear, B.P., "The impact of early childhood lead exposure on brain organization: a functional magnetic resonance imaging study of language function". Pediatrics, 118:971-7, 2006.

Jacola, L.M., Schapiro, M.B., Schmithorst, V.J., Byars, A.W., Strawsburg, R.H., Szaflarski, J.P., Plante, E. and Holland, S.K., "Functional magnetic resonance imaging reveals atypical language organization in children following perinatal left middle cerebral artery stroke". Neuropediatrics, 37:46-52, 2006.

Adhami, F., Liao, G., Schloemer, A., Morozov, Y.M., Schmithrost, V.J., Lorenz, J.N., Dunn, R.S., Vorhees, C.V., Wills-Karp, M., Davis, R.J., Rakic, P., Dardzinski, B.J., Holland, S.K., Sharp, F.R. and Kuan, C.Y., "Cerebral Ischemia-Hypoxia Induces Intravascular Coagulation and Autophagy. "American Journal of Pathology, 169:566-83, 2006.

Szaflarski, J.P., Schmithorst, V.J., Altaye, M., Byars, A.W., Ret, J., Plante, E. and Holland, S.K., "A longitudinal functional magnetic resonance imaging study of language development in children 5 to 11 years old".Ann Neurol, 59:796-807, 2006.

Szaflarski, J.P., Holland, S.K., Schmithorst, V.J. and Byars, A.W., "fMRI study of language lateralization in children and adults". Hum Brain Mapp, 27:202-12, 2006.

Schmithorst, V.J., Plante, E. and Holland, S.K., "Cognitive Modules Utilized for Narrative Comprehension in Children: A Functional Magnetic Resonance Imaging Study". Neuroimage, 26:254-66, 2006.

Schmithorst, V.J. and Holland, S.K., "Functional MRI Evidence for Disparate Developmental Processes Underlying Intelligence in Boys and Girls". Neuroimage, 31:1366-79, 2006.

Presentations, Most Recent

Karunanayaka, P.R., Holland, S.K., Schmithorst, V.J. and Plante, E., "Age-related Connectivity Changes in fMRI Data from Children Performing a Covert Verb Generation Task.". ISMRM 16th Scientific Meeting, Toronto, CA, 2008.

Wade, S.L., Yuan, W.H., Walz, N.C., Holland, S.K., Karunanayaka, P.R. and Michaud, L.J., "White matter damage following pediatric brain injury as assessed using diffusion tensor imaging.". American Academy of Physical Medicine and Rehabilitation 68th Annual Assembly, Boston, MA, 2008.

Karunanayaka, P.R., Holland, S.K., Yuan, W.H., Altaye, M., Jones, B.V., Michaud, L.J., Walz, N.C. and Wade, S.L., "Abnormalities in language circuitry in children with traumatic brain injury: a functional magnetic resonance imaging study". American Academy of Physical Medicine and Rehabilitation 68th Annual Assembly, Boston, MA, 2008.

Rasmussen, J., Vannest, J., Schmithorst, V.J., Karunanayaka, P., Byars, A.W. and Holland, S.K., "Neural Activity in Language Areas Reflects Verb Generation Performance in Children". Cognitive Neuroscience, San Francisco, CA, 2008.

Vannest, J., Rasmussen, J., Schmithorst, V.J., Karunananayaka, P., Byars, A.W. and Holland, S.K., "Neural Activity in Language Areas Reflects Verb Generation Performance in Children". Soc. for Pediatric Radiology, 51st Meeting, Scottsdale, AZ, 2008.

Vannest, J., Karunananayaka, P., Altaye, M., Schmithorst, V.J., Plante, E. and Holland, S.K., "Comparison Between Event-Related and Block-Periodic fMRI Data from a Story Processing Task in Children". Soc. for Pediatric Radiology, 51st Meeting, Scottsdale, AZ, 2008.

Eaton, K., Ball, A.P., Altaye, M., Holland, S.K., Szaflarski, J.P. and Kissela, B.M., "Reliability of fMRI for Studies of Language Recovery and Development". Soc. for Pediatric Radiology, 51st Meeting, Scottsdale, AZ, 2008.

Vannest, J., Karunanayaka, P., Altaye, M., Schmithorst, V.J., Plante, E. and Holland, S.K., "Neural Substrate Differences in Language Networks and Associated Language-Related Behavioral Impairments in Children with TBI". Soc. for Pediatric Radiology, 51st Meeting, Scottsdale, AZ, 2008.

Holland, S.K., "Functional MRI in Children: Fundamentals and applications". Soc. for Pediatric Radiology, 51st Meeting, Scottsdale, AZ, 2008.

Yuan, W.H., Holland, S.K., Jones, B.V., Crone, K., Szalewski, K. and Mangano, F.T., "White matter characteristics in children with supratentorial temors:  A DTI study". Soc. for Pediatric Radiology, 51st Meeting, Scottsdale, AZ, 2008.

Beebe, D., DiFrancesco, M., Tlllustos, S., McNally, K. and Holland, S.K., "The effects of sleep restriction on neural function in adolescents:  An fMRI pilot study". Soc. for Pediatric Radiology, 51st Meeting, Scottsdale, AZ, 2008.

Altaye, M., Gaser, C., Mecoli, M.D., Egelhoff, J.C., Wilke, M. and Holland, S.K., "Probability Templates for Spatial Normalization and Segmentation of Infant Brain". Soc. for Pediatric Radiology, 51st Meeting, Scottsdale, AZ, 2008.

Vannest, J., Rasmussen, J., Szaflarski, J.P., Szalewski, K., Schmithorst, V.J. and Holland, S.K., "The Neural Basis of Left−Lateralized and Bilateral Language Functions in Children and Young Adults". American Academy of Neurology 60th Meeting, Chicago, IL, 2008.

Holland, S.K., Karunanayaka, P., Smith, K., Rajagopal, A., ALtaye, M., Care, M., Egelhoff, J. and Choo, D.I., "MRI Provides A Window Into Central Auditory Processing In Hearing Impaired Infants Prior To Cochlear Implantation". 10th International Conference on Cochlear Implants & Other Implantable Auditory Technologies, San Diego, CA, 2008.

Holland, S.K., P, K., Plante, E. and Smithorst, V.J., "An fMRI-based structural equation model for natural language processing shows age-dependent changes in brain connectivity." Acoustical Society of America, Paris, France, 2008.

Holland, S.K., P, K., Rajagopal, A. and Smith, K., "fMRI evidence for central auditory processing of speech in deaf infants under  sedation". Acoustical Society of America, Paris, France, 2008.

Beebe, D., DiFrancesco, M., Holland, S.K., Tlustos, S., McNally, K. and Amin, R., "The Effects of Chronic Sleep Deprivation on Attention Networks in Adolescents: An fMRI Pilot Study". 10th Cincinnati Neurofest: Environmental Factors in Neuron Health and Diease, Cincinnati, Ohio, 2008.

Hirschauer, T., DiFrancesco, M., Holland, S.K., Privitera, M.D. and Szaflarski, J.P., "Imaging absence seizures with EEG/fMRI at 4T". American Epilepsy Society, Seattle, Wash., 2008.

Rajagopal, A., Holland, S.K., Bernard, L., Walz, N.C., Staat, M.A. and Wade, S.L., "An fMRI Study of Language Function in International Adoptees". The Society for Developmental and Behavioral Pediatrics, Cincinnati, OH, 2008.

Wilke, M., Holland, S.K., Altaye, M. and Gaser, C., "Employing the general linear model for creating customized pediatric templates". 14th Annual Meeting of the Organization for Human Brain Mapping (OHBM), Melbourne, Australia, 2008.

Cahill, L.D., Sharma, A., Brown, D., Scheifele, P., Keith, R.W. and Holland, S.K., "fMRI and P1 in Pediatric Cochlear Implant Candidates". American Academy of Audiology, Charlotte, NC, 2008.

Vannest, J., Rasmussen, J., Szaflarski, J.P., Szalewski, K., Schmithorst, V.J. and Holland, S.K., "The Nerual Basis of Left-Lateralized and Bilateral Language Functions in Children and Young Adults.". 15th Annual Cognitive Neuroscience, San Francisco, CA, 2008.

Rasmussen, J., Vannest, J., Schmithorst, V.J., Karunanayaka, P., Byars, A.W. and Holland, S.K., "Nerual Activity in Language Areas Reflec ts Verb Generation Performance in Children". 15th Annual Cognitive Neuroscience, San Francisco, CA, 2008.

Beebe, D.W., DiFrancesco, M., Holland, S.K., Tlustos, S., McNally, K. and Amin, R., "Neural Response to Chronic Sleep Restriction in Adolescents: A Pilot fMRI Study". International Neuropsychology Society, 2008.

Yuan, W.H., Holland, S.K., Jones, B.V., Dardzinski, B.J., Crone, K., Bierbrauer, K. and Mangano, F.T., "Normative values of DTI parameters in young children". Am Soc of Neuroradiology, Chicago, 45:2007.

Yuan, W.H., Holland, S.K., Jones, B.V., Crone, K. and Mangano, F.T., "DTI study of children with supratentorial tumors ". Am Soc of Neuroradiology, Chicago, 45:2007.

Yuan, W., Holland, S., Walz, N., Cecil, K., Jones, B., Karunanayaka, P., Michaud, L. and Wade, S.L., "Assessing white matter diffusion abnormality with DTI in young children with traumatic brain injury". 13th Annual Meeting of the Organization for Human Brain Mapping (OHBM), Chicago, IL, 2007.

Wade, S.L., Yuan, W.H., Walz, N.C., Holland, S.K., Karunanayaka, P. and Michaud, L., "White Matter Damage following Pediatric Brain Injury as Assessed Using DTI. " 35th Itnl Neuropsych Soc. Annual Meeting, Portland, OR, 2007.

Vannest, J., Karunanayaka, P., Altaye, M., Schmithorst, V., Plante, E., Eaton, K. and Holland, S.K., "Comparison between event-related and block-periodic fMRI data from a story processing task in children. " 13th Annual Meeting of the Organization for Human Brain Mapping (OHBM), Chicago, IL, 2007.

Vannest, J., Holland, S.K., Privitera, M.D., Schefft, B.K. and Szaflarski, J.P., "fMRI activation in medial temporal areas reflects memory lateralization and memory performance in epilepsy patients". 13th Annual Meeting of the Organization for Human Brain Mapping (OHBM), Chicago, IL, 2007.

Szaflarski, J.P., Eaton, K.P., Ball, A.P., Holland, S.K., Altaye, M., Kissela, B.M. and Banks, C., "Reliability Estimates of fMRI Language Localization at 4T in Control and Left Middle Cerebral Artery (LMCA) Stroke Subjects". 58th Annual Meeting of the American Academy of Neurology, Boston, 2007.

Szaflarski, J.P., Eaton, K., Ball, A., Altaye, M., Kissela, B., Banks, C. and Holland, S.K., "Reliability Estimates of fMRI Language Localization at 4T in Control and Left Middle Cerebral Artery (LMCA) Stroke Subjects". 13th Annual Meeting of the Organization for Human Brain Mapping (OHBM), Chicago, IL, 2007.

Newmeyer, A., Tillema, J.M. and Holland, S.K., "An Event-Related fMRI Paradigm To Study Overt Speech in Pediatric Subjects". Pediatric Academic Societies' Annual Meeting, Toronto, 2007.

Mecoli, M.D., Karunanayaka, P., Altaye, M., Huei, T., Choo, D.I., Arjmand, E., Egelhoff, J.C., Schmithorst, V.J. and Holland, S.K., "fMRI of Deaf Infants Under Sedation Prior to Cochlear Implantation". Am Soc of Neuroradiology, Chicago, 45:2007.

Mecoli, M.D., Holland, S.K., Karunanayaka, P., Egelhoff, J.C., Schmithorst, V.J., Altaye, M., Cahill, L.D., Brown, D. and Choo, D.I., "Correlations of fMRI Activation in Auditory Cortex and Hearing Levels in Infants with Congenital Hearing Impairment Prior to Cochlear Implantation". 11th Int'l Conf. on Cochlear Implants in Children, Charlotte, NC, 2007.

Mecoli, M.D., Egelhoff, J.C., Karunanayaka, P., Schmithorst, V.J. and Holland, S.K., "Human Primary Auditory Cortex Volume in Deaf and Normal Hearing Infants". Am Soc of Neuroradiology, Chicago, 45:2007.

Mecoli M, Egelhoff, J.C., Karunanayaka, P.R., Schmithorst, V.J. and Holland, S.K., "Heschl’s Gyrus Volume in Hearing Impaired and Normal Hearing Infants". 13th Annual Meeting of the Organization for Human Brain Mapping (OHBM), Chicago, IL, 2007.

Altaye, M., Gaser, C., Mecoli, M., Huie, T., Egelhoff, J., Wilke, W. and Holland, S.K., "Infant brain probability templates for segmentation and normalization". 13th Annual Meeting of the Organization for Human Brain Mapping (OHBM), Chicago, IL, 2007.

Cahill, L.D., Mehta, D., Mecoli, M.D., Choo, D.I. and Holland, S.K., "fMRI of auditory function in CHARGE Syndrome prior to cochlear implantation." 11th Int'l Conf. on Cochlear Implants in Children, Charlotte, NC, 2007.

Chiu, C.-Y.P., Brown, R.D., Schmithorst, V.J. and Holland, S.K., "A Cross-sectional fMRI Investigation of Episodic Encoding: Insights from Independent Component Analysis (ICA)". Soc. Research in Child Development, Boston, MA, 2007.

Eaton, K., Ball, A., Altaye, M., Kissela, B., Banks, C., Holland, S.K. and Szaflarski, J.P., "Comparison of Reliability Estimates of fMRI Language Localization for Verb Generation and Semantic/Tone Decision Tasks at 4T in Control and Left Middle Cerebral Artery (LMCA) Stroke Subjects". 13th Annual Meeting of the Organization for Human Brain Mapping (OHBM), Chicago, IL, 2007.

Espay, A.J., DiFrancesco, M.W., Holland, S.K., Privitera, M., Turner, M. and Szaflarski, J.P., "Epilepsia Partialis Continua (EPC) Presenting as Isolated Hemifacial Spasm (IHFS): EEG/fMRI Correlates at 4T"". 58th Annual Meeting of the American Academy of Neurology, Boston, 2007.

Gaser, C., Altaye, M., Wilke, M. and Holland, S.K., "Unified Segmentation Without Tissue Priors". 13th Annual Meeting of the Organization for Human Brain Mapping (OHBM), Chicago, IL, 2007.

Huang, L., Thompson, E., Schmithorst, V.J., Holland, S.K. and Talavage, T., "Partially Adaptive STAP for fMRI: A Method for Detecting Brain Activation Regions in Simulation and Human Data". IEEE Intl' Symp on Biomedical Imaging, 2007.

Jacola, L.M., Byars, A.W., Chalfonte-Evans, M., Schmithorst, V.J., Hickey, F., Patterson, B., Hotze, S., Holland, S.K. and Schapiro, M.B., "FMRI reveals atypical activation in persons with Down syndrome during a story processing task." 13th Annual Meeting of the Organization for Human Brain Mapping (OHBM), Chicago, IL, 2007.

Kaimal, V., Holland, S.K., Chu, Z., Richardson, D.D. and Qi, X., "MR Imaging of targeted delivery of drug and contrast agents to tumors in vivo using liposomes". ISMRM Molecular Imaging Workshop 2007.

Karunanayaka, P., Holland, S.K., Mecoli, M.D., Egelhoff, J.C., Schmithorst, V.J., Altaye, M., Brown, D. and Choo, D.I., "fMRI shows differences in auditory activation between infants with normal hearing and bilateral sensorineural deafness. " 11th Int'l Conf. on Cochlear Implants in Children, Charlotte, NC, 2007.

Karunanayaka, P.R., Holland, S.K., Yuan, W.H., Altaye, M., Egelhoff, J.C., Michaud, L., Walz, N.C. and Wade, S.L., "Abnormal language processing following brain injury in young children as measured by fMRI." 13th Annual Meeting of the Organization for Human Brain Mapping (OHBM), Chicago, IL, 2007.

Kaimal, V., Holland, S.K., Schmithorst, V.J. and Qi, X., "MR Detection of Tumor Cells Labeled with USPIO using DOPS Liposomes". ISMRM 14th Scientific Meeting, Seattle, WA, 2006.

Karunanayaka, P.R., Holland, S.K., Schmithorst, V.J., Solodkin, A., Altaye, M. and Plante, E., "Functional connectivity among cognitive modules utilized for narrative story comprehension". 12th Annual Meeting of the Organization for Human Brain Mapping (OHBM), Florence, Italy, 2006.

Karunanayaka, P.R., Holland, S.K., Schmithorst, V.J., Solodkin, A. and Plante, E., "Age related connectivity changes in fMRI data from children performing a narrative story comprehension task. " 12th Annual Meeting of the Organization for Human Brain Mapping (OHBM), Florence, Italy, 2006.

DiFrancesco, M.W., Yuan, W.H., Pratt, W.H. and Holland, S.K., "Comparison of Contrast-to-Noise Ratio for in vivo Mouse Brain Imaging at 3T and 7T under Nearly Identical Scanner Configurations". ISMRM 14th Scientific Meeting, Seattle, WA, 2006.

Holland, S.K., Choo, D.I., Schmithorst, V.J., Altaye, M., Karunanayaka, P., Patel, A., Brown, D., Eads, E., Hilbert, L. and Cahill, L., "Auditory Activation in Sedated Hearing Impaired Infants". 12th Annual Meeting of the Organization for Human Brain Mapping (OHBM), Florence, Italy, 2006.

Holland, S.K., Choo, D.I., Schmithorst, V.J., Altaye, M., Karunanayaka, P.R., Patel, A., Brown, D., Eads, E., Hilbert, L. and Cahill, L., "Can fMRI Predict Outcome for Cochlear Implantation in Children?" 9TH Intl' Conf. on Cochlear Implants, Vienna, Austria, 2006.

Jacola, L.M., Schapiro, M., Patterson, B., Hickey, F., Chalfonte-Evans, M., Schmithorst, V.J., Byars, A.W., S., H. and S.K., H., "FMRI reveals altered patterns of brain activation during language processing in persons with Down syndrome. In: Organization for Human Brain Mapping". 12th Annual Meeting of the Organization for Human Brain Mapping (OHBM), Florence, Italy, 2006.

Jacola, L.M., Schapiro, M.B., Patterson, B., Hickey, F., Chalfonte-Evans, M., Schmithorst, V.j., Byars, A.W., Hotze, S. and Holland, S.K., "FMRI reveals altered patterns of brain activation during language processing in persons with Down syndrome". 9th World Downs Syndrome Congess, Vancouver, BC, 2006.

Karunanayaka, P., Holland, S.K., Schmithorst, V.J., Solodkin, A. and Plante, E., "Age Related Connectivity Changes in fMRI Data from Children Listening to Stories." SMRM 14th Scientific Meeting, Seattle, WA, 2006.

Schmithorst, V.J., DiFrancesco, M., Dardzinski, B.J. and Holland, S.K., "Sex Differences in White Matter Diffusion Anisotropy in the Normal Pediatric Population. " SMRM 14th Scientific Meeting, Seattle, WA, 2006.

Schmithorst, V.J. and Holland, S.K., "Differences between Boys and Girls in the Correlation of Functional Brain Connectivity and Intelligence". SMRM 14th Scientific Meeting, Seattle, WA, 2006.

Schmithorst, V.J. and Holland, S.K., "The development of functional and effective connectivity for narrative processing in children investigated via functional MRI and Multivariate Autoregressive Modeling." SMRM 14th Scientific Meeting, Seattle, WA, 2006.

Schmithorst, V.J. and Holland, S.K., "A Data-Driven Method for Analysis of Associated Time Courses Found from Group Independent Component Analysis." SMRM 14th Scientific Meeting, Seattle, WA, 2006.

Schmithorst, V.J., Holland, S.K. and Plante, V.J., "Object Identification and Lexical/Semantic Access in Children: A Functional Magnetic Resonance Imaging Study of Word-Picture Matching". 12th Annual Meeting of the Organization for Human Brain Mapping (OHBM), Florence

Professional Organization Memberships

  • Acoustical Society of America
  • American Association of Physicists in Medicine
  • Sigma Xi
  • Institute of Electronics and Electrical Engineers
  • International Society of Magnetic Resonance in Medicine
  • American Assn. for the Advancement of Science
  • American Society of Neuroradiology
  • Organization for Human Brain Mapping

Related Areas

This person works in these other areas at Cincinnati Children's Hospital Medical Center: