Find a Health Care Professional / Researcher

Chieh Chang, PhD

Appointment

Assistant Professor, University of Cincinnati College of Medicine

Email

chieh.chang@cchmc.org

Phone

513-803-0945

Credentials

Postdoctoral Fellowship: Rockefeller University, University of California San Francisco, and Stanford University

PhD: California Institute of Technology

Position History

2008-present: Assistant Professor, Division of Developmental Biology and Department of Pediatrics, Cincinnati Children’s Research Foundation

2006-2008: Assistant Professor of Biology, Associate member of Neurology and Neurosurgery, McGill University, Montreal, Canada

2001-2006: Postdoctoral Fellow with Marc Tessier-Lavigne at the Howard Hughes Medical Institute, Stanford University (2001-2003) and with Cornelia I. Bargmann at the Howard Hughes Medical Institute, University of California, San Francisco (2004) & Rockefeller University (2004-2006)

1995-2001: Doctoral research with Paul W. Sternberg at the Howard Hughes Medical Institute, California Institute of Technology

Awards and Honors

Whitehall Foundation Research Award, 2009
Canada Foundation for Innovation, Leaders Opportunity Award, 2006
American Cancer Society Postdoctoral Fellow, 2002

Research

We are interested in understanding how neurons connect with each other to form functional neural circuits and how neurons regenerate and repair themselves after injury and how age influences the intrinsic axon growth ability. We use nematode C. elegans as a model organism to study these questions.

Lab Infrastructure

We use primarily these instruments in our study: Axio Imager fluorescent compound microscope for deconvolution and time-lapse imaging, high power fluorescent dissecting microscope, femtosecond laser surgical setup.

Publications, Most Recent

Gabel CV, Antoine F, Chuang CF, Samuel ADT, Chang C. Distinct cellular and molecular mechanisms mediate initial axon development and adult-stage axon regeneration in C. elegans. Development 2008;135:1129-36.

Samuel ADT, Chung SH, Clark DA, Gabel CV, Chang C, Murthy V, Mazur E. Femtosecond laser dissection in C. elegans neural circuits. Proceedings of the International Society for Optical Engineering 2006;6108:6108011-16.

Chang C, Adler C, Krause M, Clark S, Hao J, Gertler F, Tessier-Lavigne M, Bargmann CI.MIG-10/Lamellipodin and the lipid modulator AGE-1/PI3K promote axon guidance and outgrowth in response to Slit and Netrin. Current Biology 2006;16:854-62.

Chang C, Yu TW, Bargmann CI, Tessier-Lavigne M. Inhibition of Netrin-mediated axon attraction by a receptor protein tyrosine phosphatase. Science 2004;305:103-6.

Chang C, Werb Z. The many faces of metalloproteases: cell growth, invasion, angiogenesis, and metastasis. Trends in Cell Biology 2001;11:S37-43.

Yoon CH*, Chang C*, Hopper NA*, Lesa GM, Sternberg PW. Requirements of multidomains of SLI-1, a C. elegans homolog of c-Cbl, and an inhibitory tyrosine in LET-23 in regulating vulval differentiation. Molecular Biology of the Cell 2000;11:4019-31. *authors of equal contribution

Chang C, Hopper NA, Sternberg PW. Caenorhabditis elegans SOS-1 is necessary for multiple RAS-mediated developmental signals. EMBO Journal 2000;19:3283-94.

Chang C, Sternberg PW. C. elegans vulval development as a model system to study the cancer biology of EGFR signaling. Cancer and Metastasis Reviews 1999;18:203-13.

Chang C, Newman AP, Sternberg PW. Reciprocal EGF signaling back to the uterus from the induced C. elegans vulva coordinates morphogenesis of epithelia. Current Biology 1999;9:237-46.

Hsieh J, Liu J, Kostas SA, Chang C, Sternberg PW, Fire A. The RING finger/B-box factor TAM-1 and a retinoblastoma-like proteins LIN-35 modulate context-dependent gene silencing in C. elegans. Genes & Development 1999;13:2958-70.

Bogarad LD, Arnone MI, Chang C, Davidson EH. Interference with gene regulation in living sea urchin embryos: transcription factor knock out (TKO), a genetically controlled vector for blockade of specific transcription factors. Proceedings of the National Academy of Sciences USA 1998;95;14827-32.