Find a Health Care Professional / Researcher

Paul R. Andreassen, PhD

Appointment

Assistant Professor of Pediatrics, University of Cincinnati College of Medicine

Email

paul.andreassen@cchmc.org

Phone

(513) 636-0499

Fax

(513) 803-0783

Credentials

BS: Willamette University, Salem, Oregon, 1984

PhD: University of Washington, Seattle, Washington, 1995

Position History

2009-Present: Member, Graduate Program in Molecular and Developmental Biology, Cincinnati Children's Hospital, Cincinnati,OH.
2006-Present: Member, Graduate Program in Cancer and Cell Biology, University of Cincinnati, Cincinnati, OH.
2004-Present: Assistant Professor of Pediatrics, Cincinnati Children's Hospital Medical Center, Division of Experimental Hematology, Leukemia Biology Program, Cincinnati, OH.
2000-2004: Postdoctoral Research Fellow, Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA.
1993-1999: Researcher, Institut de Biologie Structurale (CEA-CNRS), Grenoble, France.
1986-1992: Predoctoral Research Fellow, Department of Pathology, Fred Hutchinson Cancer Research Center and the University of Washington, Seattle, WA.

Awards and Honors

Special Fellow Award, Leukemia and Lymphoma Society (2001-2004)

Magna Cum Laude, Willamette University (1984)

Research

Connect to Paul Andreassen's laboratory page

Our research focuses on the relationship of cell cycle checkpoints and DNA damage responses to the genetic instability that underlies the development of cancer. We are studying the rare disease Fanconi Anemia (FA) and breast cancer susceptibility (BRCA) to gain insight into this process. Some breast and ovarian cancer genes are also FA genes.FA is characterized by chromosome instability, progressive bone marrow failure, and a predisposition to leukemia and other cancers. The lab is using molecular and cell biological, biochemical, and genetic approaches ti understand the regulation and function of FA/BRCA proteins in DNA repair. The lab is also interested in applying these studies to improved approaches to cancer therapy.

Research Grants and Contracts

NIH R01 HL085587 (PI: Paul Andreassen)

National Heart, Lung, and Blood Institute 7/8/2008 - 6/30/2013

"FANCD2 monoubiquitination in DNA damage responses"

Publications, Most Recent

Connect to Paul Andreassen's publications on PubMed

Andreassen PR and Niedernhofer LJ. Fanconi Anemia: A paradigm of discovering molecular pathways from patients. Mutat. Res. 2009 668 (1-2):1-3.

Andreassen PR and Ren K. Fanconi Anemia proteins, DNA interstrand crosslink repair patways, and cancer therapy.CurrentCancer Drug Targets. 2009 9(1): 101-17.

Fan Q, Zhang F, Barrett B, Ren K and Andreassen PR. A role for monoubiquitinated FANCD2 at telomeres in ALT cells. Nucleic Acids Res. 2009 37(6): 1740-54.

Pang Q and Andreassen PR. Fanconi anemia proteins and endogenous stresses. Mutat. Res. 2009 668(1-2):42-53.

Singh TR, Bakker ST, Agarwal S, Jansen M, Grassman E, Godthelp BC, Ali AM, Du CH, Rooimans MA, Fan Q, Wahengbam K, Steltenpool J, Andreassen PR, Williams DA, Joenje H, de Winter JP and Meetei AR. Impaired FANCD2 monoubiquitination and hypersensitivity to camtothecin uniquely characterize Fanconi anemia complementation group M. Blood. 2009 114(1):174-180.

Zhang F, Fan Q, Ren K and Andreassen PR. PALB2 functionally connects the breast cancer susceptibility proteins BRCA1 abd BRCA2. Mol Cancer Res. 2009 7(7):1110-18.

Krejci O, Wunderlich M, Geiger H, Chou FS, Schleimer D, Jansen M, Andreassen PR and Mulloy JC. p53 signaling in response to increased DNA damage sensitizes AML-ETO cells to stress-induced death. Blood 2008 111(4):2190-9.

Singh TR, Ali AM, Busygina V, Raynard S, Fan Q, Du CH, Andreassen PR, Sung P and Meetei AR. BLAP18/RMI2, a novel OB-fold-contatining protein, is an essential component of the Bloom helicase-double Holliday junction dissolvasome. Genes Dev. 2008 22(20):2856-68.

Andreassen PR, Ho GP, D'Andrea AD. DNA damage responses and their many interactions with the replication fork. Carcinogenesis. 2006 27:883-92.

Cantor SB and Andreassen PR. Assessing the link between BACH1 and BRCA1 in the FA pathway. Cell Cycle. 2006 5(2):164-7.

Litman R, Peng M, Jin Z, Zhang F, Zhang J, Powell S, Andreassen PR and Cantor SB. BACH1 is critical for homologous recombination and appears to be the Fanconi anemia gene product FANCJ. Cancer Cell. 2005 8(3):255-65.

Montes de Oca R, Andreassen PR, Gregory RC, Taniguchi T, Houghtaling S, Grompe M and D'Andrea AD. Regulated interaction of the Fanconi Anemia protein, FANCD2, with chromatin. Blood. 2005;105(3):1003-9.

Skoufias DA, Lacroix FB, Andreassen PR, Wilson L, Margolis RL. Inhibition of DNA decatenation, but not DNA damage, arrests mammalian cells at metaphase. Mol Cell. 2004;15(6):977-90.

Andreassen PR, Skoufias D and Margolis RL. Analysis of the spindle assembly checkpoint in HeLa cells. Methods Mol Biol. 2004 281:213-25.

Andreassen PR, D'Andrea AD and Taniguchi T. Phosphorylation by ATR couples FANCD2 monoubiquitination to the DNA damage response. Genes Dev. 2004 18(16):1958-63.

Wang XZ, Andreassen PR, and D'Andrea AD. Functional Interaction of FANCD2 and BRCA2/FANCD1 in chromatin. Mol Cell Biol. 2004 (13):5850-62.