Clinical Studies, Including Trials and Interventions
Research is an essential part of the mission of the Division of Rheumatology at Cincinnati Children's Hospital Medical Center. The division is doing research in many areas. In our research labs we study genetics, outcomes and treatment of many pediatric rheumatic diseases, including Juvenile Rheumatoid Arthritis (JRA). Currently active research protocol, including clinical trials, involving children with rheumatic diseases (and their families) are listed below:
Juvenile Rheumatoid Arthritis and Other Inflammatory Joint Diseases
- Gene Expression in Juvenile Rheumatoid Arthritis (JRA) and Juvenile Spondyloarthopathy (JSpA): David Glass, MD, and Bob Colbert, MD PhD
- Quantitative MR Imaging of Cartilage and Synovium in JRA: Bernard Dardzinski, PhD
- Phase III, Multi-Center, Multi-National, Randomized, Withdrawal Study to Evaluate the Safety and Efficacy of Abatacept for the Treatment of JRA: Daniel Lovell, MD, MHP, and Edward Giannini, DrPH
- Phase IV Registry of Etanercept in JRA: Daniel Lovell, MD, MHP, and Edward Giannini, DrPH
- Juvenile Rheumatoid Arthritis (JRA) - Family Blood Samples: David Glass, MD
- Long Term Outcome of JRA: Daniel Lovell, MD, MHP
- Advanced CHAQ Study – Development of an improved Measure of Physical Function of Children with Arthritis: Hermine Brunner, MD, MSc
- Etanercept Use in Clinical Pediatric Rheumatology - A Descriptive of Clinical Effect and Adverse Events in Eighty Consecutive Patients: Daniel Lovell, MD, MHP
- Altered Sibship Size and Sex Ratios in Families with Early Onset Pauciarticular Juvenile Rheumatoid Arthritis: David Glass, MD
- Persistence of Systemic Features in Hispanics with Persistent Systemic Onset JRA: Daniel Lovell, MD, MHP
- Improved Assessment of Children with Juvenile Idiopathic Arthritis using Biomechanical Testing: Hermine Brunner, MD, MSc
- Cost and Outcomes in Juvenile Rheumatoid Arthritis: Cost effectiveness Analysis: Hermine Brunner, MD, MSc
Systemic Lupus Erythematosus (SLE, Lupus)
- Lupus APPLE Study – Phase II/III Multicenter Randomized Trial of Atorvastatin (Lipitor") for the Prevention of Atherosclerosis in Children with Lupus: Hermine Brunner, MD, MSc
- Nitric Oxide Metabolism in Atorvastatin-treated Lupus (APPLE Substudy): Hermine Brunner, MD, MSc
- Multisite, Multinational Study: Towards Guidelines for the Use of Steroids in Children with Lupus: Hermine Brunner, MD, MSc
- Variations of Complement in Health and Diseases in Lupus: Hermine Brunner, MD, MSc
- Meaningful Outcomes for Pediatric Lupus Clinical Trials: Hermine Brunner, MD, MSc
- Long-Term Outcomes in Childhood-Onset Lupus - Neurocognitive Function: Hermine Brunner, MD, MSc
- Development of Autoimmunity in Puberty in Childhood SLE: Hermine Brunner, MD, MSc
- Lupus Clinical and Research Database: Hermine Brunner, MD, MSc
- Phase II/III Multicenter Randomized Clinical Trial of Triptorelin for Ovary Protection in Childhood Lupus: Hermine Brunner, MD, MSc
Mixed Connective Tissue Disease (MCTD)
Juvenile Fibromyalgia
Juvenile Dermatomyositis
- Clinical and Pathogenetic Significance of the Vasculopathy in Juvenile Dermatomyositis: Alexei Grom, MD
For more information about the Rheumatology Division at Cincinnati Children's Hospital Medical Center, please call 513-636-4676.
