Find a Health Care Professional / Researcher

Claire A. Chougnet, PhD

Appointment

Associate Professor

Email

claire.chougnet@chmcc.org

Phone

513-636-8847

Fax

513-636-4278

Credentials

Diplôme de Pharmacien (DPharm.): Université Paris XI, Paris, France, 1980.

CES (French specialized degrees; clinical biologist): Immunology, Hematology, Bacteriology-Virology, Parasitology, 1984.

PhD: Université Paris V, 1991.

Awards and Honors

1985 Gold Medal, Pharmacy residency program, Toulouse, France.
1991 PhD award, University Paris V, France
1998 "Habilitation à diriger les recherches" (diploma allowing the supervision of research trainees), France
1999- 2000 Ad hoc reviewer for grant proposals: Swiss National Science Foundation
2001 Co-Organizer, Think Tank meeting "Antigen-presenting cells in HIV Pathogenesis and Therapy"
2002- 2005 Ad hoc reviewer for grant proposals: Ontario HIV Treatment Network
2006- 2011 Ad hoc member, and Member of NIH AIDS Immunology and Pathogenesis Study Section
2006 Co-Organizer, workshop "Regulatory T cells and HIV/AIDS"
2006 Member "Faculty of 1000 Biology" (Faculty: Immunology, Section: Immunity to Infections).
2007 Member of NIH AIDS Immunology and Pathogenesis Study Section.
2008 Cp-organizer, 5th Axel Key Symposium, "Mucosal Immunity and novel anti-HIV vaccine concepts"

Research

HIV/AIDS Pathogenesis
Immune dysfunction in aging
Ontogeny of immune system

Research Grants and Contracts

NIH R01 AI056927
01/01/05 - 12/31/09
CD40 Ligand dysregulation and HIV pathogenesis
NIH R01
8/1/06 - 7/31/11
Role of Regulatory T cells in HIV Pathogenesis
NIH R01 DK 065008
8/1/03 - 12/31/11
Dysfunction in biliary atresia
NIH R01 AG033057 ARRA
9/15/09 - 9/14/11
Homeostasis and function of regulatory T cells in aging
Center for Microbial Pathogenesis
9/15/09 - 9/14/10
A new role for C5aR in HIV infection
Abbott Laboratories
12/01/05 - 12/01/09
NIH R01 DK 065008
8/1/03 - 12/31/11
Dysfunction in biliary atresia
NIH R01 HL097064-01
9/24/09 – 7/31/13
Late Preterm Birth, Ureaplasma Species and Childhood Lung Disease.

Publications, Most Recent

Tripathi P, Madan R, Chougnet C, Divanovic S, Ma X, Wahl LM, Gajewski T, Karp CL, Hildeman DA. (2006) An adenoviral vector for probing promoter activity in primary immune cells.J Immunol Methods 311:19-30.
Montoya CJ, Velilla PA, Chougnet C, Landay AL, Rugeles MT. (2006) Increased IFN-gamma production by NK and CD3+/CD56+ cells in sexually HIV-1-exposed but uninfected individuals.Clin Immunol 120:138-46.

Hryniewicz A, Boasso A, Edghill-Smith Y, Vaccari M, Fuchs D, Venzon D, Nacsa J, Betts MR, Tsai WP, Heraud JM, Beer B, Blanset D, Chougnet C, Lowy I, Shearer GM, Franchini G. (2006) CTLA-4 blockade decreases TGF-{beta}, indoleamine 2,3- dioxygenase, and viral RNA expression in tissues of SIVmac251-infected macaques.Blood.
Nilsson J, Boasso A, Velilla PA, Zhang R, Vaccari M, Franchini G, Shearer GM, Andersson J, Chougnet C. (2006) HIV-1 driven regulatory T cell accumulation in lymphoid tissues is associated with disease progression in HIV/AIDS.Blood.
Chougnet C, Gessani S. (2006) Role of gp120 in dendritic cell dysfunction in HIV infection.J Leukoc Biol.
Szigligeti P, Neumeier L, Duke E, Chougnet C, Takimoto K, Lee SM, Filipovich AH, Conforti L. (2006) Signalling during hypoxia in human T lymphocytes--critical role of the src protein tyrosine kinase p56Lck in the O2 sensitivity of Kv1.3 channels.J Physiol 573:357-70.
PA Velilla, MT Rugeles, C Chougnet. Defective antigen-presenting cell function in human
neonates.Clin Exp Immunol, 2006, 121, 251.
C. Chougnet, G.M. Shearer. Regulatory T Cells and HIV/AIDS. Summary of the September 7-8, 2006 Workshop. AIDS Research and Human Retroviruses, 2007, 23, 945.
A. Boasso, M. Vaccari, A. Hryniewicz, J. Nacsa, D. Fuchs, G. Franchini, G.M. Shearer, C. Chougnet. Increased expression of regulatory T cell markers and indoleamine 2,3 dioxygenase in spleen and gut during active viral replication in SIV-infected macaques.J. Virol. 2007, 81, 11593-11603.
P.A. Velilla, M.T. Shata, C. Silva Lages, J. Ying, C. Fichtenbaum, C. Chougnet. Effect of low-dose IL-2 immunotherapy on frequency and phenotype of regulatory T cells and NK cells in HIV/HCV co-infected patients.AIDS Research and Human Retroviruses, 2008, 24, 52-61.
S. Li, E.J. Gowans, C. Chougnet, M. Plebanski, U. Dittmer. Natural regulatory T cells and persistent viral infection.J. Virol. 2008, 82, 21-30 (Review).
P.A. Velilla, C.J. Montoya, A. Hoyos, M.E. Moreno, C. Chougnet, M.T. Rugeles. Effect of intrauterine HIV-1 exposure on the frequency and phenotype of uninfected newborns’ dendritic cells.Clin Immunol, 2008, 126, 243-50.
C.S. Lages, I. Suffia, P. Velilla, B. Huang, G. Warshaw, D. Hildeman, Y. Belkaid, C. Chougnet. Functional regulatory T cells accumulate in aged hosts and promote reactivation of chronic infectious disease reactivation. J. Immunol. 2008, 181(3):1835-48.
A. Boasso, G.M. Shearer, C. Chougnet. Immune dysregulation in HIV infection: know it, fix it, prevent it? J Intern Med, 2009, 265(1):78-96 (Review).
A.M. Nyakeriga, C.J. Fichtenbaum, J. Goebel, S.A. Nicolaou, L. Conforti, C.A. Chougnet. Engagement of the CD4 receptor affects the redistribution of lck to the immunological synapse in primary T cells: implications for T cell activation during HIV-1 infection. J. Virol., 2009 Feb;83(3):1193-200.
P. Shivakumar, G.E. Sabla, P. Whitington, L.L. Lanier, C. Chougnet, J.A. Bezerra. NeonatalNK cells target the duct epithelium via Nkg2d and drive the tissue-specific injury in biliary atresia.J. Clin Invest., 2009 Aug;119(8)2281-90.

Professional Organization Memberships

American Association of Immunologists
Society for Pediatric Research

Teaching

1987-1991: Post-graduate course, "Prevention of Endemic Diseases", Section: Malaria, Paris VII University, Paris, France.
1992: Post-graduate course, "Tropical Microbiology", Section: Immunology, Pasteur Institute, Paris, France.
1998: Post-graduate course, "Host-Parasites Interactions", Section: Mucosal Biology, Physiology and Immunity. Paris V University, Paris, France
2003-present: Member of the Admission Committee, Immunobiology Graduate Program, University of Cincinnati.
2004-present: Teaching in "Immunobiology Foundations I" and "Immunobiology Foundations II", Immunobiology Graduate Program, University of Cincinnati.

Special Interests

antigen-presenting cells, HIV research, ontogeny of immune responses

Honors:

"Medaille d'Or de l'Internat en Pharmacie" (gold metal, Pharmacy residency program), CHU Toulouse, France, 1985

Ph. D. award from Paris V University, Paris, France, 1991

Habilitation à diriger les recherches" (qualification to direct investigations, awarded by the French University), Université Paris V, Paris, France, 1998.

Presentations:

DOMESTIC
Involvement of monocytes in the Pathogenesis of HIV/AIDS. Joint meetings of The Cell Proliferation Society and 6th annual Chesapeake Cytometry Consortium Conference, Greenbelt, MD, USA, March 1999.

Monocyte-derived dendritic cells from HIV+ patients produce normal amounts of Interleukin-12. The Hopkins, NIH, Wistar Joint IL-12 meeting, Baltimore, MD, USA, May 1999.

Involvement of monocytes in the Pathogenesis of HIV/AIDS. Twelfth Annual Meeting of the Association of Medical Laboratory Immunologists, Bethesda , MD, USA, July 1999.

Antigen-presenting cells in the Pathogenesis of HIV/AIDS: Dysregulated cytokine profile and modified phenotype. 2000 Keystone Symposium on Cytokines and disease, Snowbird, UT, USA, April 2000.

In vivo CD40-CD154 (CD40Ligand) interaction induces integrated HIV expression by antigen-presenting cells in an HIV-1-transgenic mouse model. NIH Cytokine interest group, Frederick, MD, September 2000.

Co-organizer of an international workshop, entitled "Antigen-presenting cell defects in HIV/AIDS", sponsored by the Office of AIDS Research and the National Cancer Institute. October 2001, Arlie House, VA, USA.

Chairperson: Antigen-presenting cells/HIV interactions. Workshop on "Antigen-presenting cell defects in HIV/AIDS", sponsored by the Office of AIDS Research and the National Cancer Institute. October 2001, Arlie House, VA, USA.

INTERNATIONAL
Antigen-presenting cells: a common immunologic problem in HIV/AIDS and Cancer? 1999 International Meeting of the Institute of Virology, Baltimore, USA, August 1999.

Maternal influence on fetal/neonatal antigen-presenting cell function. MRC Gambia/WHO symposium on Immunisation of newborns in the tropics, Banjul, The Gambia, November 1999.

Disscussant: Immune response in early life: limitations and prespectives. MRC Gambia/WHO symposium on Immunisation of newborns in the tropics, Banjul, The Gambia, November 1999.

Editing:

Reviewer for: Blood, Clinical and Diagnostic Laboratory Immunology, Immunology Letters, Journal of Infectious Diseases, Journal of Leukocyte Biology, Pediatric Research

Ad hoc reviewer for grant proposals: Swiss National Science Foundation