Yi Gu, PhD
Appointment
Assistant Professor of Pediatrics
Email
yi.gu@cchmc.org
Phone
513-636-0537
Fax
513-636-3768
Credentials
PhD University of Rochester, Rochester, NY, 1997.
Postdoctoral Fellow Department of Biochemistry, Molecular Biology and Cellular Biology, Northwestern University, Evanston, IL, 1999.
HHMI Research Associate Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, IN, 2001.
Position History
- 2001-2004, Research Instructor, CCHMC
- 2000-2001, Howard Hughes Medical Institute Research Associate, Herman B Wells Center for Pediatric Research, Indiana University School of Medicine.
- 1998 to 1999, Postdoctoral Research Fellow, Department of Biochemistry, Molecular Biology and Cellular Biology, Northwestern University.
- 1991 to 1997, Predoctoral Research Fellow and Teaching Assistant, Biology Department, University of Rochester.
Awards and Honors
- 2005-2010 - NCI Career Development Award (Howard Temin Award)
- 2004 - Children's Hospital Research Foundation nominee for the Pew Scholar Award
- 2003-2004 - Trustee Fund, Cincinnati Children's Hosptial Research Foundation
- 2003 - Travel Award, International Society of Experimental Hematology
- 1999-2001 - Howard Hughes Medical Institute Fellowship
- 2000 - Travel Award, American Society of Hematology
- 1999 - American Heart Association Postdoctoral Award
Research
Connect to Yi Gu's laboratory page
Research Grants and Contracts
K01 CA107110 (PI: Y. Gu) 2/1/05-01/31/10 NIH/NCI (Howard Temin Award)
"RhoH GTPase in blood cell and cancer development"
R01 GM53943 (Co-Investigator: Y. Gu) 4/1/05-3/31/09 NIH/NIGMS
"Studies of Dbl-like regulators of small GTP-binding proteins"
No number assigned (PI: Y. Gu) 7/1/06-6/30/08 Ohio Cancer Research Associates
"Role of Rac GTPases in p53-mediated lymphomagenesis"
Publications, Most Recent
Gu Y (correspondence author), Siefring JE, Wang L, Chae HD, Bailey JR, Zheng Y. Oncogenic Vav1 induces Rac-dependent apoptosis via inhibition of Bcl-2 family proteins and collaborates with p53 deficiency to promote hematopoietic progenitor cell proliferation. Oncogene. 2006 Jun 29;25(28):3963-3972.
Gu Y (co-correspondence author), Chae H-D, Siefrieng JE, Jasti AC, Hildeman DA, Williams DA. A critical role of RhoH GTPase in T-cel receptor signaling and thymocyte developmemt. Nature Immunology. In press.
Gu Y, Zheng Y and Williams DA. RhoH GTPase: a key regulator of hematopoietic cell proliferation and apoptosis?Cell Cycle. 2005 Feb;4(2):201-2.
Gu Y (correspondence author), Jasti AC, Jansen M and Siefring JE. RhoH, a hematopoietic-specific Rho GTPase, regulates proliferation, survival, migration and engraftment of hematopoietic progenitor cells.Blood. 2005 Feb 15;105(4):1467-75.
Filippi MD, Harris CE, Meller J, Gu Y, Zheng Y, Williams DA. Localization of Rac2 specifies superoxide generation, actin polarity and chemotaxis in neutrophils.Nat Immunol. 2004 Jul;5(7):744-51.
Trang TT, Tannous V, Gu Y, Mosher J and Fleming RJ. The Ser+r83k mutation is a second site mutation of SerD affecting the N-terminus of serrate.Genesis. 2004 May;39(1):42-51.
Yan SJ, Gu Y, Li WX and Fleming RJ. Multiple signaling pathways and a selector protein sequentially regulate Drosophila wing development.Development. 2004 Jan;131(2):285-98.
Gu Y, Filippi MD, Cancelas JA, Siefring JE, Williams EP, Jasti AC, Harris CE, Lee AW, Prabhakar R, Atkinson SJ, Kwiatkowski DJ, Williams DA. Hematopoietic cell regulation by Rac1 and Rac2 guanosine triphosphatases.Science. 2003 Oct 17;302(5644):445-9.
Presentations, Most Recent
Gu Y, Chae H-D, Siefring JE, Jasti AC, Hildeman DA and Williams DA. The RhoH GTPase interacts with ZAP-70 kinase and is required for T cell receptor signaling and T cell development.Blood 106(11): 103a. Oral presentation at the 47th ASH meeting, Atlanta, GA. December 10-13th, 2005.
Schore R, Zheng Y, Williams DA, and Gu Y. Inhibition of the Rho GTPase, Rac, differentially inhibits proliferation of AML cell lines and may serve as a novel molecular Target.Blood 106(11): 351a. Poster presentation at the 47th ASH meeting, Atlanta, GA. December 10-13th, 2005.
Chae H-D, Lee KE, Jasti AC, Williams DA and Gu Y. Cross-talk between Rho GTPases regulates actin cytoskeleton and chemotaxis of hematopoietic progenitor cell.Blood 106(11): 81a. Oral presentation at the 47th ASH meeting, Atlanta, GA. December 10-13th, 2005.
Gu Y, Jasti AC, Jansen M, Siefring JE and Lee KE. RhoH, a hematopoietic-specific Rho GTPase, regulates proliferation, survival, migration and engraftment of hematopoietic progenitor cells.Blood 104(11): 36a. Oral presentation at the 46th ASH meeting, San Diego, CA. December 5th, 2004.
Gu Y, Siefring JE, Williams EP, Cancelas J, Jasti AC, Atkinson SJ, Kwiatkowski DJ and Williams DA. The Rho GTPases, Rac1 and Rac2, are critical regulators of hematopoietic stem cell adhesion, survival and proliferation. Exp. Hematology 31(7, supplement 1): 65. Oral Communications (Hematopoietic stem cell biology) at the 32th ISEH meeting, Paris, France. July 5-8, 2003.
Filippi M-D, Gu Y, Williams EP, Jasti AC, Rethinasamy P, Kwiatkowski DJand Williams DA. Rac1 and Rac2 play both overlapping and non-redundant roles in control of neutrophil functions.Blood 100(11): 147a. Oral presentation by M-D. Fillippi at the 44th ASH meeting, Philadelphia, PA. December 9, 2002.
Gu Y, Filippi M-D, Cancelas J, Siefring JE, Williams EP, Jasti AC, Rethinasamy P, Kwiatkowski DJ and Williams DA. The highly related Rho GTPases, Rac1 and Rac2, separately control hematopoieitc cell survival and cycle progression, but together regulate the engraftment phenotype.Blood 100(11): 191a. Oral presentation at the 44th ASH meeting, Philadelphia, PA. December 10, 2002.
Professional Organization Memberships
The American Society of Hematology (2002 - Present)
Special Interests
Rho GTPase signaling in normal and malignant hematopoiesis.
