Tourette Syndrome Research
The Tourette Syndrome Clinic at Cincinnati Children's Hospital Medical Center is committed to developing new and better treatments for Tourette Syndrome and associated neuropsychiatric symptoms. New and promising treatments will be offered to children and their families only as part of safe, ethical, carefully designed studies, approved by Cincinnati Children's investigational review board. In addition, we are doing research to determine possible causes of Tourette's Syndrome.
Current Research
Two related epidemiologic studies of Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcal infections (PANDAS). The purpose of these multi-center studies is to determine whether some patients with Tourette's Syndrome or Obsessive Compulsive Disorder / OCD can have their symptoms caused or made worse by exposure to Group A Beta Hemolytic Streptococcal bacteria (strep throat). These studies are funded by the National Institutes of Health.
A multi-center trial of a new agent for treatment of ADHD, atomoxetine, in children and adolescents with tics or Tourette's Syndrome. This trial is being performed in conjunction with the Cincinnati Children's Division of Child Psychiatry, directed by F. Randy Salle, MD, PhD, and is funded by Lilly Pharmaceuticals.
A study of the neurophysiology of motor cortex in persons with or at risk for Tourette Syndrome. This study uses an investigational device called a Transcranial Magnetic Stimulator. The purpose of this study is to better understand the brain abnormalities which produces unwanted movements. This study is funded by a research grant from the Tourette Syndrome Association.
Phase II study of investigational novel dopamine receptor agonist/antagonist aripiprazole for conduct disorder. This trial is being performed in conjunction with the Cincinnati Children's Division of Psychiatry, directed by F. Randy Salle, MD, PhD, and is funded by Bristol-Myers Squibb.
