Simon P. Hogan, PhD
Title
Associate Professor of Pediatrics
Email
simon.hogan@cchmc.org
Phone
513-636-6620
Fax
513-636-3310
Credentials
BSC: Australian National University, Canberra, Australia, 1998.
PhD: John Curtin School of Medical Research, Australian National University, Canberra, Australia, 1998.
Awards and Honors
- Crohn’s Colitis Foundation Career Development Award, 2007
- American Academy of Asthma, Allergy, and Immunology Interest Section Award
- Australian National University Postgraduate Research Scholarship
- Frank Fenner Medal for the Most outstanding PhD thesis at the John Curtin School of Medical Research, Canberra, Australia, 1998
- NHMRC CJ Martin Post-doctoral Fellowship Award, 1998
- Jaffe Family Foundation Food Allergy Research Award, American Academy of Allergy, Asthma and Immunology, 1998-2000
- Travel Grant Award, American Academy of Allergy, Asthma and Immunology, Annual Meeting, San Diego, CA, 2000
- AMRAD Post-Doctoral Fellowship Award, 2001
- ACT Tall Poppy Award, 2002
- NSW Biofirst Award, 2003
Research Grants and Contracts
Ongoing Research Support:
NIH RO1 A1073553-01(Hogan) 12/01/2007-11/30/2012
Interleukin-9 in Experimental Intestinal Anaphylaxis.
The major goal of this project is to delineate the role of IL-9 in oral antigen Sensitization and intestinal anaphylaxis.
Role: Primary Investigator
American Heart Association (AHA) 07/01/2007-06/31/2009
Beginning Grant in Aid
Mast cell derived PAF-dependent intravascular leakage in food-induced anaphylaxis.
The major goal of this project is to define the role of mast cells and PAF in intravascular leakage in experimental model of food allergy.
Role: Primary investigator.
Basic and Clinical Career Development Award; 1708 Hogan, SP (PI) 01/01/2007-01/01/2010 20%
Crohn’s and Colitis Foundation of America (CCFA) $270,000
Eosinophils and Pediatric Inflammatory Bowel Disease (IBD)
This project focuses on the role of eosinophils in steroid dependent/refractory Crohn's disease. There is no relationship with the proposed project.
Role: Primary Investigator
Publications, Most Recent
Forbes, E., Smart, S., D'Aprile, A., Henry, P., Yang, M., Matthaei, K., Rothenberg, ME., Foster, PS., Hogan, SP., (2004). T helper-2 Immunity regulates bronchial hyperresponsiveness in eosinophil-associated gastrointestinal disease in mice.Gastroenterology. 127:105-18.
Forbes, E., Murase, T., Yang, M., Matthaei, KI., Lee, JJ., Lee, NA., Foster, PS., Hogan, SP., (2004). Immunopathogenesis of experimental ulcerative colitis is mediated by eosinophil peroxidase.J. Immunology. 172(1): 5664-5675.
Smart, V., Foster, PS., Mattes, J., Rothenberg, ME., Higgins, TJV., Hogan, SP., (2005). Oral administration of peas containing bean α-Amylase inhibitor predisposes to allergy in mice.J. Agriculture and Chemistry. 53:9023-9030.
Farzaneh, P., Hassan, ZM., Pourpak, Z., Haseini, AZ., Baghestani, AR., Hogan, SP., (2005). Experimental model of pulmonary allergic inflammation induced by latex in Balb/C.Yakhteh Medical Journal, 7. No 2:92-97.
Blanchard, C., Wang, N., Stringer, KF., Mishra, A., Fulkerson, PC., Jameson, SC., Kirby, C., Konikoff, MR., Collins, MH., Akers, R., Hogan, SP., Assa'ad, AH., Putnam, PE., Aronow, B., Rothenberg, ME., (2006). Eotaxin-3 and a uniquely conserved gene-expression profile in eosinophilic esophagitis.J. Clin. Invest. 116(2):536-47.
Brandt, EB., Zimmermann, N., Muntel, EE., Pope, SM., Yamada, Y., Hogan, SP., Rothenberg, ME., (2006). The α4β7-intergrin is dramatically expressed on murine eosinophils and involved in eosinophil trafficking to the intestine.Clin. Exp. Allergy. 36:543-53.
Forbes, E., Hulett M., Ahrens, R., Tang, M., Brandt, E., Rothenberg, ME., Foster, PS., Hogan, SP., (2006). ICAM-1 dependent pathways regulate colonic eosinophilic inflammation.J. Leuko. Biol. 80:330-341.
Prescott, V., Foster, PS., Matthaei, K., Higgins, TJV., Hogan, SP., (2006). Mechanisms of food antigen-induced subcutaneous hypersensitivity responses and Th2-type pulmonary inflammation.J. Leuko. Biol. 80:258-266.
Farzaneh, P., Hassan, ZM., Pourpak, Z., Haseini, AZ., Baghestani, AR., Hogan, SP., (2006). Experimental model of pulmonary allergic inflammation induced by latex in Balb/C.Basic and Clinical Pharmacology and Toxicity. 99(6):405-11.
Hogan, SP., Seidu, L., Blanchard, C., Groschwitz, K., Mishra, A., Karow, ML., Ahrens, R., Artis, D., Murphy, AJ., Valenzuela, DM., Yancopoulos, GD., Rothenberg, ME., (2006). Resistin-like molecule (RELM)-β regulates innate colonic function: Barrier integrity and inflammation susceptibility.J. Allergy and Clin. Immunol. 118(1):257-68.
Yang, M., Rangasamy, D., Frew, AJ., Mahalingham, S., Webb, DC., Tremethick, DJ., Thompson, PJ., Hogan, SP., Matthaei, KI., Rothenberg, ME., Cowden, WB., Foster, PS., (2006). Inhibition of arginase I activity by RNA interference attenuated interleukin-13 induced airways hyperresponsiveness.J. Immunol. 15:177(8):5595-603.
Sharkhuu, T., Mahalingham, S., Hogan, SP., Rennick, DM., Matthaei, KI., Foster, P., (2006). Mechanism of IL-25 (IL-17E) induced pulmonary inflammation and airways hyperreactivity.Clin. Exp. Allergy. 36(12):1575-83
Fulkerson, PC., Fischetti, CA., Hassman, LM., Pope, SM., Hogan, SP., Rothenberg, ME., (2006). A central regulatory role for eosinophils and the eotaxin/CCR3 axis in chronic experimental asthma.Proc. Natl. Acad. Sci. USA. 103(44):16418-23
Nikolaidis, NM., Wang, TC., Hogan, SP., Rothenberg, ME., (2006). Expression of TFF2 by mucus-producing airway epithelial cells modulates allergen-induced leukocyte recruitment in experimental asthma.Exp. Lung Res. 32(10):483-497.
Bullock, JZ., Villanueva, JM., Blanchard, C., Filipovich, AH., Assa’ad, AH., Putnam, PE., Collins, MH., Hershey, GKK., Risma, KA., Akers, RM., Jameson, SC., Kirby, CL., Buckmeier, BK., Rothenberg, ME., Hogan, SP., (2006). Eotaxin-3, CCR3, and T Cell-derived IL-5 in pediatric eosinophilic esophagitis.J. Ped. Gastroenterol. Nut. July 2007, 45(1): 22-31.
Forbes, EE., Groschwitz, K., Abonia, JP., Brandt, EB., Cohen, E., Blanchard, C., Ahrens, R., Seidu, L., McKenzie R., Finkelman, FD., Foster, PS., Matthaei, K., Rothenberg, ME., Hogan, SP., (2008). IL-9/Mast cell-mediated intestinal permeability predisposes to oral antigen hypersensitivity. J. Exp. Med. 205:897-913
Ahrens, R., Beichler, A., Seidu, L., Blanchard, C., Carey, R. Willson, T., Forbes, E., Cohen, E., Ballard, E., Munitz, A., Xu, H., Lee, N., Lee, JJ., Rothenberg, ME., Denson, L., Hogan, SP. (2008). Intestinal macrophage/epithelial cell-derived CCL11/eotaxin-1 mediates eosinophil recruitment and function in Pediatric Ulcerative Colitis. Accepted. J. Immunology.
Khodoun, M., Strait, R., Orekov, T., Hogan, SP., Herbert, D., Koehl, J., Finkelman, FD. (2008). Peanuts induce shock by activating complement. Accepted. J. Allergy and Clinical Immunology.
Munitz, A., Beichler A., Seidu, L., Cole, ET., Ahrens, R., Hogan, SP., Rothenberg, ME., (2008). Resistin-like molecule α: a novel link between colonic inflammation and glucose tolerance. Accepted. J. Allergy and Clinical Immunology.
Knott, ML., Hogan, SP., Wang, Hui., Matthaei, KI., Dent, LA. (2008). FVB/N mice are highly resistant to primary infection with Nippostrongylus brasiliensis. Accepted. Parasitology.
DeBroski, RH., Wang, JQ., Hogan, SP., Groschwitz, K., Orekov, T., Perkins, C., Wan, Q., Urban Jr, JF., Rothenberg, ME., Finkelman, FD., (2008). RELM-β Mediates Th2 dependent immunity against adult gastrointestinal helminths. Submitted.
Han, X., Ren, X., Jurickova, I., Groschwitz, K., Pasternak, BA., Xu, H., Wilson, TA., Hogan, SP., Denson, LA., (2008). Regulation of intestinal barrier function by signal transducer and activators of transcription 5b. Accepted. Gut.
Munitz, A., Seidu, L., Cole, ET., Ahrens, R., Hogan, SP., Rothenberg, ME., (2008) Resistin-like molecule a decreases glucose tolerance during intestinal inflammation. Submitted.
Presentations, Most Recent
Symposium Invitation:
Gastrointestinal Microbia and Advances in Prebiotic and Probiotic Research “Animal Models of Gastrointestinal Function”, Rockville, Maryland, December 11-12, 2007.
American Gastroenterological Association Institute: Gastrointestinal Response to Injury, “Eosinophil and Mediator in Gut Mucosal Disease”, Montebello, Quebec Canada, October 3-6, 2007.
5th Biannual Symposium International Eosinophil Society, “Eosinophil, 2007”. Cliff Lodge, Snowbird, Utah, July 18-22, 2007.
5th Annual Advances in the inflammatory Bowel Disease CCFA National Research and Clinical Conference, “Eosinophils and Eosinophil Chemokines, CCL11, CCL24, and CCL26, in Refractory Pediatric Crohn’s Disease, 2006. Miami, Florida, USA, December 1-3, 2006,
North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition, “The First International Gastrointestinal Eosinophil Research Symposium, “How does Eosinophils Contribute to Inflammation?”, Orlando Florida, October 17th – 18th, 2006.
American Academy of Allergy, Asthma, and Immunology, “Pathophysiology of Eosinophil Gastrointestinal disease”, Miami Florida, March 3rd – 5th, 2006.
The Canadian Association of Gastroenterology, CDDW-2006 Symposium: It Can Be Difficult to Pass Through A Sea Of Red: Eosinophilic Disorders of the Gastrointestinal Tract, Research in the area of eosinophilic esophagitis. Banff Canada, February 24th – 27th, 2006.
Perspectives in pediatric Gastroenterology, International Symposium: Food Allergy in child hood causes and consequences “eosinophil associated GI diseases”, Fulda Germany, February 8-10, 2006.
BCTS/BCSAI Case Challenge and CME, “Role of IL-5 in Respiratory and Systemic Eosinophilia”. British Columbia Children’s Hospital, Vancouver, BC. January 21, 2006
BCTS/BCSAI Case Challenge and CME, “Targeted Therapies for Eosinophilic Diseases” British Columbia Children’s Hospital, Vancouver, BC. January 20, 2006.
Fifth Multi-Disciplinary International Symposium, “Reflux Disease and Pulmonary Complication: Aspiration Syndrome”, February, 24, 2005, Miami, Florida.
SHS North America Pediatric Conference Advances in Gastrointestinal Food Allergy, October 29th 2004, Vancouver, British Columbia, Canada.
60th Annual Meeting of The American Academy of Allergy, Asthma and Immunology, Symposium, “Food Allergy: What’s new from the bench”, March 2004.
Transgenic Plants, Vaccines and Allergens. Vaccines and Vaccinations in the 21st Century. The 10th Frank and Bobbie Fenner Conference. October 20th-22nd 2002, Canberra Australia.
Eosinophils at mucosal surfaces. Meeting of the Federation of Brazilian Societies for Experimental Biology. August 22-25, 2001, in Caxambu, Minas Gerais, Brazil.
Molecular Mechanisms of Allergic Inflammation, Mini-Symposium, “Role of eotaxin and IL-5 in eosinophil-associated gastrointestinal allergic inflammation”, Children’s Hospital Medical Center, Cincinnati, Ohio, May 2000.
55th Annual Meeting of The American Academy of Allergy, Asthma and Immunology Annual Meeting, “Life-Cycle of the eosinophil”, Orlando, Florida, March 1999.
“Cytokine and Chemokine Receptors: Role of Allergic Inflammation”, McGill University, Montreal, Canada, February 1999.
The Australian Pediatric Respiratory Group and The Pediatric Immunology/Allergy Group Annual Meeting, Twin Towers, Queensland, May 1996.
Curtin Conference, “Cytokines and the Immune Response”, Canberra, Australia, January 1996.
National Asthma Conference, “Cells and Cytokines”, Hilton on the Park, Melbourne, October 1995.
National Asthma Workshop, Prince of Wales Medical Research Institute, Prince of Wales Hospital, Sydney, Australia, November 1994.
Division of Allergy and Immunology, Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio, USA, December, 2007
Personal Invitation:
“Eosinophil and IBD”. Department of Gastroenterology, Queen’s University, Kingston, ON. Canada, June 2008.
IL-9/Mast cells and Food anaphylaxis. Department of Molecular and cellular Physiology, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA, June, 2007.
Pediatric Grand Rounds, “Eosinophil Gastrointestinal Disease (EGID)”. British Columbia Children’s Hospital, Vancouver, BC. January 20, 2006
“Eosinophil-Associated Gastrointestinal Allergy: Mechanisms and Implications.” Discipline of Immunology & Microbiology, Faculty of Health, University of Newcastle, Newcastle Australia October 2002.
“Potential Impact of GM plants on health and disease”, Plant Biotechnology Center, Kansas State University, Kansas, USA, July 2002.
Grand Rounds “Potential Impact of GM plants on health and disease”, Mayo Clinic Scottsdale Arizona, USA, July 2002.
Eosinophils at mucosal surfaces: August 22-25, 2001, Department of Immunology, University Sao Paulo, Sao Paulo, Brazil.
Special Interests
Allergies; food allergies; eosinophil biology; gastrointestinal inflammation
Related Areas
This person works in these other areas at Cincinnati Children's Hospital Medical
Center:
