Nadean L. Brown, PhD
Appointment
Associate Professor, University of Cincinnati College of Medicine
Email
nadean.brown@cchmc.org
Phone
513-636-1963
Fax
513-636-4317
Credentials
Ph.D., Cellular and Molecular Biology, University of Wisconsin, Madison, WI 1994
Postdoctoral Fellowship, Department of Biology, University of Michigan 1995-1996
Postdoctoral Fellowship, Departments of Human Genetics and Internal Medicine, University of Michigan 1996-1999
Assistant Professor, Division of Developmental Systems Biology, Department of Pediatrics, Northwestern University Medical School, Chicago, IL, 2000-2002
Awards and Honors
1995 - 1996 NRSA Postdoctoral Research Fellowship
1995 NSF Postdoctoral Fellowship
Research
Visit the Brown Lab Site.
Research Grants and Contracts
Active:
NIH EY13612 (NL Brown, PI): Investigation of Mammlian Retinal Neuron Development. 8/2009-7/2013
NIH EY18097 (NL Brown, PI): Cell-Cell Signaling during Mammalian Eye Formation 4/2008-4/2012
Past:
Grant-In-Aid from The Glaucoma Foundation (NL Brown, PI): In Vivo Investigation of Optic Nerve Formation and Connectivity within the Mouse Brain 1/2007-12/2007
NIH EY13612 (NL Brown, PI): Investigation of Mammalian Retinal Neuron Development 8/2001-8/2008
Publications, Most Recent
Nadean Brown's publications as listed by PubMed
Welgus HG, Brown NL and Stricklin, GP. The Influence of Cell Culture Variables on Human Collagenase Inhibitor Expression Collagen Rel. Res 1984; 4:377-388.
Brown NL, Sattler CA, Markey DR and Carroll SB. hairy Gene Function in the Drosophila Eye: Normal Expression is Dispensable but Ectopic Expression Alters Cell Fates. Development 1991; 113:1245-1256.
Brown NL, Sattler CA, Paddock SW, and Carroll SB. Hairy and Emc Negatively Regulate Morphogenetic Furrow Progression in the Drosophila Eye. Cell 1994; 80: 879-887.
Brown NL, Paddock SW, Sattler CA, Cronmiller C, Thomas BJ, and Carroll SB. daughterless is Required for Drosophila Photoreceptor Cell Determination, Eye Morphogenesis, and G1 Progression. Developmental Biology 1996; 179: 65-78.
Brown NL, Kanekar S, Vetter ML, Tucker PK, Gemza DL, and Glaser T. Math5 Encodes a Murine Basic Helix-Loop-Helix Transcription Factor Expressed During Early Stages of Retinal Neurogenesis. Development 1998; 125: 4821-4833.
Brown NL, Patel S, Brzezinski JA and Glaser T. Math5 is required for retinal ganglion cell and optic nerve formation. Development 2001; 128: 2497-2508.
Tucker P, Laemle L, Munson A, Kanekar S, Oliver E, Brown NL, Schlecht H, Vetter ML and Glaser T. The eyeless mouse mutation (ey1) removes an alternative start codon from the Rx/rax homeobox gene and acts as a hypomorphic allele. Genesis 2001; 31: 43-53.
Vetter ML and Brown NL The Role of Basic Helix-Loop-Helix Genes in Vertebrate Retinogenesis. Seminars in Cell and Developmental Biology 2001; 12: 491-498.
Brown NL, Dagenais SL, Chen CM, and Glaser T. Molecular characterization and mapping of ATH5/ATOH7, a human atonal homolog with a predicted role in retinal ganglion cell development. Mammalian Genome 2002; 13: 95-101.
Sun Y, Kanekar SL, Vetter ML, Gorski S, Jan YN, Glaser T, and Brown NL. Conserved and Divergent Functions of Drosophila atonal, amphibian and mammalian Ath5 genes. Evolution and Development. 2003; 5: 532-541.
Song MH, Brown NL and Kuwada JY. The cfy mutation disrupts cell divisions in a stage-dependent manner in zebrafish embryos. Developmental Biology 2004; 276: 194-206.
Lee HY, Wroblewski E, Philips GT, Stair CN, Conley K, Reedy M, Mastick GS, Brown NL. Multiple requirements for Hes1 during early eye formation. Developmental Biology 2005; 284: 464-478.
Hutchenson D, Hanson M, Moore KB, Le TT, Brown NL, Vetter ML. bHLH-dependent and -independent modes of Ath5 gene regulation during retinal development. Development 2005; 132: 829-839.
Philips GT, Stair CN, Lee HY, Wroblewski E, Berberoglu MA, Brown NL, Mastick GS. Precocious retinal neurons: Pax6 regulates the timing of differentiation and the determination of cell type. Developmental Biology 2005; 279: 308-321.
Brzezinski J*, Brown NL*, Tanikawa A, Bush RA, Sieving P, Vittaterna MH, Takahashi J, Glaser T. Abnormalities in circadian behavior and retinal electrophysiology in Math5 mutant mice. Invest Ophth Vis Sci 2005; 46: 2540-2551. *Co-First Authors
Harzsch S., Vilpoux SK, Blackburn DC, Platchetzki D, Brown NL, Melzer R, Battelle BA. Evolution of arthropod visual systems: development of the eyes and central visual pathway of the horseshoe crab Limulus polyphemus. Developmental Dynamics 2006; 235: 2641-2655.
Le TT, Wroblewski E, Patel S, Riesenberg AN, Brown NL. Math5 is required for both early retinal neuron determination and cell cycle progression. Developmental Biology 2006; 295: 764-778.
Hufnagel R, Riesenberg AN, Saul SM, Brown NL. Conserved regulation between Math5 and Math1 as revealed by Math5-GFP transgenes. Molecular and Cellular Neuroscience 2007; 36: 435-488.
Blackburn DC*, Conley K*, Platchetzki D, Kempler K, Battelle BA, Brown NL. Isolation and expression of Pax6 and atonal homologues in the American Horseshoe Crab, Limulus polyphemus. Developmental Dynamics 2008; 237: 2209-2219. *Co-First Authors
Rowan S, Conley K, Le TT, Donner AL, Maas RL, Brown, NL. Notch signaling is required for mouse lens growth and differentiation. Developmental Biology 2008; 321: 111-122.
Fuhrmann S, Riesenberg AN, Mathiesen AM, Brown EC, Vetter ML, Brown NL. Characterization of a transient TCF/LEF-responsive progenitor population in the embryonic mouse retina. Invest. Ophth. Vis Sci 2009; 50: 432-440.
Willardson MI, Suli A, Pan, Y, Marsh-Armstrong N, El-Hodiri, H, Chen CB, Moore KB, Brown NL, Vetter ML. Temporal regulation of Ath5 gene expression during eye development. Developmental Biology 2009; 326: 471-481.
Le TT, Conley K, Brown NL. Jagged1 is necessary for normal mouse lens development. Developmental Biology 2009; 328: 118-126.
Riesenberg AN, Le TT, Willardson MI, Blackburn DC, Vetter ML, Brown NL. Pax6 regulation of Math5 during mouse retinal neurogenesis. Genesis 2009; 47: 175-187.
Riesenberg AN, Liu Z., Kopan R., Brown NL. Rbpj cell autonomous regulation of retinal ganglion cell and cone photoreceptor fates in the mouse retina. Journal of Neuroscience 2009; In Press
Brown N.L. “Ganglion cell development: early steps/fate" in Encyclopedia of the Eye. Editor, Tom Reh. Oxford: Elsevier. 2010; In Press.
Brzezinski JA, Rao S, Konheim A, Saul S, Lang RA, Brown NL and Glaser T. Retinal ganglion cells are required for normal vascular development and hyaloid regression. Developmental Biology 2009; In revision.
Professional Organization Memberships
Teaching
I contribute lectures to the Intro to the Developmental Biology (MDB program), Advanced Developmental Biology (MDB program) and Neurodevelopment (Neuroscience Program) graduate courses.
Special Interests
Developmental genetics of mammalian lens and retinal formation
Invited Research Presentations
2000, 41st Annual Drosophila Research Conference, Pittsburg, PA
2000, Visual Systems Development Gordon Research Conference, Bristol, RI
2000, First International Symposium on bHLH Genes, Amsterdam,The Netherlands
2001, ASIP/FASEB Meeting, Orlando, FL
2002, Vision Research Symposium, ARVO Meeting, Ft. Lauderdale, FL
2002, Visual System Development Gordon Research Conference, Newport, RI
2004, Visual System Development Gordon Research Conference, Newport, RI
2006, Visual System Development Gordon Research Conference, Il Ciocco Italy
2008, Assoc. for Research in Vision and Ophthalmology Meeting, Ft. Lauderdale, FL
2008, Midwest Society for Developmental Biology Meeting, Iowa City, IA
2008, Visual System Development Gordon Research Conference, Newport, RI
2009, Assoc. for Research in Vision and Ophthalmology Meeting, Ft. Lauderdale, FL
Related Areas
This person works in these other areas at Cincinnati Children's Hospital Medical
Center:
