Gregory A. Grabowski, MD
Title
Director, Division of Human Genetics
Director, Medical Genetics Training Program
Appointment
Professor of Pediatrics and Molecular Genetics, Biochemistry and Microbiology, University of Cincinnati College of Medicine
Email
greg.grabowski@cchmc.org
Phone
513-636-7290
Credentials
MD: University of Minnesota Medical School, Minneapolis, MN, 1970 to 1974.
Residency: Department of Pediatrics, University of Minnesota, Minneapolis, MN, 1974 to 1976.
Fellowship: Medical Genetics, Department of Pediatrics and the Dight Institute for Human Genetics, University of Minnesota, Minneapolis, MN, 1976 to 1979.
Certification: American Board of Pediatrics, 1980; American Board of Medical Genetics; Clinical Genetics, 1987; Clinical Biochemical Genetics, 1987; Clinical Molecular Genetics, 1993.
Awards and Honors
Research
Molecular pathogenesis and therapy of human genetic disease
Publications, Most Recent
Greg Grabowski's publications as listed by PubMed.
Sun Y, Jia L, Williams MT, Zamzow M, Ran H, Quinn B, Aronow BJ, Vorhees CV, Witte DP, Grabowski GA. Temporal gene expression profiling reveals CEBPD as a candidate regulator of brain disease in prosaposin deficient mice.BMC Neurosci 2008;9:76.
Sun Y, Witte DP, Ran H, Zamzow M, Barnes S, Cheng H, Han X, Williams MT, Skelton M, Vorhees CV, Grabowski GA. Neurological deficits and glycosphingolipid accumulation in Saposin B deficient mice.Hum Mol Genet 2008;17:2345-56.
Cox TM, Aerts JMFG, Belmatoug N, Cappellini MD, vom Dahl S, Goldblatt J, Grabowski GA, Hollak CEM, Hwu P, Maas M, Martins AM, Mistry PK, Pastores GM, Tylki-Szymanska A, Yee J, Weinreb N. Management of non-neuronopathic Gaucher disease with special reference to pregnancy, splenectomy, bisphosphonate therapy, use of biomarkers and bone disease monitoring.J Inherit Metab Dis 2008;31:319-36.
Koochekpour S, Lee TJ, Sun Y, Hu S, Grabowski GA, Liu Z, Garay J. Prosaposin is an AR-target gene and its neurotrophic domain upregulates AR expression and activity in prostate stromal cells.J Cell Biochem 2008;104:2272-85.
Du H, Cameron TL, Garger SJ, Pogue GP, Hamm LE, White E, Hanley KM, Grabowski GA. Wolman disease/cholesteryl ester storage disease: Efficacy of plant produced human lysosomal acid lipase in mice.J Lipid Res 2008;49:1646-57.
Grabowski GA, Hopkin R. Lysosomal storage diseases, Chapter 355. In: Harrison’s Principles of Internal Medicine, 17th Edition. A.S. Fauci, E. Braunwald, D.L. Kasper, S.L. Hauser, J.L. Jameson and J. Loscalzo, editors. New York: McGraw-Hill. 2452-2456, 2008.
Xu YH, Reboulet R, Quinn B, Huelsken J, Witte D, Grabowski GA. Dependence of reversibility and progression of mouse neuronopathic Gaucher disease on acid b-glucosidase residual activity levels.Mol Genet Metab 2008;94:190-203.
Grabowski GA. Treatment perspectives for the lysosomal storage diseases.Expert Opin Emerg Drugs 2008;13:197-211.
Weinreb NJ, Andersson HC, Banikazemi M, Barranger J, Beutler E, Charrow J, Grabowski GA, Hollak CE, Kaplan P, Mankin H, et al. Prevalence of type 1 Gaucher disease in the United States.Arch Intern Med 2008;168:326-7.
Maas M, Hangartner T, Mariani G, McHugh K, Moore S, Grabowski GA, Kaplan P, Vellodi A, Yee J, Steinbach L. Recommendations for the assessment and monitoring of skeletal manifestations in children with Gaucher disease.Skeletal Radiol 2008;37:185-8.
Professional Organization Memberships
Special Interests
Lysosomal storage diseases; molecular enzymology; gaucher disease; fabry disease; molecular pathogenesis
Related Areas
This person works in these other areas at Cincinnati Children's Hospital Medical
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