Rheumatology

Matthew J. Flick, PhD

Title

Instructor

Appointment

Instructor

Email

matthew.flick@cchmc.org

Phone

513-636-6628

Fax

513-636-4317

Credentials

BS: Xavier University, Cincinnati, OH
PhD: Purdue University, West Lafayette, IN
Research Fellow: Children's Hospital Research Foundation

Awards and Honors

Arthritis Foundation Research Conference Travel Award, 2007
International Fibrinogen Research Society Young Investigator Award for the XVIII Workshop, 2004

Research

Hemostatic factors and arthritis pathogenesis

Publications, Most Recent

Flick, M.J., Du, X., Witte, D.P., Jirousková, M., Soloviev., D.A., Busuttil., S.J., Plow, E.F., and Degen, J.L. (2004) Leukocyte engagement of fibrin(ogen) via the integrin receptor alphaMbeta2 / Mac-1 is critical for host inflammatory response in vivo.Journal of Clinical Investigation. 113:1596-1606.

Flick M.J., Du X, Degen J.L. (2004) Fibrin(ogen)-alpha M beta 2 interactions regulate leukocyte function and innate immunity in vivo.Experimental Biology and Medicine. 229(11):1105-1110.

Palumbo J.S., Talmage K.E., Massari J.V., La Jeunesse C.M., Flick M.J., Kombrinck K.W., Jirouskova M., Degen J.L. (2005) Platelets and fibrin(ogen) increase metastatic potential by impeding natural killer cell-mediated elimination of tumor cells.Blood. 105(1):178-185.

Adams, R.A., Bauer, J., Flick, M.J., Sikorski, S., Nuriel, T., Hans Lassmann, Degen, J.L., Akassoglou, K. (2007) The fibrin-derived ?377-395 peptide inhibits microglia activation and reverses relapsing paralysis in central nervous system autoimmune disease.Journal of Experimental Medicine, 204(3):571-582.

Palumbo, J.S., Talmage, K.E., Massari, J.M., La Jeunesse, C.M., Flick, M.J., Kombrinck, K.W., Hu, Z., Barney, K.A., Degen, J.L. (2007) Tumor cell-associated tissue factor and circulating hemostatic factors cooperate to increase metastatic potential through natural killer cell-dependent and -independent mechanisms.Blood, Accepted for publication.

Flick, M.J., La Jeunesse C.M., Talmage K.E., Witte, D.P., Palumbo, J.S., Pinkerton, M.D., Thornton, S., Degen, J.L. (2007) Fibrin(ogen) promotes inflammatory joint disease progression via its αMβ2 binding domain.Journal of Clinical Investigation, Accepted for publication.

Presentations, Most Recent

Flick, M.J., Du, X., Talmage†,K.E., Christine M. La Jeunesse, C.M., Witte, D.P., Soloviev, D.A., Plow,E.F., and Degen, J.L. (2004) Leukocyte Clearance of S. Aureus is Regulated by Fibrin(ogen) Interaction With the Integrin αMβ2/Mac-1. XVIII International Fibrinogen Workshop, Chapel Hill, North Carolina (Oral Presentation).

Flick, M.J., La Jeunesse, C. M., Talmage, K.E., Pinkerton, M.D., Thornton, S., Degen, J.L. (2004) Fibrinogen deficiency diminishes collagen-induced arthritis but not inflammatory joint disease driven by TNFα. American College of Rheumatology Meeting, San Antonio, Texas.

Flick, M.J., Thornton, S., LaJeunesse, C.M., Talmage, K.E., Witte, D.P., and Degen J.L. (2005) Plasminogen is a determinant of cytokine-driven inflammatory joint disease. Xth International Workshop on Molecular & Cellular Biology of Plasminogen Activation. Washington DC (Oral Presentation).

Flick, M.J., La Jeunesse, C.M., Talmage, K.E., Witte, D.P., Palumbo, J.S., Pinkerton, M.D., Thornton, S., and Degen, J.L. (2005) Hemostatic factors regulate immune surveillance and contribute to the rapid clearance of bacteria pathogens in vivo. American Society of Hematology.

Flick, M.J., Welch, S., La Jeunesse, C.M., Talmage, K.E., Mullins, E.S., Palumbo, J.S., Thornton, S. and Degen, J.L. (2006) Mice expressing a thrombin variant engineered to favor anticoagulant function are resistant to S. aureus-induced sepsis. 18th International Congress on Fibrinolysis and Proteolysis. (Oral Presentation).

Flick, M.J., La Jeunesse C.M., Talmage K.E., Witte, D.P., Palumbo, J.S., Pinkerton, M.D., Thornton, S., Degen, J.L. (2006) Fibrin(ogen) promotes inflammatory joint disease progression via its αMβ2 binding domain. American Society of Hematology. (Oral Presentation).

Flick, M.J., La Jeunesse C.M., Talmage K.E., Witte, D.P., Palumbo, J.S., Pinkerton, M.D., Thornton, S., Degen, J.L. (2007) Fibrinogen deficiency ameliorates collagen-induced arthritis. Arthritis Foundation Research Conference. (Oral Presentation).