Carine Blanchard, PhD
Title
Research Instructor
Email
carine.blanchard@cchmc.org
Phone
513-636-1851
Fax
513-636-3310
Credentials
PhD: Universite Claude Bernard Lyon I, FRANCE, 2004.
Awards and Honors
2006 - Travel award, TIGER meeting, NASPGHAN Society
2007 - Fellow in Training Travel Award, American Academy of Allergy Asthma and Immunology
2007 - New Investigator Award, International Eosinophil Society Meeting
2007 - First place abstract award, Cincinnati Digestive Health Center
Research
Our primary interest is to understand the molecular pathogenesis involved in food allergy related disorders in particular in eosinophilic esophagitis.
In order to better understand the molecular mechanisms underlying food anaphylaxis, our laboratory has extensively studied a murine model of oral allergen-induced IgE-dependent intestinal anaphylaxis. Interestingly, we recently uncovered that this model was characterized by an increased expression of the secreted protein TSG6 mRNA, tumor necrosis factor induced gene 6. At the same time, we also discovered that TSG6 mRNA was upregulated in a human food allergy related disease, eosinophilic esophagitis (EE). Taken together, these sets of observations have focused our attention on uncovering the regulation of expression and role of TSG6 in food allergy related responses.
Our second objective is to understand the role of the molecule periostin in inflammation. We have premimnary evidance that this moelcule is involved in inflammatory cell recruitment in several allergy models. Its role in other inflammatory models, is under investigation.
Publications, Most Recent
Blanchard C, Wang N, Stringer KF, Mishra A, Fulkerson PC, Abonia JP, Jameson SC, Kirby C, Konikoff MR, Collins MH, Cohen MB, Akers R, Hogan SP, Assa’ad AH, Putnam PE, Aronow BJ, Rothenberg ME. Eotaxin-3/CCL26 and a uniquely conserved gene-expression profile in eosinophilic esophagitis. J. Clin Invest, Feb 2006; (116):536-547.
Akei HS, Brandt EB, Mishra A, Strait RT, Finkelman FD, Warrier MR, Hershey GK, Blanchard C, Rothenberg ME. Epicutaneous aeroallergen exposure induces systemic TH2 immunity that predisposes to allergic nasal responses. J Allergy Clin Immunol, Jul 2006; 118(1):62-9.
Dixon H, Blanchard C, Deschoolmeester ML, Yuill NC, Christie JW, Rothenberg ME, Else KJ. The role of Th2 cytokines, chemokines and parasite products in eosinophil recruitment to the gastrointestinal mucosa during helminth infection. Eur J Immunol, Jul 2006; 36(7):1753-63.
Hogan SP, Seidu L, Blanchard C, Groschwitz K, Mishra A, Karow ML, Ahrens R, Artis D, Murphy AJ, Valenzuela DM, Yancopoulos GD, Rothenberg ME. Resistin-like molecule beta regulates innate colonic function: barrier integrity and inflammation susceptibility. J Allergy Clin Immunol, Jul 2006; 118(1):257-68.
Konikoff MR, Blanchard C, Kirby C, Buckmeier BK, Cohen MB, Heubi JE, Putnam PE, Rothenberg ME. Potential of Blood Eosinophils, Eosinophil-Derived Neurotoxin, and Eotaxin-3 as Biomarkers of Eosinophilic Esophagitis. Clin Gastroenterol Hepatol, Nov 2006; 4(11):1328-1336.
Konikoff MR, Noel RJ, Blanchard C, Kirby C, Jameson SC, Buckmeier BK, Akers R, Cohen MB, Collins MH, Assa'ad AH, Aceves SS, Putnam PE, Rothenberg ME. A Randomized, Double-Blind, Placebo-Controlled Trial of Fluticasone Propionate for Pediatric Eosinophilic Esophagitis. Gastroenterology, Nov 2006; 131(5):1381-1391.
Bullock JZ, Villanueva JM, Blanchard C, Filipovich AH, Putnam PE, Collins MH, Risma KA, Akers RM, Kirby CL, Buckmeier BK, Assa'ad AH, Hogan SP, Rothenberg ME. Interplay of adaptive th2 immunity with eotaxin-3/C-C chemokine receptor 3 in eosinophilic esophagitis. J Pediatr Gastroenterol Nutr, Jul 2007; 45(1):22-31.
Mishra A, Wang M, Pemmaraju VR, Collins MH, Fulkerson PC, Abonia JP, Blanchard C, Putnam PE, Rothenberg ME. Esophageal remodeling develops as a consequence of tissue specific IL-5-induced eosinophilia. Gastroenterology, 2007.
Blanchard C, Mingler MK, Vicario M, Abonia JP, Wu YY, Lu TX, Collins MH, Putnam PE, Wells SI, Rothenberg ME. IL-13 involvement in eosinophilic esophagitis: transcriptome analysis and reversibility with glucocorticoids. J Allergy Clin Immunol, 2007.
Blanchard C, Mingler MK, McBride M, Putnam PE, Collins MH, Abonia JP, Molkentin JD, Rothenberg ME. Periostin facilitates eosinophil tissue infiltration in vivo and in vitro. Mucosal Immunology, 2008.
Reviews
Blanchard C, Wang N, Rothenberg ME. Eosinophilic esophagitis: Pathogenesis, genetics, and therapy. J Allergy Clin Immunol, Nov 2006; 118(5):1054-9.
Blanchard C, Rothenberg ME. Basic Pathogenesis of Eosinophilic Esophagitis. Gastrointestinal Endoscopy Clinics of North America, 2008.
Professional Organization Memberships
- Club d’etude des Cellules Epitheliales
- Cincinnati Center for Eosinophilic disorders
- American Association of Allergy And Immunology
- American Gastroenterology Association (AGA)
