Ralph A. Gruppo, MD
Title
Director, Comprehensive Hemophilia and Thrombosis Center; Director, Research Coagulation Laboratory
Appointment
Professor of Clinical Pediatrics
Email
ralph.gruppo@cchmc.org
Phone
513-636-4269
Fax
513-636-5845
Credentials
MD: Johns Hopkins Medical School, Baltimore, Md., 1967.
Residency: Pediatrics, Children's Hospital Medical Center, Cincinnati, Ohio; Johns Hopkins School of Medicine, Baltimore, Md.
Fellowship: Pediatric Hematology/ Oncology, Children's Hospital Medical Center, Cincinnati, Ohio, 1975.
Certification: Pediatrics, 1975; Pediatric Hematology/Oncology, 1976.
Awards and Honors
- Junior Faculty Clinical Fellow, American Cancer Society (1973 - 1976)
- Alpha Nu Alpha (Jesuit National Honor Society)
- American Society of Pediatric Hematology/Oncology Editorial Board
- Board Member, Hemophilia Research Society of North America, Board of Directors (1996 - present)
- FamOhio Ira Gaffin Memorial Award for Hemophilia (1997)
- Best Doctors in America, 2008
Publications, Most Recent
Connect to Ralph Gruppo's publications on PubMed
Morris TA, Marsh JJ, Chiles PG, Kim NH, Noskovack KJ, Magana MM, Gruppo RA, Woods VL, Jr. Abnormally sialylated fibrinogen -chains in a patient with chronic thromboembolic pulmonary hypertension. Thromb Res 2007;119:257-259.
Chan, E.L., Harris R.E., Emery, K.H., Gelfand, M.J., Collins, M.H., Gruppo, R.A. Favorable histology, MYCN-amplified 4S neonatal neuroblastoma. Pediatr Blood Cancer, Published Online December 6, 2005.
Tamary, H., Dgany, O., Proust, A., Krasnov, T., Avidan, N., Eidelitz-Markus, T., Tchernia, G., Genevieve, D., Cormier-Daire, V., Bader-Meunier, B., Ferrero-Vacher, C., Munzer, M., Gruppo, R.A., Fibach, E., Konen, O., Yaniv, I., Delaunay, J. Clinical and molecular variablility in congenital dyserythropoeitic anaemia type I. British Journal of Haematology, 130: 628-634, 2005
Liu, J., Jackson, C.W., Gruppo, R.A., Jennings, L.K., Gartner, T.K. The β3 subunit of the integrin αІІbβ3 regulates αІІb-mediated outside-in signaling. Blood, 105: 4345-4352, 2005
Balasa, V.V., Gruppo, R.A., Glueck, C.J., Wang, P., Roy D.R., Wall, E.J., Mehlman, C.T., Crawford, A.H. Legg-Calve-Perthes disease and thrombophilia. J Bone Joint Surg Am, 86-A:2642-7, 2004.
Gruppo, R.A., Brown, D., Wilkes, M.M., Navickis, R.J. Meta-analytic evidence of increased breakthrough bleeding during prophylaxis with B-domain deleted factor VIII. Haemophilia, 10:747-50, 2004.
Tarantino, M.D., Collins, P.W., Hay, C.R.M., Shapiro, A.D., Gruppo, R.A., Berntorp, E., Bray, G.L., Tonetta, S.A., Schroth, PC., Retzios, A.D., Rogy, S.S., Sensel, M.G., Ewenstein, B.M., and the RAHF-PFM Clinical Study Group. Clinical evaluation of an advanced category antihaemophilic factor prepared using a plasma/albumin-free method: pharmacokinetics, efficacy, and safety in previously treated patients with haemophilia A. Haemophilia, 10:428-437, 2004.
Gruppo, R.A., Brown, D., Wilkes, M.M., and Navickis, R.J. Increased breakthrough bleeding during prophylaxis with B-domain deleted factor VIII – a robust meta-analytic finding. Haemophilia, 10:449-451, 2004.
Morrison, J.A., Gruppo, R.A., Glueck, C.J., Stroop, D., Fontaine, R.N., Wang, P., Smyth, K. Population-specific alleles: the polymorphism (K121Q) of the human glycoprotein PC-1 gene coding region is strongly associated with race but not with insulin resistance in black and white children. Metabolism, 53:465, 2004.
Abstracts
Balasa VV, Kim M, Gruppo RA. Thrombophilic Polymorphisms in Pediatric Catheter-related Versus Non Catheter-related Venous Thromboembolism. International Society of Hemostasis and Thrombosis, July 2007.
Gruppo RA, Davies S, Balasa VV. Increased Age-related Expression of FVIII In Two Unrelated Females With Severe Hemophilia A and Nonrandom X-inactivation. International Society of Hemostasis and Thrombosis, July 2007.
Morris TA, Magana M, Marsh JJ, Chiles PG, DiSantis D, Gruppo RA, Woods VL. Heterozygous Fibrinogen γ-375 arg_trp Mutation Associated with Excessive Disialylation, Plasmin Resistance and Chronic Thromboembolic Pulmonary Hypertension. International Society of Hemostasis and Thrombosis, July 2007.
Gelfand, Michael J.; Gruppo Ralph A. Ventilation Perfusion Scintigraphy in Children and Adolescents is Associated with a Low Rate of Indeterminate Studies. Society of Nuclear Medicine, 2006
Negrier C, Shapiro A, Berntorp E, Pabinger I, Tarantino M, Gruppo R, Scharrer I, Retzios A, Fritsch S, Patrone L, Luu H, Ewenstein B Clinical Efficacy and Safety of ADVATE Antihemophilic Factor (Recombinant), Plasma/Albumin-Free Method (rAHF-PFM) for Peroperative Management of Hemostasis. World Federation of Hemophilia, 2006
Gruppo R, Collins P, Shapiro A, Hay C, Tarantino M, Retzios A, Schroth P, Aug C, Spotts G, and Ewenstein B for the rAHF-PFM Clinical Study Group Long-term Clinical Evaluation of Safety, Efficacy and Immunogenicity of rFVIII Plasma/Albumin Free Method (rAHF-PFM) in Previously Treated Hemophilia A Patients – Final Report. World Federation of Hemophilia, 2006
Shapiro A, Abshire T, Hernandez F, Gruppo R, Tarantino M, Warrier I, Schroth P, Spotts G, Ewenstein E Efficacy and Safety of ADVATE rAHF-PFM for Perioperative Management of Hemostasis in Previously Treated Children with Hemophilia A. World Federation of Hemophilia, 2006.
Liu, J., Jackson, C.W., Gruppo R.A., Jennings, L.K., Gartner, T.K. The β3 Subunit of the IntegrinαIIbβ3 Regulates IIbβ-Mediated Outside-In Signaling. American Society of Hematology, 2004 published in Blood 104: 104:62b, 2004.
Professional Organization Memberships
- American Academy of Pediatrics
- American Academy of Pediatrics/Ohio Chapter
- American Association for the Advancement of Science
- American Society of Clinical Oncology
- American Society of Hematology
- American Society of Internal Medicine
- American Society of Pediatric Hematology/Oncology
- Cincinnati Pediatric Society
- International Society of Thrombosis and Hemostasis
- Midwest Foundation for Medical Care
- National Hemophilia Foundation (local chapter)
- World Federation of Hemophilia
- Academy of Clinical and Applied Thrombosis/Hemostasis
Abstracts
Liu, J., Jackson, C.W., Gruppo R.A., Jennings, L.K., Gartner, T.K. The β3 Subunit of the IntegrinαIIbβ3 Regulates IIbβ-Mediated Outside-In Signaling. American Society of Hematology, 2004 published in Blood 104: 104:62b, 2004.
Musselman, M.S., Jacobs, B., Brilli, R., Becker, A., Gruppo, R.A. Increased Tissue Factor and Tissue Factor Pathway Inhibitor Is Associated with Extensive Cutaneous Thrombosis in Children with Sepsis Associated Purpura Fulminans. American Society Hematology, 2003.
Balasa, V,.V., Gruppo, R.A., Pillow, A.G., Becker, A., Stroop, D., Glueck, C.J. Legg-Perthes disease and thrombophilia: A causal association? International Society of Hemostasis and Thrombosis, 2003.
Friedman, K.D., Gruppo, R.A., Ebert, D.D., Kakela, J.K., Bellissimo, D.B., Endres, J.L., Montgomery, R.R. International Society of Hemostasis and Thrombosis, 2003.
Shapiro, A., Collins, P., Tarantino, M., Gruppo, R.A., Hay, C., Berntorp, E., Retzios, A., Sensel, M., Tonetta, S. B Ewenstein for the r-AHF-PFM Clinical Study Group. International Society of Hemostasis and Thrombosis, 2003.
Gruppo, R.A., Brown, D., Wilkes, M.M., Navickis, R.J. Comparative effectiveness of full-length and B-Domain deleted factor VIII for prophylaxis – a meta-analysis. International Society of Hemostasis and Thrombosis, 2003.
Special Interests
Coagulation; hemophilia; thrombosis
Editorial Responsibilities:
Reviewer, Journal of Pediatrics
Reviewer, American Journal Pediatric Hematology/Oncology
American Society Pediatric Hematology/Oncology Publications Committee (1996 - present)
American Society Pediatric Hematology/Oncology Newsletter Editor, (1997 - present)
Related Areas
This person works in these other areas at Cincinnati Children's Hospital Medical Center:
