Jorge A. Bezerra, MD
Appointment
Professor of Pediatrics
Phone
513-636-4415
Fax
513-636-7851
Bio
Jorge A. Bezerra, MD, joined the Cincinnati Children's Hospital Medical Center Division of Gastroenterology, Hepatology and Nutrition in 1990, when he began his fellowship training in pediatric gastroenterology and nutrition and graduated in 1993.
From 1992-1994, Dr. Bezerra was a research scholar in the Division of Basic Sciences. He was appointed to the division in 1994 as an assistant professor of pediatrics.
Dr. Bezerra completed his residency in pediatrics at the University of Arizona in Tucson, Arizona.
Dr. Bezerra has an active research career with his primary interests in molecular control of liver regeneration, biliary atresia, and genetic basis of intrahepatic cholestasis.
In addition to his research work, Dr. Bezerra is an active clinician for the outpatient GI clinical service and the inpatient liver service.
Credentials
MD: Federal University Rio Grande Norte, Natal, Brazil, 1984
Residency: University of Arizona, Tuscon, AZ, 1989
Fellowship: Gastroenterology, Hepatology and Nutrition, Cincinnati Children's Hospital Medical Center, University of Cincinnati, Cincinnati, OH, 1994
Certification: Pediatrics, Pediatric Gastroenterology, Hepatology and Nutrition
Awards and Honors
- 1984 - Best Graduating Student, Merit Medal - Federal University of Rio Grande do Norte School of Medicine, Natal, Brazil
- 1989 - Graduating Resident Award for Excellence in Teaching - Department of Pediatrics, University of Arizona Health Sciences Center, Tucson, AZ
- 1989 - Graduating Resident Award for Excellence in Clinical Service - Department of Pediatrics, University of Arizona Health Sciences Center, Tucson, AZ
- 1989 - Graduating Resident Award for Excellence in Research - Department of Pediatrics, University of Arizona Health Sciences Center, Tucson, AZ
- 1989 - Pediatric Resident Research Award - American Academy of Pediatrics
- 1991 - William C. Procter Pediatric Research Scholarship Award - Children's Hospital Research Foundation, University of Cincinnati, Cincinnati, OH
- 1997 - AASLD Research Workshop Young Investigator Award
- 1998 - Guest editor: Seminars in Liver Disease - "Hepatobiliary disorders of childhood: Pathophysiology, clinical features and treatment"
- 2000 - Guest editor: Clinics in Liver Disease -"Pediatric liver: helping adults by treating children"
- 2004 - Chairman, Pediatric Liver Disease Working Group, NIH Action Plan for Liver Disease Research
- 2004 - Present Standing Member, Hepatobiliary Pathophysiology Study Section, NIDDK
- 2005 Best Doctors in America
- 2005 - Present Member of the American Society for Clinical Investigation
- Best Doctors in America, 2008
Research
Liver development, regeneration, and repair
Molecular basis of biliary atresia
Genetic basis of intrahepatic cholestasis
Research Grants and Contracts
- Source: NIH R01 DK 55710 - Title: The plasminogen system and liver repair, 2000-2011, Principal Investigator
- Source: NIH R01 DK 64008 - Title: Imunologic Dysfunction in biliary atresia, 2003-2007, Principal Investigator
- Source: NIH U01 DK62497 - Title: Clinical center for biliary atresia: etiopathgenesis and clinical outcome, 2002-2009, Principal Investigator
- Source: NIH R41 DK75162 - Title: The jaundice chip: a diagnostic tool for cholestatic liver disease, 2006-2009, Principal Investigator
- Souce: NIH R56 DK70820 - Title: Molecular determinants of clinical phenotypes in biliary atresia, 2006-2008, Principal Investigator
- Source: American Liver Foundation - Title: Pre-clinical trial to block progression of duct obstruct
Publications, Most Recent
View Jorge Bezerra's publications at Cincinnati Children's as listed by PubMed
- Campbell KM, Bezerra JA (2004). Biliary atresia. Pediatric Gastrointestinal Disease: Pathophysiology, Diagnosis, Management, 4th Edition. WA Walker, O Goulet, RE Kleinmanet al. Hamilton, Ontario, B.C. Decker: 1122-1138.
- Shivakumar P, Campbell KM, Sabla GE, Miethke A, Tiao G, McNeal MM, Ward RL, Bezerra JA. (2004) Obstruction of extrahepatic bile ducts by lymphocytes is regulated by IFN-g in experimental biliary atresia.J Clin Invest 114:322-9.
- Shivakumar P, Bezerra JA. (2004) Biliary atresia and Th1 function: linking lymphocytes and bile ducts.Pediatr Res 56:9-10.
- Bezerra JA, Sokol RJ. (2005) Hepatic gene expression profile and clinical phenotypes: Letter to the editor.Hepatology 41:403-405.
- Carvalho E, Liu C, Shivakumar P, Sabla G, Aronow B, Bezerra JA. (2005) Analysis of the biliary transcriptome in experimental biliary atresia.Gastroenterology 129:713-7.
- Tiao GM, Alonso M, Bezerra J, Yazigi N, Heubi J, Balistreri W, Bucuvalas J, Ryckman F. (2005) Liver transplantation in children younger than 1 year--the Cincinnati experience.J Pediatr Surg 40:268-73.
- Tiao GM, Alonso M, Bezerra J, Yazigi N, Heubi J, Balistreri W, Bucuvalas J, Ryckman F. (2005) Liver transplantation in children younger than 1 year–the Cincinnati experience.J Pediatr Surg 40:268-73; discussion 273.
- Balistreri WF, Bezerra JA, Jansen P, Karpen SJ, Shneider BL, Suchy FJ. (2005) Intrahepatic cholestasis: summary of an American Association for the Study of Liver Diseases single-topic conference.Hepatology 42:222-35.
- Shanmukhappa K, Mourya R, Sabla GE, Degen JL, Bezerra JA. (2005) Hepatic to pancreatic switch defines a role for hemostatic factors in cellular plasticity in mice.Proc Natl Acad Sci U S A.
- Bezerra J. (2006) Biliary atresia: Translational research on key molecular processes regulating biliary injury and obstruction.Chang Gung Med J 29:222-230.
- Mohanty SK, Shivakumar P, Sabla G, Bezerra JA. (2006) Loss of interleukin-12 modifies the pro-inflammatory response but does not prevent duct obstruction in experimental biliary atresia.BMC Gastroenterol 6:14.
- Shneider BL, Brown MB, Haber B, Whitington PF, Schwarz K, Squires R, Bezerra J, Shepherd R, Rosenthal P, Hoofnagle JH, Sokol RJ. (2006) A multicenter study of the outcome of biliary atresia in the United States, 1997 to 2000.J Pediatr 148:467-474.
- Balistreri WF, Bezerra JA. (2006) Whatever happened to "neonatal hepatitis"?Clin Liver Dis 10:27-53, v.
- Bezerra J, Shneider BL. (2006) Genetic modifiers of cholestatic liver disease: an evolving field.J Pediatr Gastroenterol Nutr 42:7-8.
- Bezerra JA. (2006) The next challenge in pediatric cholestasis: deciphering the pathogenesis of biliary atresia.J Pediatr Gastroenterol Nutr 43:S23-9.
- Shanmukhappa K, Sabla GE, Degen JL, Bezerra JA. (2006) Urokinase-type plasminogen activator supports liver repair independent of its cellular receptor.BMC Gastroenterol 6:40.
- Shivakumar P; Sabla G; Mohanty SK; McNeal M; Ward R; Stringer K; Caldwell C; Chougnet C; Bezerra JA. (2007) Effector role of neonatal hepatic CD8+ lymphocytes in epithelial injury and autoimmunity in experimental biliary atresia. Gastroenterology 133(1): 268-77.
Professional Organization Memberships
- 1994- North American Society for Pediatric Gastroenterology and Nutrition
- 1994- American Gastroenterological Association
- 1994- American Association for Studies of Liver Diseases
- 2000- Society for Pediatric Research
- 2000- American Association for Advancement of Science
- 2003- American Physiological Society
- 2005- American Pediatric Society
- 2005- American Society for Clinical Investigation
Special Interests
Liver diseases; liver transplantation.
Related Areas
This person works in these other areas at Cincinnati Children's Hospital Medical
Center:
